15 results on '"Zhao, Zhen-Gang"'
Search Results
2. Transcatheter mitral valve implantation in severely calcified rheumatic mitral stenosis without annular calcification.
- Author
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Zhao ZG, Chen F, Wei X, Feng Y, and Chen M
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- Cardiac Catheterization, Humans, Mitral Valve diagnostic imaging, Mitral Valve surgery, Treatment Outcome, Calcinosis complications, Calcinosis diagnostic imaging, Calcinosis surgery, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation, Mitral Valve Stenosis complications, Mitral Valve Stenosis diagnostic imaging, Mitral Valve Stenosis surgery
- Published
- 2022
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3. Understanding the Interaction Between Transcatheter Aortic Valve Prostheses and Supra-Annular Structures From Post-Implant Stent Geometry.
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Xiong TY, Li YJ, Feng Y, Liao YB, Zhao ZG, Mylotte D, Wei X, Xu YN, Peng Y, Wei JF, Zheng MX, Zhou X, Meng W, Piazza N, and Chen M
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- Aged, Aortic Valve diagnostic imaging, Aortic Valve physiopathology, Female, Heart Valve Prosthesis Implantation adverse effects, Hemodynamics, Humans, Male, Multidetector Computed Tomography, Prosthesis Design, Retrospective Studies, Treatment Outcome, Aortic Valve surgery, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation instrumentation, Stents
- Abstract
Objectives: The authors sought to better understand the stent geometry of the Lotus valve after transcatheter aortic valve replacement (TAVR) and its potential implications for valve size selection., Background: The authors hypothesized that the greatest interference between the frame and aortic valvar complex occurs across the aortic valve leaflets., Methods: The authors retrospectively analyzed the multidetector computed tomography (MDCT) scans of 32 consecutive patients undergoing Lotus valve (Boston Scientific, Natick, Massachusetts) implantation. The prosthesis cross section was analyzed at 3-mm increments along its length. The plane where the frame had the smallest area was defined as the waist. The corresponding plane of the waist on pre-procedural MDCT was identified by surrounding structures such as calcium deposits, commissural fusion, and commissural gaps, and was referred to as the supra-annulus. The spline of the supra-annulus was circumscribed with reference to the post-implant stent geometry at the waist., Results: The waist was 5.8 ± 1.7 mm higher than the native annulus on post-procedural MDCT. The waist had a nearly 2-fold larger compression rate than the stent at the native annulus level (36.3 ± 10.4% vs. 18.9 ± 9.6%; p < 0.01), irrespective of valve morphologies. The supra-annulus was 5.9 ± 1.6 mm higher than the annulus on pre-procedural MDCT. Patients had an approximately 17% decrease in area from the annulus to the supra-annulus (18.3 ± 4.4% for bicuspid morphology and 16.0 ± 3.5% for tricuspid morphology)., Conclusions: Major interference between the implanted prosthesis and anatomy occurred at a level above the annulus. The decrease in area from the annulus to supra-annulus may explain the feasibility of implanting a smaller valve than that suggested by traditional annular measurements., (Copyright © 2019. Published by Elsevier Inc.)
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- 2019
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4. Incidence, Predictors and Outcome of Prosthesis-Patient Mismatch after Transcatheter Aortic Valve Replacement: a Systematic Review and Meta-analysis.
