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This work aims to create and validate a Bilingual Video Material (BVM), supported by the concepts of Environmental Education (EE), Green Chemistry (GC) and Sustainable Development Goals (SDGs) in an inclusive class of the high school level in Brazil, thus enabling the inclusion of the deaf in a more accessible way, based on the cultural artifacts of the Deaf Community. Therefore, through a qualitative and participatory research, it was possible to verify the efficiency in the adoption of the bilingual teaching methodology. This didactic strategy proved to be a great ally of accessibility (in Portuguese and in Brazilian Sign Language - LIBRAS) for the inclusion of deaf people, especially when based on the contextualization with EE, GC and SDGs in an interdisciplinary approach.

The year 2020 was marked by the beginning of the intense journey against Covid-19, which brought strong impacts to Brazilian education. In view of this, the educational system began to adapt to the “new normal” and, with this, problems arose in adapting to virtual education, especially in the scope of School Inclusion (SI) of the deaf public, since social distancing requires significant attention in the use of aspects of communication and online technologies. These difficulties were more prominent, especially in the discipline of Chemistry, which is not detached from experimentation. Thus, the research demonstrates the need for better approaches to SI in Emergency Remote Education (ERE), especially in Chemistry contextualized to Environmental Education (EE). This work aims to adopt Active Methodologies (AM) and it is justified in offering activities aimed at the interassociations between Chemistry and EE, through the Case Study (CS) method. These actions addressed the principles of Green Chemistry (GC) and the 6th Sustainable Development Goal (SDG) on drinking water and sanitation. The development of the work occurred remotely in an inclusive class. The results of the research demonstrated the importance of using inclusive methodologies that favor the construction of effective knowledge and enable the exchange of knowledge in a bilingual and accessible environment. Thus, the adaptation or development of new didactic methodologies can change the reality of Brazilian education.

The Covid-19 pandemic brought several challenges to the educational system with regard to the continuity of classes in the context of an Emergency Remote Education (ERE). Among these challenges, we highlight the intensification of disinterest and low participation of students in chemistry classes and the insufficiency of didactic proposals that work with School Inclusion (SI), with a focus on accessibility for the deaf. The ERE model lasted 2 (two) years, after this period, teachers had to face a new change in the school scenario: Post-pandemic Face-to-Face Teaching (post-pandemic FFT). Thus, with the return to classes, the challenges mentioned were accentuated, bringing again the demand for the adoption of new educational strategies. Within this context, this article is justified in the development of a pedagogical intervention focused on the inclusive teaching of Chemistry in the post-pandemic FFE, linked to the principles of Green Chemistry (GC) and the 6th Sustainable Development Goal (SDG). This action aimed at the elaboration of accessible didactic materials, together with the application of an experimental, contextualized, and sustainable practical class called: Batch Adsorption with activated charcoal from the endocarp of the coconut (biodegradable adsorbent). The results of the research showed that the adoption of the contextualization methodology, concomitantly with the development of the practical activity, pointed to an improvement in the teaching of Chemistry in the post-pandemic face-to-face model. Therefore, sustainable experimentation effectively contributed to the learning process and a more critical look at the socio-environmental issues discussed.

Existe uma crescente preocupação quanto as boas práticas de manipulação de medicamentos estéreis em unidades hospitalares, devido ao próprio ambiente de manipulação e ao público que fará uso desses produtos. A identificação da microbiota da sala limpa na Unidade de Manipulação de Antineoplásicos (UMA) de um hospital terciário de Brasília, teve como objetivo avaliar a qualidade do serviço executado e sugerir correções caso necessário. A metodologia empregada baseou-se nas RDC n°67/2007 e RDC n°220/2004 da Agência Nacional de Vigilância Sanitária, como também na Farmacopéia dos Estados Unidos (USP), considerando dois tipos de acompanhamentos: ambiental e operacional. O monitoramento ambiental foi realizado a partir da identificação de microrganismos do ar e das superfícies, em condições de operação e em repouso empregando placas de Petri com ágar nutriente; e o monitoramento operacional foi realizado a partir da avaliação microbiológica da luva do farmaceutico, que foi autorizado pelo Comitê de Ética Humano da Universidade de Brasília. Em ambas situações avaliadas – in process e at rest houve contagem microbiana da ordem de 6,09 e 1,58 unidades formadoras de colônia (UFC), respectivamente. Como resultado verificou-se que quanto maior o número de movimentação de pessoas dentro da área limpa e o número de medicamentos manipulados durante o processo, mais dificil é manter as condições exigidas pela legislação. Os microrganismos identificados são comuns em área de manipulação de estéreis, devido a presença do manipulador e das condições estruturais da área limpa, por isso a necessidade constante de treinamento do pessoal e adequação das condições estruturais do ambiente para melhor atender as exigências da legislação

In the Brazilian semi-arid, sustainable growth rates and higher standards of living in society may be attained by the use of irrigation aiming at obtaining the best economical function without disregarding several factors, such as labor, soil, and water supply. The objective of this work is presenting an alternative design procedure for low-head bubble irrigation systems so as to make the technology more accessible to users. An electronic spreadsheet was developed and made available for sizing laterals and delivery hoses at ground level based on the principles of mass conservation, energy conservation and friction head loss. 9 combinations of spacings between plants and between rows were used with different lateral lengths, resulting in 22 designs operating at 9.8 kPa (1 m.w.c). Designs were subjected to hydraulic and efficiency tests. Uniformities of water application were computed using Christiansen’s uniformity coefficient and distribution uniformity coefficients. Designs were ranked according to the proposed classification of Mantovani. Irrigation uniformities, above the recommended limits and with low variability across designs, allow us to conclude that the design procedure for the proposed irrigation system is feasible.

Capillary zone electrophoresis with direct UV detection (CZE-UV) was used to investigate the hypothesis about the extract of Baccharis trimera enzymatic activities as an analytical approach to monitoring the phenomenon.The aim of this work was to investigate enzymatic bioactivities of the hydroalcoholic and infusion extracts of B. trimera through screening evaluation of the inhibition of the enzymes acetylcholinesterase (AChE) and α-glycosidase (α-GLY).An alternative approach using CZE-UV to hydroalcoholic and infusion extracts of B. trimera monitoring was applied to evaluate the inhibition ability of the enzymes AChE and α-GLY. The result of the reaction of acetylthiocholine (AThCh) with AChE was thiocholine (TCh) and acetic acid, and from the amount of TCh generated, the AChE inhibition was calculated. For the inhibition study of the two enzymes, the reactions of the extracts were optimised to be performed in situ, inside the capillary column, and the introduction of the solutions was performed through ordered sequential plug injections.Samples extracted with 70% ethanol presented 7.80% inhibition for AChE and 0.51% for α-GLY, while samples extracted with 96% ethanol resulted in 6.89% inhibition for AChE and no inhibition activity for α-GLY.In the present work, the potentialities of CZE-UV for the study of hydroalcoholic and infusion extracts of B. trimera were demonstrated. The experimental results were useful for the calculation of the percentage of the inhibition activities of the AChE and α-GLY enzymes.

