Search

Your search keyword '"Samri, Assia"' showing total 8 results
Start Over Author "Samri, Assia" Topic immunology
8 results on '"Samri, Assia"'

1. Human Immunodeficiency Virus Type-1 (HIV-1) Continues to Evolve in Presence of Broadly Neutralizing Antibodies More than Ten Years after Infection

Author

Chaillon, Antoine, Braibant, Martine, Hué, Stéphane, Bencharif, Samia, Enard, David, Moreau, Alain, Samri, Assia, Agut, Henri, and Barin, Francis

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, HIV/AIDS, Immunization, Infectious Diseases, Pediatric AIDS, Prevention, Clinical Research, Vaccine Related, Pediatric, Vaccine Related (AIDS), Infection, Good Health and Well Being, Amino Acid Sequence, Analysis of Variance, Antibodies, Neutralizing, Bayes Theorem, Evolution, Molecular, HIV Envelope Protein gp120, HIV Infections, HIV-1, Humans, Likelihood Functions, Markov Chains, Models, Genetic, Monte Carlo Method, Phylogeny, Selection, Genetic, Sensitivity and Specificity, Sequence Analysis, DNA, Survivors, General Science & Technology
Abstract

BackgroundThe evolution of HIV-1 and its immune escape to autologous neutralizing antibodies (Nabs) during the acute/early phases of infection have been analyzed in depth in many studies. In contrast, little is known about neither the long-term evolution of the virus in patients who developed broadly Nabs (bNabs) or the mechanism of escape in presence of these bNabs.ResultsWe have studied the viral population infecting a long term non progressor HIV-1 infected patient who had developed broadly neutralizing antibodies toward all tier 2/3 viruses (6 clades) tested, 9 years after infection, and was then followed up over 7 years. The autologous neutralization titers of the sequential sera toward env variants representative of the viral population significantly increased during the follow-up period. The most resistant pseudotyped virus was identified at the last visit suggesting that it represented a late emerging escape variant. We identified 5 amino acids substitutions that appeared associated with escape to broadly neutralizing antibodies. They were V319I/S, R/K355T, R/W429G, Q460E and G/T463E, in V3, C3 and V5 regions.ConclusionThis study showed that HIV-1 may continue to evolve in presence of both broadly neutralizing antibodies and increasing autologous neutralizing activity more than 10 years post-infection.

Published
2012

2. Identification of natural killer markers associated with fatal outcome in COVID-19 patients

Author

Tarantino, Nadine, Litvinova, Elena, Samri, Assia, Soulié, Cathia, Morin, Véronique, Rousseau, Alice, Dorgham, Karim, Parizot, Christophe, Bonduelle, Olivia, Beurton, Alexandra, Miyara, Makoto, Ghillani, Pascale, Mayaux, Julien, Lhote, Raphael, Lacorte, Jean-Marc, Marcelin, Anne-Geneviève, Amoura, Zahir, Luyt, Charles-Edouard, Gorochov, Guy, Guihot, Amélie, and Vieillard, Vincent

Subjects
Microbiology (medical), Infectious Diseases, Immunology, Microbiology
Published
2023
Full Text
View/download PDF

3. A Comparison of Cell Activation, Exhaustion, and Expression of HIV Coreceptors and Restriction Factors in HIV-1- and HIV-2-Infected Nonprogressors

Author

Diallo, Mariama Sadjo, Samri, Assia, Charpentier, Charlotte, Bertine, Mélanie, Cheynier, Rémi, Thiébaut, Rodolphe, Matheron, Sophie, Collin, Fidéline, Braibant, Martine, Candotti, Daniel, Appay, Victor, Brun-Vézinet, Françoise, Chaghil, Nathalie, Descamps, Diane, Hosmalin, Anne, Pancino, Gianfranco, Manel, Nicolas, Marchand, Lucie, Pedroza-Martins, Livia, Sáez-Cirión, Asier, Agut, Henri, Clauvel, Jean-Pierre, Costagliola, Dominique, Debré, Patrice, Theodorou, Ioannis, Sicard, Didier, Viard, Jean-Paul, Barin, Francis, Vieillard, Vincent, Autran, Brigitte, Centre d'Immunologie et de Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Laboratoire de Virologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Equipe de Biostatistique, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR99-ISPED, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des maladies infectieuses et tropicales, Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Epidémiologie, santé publique et développement, Virus, pseudo-virus: Morphogénèse et Antigénicité, Université de Tours (UT)-EA3856, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Tours-EA3856