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Liao YB, Li YJ, Jun-Li L, Zhao ZG, Wei X, Tsauo JY, Xiong TY, Xu YN, Feng Y, and Chen M
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- Heart Valve Prosthesis adverse effects, Heart Valve Prosthesis Implantation adverse effects, Humans, Incidence, Kaplan-Meier Estimate, Postoperative Complications epidemiology, Postoperative Complications etiology, Prognosis, Prosthesis Failure, Risk Factors, Transcatheter Aortic Valve Replacement adverse effects, Heart Valve Prosthesis standards, Heart Valve Prosthesis Implantation methods, Postoperative Complications diagnosis, Transcatheter Aortic Valve Replacement methods
- Abstract
The aim of this study was to investigate the incidence, predictors and outcome of prosthesis-patient mismatch (PPM) following transcatheter aortic valve replacement (TAVR). A total of 30 articles incorporating 4,691 patients were identified. The pooled incidences of overall, moderate and severe PPM following TAVR were 33.0%, 25.0% and 11.0% respectively. Medtronic CoreValve (MCV) had lower incidence of overall (32% vs: 40%, P < 0.0001) and moderate (23% vs 32%, P < 0.0001) than Edwards Sapien (ESV). PPM was associated with a younger age, smaller annulus diameter and lower left ventricular ejection fraction in comparison with those patients without PPM. Post-dilation (OR, 0.51, 95% CI, 0.38 to 0.68, p < 0.001) during TAVR would decrease the incidence of PPM. Although PPM was common after TAVR, no significant differences were observed both in short- and mid-term all-cause mortality (30 day: OR: 1.1, 95% CI, 0.70 to 1.73 and 2 year: OR: 1.01, 95% CI, 0.74 to 1.38) between patients with PPM and those without PPM. In conclusion, despite being common after TAVR, the incidence of PPM was lower than that of surgical aortic valve replacement (SAVR) and decreased with the experience accumulating, and PPM was not seen to impact on short- and mid-term survival, regardless of its magnitude.
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- 2017
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5. Transcatheter aortic valve implantation with the self-expandable venus A-Valve and CoreValve devices: Preliminary Experiences in China.
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Liao YB, Zhao ZG, Wei X, Xu YN, Zuo ZL, Li YJ, Zheng MX, Feng Y, and Chen M
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- Aged, Aged, 80 and over, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis mortality, Aortic Valve Stenosis physiopathology, Cardiac Catheterization adverse effects, Cardiac Catheterization methods, Cardiac Catheterization mortality, China, Female, Heart Valve Prosthesis Implantation adverse effects, Heart Valve Prosthesis Implantation methods, Heart Valve Prosthesis Implantation mortality, Humans, Male, Middle Aged, Prosthesis Design, Time Factors, Treatment Outcome, Aortic Valve diagnostic imaging, Aortic Valve physiopathology, Aortic Valve Stenosis therapy, Cardiac Catheterization instrumentation, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation instrumentation
- Abstract
Background: Transcatheter aortic valve implantation (TAVI) has been demonstrated to be an effective alternative to surgical aortic valve replacement (SAVR) in patients with aortic stenosis who are deemed high risk or inoperable. Currently, TAVI procedures in China mostly make use of the domestic Venus A-Valve and the CoreValve; however, there is no data on their comparative performance., Methods: Consecutive patients undergoing TAVI with the aforementioned devices were included. The outcomes were reported according to the Valve Academic Research Consortium-2 (VARC) definitions., Results: A total of 54 TAVI procedures were performed, 27 with the CoreValve and the other 27 with the Venus A-Valve. An additional valve was required in 4 (14.8%) and 3 (11.1%) patients, and the VARC-2 device success rates were 81.5 and 85.2%, respectively. The incidences of common complications were similar, except for the significantly less frequent pacemaker insertion in the Venus A-Valve group (7.4 vs. 37.0%, P = 0.03). Within 30 days, 2 (3.7%) patients died, 1 in each group, and both had a bicuspid aortic valve (BAV). No other serious complications, such as annular rupture, coronary obstruction and aortic dissection, occurred in the 32 BAV patients treated with the Venus A-Valve (14) or the CoreValve (18). After 2-years of follow-up, there was no significant difference between CoreValve group and Venus-A group (11.1 vs. 7.4%, P = 0.64)., Conclusion: TAVI with the domestic Venus A-Valve is feasible, safe, and can produce favorable short-term outcomes comparable to those with the CoreValve in inoperable or high-risk patients with tricuspid and bicuspid aortic valve stenosis. © 2017 Wiley Periodicals, Inc., (© 2017 Wiley Periodicals, Inc.)
- Published
- 2017
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6. The relationship between chronic obstructive pulmonary disease and transcatheter aortic valve implantation--A systematic review and meta-analysis.