Argumentamos neste artigo que a prática copie e cole, presente nas produções que recebem o nome de “escrita não criativa” (ENC) (GOLDSMITH, 2015), tem como marco a noção de colaboração desenvolvida a partir de 1968, e consolidada com a difusão da internet provocada pela criação da World Wide Web (www), em 1989. Discutiremos que tais característicos inserem o apropriacionismo do século XXI numa lógica que dialoga com as mudanças tecnológicas de nosso tempo baseada na manipulação de materiais já existentes, tal como o fazemos corriqueiramente no traslado de arquivos digitais diversos de um lugar a outro, alterando-os como, quando e o quanto quisermos; ou quando acrescentamos, modificamos ou suprimimos linhas em arquivos open source, como o Linux, ou do tipo Wikipedia. Assim como usuários e programadores manipulam dados que estão à disposição e lançam mão sobre eles, movendo a linguagem de lugar sob aspectos colaborativos, artistas podem se sentir à vontade a utilizarem procedimentos semelhantes na produção de obras literárias voltando-se para intervenções, enxertos, citações e plágio intencional. Nosso objetivo é discutir a cópia como procedimento a partir dessas questões, recorrendo a teóricos como Nathalie Heinich (2014), Reinaldo Laddaga (2012), Teixeira Coelho (2019) e Pedro Dolabela Chagas (2018). Tentaremos contextualizar a ENC a partir de nossa premissa, comentando obras como Traffic, de Kenneth Goldsmith (2007), Ensaio sobre os mestres, de Pedro Eiras (2017) e Sessão, de Roy David Frankel (2017). Encerraremos com uma lista de trabalhos que, em nosso entendimento, operam a lógica que nos empenharemos por tratar.

Before the covid-19 pandemic paradigm, the education sector has been facing several challenges. Especially in the Chemistry area, the subjectivity and complexity conditions are admitted by many students when it is about teaching the content of this science. Furthermore, the promotion of active methodologies for teaching Inclusive Chemistry is deficient, mainly, methodologies which contemplate the particularities of the deaf community. In this context, the purpose of the present work is to offer remote teaching activities that addressed the content of Organic Chemistry in a contextualized way with environmental awareness regarding Urban Waste (RU), involving the principles of Inclusive Education (IE) for a high school class consisting of hearing and deaf students from a public school in Brazil. As for the methodology, the research was based on a qualitative and participatory perspective. Aiming at a methodological proposal which contemplates the students´ educational gaps, especially the deaf population, such as accessibility in Brazilian Sign Language (LIBRAS), the classes were contextualized with support by Digital Information and Communication Technologies (TDICs). Based on the activities carried out in the school environment, it was possible to verify continuous participation of all students, especially, in the activity which involved the water pollution simulator using the "Mozaik Education" software and showing how water pollution occurs upon contact with wastewater in a safe way. Therefore, the teaching resources used in this study were efficient, because they are facilitating agents in the knowledge acquisition process.

Objective: To review the literature on complications associated with facial filling with hyaluronic acid. Materials and Methods: This study consisted of a literature review based on national and international databases such as: PubMed and SciELO. Results and Discussion: 14 studies were selected, where the existence of several complications related to the use of hyaluronic acid can be observed, early side effects can occur, which are those that appear soon after application and persist for around 15 days and can also late side effects occur. Conclusions: Despite all the safety of the filling technique with hyaluronic acid, complications can occur, requiring the professional to be able to intervene in these situations.

O Transtorno do Espectro Autista (TEA) é uma alteração do desenvolvimento neurológico com início precoce, caracterizado por comprometimento das habilidades sociais e da linguagem, além de comportamentos estereotipados. Pacientes com TEA são indivíduos que representam um grande desafio para os cirurgiões-dentistas, devido às suas manifestações clínicas complexas e variadas, sendo assim, o tratamento odontológico para este grupo, muitas vezes, é considerado desafiador para os pais e para os profissionais. Esse trabalho objetivou-se avaliar a percepção dos pais de pacientes com TEA sobre o uso da sedação leve à moderada no atendimento odontológico. Foi realizado uma pesquisa com estudo descritivo e uma abordagem qualitativa para responder às questões dinâmicas e complexas propostas aos pais sobre sedação leve à moderada em pacientes com Transtorno do Espectro autista. A pesquisa foi realizada em um consultório particular, na cidade de João Pessoa, Paraíba. Os sujeitos do estudo foram pais de pacientes com autismo que tenham sido sedados ao menos uma vez em consulta odontológica. Os entrevistados demonstraram bastante satisfação com o uso da sedação no atendimento odontológico de pacientes com TEA. A pesquisa irá contribuir proporcionando uma realidade mais assertiva devido à experiência pessoal com os filhos submetidos a sedação durante atendimento odontológico.

The filamentous actinomycete that produces the antibiotic GE23077 was isolated by the Lepetit Research Group from a soil sample collected in Thailand, and it was classified as a member of the genus Actinomadura on the basis of its morphology and cell-wall composition. Phylogenetic analysis based on 16S rRNA gene sequences indicated that this strain formed a distinct monophyletic line within the genus Actinomadura, and it was most closely related to Actinomadura bangladeshensis DSM 45347T (99.31 % similarity) and Actinomadura mexicana DSM 44485T (98.94 %). The GE23077-producing strain formed an extensively branched, non-fragmented vegetative mycelium; no pseudosporangia were formed and the arthrospores were organized in slightly twisted chains. The cell wall contained meso-2,6-diaminopimelic acid and the diagnostic sugar was madurose. The predominant menaquinone was MK-9(H6), with minor amounts of MK-9(H8) and MK-9(H4). The diagnostic phospholipids were phosphatidylinositol and diphosphatidylglycerol. The major cellular fatty acids were C16 : 0 and tuberculostearic acid (10-methyloctadecanoic acid), followed by minor amounts of C18:1ω9c, C16:1ω7c and 10-methylheptadecanoic acid. The genomic DNA G+C content was 71.77 mol%. Significant differences in the morphological, chemotaxonomic and biochemical data, and the low DNA–DNA relatedness between the GE23077-producing strain and closely related type strains clearly demonstrate that it represents a novel species of the genus Actinomadura , for which the name Actinomadura lepetitiana sp. nov. is proposed. The type strain is NRRL B-65521T(=LMG 31258T=DSM 109019T).

Objetivo: Relatar a experiência da preparação do centro cirúrgico de um hospital universitário brasileiro para o atendimento de cirurgias em pacientessuspeitos e confirmados de COVID-19. Método: Relato da experiência do centro cirúrgico de um hospital universitário do Nordeste do Brasil, em março e abrilde 2020, para o atendimento durante a pandemia da COVID-19. Resultados: A implementação do protocolo de atendimento a pacientes suspeitos e confirmadosde COVID-19 foi realizada por meio da sua elaboração por um time de profissionais norteados por diretrizes nacionais e internacionais, treinamentos e atualizações.Os ciclos de aprimoramento permitiram que o protocolo fosse aperfeiçoado ao longo dos dois meses relatados. Barreiras e facilitadores para o processosão discutidos e estratégias são elaboradas para adequações possíveis. Conclusão: Houve adequação de protocolos assistenciais relacionados à rotina de fluxo depacientes e da assistência em sala operatória no intuito de melhor atender os pacientes e reduzir os riscos de contaminação de outros pacientes e profissionais.

Background: The Frontal Behavioral Inventory (FBI) is a questionnaire designed to quantify behavioral changes in frontotemporal dementia (FTD). Literature showed heterogeneous FBI profiles in FTD versus Alzheimer’s disease (AD) with variable occurrence of positive and negative symptoms. Objective: In this study, we constructed a short FBI version (i.e., mini-FBI) with the aim to provide clinicians with a brief tool for the identification of early behavioral changes in behavioral variant of FTD (bvFTD), also facilitating the differential diagnosis with AD. Methods: 40 bvFTD and 33 AD patients were enrolled. FBI items were selected based on internal consistency and exploratory factor analysis. Convergent validity of mini-FBI was also assessed. A behavioral index (i.e., B-index) representing the balance between positive and negative mini-FBI symptoms was computed in order to analyze its distribution in bvFTD through a cluster analysis and to compare performance among patient groups. Results: The final version of the mini-FBI included 12 items, showing a significant convergent validity with the Neuropsychiatric Inventory scores (rp = 0.61, p

The article focuses on the development of innovative supply relationships that allow the use of openness innovations. At the same time, firms that want to implement these innovations must redesign their production processes. The research is basedon an in-depth study of 10 business cases of medium-sized firms belonging to a clothing sub-sector, that of knitwear. The findings have important managerial implications considering that the innovative supply chain processes, in which a leading role is assumed by firms operating in the so-called traditional manufacturing sectors, generate an increase in flexibility of the entire supply chain.