Subjects
0301 basic medicine, CD4-Positive T-Lymphocytes, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Ubiquitin-Protein Ligases, Immunology, Human immunodeficiency virus (HIV), HIV Infections, Biology, medicine.disease_cause, West africa, HIV Long-Term Survivors, Antiviral Restriction Factors, Tripartite Motif Proteins, 03 medical and health sciences, 0302 clinical medicine, Virology, medicine, Humans, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, virus diseases, 3. Good health, 030104 developmental biology, Infectious Diseases, HIV-2, HIV-1, [SDV.IMM]Life Sciences [q-bio]/Immunology, Cell activation
Abstract

Human immunodeficiency viruses induce rare attenuated diseases due either to HIV-1 in the exceptional long-term nonprogressors (LTNPs) or to HIV-2 in West Africa. To better understand characteristics of these two disease types we performed a multiplex comparative analysis of cell activation, exhaustion, and expression of coreceptors and restriction factors in CD4 T cells susceptible to harbor those viruses. We analyzed by flow cytometry the expression of HLA-DR, PD1, CCR5, CXCR6, SAMHD1, Blimp-1, and TRIM5α on CD4 T cell subsets from 10 HIV-1

Published
2020
Full Text
View/download PDF

4. Polyfunctional HIV-specific T cells in Post-Treatment Controllers

Author

Samri, Assia, Bacchus-Souffan, Charlin, Hocqueloux, Laurent, Avettand-Fenoel, Véronique, Descours, Benjamin, Theodorou, Ioannis, Larsen, Martin, Sáez-Cirión, Asier, Rouzioux, Christine, Autran, Brigitte, Group, Anrs Visconti, Sorbonne Université (SU), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional d'Orléans (CHRO), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Laboratoire de Virologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), HIV, Inflammation et persistance - HIV, Inflammation and Persistence, Institut Pasteur [Paris] (IP), The study was supported by the ANRS, the French National Agency for Research on AIDS, and Viral Hepatitis (Grant ANRS EP47). The promoter is the Centre Hospitalier Regional d’Orleans, Université Pierre et Marie Curie, Univ Paris 06 ( Sorbonne University ), Centre d'Immunologie et de Maladies Infectieuses ( CIMI ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Centre Hospitalier Régional d'Orléans ( CHR ), Université Paris Descartes - Faculté de Médecine ( UPD5 Médecine ), Université Paris Descartes - Paris 5 ( UPD5 ), CHU Necker - Enfants Malades [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP), Service d'immunologie [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], HIV, Inflammation et persistance, Institut Pasteur [Paris], Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Immunologie [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional d'Orléans (CHR), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP]

Subjects
CD4-Positive T-Lymphocytes, 0301 basic medicine, Anti-HIV Agents, Immunology, Human immunodeficiency virus (HIV), HIV Infections, CD8-Positive T-Lymphocytes, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Secondary Prevention, medicine, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, Humans, Immunology and Allergy, Cytotoxic T cell, 030212 general & internal medicine, Secondary prevention, business.industry, virus diseases, 3. Good health, 030104 developmental biology, Infectious Diseases, [SDV.IMM]Life Sciences [q-bio]/Immunology, Post treatment, business, After treatment
Abstract

International audience; To further understand the exceptional HIV-1 control observed in Post-Treatment Controllers (PTCs) from the Virological and Immunological Sustained CONtrol after Treatment Interruption study we investigated their HIV-specific T-cell responses. Polyfunctionality of HIV-specific CD4 and CD8 T cells and the ratios of HIV-specific CD4 T cells per infected cells were similar in post-treatment controllers, continuously early-treated patients and long-term non-progressors Overall early treatment appears to preserve robust HIV-specific CD4 T cells, which might contribute to the posttreatment control of HIV.

Published
2016
Full Text
View/download PDF

5. Persistent deficiency of mucosal-associated invariant T cells during dermatomyositis.

Author

Cassius, Charles, Branchtein, Mylene, Battistella, Maxime, Amode, Reyhan, Lepelletier, Clémence, Jachiet, Marie, Masson, Adèle de, Frumholtz, Laure, Chasset, François, Amoura, Zahir, Mathian, Alexis, Samri, Assia, Monfort, Jean-Benoit, Bachmeyer, Claude, Bengoufa, Djaouida, Cordoliani, Florence, Bagot, Martine, Bensussan, Armand, Bouaziz, Jean-David, and Buanec, Hélène Le

Subjects
ATOPIC dermatitis, COMPARATIVE studies, DERMATOMYOSITIS, FLOW cytometry, IMMUNITY, PSORIASIS, T cells, PHENOTYPES, CYTOTOXINS
Abstract

