7 results on '"Asiyeh Sadat Zahedi"'
Search Results
2. Sex, age, and ethnic dependency of lipoprotein variants as the risk factors of ischemic heart disease: a detailed study on the different age-classes and genders in Tehran Cardiometabolic Genetic Study (TCGS)
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Hossein Lanjanian, Leila Najd Hassan Bonab, Mahdi Akbarzadeh, Maryam Moazzam-Jazi, Asiyeh Sadat Zahedi, Sajedeh Masjoudi, and Maryam S. Daneshpour
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Male ,Myocardial infarction (MI) ,Physiology ,Myocardial Infarction ,Coronary Disease ,LPA locus ,Iran ,Age-of-onset ,Gender Studies ,Age ,Endocrinology ,Lp(a) ,Risk Factors ,Lipoprotein (a) ,Ethnicity ,Humans ,QP1-981 ,Longitudinal Studies ,TCGS ,Research ,Middle Aged ,Single nucleotide polymorphism ,Medicine ,Female ,Sex ,Lipoprotein(a) - Abstract
Biological processes involving environmental and genetic factors drive the interplay between age- and sex-regulating lipid profile. The relation between variations in the LPA gene with increasing the risk of coronary heart disease is dependent on population differences, sex, and age. The present study tried to do a gene candidate association analysis in people with myocardial infarction (MI) in a 22 year cohort family-based longitudinal cohort study, Tehran Cardiometabolic Genetic Study (TCGS). After adjusting p value by the FDR method, only the association of rs6415084 with the MI probability and the age-of-CHD-onset was significant in males in their middle age (p LPA and heart disease risk. Our observations may provide new insights into the biology that underlies lipid profile with age or the sexual dimorphism of Lp(a) metabolism. Finally, Lp(a) appears to be an independent risk factor; however, the role of sex and ethnicity is important.
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- 2022
3. Diverse effect of MC4R risk alleles on obesity-related traits over a lifetime: Evidence from a well-designed cohort study
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Maryam S. Daneshpour, Asiyeh Sadat Zahedi, Mahdi Akbarzadeh, Maryam Moazzam-Jazi, and Fereidoun Azizi
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Adult ,Male ,Longitudinal study ,Waist ,Genotype ,Population ,Single-nucleotide polymorphism ,Biology ,Iran ,Polymorphism, Single Nucleotide ,Body Mass Index ,Cohort Studies ,Gene Frequency ,Risk Factors ,Genetics ,medicine ,Humans ,Mass Screening ,Genetic Predisposition to Disease ,Longitudinal Studies ,Obesity ,education ,Alleles ,education.field_of_study ,Framingham Risk Score ,Waist-Hip Ratio ,General Medicine ,Middle Aged ,medicine.disease ,Phenotype ,Cohort ,Receptor, Melanocortin, Type 4 ,Female ,Waist Circumference ,Demography ,Cohort study - Abstract
This population-based longitudinal study is the first investigation that assesses the association of common MC4R SNPs with the obesity-related parameters over time and determines the effect of risk alleles during the three adulthood life periods (early, middle, and late) in a large Iranian cohort, a population with a unique genetic make-up that has been understudied and relatively unexplored. We obtained the genotype of 5370 unrelated adults who participated in the ongoing Tehran Cardiometabolic Genetic Study (TCGS) cohort project for the common MC4R SNPs. Linear regression and linear mixed model analyses were performed to examine the effect of MC4R polymorphisms on maximum BMI and other obesity-related factors over time. We recognized that several SNPs associated with the maximum BMI and the increased BMI, waist circumference, and waist-hip ratio across Iranian adults over a lifetime. Interestingly, we found that rs9954571-A has a yet unreported protective role against obesity-related factors, including BMI, waist circumference, waist-hip ratio, and triglyceride level. Additionally, a survey of the impact of the MC4R risk score throughout the adulthood life periods indicated that the MC4R risk score is influenced both the elevated BMI and waist circumference only during the early adulthood period. Our findings can expand our knowledge about the MC4R genetic variant's contributions to adulthood obesity and highlight the importance of evaluating the genetic components affecting obesity over a lifetime, which could be considered for obesity clinical screening and treatment.