Background: Severe socio-emotional impairments characterize the behavioral variant of frontotemporal dementia (bvFTD). However, literature reports social cognition disorders in other dementias. Objective: In this study, we investigated the accuracy of social cognition performances in the early and differential diagnosis of bvFTD. Methods: We included 131 subjects: 32 bvFTD, 26 Alzheimer’s disease (AD), 16 primary progressive aphasia (PPA), 17 corticobasal syndrome (CBS), and 40 healthy control (HC). Each subject completed the Ekman 60 faces (Ek-60F) test assessing basic emotion recognition and the Story-based Empathy Task (SET) assessing attribution of intentions/emotions. A combined social measure (i.e., Emotion Recognition and Attribution (ERA) index) was calculated. One-way ANOVA has been used to compare performances among groups, while receiver operating characteristic (ROC) curve tested measures ability to distinguish subjects with and without bvFTD. Results: Ek-60F and ERA index scores were significantly lower in bvFTD versus HC, AD, and PPA groups. ROC analyses significantly distinguished bvFTD from HC (AUC 0.82–0.92), with the Ek-60F test showing the highest performance, followed by the ERA index. These two social measures showed the best accuracy in detecting bvFTD from AD (AUC 0.78–0.74) and PPA (AUC 0.80–0.76). Investigated measures failed in detecting bvFTD from CBS. Conclusion: Accuracy analyses support the advantage of using social cognition tests for bvFTD diagnosis. Short social battery may reduce uncertainties and improve disease identification in clinical settings. We recommend a revision of current clinical criteria considering neuropsychological deficits in emotion recognition and processing tasks as key cognitive markers of this neurodegenerative syndrome.

Introduction Treatment of cancer-associated venous thromboembolism (CAVTE) remains challenging. The aim of this study was to assess the outcomes of direct acting oral anticoagulants (DOAs) for the treatment of CAVTE. Materials and methods A network meta-analysis of randomized clinical trials comparing DOAs (Apixaban, Rivaroxaban, and Edoxaban) versus Dalteparin for the treatment of CAVTE was performed. Outcomes of interest included, VTE recurrence, all-cause mortality, event-free survival, major bleeding, and clinically relevant non-major bleeding (CRNMB). Analysis was based on a random effects model and Bayesian Markov-chain Monte Carlo method was used for indirect comparisons. Results Four RCTs involving 2894 patients were included. Overall certainty of evidence was moderate regarding all outcomes. DOAs exhibited lower risk of VTE (RR 0.62; 95% CI 0.44, 0.87; P = 0.007), similar risk of major bleeding (RR 1.33; 95% CI 0.84, 2.11; P = 0.23), and higher risk of CRNMB (RR 1.66, 95% CI 1.08, 2.56; P = 0.02), compared with Dalteparin. Risk of all-cause mortality and event-free survival were similar between groups with RR 0.99 (95% CI 0.84, 1.16) and RR 1.03 (95% CI 0.94, 1.13), respectively. Apixaban ranked first for recurrent VTE (42.4%) and major bleeding (62.3%) and Dalteparin ranked first for CRNMB (54.7%). Rivaroxaban ranked best considering all-cause mortality (58.7%); Apixaban ranked best for event-free survival (83.6%). Conclusions DOAs presented a reduced risk of recurrent VTE with similar risk of major bleeding compared to Dalteparin. However, a higher risk of CRNMB is expected when this cohort of patients are treated with DOAs instead of Dalteparin.

O artigo apresenta um estudo teórico que teve como objetivo analisar as inspirações recentes da Educação Matemática Crítica (EMC), quando comparadas com os eventos que motivaramsua criação por Ole Skovsmose na década de 70. A entrevista dada por Skovsmose à Revista Paranaense de Educação Matemática, em 2012, sobre a criação da EMC, é tomada como base e pontode partida para o presente estudo. Essa mesma revista, em 2017, publicou uma edição especial sobre EMC com dezesseis artigos científicos. Como procedimento metodológico, realizou-se uma metaanálise desses artigos. Percebeu-se que noções da EMC são amplamente utilizadas pelos autores desses textos para compreender e refletir sobre a sala de aula de Matemática, sendo que a maioria faz referência aos cenários para investigação e o paradigma do exercício. Essas duas noções são apresentadas, na língua portuguesa, por Ole Skovsmose, em uma publicação no BOLEMA em 2000. No referido texto, o educador matemático traz uma matriz de ambientes de aprendizagem, a qual é utilizada explicitamente em cinco dos 16 artigos analisados com duas intenções: produzir novos conhecimentos teóricos para discutir e evidenciar aspectos antes não apontados diretamente na matrize analisar situações relacionadas às aulas de Matemática. Os movimentos feministas e estudantis que motivaram as teorias críticas continuam refletidos nas pesquisas atuais. Percebe-se, ainda, uma ascensão da educação inclusiva e financeira dentro da EMC.

Las infecciones respiratorias agudas (IRA) son una causa habitual de morbimortalidad en infantes y los virus respiratorios son los agentes causales más frecuentes. El objetivo de este trabajo fue determinar la frecuencia de patógenos respiratorios, sus características y la evolución clínica de infantes menores de dos meses internados por IRA. Se realizó un estudio retrospectivo que comprendió 5 anos ˜ (2008-2011, 2014-2016). Se estudiaron los virus respiratorios y las bacterias atípicas utilizando el panel respiratorio FilmArray. Se evaluaron las características demográficas y clínicas, así como la evolución durante la internación. En 137 infantes menores de dos meses internados por IRA se determinó una positividad del 94,9% en 117 lactantes con infección adquirida en la comunidad (IRA-C) y del 20,0% en 20 lactantes que adquirieron la infección durante su hospitalización en la unidad de cuidados intensivos neonatal (IRA-N) (p < 0,001). En los infantes con IRA-C los virus más frecuentes fueron sincicial respiratorio (RSV) (52,1%) y rinovirus/enterovirus (RV/EV) (41,0%). Se determinaron coinfecciones en un cuarto de los infantes, la combinación RSV-RV/EV fue la más frecuente. En los infantes con IRA-N se detectó RV/EV, RSV o parainfluenza-3 como únicos patógenos. La mayoría de los infantes con IRA-C presentaron IRA baja (81,2%), mientras que más de la mitad de los infantes en UCIN tenían IRA alta (55,0%). La mediana de la duración de la internación en infantes con IRA-C fue de 4 días (RIC: 2-6). Los infantes positivos con IRA-N tuvieron una mediana de internación más larga (71 días [RIC: 42-99]) en comparación con los infantes negativos (58 días [RIC: 49-71]) (p = 0,507). Los virus respiratorios fueron los principales agentes causales de IRA adquirida en la comunidad en infantes menores de dos meses que requirieron internación; los virus más frecuentes fueron RSV y RV/EV. Aunque se observó una baja tasa de positividad de patógenos en infantes con infección nosocomial, estos agentes podrían prolongar la duración de la internación. Lower acute respiratory infections (ARI) are a frequent cause of morbidity and mortality in infants, respiratory viruses being the major causative agents. The aim of this work was to determine the respiratory pathogen frequency, the clinical characteristics and the outcome in infants

In this cross-sectional analysis, 140 patients diagnosed with deep vein thrombosis (DVT) of the lower limbs and submitted to Doppler ultrasound (DU) were initially assessed. The ratio between left and right limbs (L:R Ratio) was 1.71:1 for all patients, 2.53:1 for females and 1.03:1 for males (p = 0.0201). L:R Ratio showed a linear correlation in all affected segments (p = 0.0020).

