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1. Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors: the profound effect of polarity on antiviral activity.

Author

Hagen SE, Prasad JV, Boyer FE, Domagala JM, Ellsworth EL, Gajda C, Hamilton HW, Markoski LJ, Steinbaugh BA, Tait BD, Lunney EA, Tummino PJ, Ferguson D, Hupe D, Nouhan C, Gracheck SJ, Saunders JM, and VanderRoest S

Subjects
Animals, Anti-HIV Agents pharmacokinetics, Chemical Phenomena, Chemistry, Physical, HIV Protease Inhibitors pharmacokinetics, HIV-1 drug effects, Kinetics, Mice, Pyrones pharmacokinetics, Structure-Activity Relationship, Anti-HIV Agents chemical synthesis, Anti-HIV Agents pharmacology, HIV Protease Inhibitors chemical synthesis, HIV Protease Inhibitors pharmacology, HIV-1 enzymology, Pyrones chemical synthesis, Pyrones pharmacology
Published
1997
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