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BACKGROUND: Case fatality rate (CFR) for global COVID-19 infections since June 14, 2021 was 2.17%, while CFR for Southest Asia were 1.39%. CFR in Indonesia so far were 3.05%. This missed from the target of the 2005-2025 RPJMK (Middle long run national health planning) in achieving healthy Indonesia; handling epidemic diseases must be able to reduce the mortality rate below 1%. The government issued the Decree of the Minister of Health Republic of Indonesia No. HK.01.07/Menkes/2020 concerning the Determination of Vaccine Types for the Management of COVID-19. However, the existence of this policy did not reduce the mortality rate trend of COVID-19 in Indonesia. Hypertension and diabetes mellitus were the larger risk factors for COVID-19 mortality. Guo et al. 2020 found comorbid COVID-19 sufferers were hypertension 24.7% and diabetes mellitus 21.2%. However, Mikami et al., 2020 stated differently that hypertension and diabetes mellitus were not at risk of COVID-19 mortality. AIM: Objective of this study was to estimate the average tendency of hypertension and diabetes mellitus as risk factor for COVID-19 mortality. METHODS: Meta-analysis with 16 articles analyzed by RevMan 5.4. RESULTS: pHR for hypertension was 1.15 (95% CI 1.00 - 1.32) and diabetes mellitus was 1.21 (95% CI 1.13 - 1.29). CONCLUSION: Hypertension had risk 1.15 times and diabetes mellitus had risk 1.21 times for COVID-19 mortality.

This study aimed to investigate the mineral characteristics, hydroxyapatite crystal, and mesostructure among heavy smoker teeth. Twenty five subjects were divided into two groups including non smoker group (15 subjects) and heavy smoker group (10 subjects). Teeth mineral element was measured using X-Ray Fluorescence. The hydroxyapatite crystal structure was analyzed using X-Ray Diffraction. Mesostructure was determined using Scanning Electron Microscope. The level of Ca, P, Fe, Cu, Zn, S, Si, Cr, Ti, Mn, Ni, In, Re, Ba, K, Mo, V, Sr, Co, Er, Yb, Zr, and Ca/P ratio were not significantly different in the smoker group compared with a non smoker group (P > 0.05). The lattice parameter of smoker was different compared with non smoker group. In addition, the crystal size of the smoker was higher compared with control. We also found that mesostructure of the smoker was different compared with non smoker. In conclusion, smoking activity affect the hydroxyapatite crystal and disrupt the remodeling surface of teeth. Key words: smoking; dental; structure; surface; remodeling