Uma das premissas da escrita não criativa prevê que o procedimento (o copie e cole) seja tão ou mais importante que o resultado final da obra, legando à audiência o entendimento que melhor lhe aprouver (GOLDSMITH, 2015). Queremos discutir formas desse “entendimento”, considerando alguns conceitos da neurociência, em particular os que se detêm sobre a relação mente, corpo e estética – a neuro-estética. Com o desenvolvimento das ciências cognitivas, passou-se à discussão dos processos artísticos, na qual termos como “emoção”, “sentimento estético”, “empatia” etc., foram vistos como objetos que funcionam segundo regras identificáveis na naturalização da relação espectador-obra-autor (COUCHOT, 2018). Exporemos o “não original” a isso, arriscando comentar obras como Traffic (2007), Trânsito (2016) e Hillary: The Hillary Clinton emails (2019), de Kenneth Goldsmith, Statement of facts, de Vanessa Place (apud Goldsmith, 2015), e a instalação Uma e três cadeiras (1965), de Joseph Kosuth.

Neste artigo, discutimos preocupações urgentes da Educação Matemática Crítica por meio de cenários que buscam problematizar a importância de se refletir sobre equidade e justiça social noatual contexto em que vivemos. Em um primeiro momento, apresentamos uma fundamentação teórica que estabelece entendimentos acerca de equidade e justiça social, além disso, algumas implicações para a educação matemática. Em seguida, discutimos três crônicas, as quais buscam ilustrar a relevância dos temas centrais deste artigo. Enfatizamos que práticas promovedoras de equidade não podem estar desvinculadas de questões de justiça social, determinantes sociais, discussões sobredesigualdades sociais, bem como das disparidades socioeconômicas que provocam tais desigualdades.

Made available in DSpace on 2021-06-25T12:21:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-06 Background The COVID-19 pandemic has made a significant impact on all spheres of society. The objective of this study was to examine the impact of COVID-19 on the practices, finances, and social aspects of Brazilian vascular surgeons' lives. Methods This is a descriptive analysis of the responses from Brazilian vascular surgeons to the cross-sectional anonymous Society for Vascular Surgery Wellness Task Force Pandemic Practice, Anxiety, Coping, and Support Survey for Vascular Surgeons disseminated 14-24 April 2020. Survey dissemination in Brazil occurred mainly via the Brazilian Society of Angiology and Vascular Surgery (SBACV) and social media. The survey evaluated the impact of the COVID-19 pandemic on vascular surgeons' lives by assessing COVID-19-related stressors, anxiety using theGeneral Anxiety Disorder (GAD)-7 scale, and coping strategies using the Brief Coping Orientation to Problems Experienced (Brief-COPE) inventory. Results A total of 452 responses were recorded from Brazil, with 335 (74%) respondents completing the entire survey. The majority of respondents were males (N = 301, 67%) and practiced in an urban hospitals. The majority of respondents considered themselves at high risk to be infected with COVID-19 (N = 251, 55.8%), and just over half the respondents noted that they had adequate PPE at their primary hospital (N = 171, 54%). One hundred and nine (35%) surgeons confirmed that their hospitals followed professional surgical society guidelines for prioritizing surgeries during the pandemic. At the time of the survey, only 33 (10%) surgeons stated they have pre-operative testing of patients for COVID-19 available at their hospital. Academic vascular surgeons reported being redeployed more often to help with other non-vascular duties compared to community-based or solo practitioners (43% vs. 30% vs. 21% respectively,P = .01). Severe anxiety due to pandemic-related financial concerns was similar in those surgeons practicing solo compared to those in community- or academic-based/group practice (46% vs. 38% vs. 22%;P = .54). The respondents reported their anxiety levels as mild based on the stressors investigated instead of moderate-severe (54% vs. 46%;P = .04). Social media was utilized heavily during the pandemic, with video gatherings being the most commonly used tool (76%). Self-distraction (60%) and situational acceptance (81%) were the most frequently reported coping mechanisms used among Brazilian vascular surgeons. Conclusion The COVID pandemic has greatly affected healthcare providers around the world. At the time of this survey, Brazilian vascular surgeons are reporting low anxiety levels during this time and are using mostly active coping mechanisms. Univ Colorado, Anschutz Med Ctr, Div Vasc Surg & Endovasc Therapy, Aurora, CO USA Sao Paulo State Univ, Div Vasc Surg, Botucatu Sch Med, Botucatu, SP, Brazil McLaren Hlth Syst, Vasc & Endovasc Surg, Bay City, MI USA New York Presbyterian Weill Cornell Sch Med, New York, NY USA Univ Texas Houston, Dept Cardiovasc Surg, Houston, TX USA Spectrum Hlth Med Grp, Vasc Surg, Grand Rapids, MI USA Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA Louisiana State Univ, Hlth Sci Ctr, Div Vasc & Endovasc Surg, New Orleans, LA USA Univ Calif Los Angeles, Div Vasc Surg, Los Angeles, CA USA Univ Washington, Dept Surg, Div Vasc Surg, Seattle, WA 98195 USA Sao Paulo State Univ, Div Vasc Surg, Botucatu Sch Med, Botucatu, SP, Brazil

Background Corticobasal syndrome (CBS) is the usual clinical presentation of patients with corticobasal degeneration pathology. Nevertheless, there are CBS individuals with postmortem neuropathology typical of Alzheimer's disease (AD). Objective In this study, we aim to detect FDG-PET metabolic signatures at the single-subject level in a CBS sample, also evaluated with cerebrospinal fluid (CSF) markers for AD pathology. Methods 21 patients (68.9±6.4 years; MMSE score = 21.7±6.3) fulfilling current criteria for CBS were enrolled. All underwent a clinical-neuropsychological assessment and an instrumental evaluation for biomarkers of neurodegeneration, amyloid and tau pathology (i.e., FDG-PET imaging and CSF Aβ42 and tau levels) at close intervals. CBS subjects were classified according to the presence or absence of CSF markers of AD pathology (i.e., low Aβ42 and high phosphorylated tau levels). Optimized voxel-based SPM procedures provided FDG-PET metabolic patterns at the single-subject and group levels. Results Eight CBS had an AD-like CSF profile (CBS-AD), while thirteen were negative (CBS-noAD). The two subgroups did not differ in demographic characteristics or global cognitive impairment. FDG-PET SPM t-maps identified different metabolic signatures. Namely, all CBS-AD patients showed the typical AD-like hypometabolic pattern involving posterior cingulate cortex, precuneus and temporo-parietal cortex, whereas CBS-noAD cases showed bilateral hypometabolism in fronto-insular cortex and basal ganglia that is typical of the frontotemporal lobar degeneration spectrum. Discussion These results strongly suggest the inclusion of FDG-PET imaging in the diagnostic algorithm of individuals with CBS clinical phenotype in order to early identify functional metabolic signatures due to different neuropathological substrates, thus improving the diagnostic accuracy.

Resumo Estudos sobre violência no século XVIII abrangem especialmente questões relacionadas à justiça e à criminalidade, mas não à saúde. A pesquisa objetivou compreender como os corpos nas Minas Gerais setecentistas eram afetados por atos violentos. Foram investigados autos de devassas do termo de Vila Rica pertencentes ao acervo do Arquivo Histórico do Museu da Inconfidência. Os resultados mostraram crimes causados por motivos distintos e de tipologias diferentes, predominando os crimes contra o corpo, com consequentes lesões corporais provocadas predominantemente por objetos/instrumentos perfurocortantes. Os homens foram os mais acometidos, sendo a cabeça a principal região atingida. Atos criminosos e violentos, muito comuns nessa sociedade, interferiam na saúde e no adoecimento dos corpos. Abstract Studies into violence in the eighteenth century tend to address questions related to justice and criminality, but not health. The aim of this study is to understand how, in eighteenth century Minas Gerais, Brazil, bodies were affected by violent acts. The investigation records from the parish of Vila Rica held at the historical archive of the Museu da Inconfidência were investigated. The results showed crimes of different kinds associated with a variety of motives, primarily crimes against the body, with the resulting bodily injuries being caused by sharp or pointed objects/instruments. There were more male victims than female, the head being the principal part of the body affected. Criminal and violent acts, very commonplace in this society, interfered in the health and disease processes of the bodies.

