1. In silico prediction of Leishmania major-specific CD8+ epitopes.
- Author
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Dietze‐Schwonberg, Kirsten, Grewe, Beatrix, Brosch, Sven, Kuharev, Joerg, Zandbergen, Ger, Rammensee, Hans‐Georg, Tenzer, Stefan, and Stebut, Esther
- Subjects
LEISHMANIA ,IMMUNOCOMPETENT cells ,EPITOPES ,PATHOGENIC microorganisms ,IMMUNE response - Abstract
Infections with Leishmania (L.) major induce protective IFN-γ-dependent Th1/Tc1 immunity in C57 BL/6 mice as well as in immunocompetent humans. Even though antigen-specific immunity provides lifelong immunity against reinfection, a vaccine against this pathogen does not yet exist. Here, we compared the results obtained from in silico predictions of murine CD8-specific L. major peptides using the algorithm SYFPEITHI with the number and predicted affinity of known proteins/peptides. Our results indicate that the majority of 'immunodominant' epitopes of L. major have not been identified so far; thus, computer-based prediction algorithms may aid the development of an effective vaccine. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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