1. Perforation predicts poor prognosis in patients with primary intestinal diffuse large B-cell lymphoma.
- Author
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Chuang, S.-S., Ye, H., Yang, S.-F., Huang, W.-T., Chen, H.-K., Hsieh, P.-P., Hwang, W.-S., Chang, K.-Y., Lu, C.-L., and Du, M.-Q.
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SMALL intestine ,B cell lymphoma ,FLUORESCENCE in situ hybridization ,IMMUNOHISTOCHEMISTRY ,ANESTHESIA in oncology ,LYMPHOID tissue ,ORGANS (Anatomy) ,ONCOLOGY - Abstract
Aims: To elucidate the clinicopathological features and prognostic factors of primary intestinal diffuse large B-cell lymphoma (PI-DLBL). Methods and results: Archival tissues from 30 tumours were used for tissue microarray construction, immunohistochemistry and interphase fluorescence in situ hybridization for chromosomal translocation. The M:F ratio was 1.7:1, with a median age of 60 years. The ileum and ileocaecum were most frequently involved (40% each). Fourteen (47%) were at stage I
E disease, 15 (50%) at stage IIE . Five (17%) tumours were perforated at presentation. The tumours expressed Bcl-6 (73%), MUM1 (70%), Bcl-2 (67%) and CD10 (23%). Nine (30%) were classified as germinal centre B-cell (GCB) phenotype and 21 non-GCB. Eight of 30 (27%), 7/30 (23%) and 2/29 (7%) cases were positive for rearrangements involving IGH, BCL6, and C-MYC loci, respectively, whereas all cases were negative for BCL2 and CCND1 translocation. Perforation was a poor prognostic indicator, with a hazard ratio of tumour-related death at 8.75 ( P = 0.001). The differentiation antigens, GCB versus non-GCB phenotype, or lymphoma-associated translocations were of no prognostic significance. Conclusions: We found a higher rate of perforation and lower frequency of GCB phenotype in PI-DLBL in Taiwan compared with other geographical areas; perforation is a poor prognostic indicator. [ABSTRACT FROM AUTHOR]- Published
- 2008
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