Objectives Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that are important for antibacterial immunity and may have regulatory roles. MAIT cells are decreased during SLE. However, their frequencies and phenotype have not been investigated in DM. We studied MAIT cell frequencies and phenotype in DM patients with active and inactive disease (after treatment). Methods Peripheral blood flow cytometry analysis of MAIT cells was compared between DM (n  = 22), SLE (n  = 10), psoriasis (n  = 7) and atopic dermatitis (n  = 5) patients, and healthy controls (n  = 19). Results A dramatic decrease of circulating MAIT cell frequency was observed in active DM and SLE patients compared with healthy controls and other inflammatory skin diseases [active DM: median = 0.25% (interquartile range 0.19–0.6%), P  < 0.0001; active SLE: median = 0.61 (0.55–0.77), P  < 0.0001 vs healthy controls: 2.32% (1.18–4.45%)]. MAIT cells from active DM patients had an abnormal phenotype including increased expression of CD25 and cytotoxic T-lymphocyte-associated protein 4 that correlated with their low frequency in the blood. Conclusion In DM, peripheral blood MAIT cells are dramatically reduced and have an activated/exhausted phenotype that may be linked to increased activation-induced cell death. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

6. Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission

Author

Cheret , Antoine, Bacchus-Souffan , Charline, Avettand-Fenoël , Véronique, Mélard , Adeline, Nembot , Georges, Blanc , Catherine, Samri , Assia, Saez-Cirion , Asier, Hocqueloux , Laurent, Lascoux-Combe , Caroline, Allavena , Clotilde, Goujard , Cécile, Valantin , Marc Antoine, Leplatois , Anne, Meyer , Laurence, Rouzioux , Christine, Autran , Brigitte, Group , OPTIPRIM ANRS-147 Study, Centre Hospitalier de Tourcoing, Infection à VIH, réservoirs, diversité génétique et résistance aux antirétroviraux (ARV) ( EA 7327 ), Université Paris Descartes - Paris 5 ( UPD5 ), Laboratoire de Virologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Immunité et Infection, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IFR113-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de santé publique et d'épidémiologie, Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Bicêtre, Plateforme Cytométrie Pitié-Salpêtrière ( CyPS ), Unité Mixte de Service d'Imagerie et de Cytométrie ( UMS LUMIC ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Assistance publique - Hôpitaux de Paris (AP-HP), Régulation des Infections Rétrovirales, Institut Pasteur [Paris], Centre Hospitalier Régional d'Orléans ( CHR ), Service de maladies infectieuses et tropicales [Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Diderot - Paris 7 ( UPD7 ) -Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Service de maladies infectieuses et tropicales [Nantes], Université de Nantes ( UN ) -Hôtel-Dieu-Centre hospitalier universitaire de Nantes ( CHU Nantes ), Médecine interne [CHU Bicêtre], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Service de Maladies Infectieuses [Nice], These trials were funded by the French National Agency for Research on AIDS and Viral Hepatitis (ANRS) and conducted with the support of MSD, Janssen, ViiV Healthcare and GILEAD Laboratories., OPTIPRIM ANRS-147 Study Group, Infection à VIH, réservoirs, diversité génétique et résistance aux antirétroviraux (ARV) (EA 7327), Université Paris Descartes - Paris 5 (UPD5), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR113-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Plateforme Cytométrie Pitié-Salpêtrière (LUMIC-CYPS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Unité Mixte de Service d'Imagerie et de Cytométrie (UMS LUMIC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional d'Orléans (CHRO), Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR113-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Service de Maladies Infectieuses et Tropicales [CHU Pitié-Salpêtrière], Institut Pasteur [Paris] (IP), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Microbiology (medical), Male, Adult, CD4-Positive T-Lymphocytes, T cell, Human immunodeficiency virus (HIV), Antiretroviral Therapy, HIV Infections, reservoirs, Biology, medicine.disease_cause, Immunophenotyping, 03 medical and health sciences, Young Adult, 0302 clinical medicine, HIV DNA, Antiretroviral Therapy, Highly Active, medicine, Secondary Prevention, Humans, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, Pharmacology (medical), Highly Active, 030212 general & internal medicine, Young adult, 030304 developmental biology, Pharmacology, 0303 health sciences, post-treatment controllers, T lymphocyte, Middle Aged, 3. Good health, Peripheral, Infectious Diseases, medicine.anatomical_structure, Treatment Outcome, Viral replication, Anti-Retroviral Agents, Immunology, primary HIV infections, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Off Treatment
Abstract

BackgroundTherapeutic control of HIV replication reduces the size of the viral reservoir, particularly among central memory CD4+ T cells, and this effect might be accentuated by early treatment.MethodsWe examined the effect of ART initiated at the time of the primary HIV infection (early ART), lasting 2 and 6 years in 11 and 10 patients, respectively, on the HIV reservoir in peripheral resting CD4+ T cells, sorted into naive (TN), central memory (TCM), transitional memory (TTM) and effector memory (TEM) cells, by comparison with 11 post-treatment controllers (PTCs).ResultsBetween baseline and 2 years, CD4+ T cell subset numbers increased markedly (P ConclusionsEarly prolonged ART thus limits the size of the HIV reservoir, protects long-lived cells from persistent infection and may enhance post-treatment control.