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Liao YB, He ZX, Zhao ZG, Wei X, Zuo ZL, Li YJ, Xiong TY, Xu YN, Feng Y, and Chen M
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- Acute Kidney Injury epidemiology, Aged, 80 and over, Aortic Valve Stenosis diagnosis, Aortic Valve Stenosis mortality, Body Mass Index, Cardiac Catheterization instrumentation, Cardiac Catheterization mortality, Chi-Square Distribution, Comorbidity, Exercise Test, Exercise Tolerance, Female, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation instrumentation, Heart Valve Prosthesis Implantation mortality, Humans, Logistic Models, Lung physiopathology, Male, Multivariate Analysis, Odds Ratio, Prevalence, Pulmonary Disease, Chronic Obstructive diagnosis, Pulmonary Disease, Chronic Obstructive mortality, Pulmonary Disease, Chronic Obstructive physiopathology, Renal Insufficiency, Chronic epidemiology, Risk Factors, Severity of Illness Index, Time Factors, Treatment Outcome, Walking, Aortic Valve Stenosis therapy, Cardiac Catheterization methods, Heart Valve Prosthesis Implantation methods, Pulmonary Disease, Chronic Obstructive epidemiology
- Abstract
Objective: The present study was performed to investigate the relationship between chronic obstructive pulmonary disease (COPD) and transcatheter aortic valve implantation (TAVI)., Background: Controversies regarding the relationship between COPD and TAVI have intensified., Methods: A literature review of the PubMed online database was performed, and articles published between January 1, 2002 and March 20, 2015 were analyzed. Random-effect and fixed-effect models were used, depending on the between-study heterogeneity., Results: A total of 28 studies, involving 51,530 patients, were identified in our review. The burden of COPD ranged from 12.5% to 43.4%, and COPD negatively impacted both short-term and long-term all-cause survival (30 days: odds ratio [OR], 1.43, 95% CI, 1.14-1.79; >2 years: hazard ratio [HR], 1.34, 95% CI, 1.12-1.61). COPD was also associated with increased short-term and mid-term cardiac-cause mortality (30 days: OR, 1.29, 95% CI, 1.02-1.64; 1 year: HR: 1.09, 1.02-1.17). Moreover, COPD (OR, 1.97, 95% CI, 1.29-3.0) predicted post-TAVI acute kidney disease. Importantly, chronic kidney disease (CKD) (HR, 1.2, 95% CI, 1.1-1.32) and the distance of the 6 minute walk test (6MWT) (HR, 1.16, 1.06-1.27) predicted TAVI futility in patients with COPD., Conclusion: COPD is common among patients undergoing TAVI, and COPD impacts both short- and long-term survival. COPD patients, who had a lower BMI, shorter distance of 6MWT and CKD, were at higher risk for TAVI futility., (© 2016 Wiley Periodicals, Inc.)
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- 2016
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7. Causes of Death Following Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.
- Author
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Xiong TY, Liao YB, Zhao ZG, Xu YN, Wei X, Zuo ZL, Li YJ, Cao JY, Tang H, Jilaihawi H, Feng Y, and Chen M
- Subjects
- Aortic Valve Stenosis diagnosis, Aortic Valve Stenosis mortality, Cardiac Catheterization adverse effects, Cardiac Catheterization instrumentation, Cause of Death, Chi-Square Distribution, Heart Failure diagnosis, Heart Failure etiology, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation adverse effects, Heart Valve Prosthesis Implantation instrumentation, Humans, Multiple Organ Failure diagnosis, Multiple Organ Failure etiology, Prosthesis Design, Risk Assessment, Risk Factors, Sepsis diagnosis, Sepsis etiology, Time Factors, Treatment Outcome, Aortic Valve Stenosis therapy, Cardiac Catheterization mortality, Death, Sudden etiology, Heart Failure mortality, Heart Valve Prosthesis Implantation mortality, Multiple Organ Failure mortality, Sepsis mortality
- Abstract
Background: Transcatheter aortic valve replacement (TAVR) is an effective alternative to surgical aortic valve replacement in patients at high surgical risk. However, there is little published literature on the exact causes of death., Methods and Results: The PubMed database was systematically searched for studies reporting causes of death within and after 30 days following TAVR. Twenty-eight studies out of 3934 results retrieved were identified. In the overall analysis, 46.4% and 51.6% of deaths were related to noncardiovascular causes within and after the first 30 days, respectively. Within 30 days of TAVR, infection/sepsis (18.5%), heart failure (14.7%), and multiorgan failure (13.2%) were the top 3 causes of death. Beyond 30 days, infection/sepsis (14.3%), heart failure (14.1%), and sudden death (10.8%) were the most common causes. All possible subgroup analyses were made. No significant differences were seen for proportions of cardiovascular deaths except the comparison between moderate (mean STS score 4 to 8) and high (mean STS score >8) -risk patients after 30 days post-TAVR (56.0% versus 33.5%, P=0.005)., Conclusions: Cardiovascular and noncardiovascular causes of death are evenly balanced both in the perioperative period and at long-term follow-up after TAVR. Infection/sepsis and heart failure were the most frequent noncardiovascular and cardiovascular causes of death. This study highlights important areas of clinical focus that could further improve outcomes after TAVR., (© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.)