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- 2021
4. Familial genetic and environmental risk profile and high blood pressure event: a prospective cohort of cardio-metabolic and genetic study
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Siamak Sabour, Asiyeh Sadat Zahedi, Saeid Rasekhi Dehkordi, Bahareh Sedaghati-khayat, Goodarz Kolifarhood, Forough Ghanbari, Kamran Guity, Farzad Hadaegh, Mahdi Akbarzadeh, Mahmoud Amiri Roudbar, Maryam S. Daneshpour, Fereidoun Azizi, and Nasim Khosravi
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Oncology ,Male ,medicine.medical_specialty ,Cell Adhesion Molecules, Neuronal ,Blood Pressure ,030204 cardiovascular system & hematology ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Quantitative Trait, Heritable ,Environmental risk ,Cardio metabolic ,Risk Factors ,Internal medicine ,Internal Medicine ,Medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Risk factor ,Prospective cohort study ,Retrospective Studies ,Models, Genetic ,business.industry ,Models, Cardiovascular ,Family aggregation ,Genetic Variation ,Tenascin ,General Medicine ,Environmental Exposure ,Blood pressure ,Hypertension ,Female ,Waist Circumference ,Cardiology and Cardiovascular Medicine ,business ,Genome-Wide Association Study - Abstract
High blood pressure is the heritable risk factor for cardiovascular diseases. We investigated whether the presence of familial genetic and environmental risk factors are associated with increased risk of high blood pressure.A total of 4,559 individuals from 401 families were included in this study. Familial aggregation analysis was carried out on systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI) and waist circumference (WC), and heritability was estimated for SBP and DBP. The association between familial risk factors and blood pressure traits including, incidence of hypertension, SBP and DBP was estimated separately using regression-based two-level Haseman-Elston (HE) method, with individual and familial BMI and WC as environmental exposures and familial genetic profile of known variants as genetic risk factors in 210 index families (≥2 hypertensive cases). Models were adjusted for the two nested sets of covariates.During a follow-up of 15 years, the SBP, DBP, BMI and WC were highly correlated in inter class of mother-offspring and intraclass of sister-sister with heritability of 30 and 25% for DBP and SBP, respectively. Among index families, those whose members with higher familial BMI or WC had significantly increased risk of hypertension and consistent, strong signals of rs2493134 (Findings from this study show that familial genetic and environmental risk profile increase risk for high blood pressure beyond the effect of the individuals' own risk factors.
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- 2021
5. Resemblance of nutrient intakes in three generations of parent-offspring pairs: Tehran lipid and Glucose Study
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Parvin Mirmiran, Asiyeh Sadat Zahedi, Glareh Koochakpour, Firoozeh Hosseini-Esfahani, Mahdi Akbarzadeh, Maryam S Daneshpour, and Fereidoun Azizi
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Adult ,Parents ,Eating ,Cross-Sectional Studies ,Glucose ,Multidisciplinary ,Humans ,Mothers ,Female ,Iran ,Middle Aged ,Lipids ,Aged - Abstract
The degree of maintaining nutrient intake patterns, conformed in the family, for offspring into adulthood is unknown. The aim of this study was to investigate the correlation between nutrient intakes in three younger-middle-older generations of Tehranian adults by sex. Of individuals who participated in 2012–15 phase of the Tehran Lipid and Glucose Study, 1286 families (4685 subjects), who had at least two members of the family with complete data in two or three generations were entered in this cross-sectional study. The energy and nutrient intakes of parents and their young or adult offspring or grandparents-grandson/granddaughter dyads were compared. The differences were estimated using pairwise t-test and partial correlation. Data of parents with their offspring were paired based on living arrangement. There were 857 fathers (mean age: 55.4±11.1) and 1394 mothers (mean age: 50.1±11.4). The mean age of grandfathers and grandmothers were 69.4±7.9 and 63.7±8.5 respectively. The significant correlation in fathers-sons and father-daughter (living with their parents) pairs were observed for 9 and 7 nutrients, respectively. Correlations for most nutrients were significant for mother-daughter or sons (living with their parents) dyads. The mean percentage of energy from total fat and trans-fatty acids of sons or daughters (living with their parents) were higher than their parents. For most nutrients, there were no significant adjusted correlations between parents-adult offspring (living independent of their parents) dyads. Also few nutrient intakes of grandparents-grandson or granddaughter dyads were correlated. The nutrient intakes of adult offspring were not associated with their parents; this correlation for younger and older generations disappeared. There were weak to moderate correlation between nutrient intakes of parent-offspring dyads that lived with their parents. The resemblance was higher for mother-offspring than father-offspring. Overall, total fat and trans-fatty acid intakes of young offspring were higher than their parents.