In order to identify those potatoes which exert a low glycemic impact after processing, eight early potato varieties and four processing methods were evaluated for their total starch content, amylose content, rapidly digestible starch (RDS), slowly digestible starch (SDS), and resistant starch (RS), estimated glycemic index (eGI), glycemic load (eGL) as well as their relationship among each other. While all these profiles were highly dependent on the potato variety and processing methods, all the eight varieties were classified as low GL foods (p ≤ 0.05). A strong positive correlation was observed between eGI and RDS (r = 0.84, 0.79, and 0.74) for retrograded and reheated, baked and microwaved varieties, respectively), whereas a moderate negative correlation was observed between eGI and RS for retrograded and reheated (r = -0.39) and microwaved (-0.37) varieties (p ≤ 0.05). On the basis of these findings, it can be concluded that potato variety, processing methods, and starch characteristics define the eGI and eGL. Furthermore, for the varieties examined, the present study identified RDS as a major starch factor contributing to eGI.

Made available in DSpace on 2022-04-29T08:46:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 Background: Patients hospitalised with COVID-19 are at risk for thrombotic events after discharge; the role of extended thromboprophylaxis in this population is unknown. Methods: In this open-label, multicentre, randomised trial conducted at 14 centres in Brazil, patients hospitalised with COVID-19 at increased risk for venous thromboembolism (International Medical Prevention Registry on Venous Thromboembolism [IMPROVE] venous thromboembolism [VTE] score of ≥4 or 2–3 with a D-dimer >500 ng/mL) were randomly assigned (1:1) to receive, at hospital discharge, rivaroxaban 10 mg/day or no anticoagulation for 35 days. The primary efficacy outcome in an intention-to-treat analysis was a composite of symptomatic or fatal venous thromboembolism, asymptomatic venous thromboembolism on bilateral lower-limb venous ultrasound and CT pulmonary angiogram, symptomatic arterial thromboembolism, and cardiovascular death at day 35. Adjudication was blinded. The primary safety outcome was major bleeding. The primary and safety analyses were carried out in the intention-to-treat population. This trial is registered at ClinicalTrials.gov, NCT04662684. Findings: From Oct 8, 2020, to June 29, 2021, 997 patients were screened. Of these patients, 677 did not meet eligibility criteria; the remaining 320 patients were enrolled and randomly assigned to receive rivaroxaban (n=160 [50%]) or no anticoagulation (n=160 [50%]). All patients received thromboprophylaxis with standard doses of heparin during hospitalisation. 165 (52%) patients were in the intensive care unit while hospitalised. 197 (62%) patients had an IMPROVE score of 2–3 and elevated D-dimer levels and 121 (38%) had a score of 4 or more. Two patients (one in each group) were lost to follow-up due to withdrawal of consent and not included in the intention-to-treat primary analysis. The primary efficacy outcome occurred in five (3%) of 159 patients assigned to rivaroxaban and 15 (9%) of 159 patients assigned to no anticoagulation (relative risk 0·33, 95% CI 0·12–0·90; p=0·0293). No major bleeding occurred in either study group. Allergic reactions occurred in two (1%) patients in the rivaroxaban group. Interpretation: In patients at high risk discharged after hospitalisation due to COVID-19, thromboprophylaxis with rivaroxaban 10 mg/day for 35 days improved clinical outcomes compared with no extended thromboprophylaxis. Funding: Bayer. Science Valley Research Institute Hospital e Maternidade Christóvão da Gama Grupo Leforte Santo André Unidade de Medicina Interdisciplinar em Cardiologia Instituto do Coração Hospital das Clínicas HCFMUSP Faculdade de Medicina Universidade de São Paulo Zucker School of Medicine at Hofstra/Northwell and the Feinstein Institutes for Medical Research Department of Obstetrics and Gynecology I M Sechenov First Moscow State Medical University Universidade Estadual Paulista Hospital das Clínicas de Ribeirão Preto São Paulo University Medical School Ribeirão Preto Hospital do Rocio, Campo Largo Instituto Couto Maia Salvador Hospital Municipal de Barueri São Paulo State Public Women's Health Reference Center Hospital Israelita Albert Einstein Instituto do Coração Hospital das Clínicas HCFMUSP Faculdade de Medicina Universidade de São Paulo Institute of Teaching and Research Hapvida Hospital Nossa Senhora das Graças Department of Statistics Institute of Mathematics and Statistics University of São Paulo Northshore University Health System Hemostasis and Thrombosis Research Laboratories at Loyola University Medical Center Duke Clinical Research Institute Duke University School of Medicine Universidade Estadual Paulista

Made available in DSpace on 2022-10-10T13:56:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-06-13. Added 1 bitstream(s) on 2022-10-10T15:40:18Z : No. of bitstreams: 1 S0102-76382022005004209.pdf: 709911 bytes, checksum: f21e3f676bb487261dd70ff0fce4e4e5 (MD5) Inferior vena cava filter embolization is not uncommon and can reach 11.8%. However, device migration to the heart is not frequent and occurs in cases after inferior vena cava filter fracture. We present the case of a young woman who was submitted to a routine inferior vena cava filter placement three days before and presented with hemodynamic instability. Since the device was not retrievable, the surgical team opted for an open cardiac surgery under cardiopulmonary bypass to remove the inferior vena cava filter and avoid other further complications. Universidade Estadual Paulista (UNESP), Department of Surgery Universidade Estadual Paulista (UNESP), Department of Surgery

Transfemoral carotid artery stenting (TF-CAS) and carotid endarterectomy (CEA) are alternative strategies for stroke prevention in patients with atherosclerotic carotid disease. Because their main objective is to prevent future ischemic events, regular reassessment of the outcomes is mandatory for providing the best therapy. The purpose of this study was to describe the practice and the outcomes of TF-CAS and CEA in symptomatic patients in public university hospitals in Brazil, using data from a prospective multicentric registry.A prospective 8-year observational study of patients with symptomatic carotid artery atherosclerotic disease that underwent TF-CAS and CEA in 5 public university hospitals affiliated with the RHEUNI (Registry Project of Vascular Disease in the Public University Hospitals of São Paulo). All consecutive procedures were included. The indications for the procedures were determined by each surgeon's individual discretion, in accordance with a preoperative risk evaluation. The outcome measures were any 30-day follow-up death, stroke, myocardial infarction (MI), and their combined outcome (major adverse cardiovascular events [MACE]). The registration of the study was made at clinicaltrials.gov NCT02538276.From January 2012 through December 2019, 376 consecutive and symptomatic patients were included in the study records. There were 152 TF-CAS procedures (40.4%) and 224 CEA procedures (59.5%). All completed the 30-day follow-up period. Occurrence of death (TF-CAS: 0.66% × CEA: 0.66%, P = 0.99), stroke (TF-CAS: 4.61% × CEA: 4.46%, P = 0.99), and MI (TF-CAS: 0.66% × CEA: 0%, P = 0.403) were similar in both groups, without statistically significant differences. MACE rate did not differ in both groups (TF-CAS: 5.92% × CEA: 4.46%, P = 0.633).Data from a prospective registry of 5 Brazilian university hospitals showed that TF-CAS and CEA in symptomatic patients had similar 30-day perioperative rates of death, stroke, and MI and their combination.