- Published
- 2015
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8. Transcatheter aortic valve implantation in a patient with severe bicuspid aortic valve stenosis and ascending aortic aneurysm.
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Chen M, Feng Y, Mazzitelli D, Tang H, Wei X, Zhao ZG, Xu YN, Liao YB, and Huang DJ
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- Aged, Aortic Aneurysm diagnosis, Aortic Valve physiopathology, Aortic Valve Stenosis diagnosis, Aortic Valve Stenosis etiology, Aortic Valve Stenosis physiopathology, Aortography methods, Bicuspid Aortic Valve Disease, Female, Heart Valve Diseases diagnosis, Heart Valve Diseases physiopathology, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation instrumentation, Humans, Severity of Illness Index, Tomography, X-Ray Computed, Treatment Outcome, Aortic Aneurysm complications, Aortic Valve abnormalities, Aortic Valve Stenosis therapy, Cardiac Catheterization instrumentation, Heart Valve Diseases complications, Heart Valve Prosthesis Implantation methods
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- 2014
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9. Transcatheter aortic valve implantation: preliminary experience in West China Hospital.
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Chen M, Feng Y, Tang H, Wei X, Zhao ZG, Xu YN, and Huang DJ
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- Aged, Aged, 80 and over, China, Female, Humans, Male, Middle Aged, Aortic Valve Stenosis surgery, Heart Valve Prosthesis Implantation methods
- Published
- 2013
10. Snaring Self-Expanding Devices to Facilitate Transcatheter Aortic Valve Replacement in Patients with Complex Aortic Anatomies.
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Yao, Yi-Jun, Zhao, Zhen-Gang, Wang, Xi, Peng, Yong, Wei, Jia-Fu, He, Sen, Li, Yi-Jian, He, Jing-Jing, Zhu, Zhong-Kai, Feng, Yuan, and Chen, Mao
- Subjects
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CARDIAC pacemakers , *HEART valve prosthesis implantation , *AORTA , *MITRAL valve , *AORTIC valve , *PROPENSITY score matching , *AORTIC stenosis - Abstract
The snare-assisted technique has been described to facilitate transcatheter aortic valve replacement (TAVR) delivery system advancement in complex aortic anatomies. However, the evidence is limited to case reports. To evaluate the safety profile of the snare-facilitated approach and its impact on self-expanding (SE) TAVR outcomes, we collected consecutive patients who underwent transfemoral SE-TAVR for aortic stenosis, using propensity score matching (PSM) separately in tricuspid and type-0 and type-1 bicuspid aortic valve morphology between the snare and non-snare groups. In 766 patients, despite the snare group having significantly larger annulus angulation and maximal ascending aortic diameter, both groups achieved comparable 30-day device success rates, regardless of first-generation or new-generation valve use. After PSM, the snare group had a significantly lower new permanent pacemaker implantation rate among 193 type-0 patients (3.3% vs. 18.3%, p = 0.01). The ipsilateral group used new-generation valves less frequently (23.0% vs. 75.4%, p < 0.001), but there were no significant inter-group differences in procedure-related events, except for a lower incidence of PVL ≥ mild in the ipsilateral group (14.9% vs. 32.3%, p = 0.01). In conclusion, the snare-assisted technique appears useful in SE-TAVR with angulated aortic root anatomy, and the benefits were comparable between ipsilateral and contralateral snare techniques. [ABSTRACT FROM AUTHOR]
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- 2023
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11. Treating patients with excessively large annuli with self-expanding transcatheter aortic valves: insights into supra-annular structures that anchor the prosthesis.