Published
2015
Full Text
View/download PDF

7. Limited HIV-2 reservoirs in central-memory CD4 T-cells associated to CXCR6 co-receptor expression in attenuated HIV-2 infection.

Author

Samri, Assia, Charpentier, Charlotte, Diallo, Mariama, Bertine, Mélanie, Even, Sophie, Morin, Véronique, Oudin, Anne, Parizot, Christophe, Collin, Gilles, Hosmalin, Anne, Cheynier, Rémi, Thiébaut, Rodolphe, Matheron, Sophie, Collin, Fideline, Zoorob, Rima, Brun-Vézinet, Françoise, Autran, Brigitte, and null, null

Subjects
*HIV, *CD4 antigen, *T cells, *TRANSCRIPTOMES, *FLOW cytometry
Abstract

The low pathogenicity and replicative potential of HIV-2 are still poorly understood. We investigated whether HIV-2 reservoirs might follow the peculiar distribution reported in models of attenuated HIV-1/SIV infections, i.e. limited infection of central-memory CD4 T lymphocytes (TCM). Antiretroviral-naive HIV-2 infected individuals from the ANRS-CO5 (12 non-progressors, 2 progressors) were prospectively included. Peripheral blood mononuclear cells (PBMCs) were sorted into monocytes and resting CD4 T-cell subsets (naive [TN], central- [TCM], transitional- [TTM] and effector-memory [TEM]). Reactivation of HIV-2 was tested in 30-day cultures of CD8-depleted PBMCs. HIV-2 DNA was quantified by real-time PCR. Cell surface markers, co-receptors and restriction factors were analyzed by flow-cytometry and multiplex transcriptomic study. HIV-2 DNA was undetectable in monocytes from all individuals and was quantifiable in TTM from 4 individuals (median: 2.25 log10 copies/106 cells [IQR: 1.99–2.94]) but in TCM from only 1 individual (1.75 log10 copies/106 cells). HIV-2 DNA levels in PBMCs (median: 1.94 log10 copies/106 PBMC [IQR = 1.53–2.13]) positively correlated with those in TTM (r = 0.66, p = 0.01) but not TCM. HIV-2 reactivation was observed in the cells from only 3 individuals. The CCR5 co-receptor was distributed similarly in cell populations from individuals and donors. TCM had a lower expression of CXCR6 transcripts (p = 0.002) than TTM confirmed by FACS analysis, and a higher expression of TRIM5 transcripts (p = 0.004). Thus the low HIV-2 reservoirs differ from HIV-1 reservoirs by the lack of monocytic infection and a limited infection of TCM associated to a lower expression of a potential alternative HIV-2 co-receptor, CXCR6 and a higher expression of a restriction factor, TRIM5. These findings shed new light on the low pathogenicity of HIV-2 infection suggesting mechanisms close to those reported in other models of attenuated HIV/SIV infection models. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

8. Association of Residual Plasma Viremia and Intima-Media Thickness in Antiretroviral-Treated Patients with Controlled Human Immunodeficiency Virus Infection

Author

Boyd, Anders, Meynard, Jean-Luc, Morand-Joubert, Laurence, Michon, Adrien, Boccara, Franck, Bastard, Jean-Philippe, Samri, Assia, Haddour, Nabila, Mallat, Ziad, Capeau, Jacqueline, Desvarieux, Moise, and Girard, Pierre-Marie

Subjects
Highly active antiretroviral therapy, FOS: Clinical medicine, HIV (Viruses)--Patients, Immunology, cardiovascular system, cardiovascular diseases, Medical sciences, 3. Good health
Abstract

Background While residual plasma viremia is commonly observed in HIV-infected patients undergoing antiretroviral treatment (ART), little is known about its subclinical consequences. Methods This cross-sectional study included 47 male, never-smoking, non-diabetic patients with ≥4 years of ART and controlled HIV-replication (HIV-viral load, VL

Catalog

Books, media, physical & digital resources
See catalog results