Made available in DSpace on 2022-04-29T08:38:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-23 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background: Coronavirus disease 2019 (COVID-19) is a viral respiratory disease that spreads rapidly, reaching pandemic status, causing the collapse of numerous health systems, and a strong economic and social impact. The treatment so far has not been well established and there are several clinical trials testing known drugs that have antiviral activity, due to the urgency that the global situation imposes. Drugs with specific mechanisms of action can take years to be discovered, while vaccines may also take a long time to be widely distributed while new virus variants emerge. Thus, drug repositioning has been shown to be a good strategy for defining new therapeutic approaches. Studies of the effect of enriched heparin in the replication of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) in vitro assays justify the advance for clinical tests. Methods and analysis: A phase I/II triple-blind parallel clinical trial will be conducted. Fifty participants with radiological diagnosis of grade IIA pneumonia will be selected, which will be allocated in 2 arms. Participants allocated in Group 1 (placebo) will receive nebulized 0.9% saline. Participants allocated in Group 2 (intervention) will receive nebulized enriched heparin (2.5 mg/mL 0.9% saline). Both groups will receive the respective solutions on a 4/4 hour basis, for 7 days. The main outcomes of interest will be safety (absence of serious adverse events) and efficacy (measured by the viral load). Protocols will be filled on a daily basis, ranging from day 0 (diagnosis) until day 8. Department of Surgery and Orthopedics São Paulo State University – UNESP Botucatu Medical School, SP Applied Biotechnology Laboratory Research Nucleus of Clinical Hospital São Paulo State University – UNESP Botucatu Medical School, SP Department of Bioprocess and Biotechnology São Paulo State University – UNESP School of Pharmaceutical Sciences, SP Internal Medicine Division São Paulo State University – UNESP Botucatu Medical School, SP Department of Microbiology Institute of Biomedical Sciences University of São Paulo – USP, SP Scientific Platform Pasteur University of São Paulo – USP, SP Bioprocessing and Biotechnology Department São Paulo State University – UNESP School of Agriculture, SP Molecular & Structural Biosciences School of Life Sciences Keele University, Newcastle-Under-Lyme Department of Biochemistry Federal University of São Paulo – UNIFESP, SP Institute of Science and Technology Federal University of São Paulo – UNIFESP, SP Department of Infectious Diseases São Paulo State University – UNESP Botucatu Medical School, SP Clinical Research Unit São Paulo State University – UNESP Botucatu Medical School, SP Biosciences Institute São Paulo State University UNESP, SP Quality Control Laboratory Cellavita Scientific Research, SP Department of Orthopedics and Traumatology University of Campinas – UNICAMP School of Medical Sciences, SP Department of Surgery and Orthopedics São Paulo State University – UNESP Botucatu Medical School, SP Applied Biotechnology Laboratory Research Nucleus of Clinical Hospital São Paulo State University – UNESP Botucatu Medical School, SP Department of Bioprocess and Biotechnology São Paulo State University – UNESP School of Pharmaceutical Sciences, SP Internal Medicine Division São Paulo State University – UNESP Botucatu Medical School, SP Bioprocessing and Biotechnology Department São Paulo State University – UNESP School of Agriculture, SP Department of Infectious Diseases São Paulo State University – UNESP Botucatu Medical School, SP Clinical Research Unit São Paulo State University – UNESP Botucatu Medical School, SP Biosciences Institute São Paulo State University UNESP, SP FAPESP: 2020/12165-8

Hop plays an essential role in brewing beer and its study and analysis is of paramount importance. - and -acids are considered two of the most important hop components. While -acids are associated with the bitter flavor, -acids have antimicrobial effects. This work aims to critically review the published analytical methods for - and -acids determination in hops employing separation methods in liquid medium: liquid chromatography (LC) and capillary electrophoresis (CE). The types of hop samples, the optimized protocols to extract the hop acids, and the main instrumental conditions for both LC and CE techniques are highlighted and discussed. Specific and critical aspects of the - and β-acids separation by LC and CE and some challenges in this field are raised. Several key aspects discussed in this review may be of practical importance for brewers, whether in the microbrewery or industry and for researchers in the brewing field.

In this article we will seek to demonstrate how the themes of natural law, freedom and private property, central to classical liberal thought, can be analyzed in a fictitious context in which a socially marginalized individual, but possessing financial assets, is restricted and limited in terms of their freedom in the face of socially accepted individuals and representatives of collective values and customs. This context will be provided by Shakespeare's splendid work, 'The Merchant of Venice', through his most emblematic character, the Jew Shylock. We will analyse Shylock's case and how it can be taken as the prototype of a case that illustrates the points that underlie modern liberalism. We hope to be able to construct an analysis that is philosophical, but, at the same time, allows an exercise in literary interpretation.

A intoxicacao por plantas e sabidamente uma das principais causas de morte debovinos adultos no Brasil. As plantas toxicas sao caracterizadas como todos osvegetais que, introduzidos no organismo dos homens ou de animais domesticos, saocapazes de causar danos a saude e vitalidade desses seres. O presente estudo tevecomo objetivo pesquisar as principais plantas toxicas potencialmente causadoras deenfermidades a bovinos, identificando os mecanismos de dispersao dessas especiese propondo alternativas para minimizar os efeitos negativos aos animais. Foramdescritas cinco especies causadoras de danos a bovinos, quais sejam: Palicoureamarcgravii, Mascagnia rigida, Tetrapterys acutifolia, Pteridium aquilinum e Cestrumlaevigatum, abordando especialmente seus processos de dispersao e regeneracao.Conclui-se que a compreensao da dispersao das sementes, aliada ao conhecimentodas caracteristicas de regeneracao e propagacao das plantas apresenta-se comouma ferramenta util para a conservacao/manutencao de areas sem infestacao porestas plantas.

This paper aims to provide the empirical evidence of the interaction mechanism in the open innovation system with particular attention to aesthetic and rational innovation in an Italian creative sector. Factors including rapid technological development, the advent of innovative openness processes involving sub-sectors belonging to diversified supply chains, shorter product life cycles, more diversified and customized, demande and fierce marketing competition, make today’s business model increasingly unpredictable and risky. Building on relational based view, resource-based view and network analysis the purpose of this paper is to empirically explore the relationships among supply chain integration (SCI) and inter-company performance in global diversified supply chain. This is an exploratory study and the qualitative research method has been employed. This research has founded its context in the Italian knitwear sector which is part of the creative industries of the Italian fashion system. The data were collected through a series of semi-structured interviews with workers belonging to various areas of activity and with external actors such as yarn suppliers, buyers, institutional and non-institutional lenders. The purpose of this research is also to promote research methodological approaches to analyse different uncertainty scenarios for the future.

Severe and poorly treated pain often accompanies breast cancer. Thus, novel mechanisms involved in breast cancer-induced pain should be investigated. Then, it is necessary to characterize animal models that are reliable with the symptoms and progression of the disease as observed in humans. Explaining cancer-induced nociception in a murine model of breast carcinoma was the aim of this study. 4T1 (104) lineage cells were inoculated in the right fourth mammary fat pad of female BALB/c mice; after this, mechanical and cold allodynia, or mouse grimace scale (MGS) were observed for 30 days. To determine the presence of bone metastasis, we performed the metastatic clonogenic test and measure calcium serum levels. At 20 days after tumor induction, the antinociceptive effect of analgesics used to relieve pain in cancer patients (acetaminophen, naproxen, codeine or morphine) or a cannabinoid agonist (WIN 55,212-2) was tested. Mice inoculated with 4T1 cells developed mechanical and cold allodynia and increased MGS. Bone metastasis was confirmed using the clonogenic assay, and hypercalcemia was observed 20 days after cells inoculation. All analgesic drugs reduced the mechanical and cold allodynia, while the MGS was decreased only by the administration of naproxen, codeine, or morphine. Also, WIN 55,212-2 improved all nociceptive measures. This pain model could be a reliable form to observe the mechanisms of breast cancer-induced pain or to observe the efficacy of novel analgesic compounds.

