1. Highly potent growth hormone secretagogues
- Author
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Lu, Zhijian, Tata, James R., Cheng, Kang, Wei, Liente, Chan, Wanda W.-S., Butler, Bridget, Schleim, Klaus D., Jacks, Thomas M., Hickey, Gerard, and Patchett, Arthur A.
- Subjects
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HORMONES , *ORGANIC compounds , *HUMAN anatomy , *ENDOCRINE glands - Abstract
Abstract: During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active in vitro than the best compound in the series we revealed before [Tata, J. R.; Lu, Z.; Jacks, T. M.; Schleim, K. D.; Cheng, K.; Wei, L.; Chan, W.-S.; Butler, B.; Tsou, N.; Leung, K.; Chiu, S.-H. L.; Hickey, G. J.; Smith, R. G.; Patchett, A. A. Bioorg. Med. Chem. Lett. 1997, 7, 2319.]. Animal studies show that compound 8 can stimulate growth hormone release at the oral dose as low as 0.06mpk. Chemistry and biological studies are discussed. [Copyright &y& Elsevier]
- Published
- 2007
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