1. Therapeutic hypothermia for pediatric refractory status epilepticus May Ameliorate post-status epilepticus epilepsy
- Author
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Pi-Lien Hung, Ming-Yi Chou, Hsuan-Chang Kuo, Jainn-Jim Lin, Ying-Jui Lin, and Mei-Hsin Hsu
- Subjects
Male ,0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,Status epilepticus ,03 medical and health sciences ,Epilepsy ,Status Epilepticus ,0302 clinical medicine ,Dravet syndrome ,Hypothermia, Induced ,Temperature management system ,medicine ,Humans ,Therapeutic hypothermia ,lcsh:QH301-705.5 ,Retrospective Studies ,Pediatric intensive care unit ,lcsh:R5-920 ,Post-status epilepticus epilepsy ,business.industry ,Glasgow Outcome Scale ,Infant ,Retrospective cohort study ,General Medicine ,medicine.disease ,Febrile infection related epilepsy syndrome ,030104 developmental biology ,Pediatric refractory status epilepticus ,lcsh:Biology (General) ,Febrile infection-related epilepsy syndrome ,030220 oncology & carcinogenesis ,Pharmacoresistant refractory status epilepticus ,Epilepsy syndromes ,Anticonvulsants ,Female ,Original Article ,medicine.symptom ,lcsh:Medicine (General) ,business - Abstract
Background: To compare the clinical characteristics and outcomes of pediatric patients with refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE) who received therapeutic hypothermia (TH) plus anticonvulsants or anticonvulsants alone. Methods: Two-medical referral centers, retrospective cohort study. Pediatric Intensive Care Unit (PICU) at Taoyuan Chang Gung Children's hospital and Kaohsiung Chang Gung Memorial Hospital. We reviewed the medical records of 23 patients with RSE/SRSE who were admitted to PICU from January 2014 to December 2017. Of these, 11 patients received TH (TH group) and 12 patients did not (control group). Results: The selective endpoints were RSE/SRSE duration, length of PICU stay, and Glasgow Outcome Scale (GOS) score. We applied TH using the Artic Sun® temperature management system (target temperature, 34–35 °C; duration, 48–72 h). Of the 11 patients who received TH, 7 had febrile infection-related epilepsy syndrome (FIRSE), one had Dravet syndrome, and three had traumatic brain injury. The TH group had significantly shortern seizure durations than did the control group (hrs; median (IQR) 24(40) vs. 96(90), p
- Published
- 2020