A series of1,2,4- and 1,3,4-oxadiazole derivatives were synthesized and evaluated for their anticancer activity. Halogenated 1,2,4-oxadiazoles were obtained from benzonitrile and coupled either lipophilic amines or with aminoalcohols. Lipophilic 1,3,4-oxadiazole derivatives were obtained through the Mannich reactions between 5-(aryl)-1,3,4-oxadiazole-2-thiol and alkylated or acylated amines. The in vitro cytotoxic effects were evaluated against 4T1– mammary carcinoma and CT26 – colon cancer cells. The best results were obtained for the 1,3,4-oxadiazole coupled to alkylated piperazine with 10–14 carbon chain moiety, with IC50 values ranging from 1.6 to 3.55μΜ for the 4T1 cell line, and from 1.6 to 3.9 μM for the CT26.WT cell line, and selectivity index up to 19. The most potent compounds were investigated with AnnexinV and PI staining as indicative of apoptosis induction.

Parboiling is a common method used in rice processing to improve milling yield and physicochemical properties. The current study evaluates parboiling as a pre-treatment step in millet decortication and its impact on phenolic profile and in vitro digestibility of two traditional millet products, steam-cooked couscous and porridge, made from pearl (Pennisetum glaucum) and proso (Panicum miliaceum) millets. Parboiling increased decorticated yield of pearl and proso millet by 37% and 28% respectively. It resulted in significant (P 0.05) rise in free and bound phenolic contents and DPPH (2,2-diphenyl-1- picrylhydrazyl) radical scavenging activity of the millet products. This method significantly (P 0.05) changed starch digestion fractions of both products thereby reducing expected glycemic index (eGI) while the in vitro protein digestibility of products decreased by 14-17%. Parboiling could be an effective way to improve millet decortication yield as well as produce millet products with higher phenolic acids antioxidant activity and lower GI.

Diosmetin is an O‑methylated flavone found naturally in citrus fruit, and it was identified in Amphilophium crucigerum (L.), a plant popularly used as an analgesic. This compound had different pharmacological effects and presented a chemical structure like the flavonoid eriodyctiol that exhibited antinociceptive effects by TRPV1 antagonism. However, the possible antinociceptive effect of this compound was not well documented. Thus, the goal of the present study was to evaluate the antinociceptive effect of diosmetin and its mechanism of action. The diosmetin effect on different pain models and its possible adverse effects were assessed on adult Swiss male mice (25–30 g). Mice spinal cord samples were used on calcium influx and binding assays using TRPV1 agonists. First, it was observed that the diosmetin reduced calcium influx mediated by capsaicin in synaptosomes and displace the specific binding to [3H]-resiniferatoxin in membrane fractions from the spinal cord of mice. Diosmetin (0.15 to 1.5 mg/kg, intragastric, i.g.) presented antinociceptive and antiedematogenic effect in the capsaicin intraplantar test and induced antinociception in a noxious heat test (48 °C). Also, treatment with diosmetin reduced mechanical and heat hypersensitivity observed in a model of inflammatory or neuropathic pain. Acute diosmetin administration in mice did not induce locomotor or body temperature changes, or cause liver enzyme abnormalities or alter renal function. Moreover, there were no observed changes in gastrointestinal transit or induction of ulcerogenic activity after diosmetin administration. In conclusion, our results support the antinociceptive properties of diosmetin which seems to occur via TRPV1 antagonist in mice.

The Disability Qualification System in Chile and its regulations have inequities as they are applied in a general way and do not consider the peculiar characteristics of vulnerable populations. These people, who are mostly unprotected, have less access to health care levels and receive a lower quality of services. The authors, using a clinical case, we analyze the three main obstacles to obtain a disability pensión. A change in applicants’ evaluation, considering a broader range of information on the process, a greater symmetry in the evaluated parameters, including biopsychosocial aspects and a better interrelation between Health Services and the Evaluation System would narrow the existing gap between vulnerable and non-vulnerable populations.

Made available in DSpace on 2021-06-25T10:35:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01 Objective: To compare the efficacy and safety of sclerosing agents injected in dorsal veins of rabbit ears. Methods: Sixty ears of 30 rabbits were randomly allocated in: 1% liquid polidocanol, 1% polidocanol foam, 0.2% polidocanol-glucose 70% solution, glucose 75% or 0.9% saline. Outcomes included efficacy (luminal occlusion), complications (phlebitis, neovascularization, ulceration at the puncture site, necrosis and local inflammation) and histology (sclerosis, recanalization vein and surrounding tissues inflammation, blood extravasation, recanalization, lymphangiogenesis, destruction of cartilage and neoangiogenesis). Results: Sclerosis was superior in Foam Group (76.9%), but also with 30.7% necrosis (p = 0.003), 46.15% ulceration (p = 0.003), and 69.2% local inflammation (p < 0.0001). Neovascularization were similar. Histology showed 38.5% phlebitis (p = 0.004) and necrosis (p = 0.03) in the foam group. Conclusions: Sclerosis with foam and liquid polidocanol were superior to the other groups, but specially polidocanol foam at the expense of greater frequency of adverse events. Department of Surgery and Orthopedics School of Medicine of Botucatu Paulista State University UNESP Department of Biostatistics-Biosciences Institute Paulista State University UNESP Histopathologie und VascPath Department of Surgery and Orthopedics School of Medicine of Botucatu Paulista State University UNESP Department of Biostatistics-Biosciences Institute Paulista State University UNESP