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- 2022
6. Parental Transmission Plays the Major Role in High Aggregation of Type 2 Diabetes in Iranian Families: Tehran Lipid and Glucose Study
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Maryam Zarkesh, Mahmoud Amiri Roudbar, Davood Khalili, Saeid Rasekhi Dehkordi, Asiyeh Sadat Zahedi, Azra Ramezankhani, Fereidoun Azizi, Maryam S. Daneshpour, Parisa Riahi, Kamran Guity, and Mahdi Akbarzadeh
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Parents ,business.industry ,Endocrinology, Diabetes and Metabolism ,Parenteral transmission ,Family aggregation ,Pedigree chart ,General Medicine ,Complex segregation analysis ,Heritability ,Iran ,Lipids ,Endocrinology ,Glucose ,Diabetes Mellitus, Type 2 ,Cohort ,Internal Medicine ,Inheritance Mode ,Medicine ,Humans ,Family history ,business ,Demography - Abstract
This study is the first to evaluate familial aggregation, heritability and inheritance mode of type 2 diabetes (T2D) in Tehran Lipid Glucose Study (TLGS) participants as a representative sample of the Iranian population.From the ongoing family-based TLGS cohort, 13,741 individuals at least 20 years of age (mean ± standard deviation, 39.71±16.56) were assessed. After correcting family structures using genomic information from the Tehran Cardiometabolic Genetic Study, 2,594 constituent pedigrees were constructed. Familial aggregation was assessed based on genealogic index testing, familial intraclass correlation and positive family history. Family-based heritability was checked with 2 linear mixed models, including 2 different random components: the kinship matrix and the genomic relationship matrix. The mode of inheritance of T2D was investigated by complex segregation analysis (CSA).Familial aggregation of T2D was significant (p0.05), and family-based heritability showed a high degree of genetic variation in T2D between individuals at 65% (standard error, 0.034). Within first-degree relatives (parent/offspring and siblings), the likelihood of a parental affect was higher than in siblings (odds ratio, 4.11 vs 1.65). Family history of T2D among first-degree relatives was more noteworthy than for second-degree relatives (odds ratio, 3.84 vs 0.59). CSA revealed that the polygenic model is best to illustrate the mode of inheritance of T2D for TLGS participants.Our findings demonstrate that the heritability of T2D with polygenic mode in the Iranian population is higher than the global average. We also found that T2D is transmitted equally into siblings, with parental affect the leading risk factor. These data suggest that policymakers should change individual-level to family-level prevention.
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- 2021
7. High genetic burden of type 2 diabetes can promote the high prevalence of disease: a longitudinal cohort study in Iran
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Leila Najd Hassan Bonab, Asiyeh Sadat Zahedi, Maryam Moazzam-Jazi, and Maryam S. Daneshpour
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0301 basic medicine ,Adult ,Male ,Population ,lcsh:Medicine ,Single-nucleotide polymorphism ,Diseases ,Disease ,Biology ,Iran ,Polymorphism, Single Nucleotide ,Article ,Cohort Studies ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Medical research ,Gene Frequency ,Risk Factors ,Genetics ,Prevalence ,Humans ,Genetic Predisposition to Disease ,Longitudinal Studies ,Allele ,education ,lcsh:Science ,Allele frequency ,Alleles ,education.field_of_study ,Multidisciplinary ,Molecular medicine ,lcsh:R ,Middle Aged ,030104 developmental biology ,Diabetes Mellitus, Type 2 ,Cohort ,lcsh:Q ,Female ,TCF7L2 ,Transcription Factor 7-Like 2 Protein ,030217 neurology & neurosurgery ,Demography ,Cohort study ,Genome-Wide Association Study - Abstract
Type 2 diabetes (T2D) is emerging as one of the serious public health issues in both developed and developing counties. Here, we surveyed the worldwide population differentiation in T2D-associated variants and assessed the genetic burden of the disease in an ongoing Tehran Cardio-Metabolic Genetic Study (TCGS) cohort represented the Iranian population. We found multiple SNPs that were significantly depleted or enriched in at least one of the five populations of 1,000 Genome Project (African, American, East Asian, European, and South Asian) as well as the Iranian population. Interestingly, TCF7L2, a well-known associated gene with T2D, harbors the highest number of enriched risk alleles almost in all populations except for East Asian, where this gene embraces the largest number of significantly depleted risk alleles. The polygenic risk score (PRS) of the enriched risk alleles was calculated for 1,867 diabetic and 2,855 non-diabetic participants in the TCGS cohort, interestingly demonstrating that the risk of developing T2D was almost two times higher in top PRS quintile compared with the lowest quintile after adjusting for other known risk factors.
- Published
- 2020
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