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Xiong, Tian-Yuan, Liao, Yan-Biao, Li, Yi-Jian, Chen, Fei, Ou, Yuanweixiang, Wang, Xi, Wang, Zi-Jie, Li, Xi, Zhao, Zhen-Gang, Meng, Wei, Feng, Yuan, and Chen, Mao
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HEART valve prosthesis implantation ,AORTIC valve ,COMPUTED tomography ,PATIENT selection - Abstract
Copyright of Herz is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2021
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12. Introduction to the Department of Cardiology in West China Hospital of Sichuan University.
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Zhao, Zhen-Gang, He, Jing-Jing, Feng, Yuan, and Chen, Mao
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CARDIOLOGY ,HOSPITAL departments ,UNIVERSITY hospitals ,HEART valve prosthesis implantation ,AORTIC stenosis - Abstract
The article focuses on the Department of Cardiology in West China Hospital of Sichuan University in China. Topics discussed include the history and status of West China Hospital, its multidisciplinary heart valve team, and its clinical research on transcatheter aortic valve implantation in bicuspid anatomy and in calcific aortic stenosis.
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- 2021
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13. Differences in metabolic profiles between bicuspid and tricuspid aortic stenosis in the setting of transcatheter aortic valve replacement.
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Xiong, Tian-Yuan, Liu, Chang, Liao, Yan-Biao, Zheng, Wen, Li, Yi-Jian, Li, Xi, Ou, Yuanweixiang, Wang, Zi-Jie, Wang, Xi, Li, Chang-Ming, Zhao, Zhen-Gang, Feng, Yuan, Liu, Xiao-Jing, and Chen, Mao
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HEART valve prosthesis implantation ,AORTIC stenosis ,BICUSPIDS ,LIQUID chromatography-mass spectrometry ,MITRAL valve ,AORTIC valve surgery ,AORTIC valve abnormalities ,HEART valve diseases ,BIOCHEMISTRY ,ENERGY metabolism ,LEFT heart ventricle ,RESEARCH ,VENTRICULAR remodeling ,CONVALESCENCE ,RESEARCH methodology ,ARGININE ,EVALUATION research ,MEDICAL cooperation ,TREATMENT effectiveness ,COMPARATIVE studies ,PROSTHETIC heart valves ,PROLINE ,RESEARCH funding ,HEMODYNAMICS ,ARACHIDONIC acid ,HEART physiology ,AORTIC valve ,LONGITUDINAL method ,DISEASE complications - Abstract
Background: To explore why bicuspid aortic stenosis has certain clinical differences from the tricuspid morphology, we evaluated the metabolomics profile involved in bicuspid aortic valve (BAV) aortic stenosis prior to and after transcatheter aortic valve replacement (TAVR) in comparison with tricuspid aortic valve (TAV).Methods: In this TAVR cohort with prospectively collected data, blood samples were obtained before TAVR valve deployment and at the 7th day after TAVR, which were then sent for liquid and gas chromatography-mass spectrometry detection. Besides comparisons between BAV and TAV, BAV patients were also divided in subgroups according to baseline hemodynamics (i.e. maximal transaortic velocity, Vmax) and post-procedural reverse left ventricular (LV) remodeling (i.e. the change in LV mass index from baseline, ∆LVMI) for further analysis. Metabolic differences between groups were identified by integrating univariate test, multivariate analysis and weighted correlation network analysis algorithm.Results: A total of 57 patients were enrolled including 33 BAV patients. The BAV group showed lower arginine and proline metabolism both before and post TAVR than TAV represented by decreased expression of L-Glutamine. In BAV subgroup analysis, patients with baseline Vmax > 5 m/s (n = 11) or the 4th quartile of change in ∆LVMI at one-year follow-up (i.e. poorly-recovered LV, n = 8) showed elevated arachidonic acid metabolism compared with Vmax < 4.5 m/s (n = 12) or the 1st quartile of ∆LVMI (i.e. well-recovered LV, n = 8) respectively.Conclusions: Difference in arginine and proline metabolism was identified between BAV and TAV in TAVR recipients. Elevated arachidonic acid metabolism may reflect more severe baseline hemodynamics and worse LV reserve remodeling after TAVR in BAV. [ABSTRACT FROM AUTHOR]- Published
- 2020
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14. Transcatheter Aortic Valve Replacement in Patients with Aortic Stenosis Having Coronary Cusp Fusion versus Mixed Cusp Fusion Nonraphe Bicuspid Aortic Valve.