Made available in DSpace on 2022-04-29T08:30:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01 National Health and Medical Research Council Objective: To describe fluid resuscitation practices in Brazilian intensive care units and to compare them with those of other countries participating in the Fluid-TRIPS. Methods: This was a prospective, international, cross-sectional, observational study in a convenience sample of intensive care units in 27 countries (including Brazil) using the Fluid-TRIPS database compiled in 2014. We described the patterns of fluid resuscitation use in Brazil compared with those in other countries and identified the factors associated with fluid choice. Results: On the study day, 3,214 patients in Brazil and 3,493 patients in other countries were included, of whom 16.1% and 26.8% (p < 0.001) received fluids, respectively. The main indication for fluid resuscitation was impaired perfusion and/or low cardiac output (Brazil: 71.7% versus other countries: 56.4%, p < 0.001). In Brazil, the percentage of patients receiving crystalloid solutions was higher (97.7% versus 76.8%, p < 0.001), and 0.9% sodium chloride was the most commonly used crystalloid (62.5% versus 27.1%, p < 0.001). The multivariable analysis suggested that the albumin levels were associated with the use of both crystalloids and colloids, whereas the type of fluid prescriber was associated with crystalloid use only. Conclusion: Our results suggest that crystalloids are more frequently used than colloids for fluid resuscitation in Brazil, and this discrepancy in frequencies is higher than that in other countries. Sodium chloride (0.9%) was the crystalloid most commonly prescribed. Serum albumin levels and the type of fluid prescriber were the factors associated with the choice of crystalloids or colloids for fluid resuscitation. Discipline of Anesthesiology Pain and Intensive Care Universidade Federal de São Paulo, Rua Napoleão de Barros, 737, 6ºandar Critical Care and Trauma Division George Institute for Global Health Hospital Sírio-Libanês Hospital das Clínicas Faculdade de Medicina Universidade de São Paulo Instituto de Pesquisa HCor - Hospital do Coração Instituto de Pesquisa Clínica Evandro Chagas Fundação Oswaldo Cruz Hospital de Clínicas Mário Lioni Hospital do Rim e Hipertensão Fundação Oswaldo Ramos Hospital Samaritano Hospital Paulistano Hospital São José Instituto D’Or de Ensino e Pesquisa Hospital Municipal São José Hospital Israelita Albert Einstein Hospital Santa Rita Hospital de Base Faculdade de Medicina de São Jose do Rio Preto Hospital Unimed de Belo Horizonte Hospital Santa Lúcia Hospital Evangélico de Sorocaba Hospital PIO XII Hospital São Camilo Pompéia Hospital Alvorada Brasília Hospital Ecoville Hospital do Trabalhador Hospital Vita Batel Hospital das Clínicas Faculdade de Medicina de Botucatu Universidade Estadual “Júlio de Mesquita Filho” Hospital Geral Dr. César Cals Hospital Copa D’Or Associação Beneficente Hospital Unimar Hospital Casa de Saúde de Santos Hospital Estadual Getúlio Vargas Hospital e Maternidade Otaviano Neves Instituto Estadual do Cérebro Paulo Niemeyer Hospital Universitário Universidade Federal de Juiz de Fora Lifecenter Hospital Geral de Fortaleza Hospital Municipal Dr. Moysés Deutsch (M’Boi Mirim) Santa Casa de Misericórdia de Presidente Prudente Hospital 9 de julho Hospital Estadual Rocha Faria Hospital Municipal Santa Isabel Hospital e Maternidade Municipal Dr. Odelmo Leão Carneiro Hospital Evangélico de Londrina Universidade Estadual de Londrina Hospital Samaritano João Pessoa Hospital de Caridade Astrogildo de Azevedo Vitória Apart Hospital Instituto de Ortopedia e Traumatologia Hospital do Subúrbio Hospital Renascentista Hospital Felício Rocho Hospital Municipal Irmã Dulce Hospital Universitário Júlio Müller Universidade Federal do Mato Grosso Hospital de Urgência Hospital Geral de Goiânia Fundação Doutor Amaral Carvalho Hospital Adventista de Belém Hospital Santa Juliana Hospital Dom Vicente Scherer Hospital Primavera Hospital Carlos da Silva Lacaz Hospital Escola Faculdade de Medicina de Jundiaí Hospital Sepaco Hospital Professor Edmundo Vasconcelos Hospital Paulo Sacramento Clínica Dom Rodrigo Complexo Hospitalar Ortotrauma de Mangabeira Hospital Nossa Senhora da Conceição Hospital Regional de Samambaia Hospital São Camilo Ipiranga Hospital da Restauração Instituto do Coração Hospital das Clínicas Faculdade de Medicina Universidade de São Paulo Hospital Estadual Jayme Santos Neves Hospital SOS Cárdio Hospital da Luz Vila Mariana Hospital Maternidade e Pronto-Socorro Santa Luci Santa Casa de Misericórdia de Vitória da Conquista Santa Casa de Misericórdia de Porto Alegre Hospital São Francisco de Assis Hospital Memorial São José Hospital Regional de Jundiaí Hospital Universitário Faculdade de Medicina de Jundiaí Hospital Regional de Presidente Prudente Santa Casa de Misericórdia de Assis Hospital de Clínicas Gaspar Vianna Hospital do Coração do Brasil Hospital Hélio Anjos Ortiz Hospital Vila da Serra Hospital Nereu Ramos Hospital Santa Maria Intensibarra Santa Casa de Misericórdia de Santo Amaro Santa Casa de Caridade de Don Pedrito Santa Casa de Misericórdia de Santana do Livramento Hospital Unimed de Macaé Hospital Municipal Pedro II Hospital Federal dos Servidores do Estado Hospital São Mateus Hospital IBR Hospital Uniclinic Santa Casa de Misericórdia de Paraguaçu Paulista Associação Hospitalar Beneficente São Vicente de Paulo Hospital do Servidor Público Municipal de São Paulo Hospital Santa Isabel Hospital Municipal Dr Jose Soares Hungria Hospital Fernandes Távora Hospital Distrital Evandro Ayres de Moura Hospital Saúde da Mulher Hospital Estadual de Urgência e Emergência de Vitória Samur Hospital e Pronto-Socorro 28 de Agosto Hospital Assunção Hospital Universitário de Santa Maria Hospital Universitário Cajuru Instituto do Câncer do Estado de São Paulo Hospital Unimed de Limeira Hospital Amecor Santa Casa de Caridade de Diamantina Hospital das Clínicas Faculdade Ribeirão Preto Universidade de São Paulo HCor - Hospital do Coração Hospital Goiânia Leste Hospital Ortopédico Hospital Santa Maria Hospital Municipal Dr. Munir Rafful Hospital Jardim Amália Hospital Madre Regina Prottman Hospital Universitário São Francisco de Paula Universidade Católica de Pelotas Hospital São Joao de Deus Hospital Nossa Senhora Monte Serrat Hospital Unimed Salto Hospital Moinhos de Vento Hospital Geral de Vitória da Conquista Hospital Marcelino Champagnat Hospital São Lucas Pontifícia Universidade Católica do Rio Grande do Sul Hospital Universitário Universidade Federal da Grande Dourados Hospital Português Hospital Brigadeiro Hospital Regional de Sousa Hospital das Clínicas Universidade Federal do Espírito Santo Santa Casa de Misericórdia de Ribeirão Preto Hospital Universitário Lauro Wanderley Santa Casa de Belo Horizonte Hospital Adventista de Manaus Santa Casa Maringá Universidade Estadual Maringá Hospital Total Cor Hospital Universitário Universidade de Santa Cruz do Sul Hospital Dom Hélder Hospital das Clínicas de Porto Alegre Universidade Federal do Rio Grande do Sul Hospital Anis Rassi Instituto de Infectologia Emílio Ribas II Hospital Unimed Rio de Janeiro Hospital Alemão Oswaldo Cruz Hospital Samaritano Rio de Janeiro São Bernardo Apart Hospital Hospital Nossa Senhora dos Prazeres Hospital Unimed ABC Hospital Municipal de Paracatu Hospital Municipal Padre Germano Lauck Hospital Santa Helena Hospital Santa Izabel Santa Casa de Misericórdia de São Paulo Hospital Tereza Ramos Hospital Alvorada Taguatinga Hospital Maternidade São José Hospital Universitário Ciências Médicas Fundação Educacional Lucas Machado Santa Casa de Belém do Pará Instituto Nacional de Cardiologia Hospital Novo Atibaia BP - A Beneficência Portuguesa de São Paulo Hospital Universitário Maria Aparecida Pedrossian Universidade Federal de Mato Grosso do Sul Hospital do Servidor Público Estadual “Francisco Morato de Oliveira” Hospital Norte D’Or Hospital Estadual Ipiranga Hospital Universitário de Maringá Universidade Estadual de Maringá Albert Sabin Hospital e Maternidade Casa de Caridade de Carangola Irmandade de Misericórdia de Guaxupé Disciplina de Emergências Clínicas Universidade Estadual de Campinas Hospital São Lucas Fundação Pio XII- Hospital de Câncer de Barretos Clínica Campo Grande Hospital das Clínicas Universidade Federal de Minas Gerais Casa de Saúde Santa Lúcia Hospital Regional de Itapetininga São Camilo Santa Casa de Angra dos Reis Grupo Hospitalar Nossa Senhora da Conceição Irmandade Misericórdia Hospital Santa Casa de Monte Alto Hospital São Marcos Hospital Unimed de Manaus Hospital Universitário Getúlio Vargas Universidade Federal do Amazonas Casa de Saúde Campinas Hospital e Maternidade Galileo Hospital das Clínicas Faculdade de Medicina de Botucatu Universidade Estadual “Júlio de Mesquita Filho” National Health and Medical Research Council: APP1039312

The essay intends to focus a on the value of a dual education. Current European Employability Policies are increasingly directed towards work-based learning models in order to counter the persistent increase in youth unemployment and so-called "Neet" and thus reduce the skills gap in school-work transitions. Furthermore, dual education enhances the advantages of alternating between classroom learning and learning in the company and therefore implies a link between formal, informal and non-formal learning, in correlation with the needs particularly emphasized by the European Union