1. FIB-4 stage of liver fibrosis is associated with incident heart failure with preserved, but not reduced, ejection fraction among people with and without HIV or hepatitis C.
- Author
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So-Armah KA, Lim JK, Lo Re V 3rd, Tate JP, Chang CH, Butt AA, Gibert CL, Rimland D, Marconi VC, Goetz MB, Ramachandran V, Brittain E, Long M, Nguyen KL, Rodriguez-Barradas MC, Budoff MJ, Tindle HA, Samet JH, Justice AC, and Freiberg MS
- Subjects
- Adult, Anti-HIV Agents adverse effects, Female, HIV Infections diagnosis, HIV Infections epidemiology, Health Status, Heart Failure diagnosis, Heart Failure physiopathology, Hepatitis C diagnosis, Hepatitis C virology, Humans, Incidence, Liver Cirrhosis diagnosis, Liver Cirrhosis virology, Male, Middle Aged, Prognosis, Risk Assessment, Risk Factors, Severity of Illness Index, Time Factors, United States epidemiology, Veterans Health, Viral Load, Anti-HIV Agents therapeutic use, HIV Infections drug therapy, HIV Long-Term Survivors, Heart Failure epidemiology, Hepatitis C epidemiology, Liver Cirrhosis epidemiology, Stroke Volume, Ventricular Function, Left
- Abstract
Background: Liver fibrosis, is independently associated with incident heart failure (HF). Investigating the association between liver fibrosis and type of HF, specifically HF with reduced ejection fraction (EF; HFrEF) or HF with preserved ejection fraction (HFpEF), may provide mechanistic insight into this association. We sought to determine the association between liver fibrosis score (FIB-4) and type of HF, and to assess whether HIV or hepatitis C status modified this association., Methods: We included patients alive on or after 4/1/2003 from the Veterans Aging Cohort Study. We followed patients without prevalent cardiovascular disease until their first HF event, death, last clinic visit, or 9/30/2015. We defined liver fibrosis as: likely advanced fibrosis (FIB-4 > 3.25), indeterminate (FIB-4 range 1.45-3.25), unlikely advanced fibrosis (FIB-4 < 1.45). Primary outcomes were HFrEF and HFpEF (defined using ICD-9 diagnoses for HF, and EF extracted from electronic medical records using natural language processing). Cox proportional hazards models were adjusted for potential confounders and used to estimate hazard ratios (HR)., Results: Among 108,708 predominantly male (96%) participants mean age was 49 years. Likely advanced fibrosis was present in 4% at baseline and was associated with an increased risk of HFpEF [HR (95% confidence interval)] [1.70 (1.3-2.3)]; and non-significantly with HFrEF [1.20 (0.9-1.7)]. These associations were not modified by HIV or hepatitis C status., Conclusion: Likely advanced fibrosis was independently associated with incident HFpEF but not HFrEF. This suggests that risk factors and/or mechanisms for liver fibrosis may have greater overlap with those for HFpEF than HFrEF., (Copyright © 2020. Published by Elsevier Inc.)
- Published
- 2020
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