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Lei, Wen-hua, Liao, Yan-biao, Wang, Zi-jie, Ou, Yuan-weixiang, Tsauo, Jiay-yu, Li, Yi-jian, Xiong, Tian-yuan, Zhao, Zhen-gang, Wei, Xin, Meng, Wei, Feng, Yuan, and Chen, Mao
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HEART valve prosthesis implantation ,MITRAL valve ,AORTIC valve transplantation ,CORONARY artery stenosis ,AORTIC stenosis - Abstract
Objectives: We aimed to assess the procedural and clinical results of transcatheter aortic valve replacement (TAVR) for nonraphe bicuspid aortic stenosis (AS) with coronary vs mixed cusp fusion.Background: It remains unclear whether cusp fusion morphology affects TAVR outcomes in patients with nonraphe bicuspid AS.Methods: This retrospective study enrolled consecutive patients with severe symptomatic AS and type-0 bicuspid aortic valve, who underwent TAVR at our institution between 2012 and 2017. TAVR outcomes were defined based on the Valve Academic Research Consortium-2 recommendations.Results: Compared to patients with mixed cusp fusion (44/71), those with coronary cusp fusion (27/71) had a larger ellipticity index for the aortic annulus (21.9% ± 9.0% vs 15.6% ± 9.3%, p=0.007) and increased left ventricular outflow tract obstruction (31.1% ± 9.4% vs 26.9% ± 7.5%, p=0.04) but comparable rates of second valve implantation (15.9% vs 14.8%), mild paravalvular leakage (PVL, 38.5% vs 30.2%), permanent pacemaker implantation (PPM, 25.9% vs 15.9%), and 30-day mortality (7.4% vs 6.8%). Use of a first-generation transcatheter heart valve was associated with higher risk for mild PVL (odds ratio (OR) = 4.37; 95% confidence interval (95% CI) = 1.14-16.75; p=0.03) but not PPM (OR = 0.77; 95% CI = 0.22-2.62; p=0.67), whereas a larger oversizing ratio tended to be associated with a higher PPM rate (OR = 1.49; 95% CI = 0.46-4.86; p=0.51) but lower incidence of mild PVL (OR = 0.51; 95% CI = 0.19-1.35; p=0.17).Conclusions: In AS patients with type-0 bicuspid valves, cusp fusion morphology does not affect the procedural or clinical results of TAVR. Use of second-generation transcatheter heart valves may provide more favorable results in such patients. This trial is registered with NCT01683474. [ABSTRACT FROM AUTHOR]- Published
- 2019
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15. TCT-121 A Highly Predictive Model for New Permanent Pacemaker Implantation after Transcatheter Aortic Valve Replacement with Contemporary Self-Expanding Valves: Importance of the Membranous Septum Length.
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Zhao, Zhen-Gang, Williams, Mathew, Staniloae, Cezar, Vapheas, Eleonora, Du, Run, Wang, Moyang, Saric, Muhamed, Neuburger, Peter, Querijero, Michael, Vainrib, Alan, Hisamoto, Kazuhiro, Amoroso, Nicholas, Collins, Tara, Clark, Emily, Pushkar, Illya, Sin, Danielle, Shah, Binita, Taylor, Zachary, Lee, Hanah, and Vidal, Samantha
- Subjects
- *
HEART valve prosthesis implantation , *AORTIC valve , *PREDICTION models , *HEART block - Published
- 2018
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