1. Injectable hemostatic hydrogel adhesive with antioxidant, antibacterial and procoagulant properties for hemorrhage wound management.
- Author
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Yang J, Wang T, Zhang L, Fan P, Zhao J, Zheng X, Lai Y, Liu H, and Wang S
- Subjects
- Animals, Rats, Hemostasis drug effects, Male, Injections, Adhesives chemistry, Adhesives pharmacology, Particle Size, Escherichia coli drug effects, Mannans, Hydrogels chemistry, Hydrogels pharmacology, Antioxidants pharmacology, Antioxidants chemistry, Antioxidants administration & dosage, Antioxidants chemical synthesis, Hemostatics pharmacology, Hemostatics chemistry, Hemostatics administration & dosage, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents administration & dosage, Hemorrhage drug therapy, Chitosan chemistry, Chitosan pharmacology, Chitosan analogs & derivatives, Rats, Sprague-Dawley
- Abstract
In emergencies, uncontrolled severe bleeding can result in undesired complications and even death of the injured. Designing advanced hemostatic agents is a potential solution for emergency hemostasis, yet it remains challenging to realize the persistent adhesion in a wet wound environment. In this study, based on dynamic reversible Schiff base bond and photo-initiated double-bond polymerization, a novel injectable hemostatic hydrogel (L-COC) consisting of methacrylated carboxymethyl chitosan (CMCSMA), oxidized konjac glucomannan (OKGM) and (+)-catechin hydrate (CH) was synthesized for emergency hemostasis. To our delight, the incorporated CH imparted enhanced blood procoagulantion to the L-COC hydrogel by intensifying the hydrogel-red blood cell interactions. As a result, the hemostatic effect of the engineered L-COC hydrogel was significantly superior to that of fluid gelatin Surgiflo
TM for liver bleeding wounds in rats (Blood loss: 0.62 ± 0.11 g (L-COC), 0.90 ± 0.08 g (SurgifloTM ); hemostasis time: 69.0 ± 2.9 s (L-COC), 84.0 ± 2.2 s (SurgifloTM )). With the favorable antioxidant and antibacterial activities, as well as multifunctional properties, the bio-adhesive L-COC hydrogel and the underlying design principles may facilitate further development of practical hemostatic hydrogels., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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