1. Biphasic Waning of Hemagglutination Inhibition Antibody Titers After Influenza Vaccination in Children.
- Author
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Xiong, Weijia, Tsang, Tim K, Perera, Ranawaka A P M, Leung, Nancy H L, Fang, Vicky J, Barr, Ian G, Peiris, J S Malik, Cowling, Benjamin J, and Malik Peiris, J S
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VACCINATION of children , *INFLUENZA vaccines , *ANTIBODY titer , *BLOOD agglutination , *HEMAGGLUTINATION tests , *BCG vaccines , *TITERS , *INFLUENZA prevention , *ANTIGEN-antibody reactions , *RESEARCH , *VACCINES , *IMMUNIZATION , *RESEARCH methodology , *EVALUATION research , *COMPARATIVE studies , *RANDOMIZED controlled trials , *INFLUENZA B virus , *VIRAL antibodies , *INFLUENZA A virus, H3N2 subtype - Abstract
We explored the potential for a biphasic pattern in waning of antibody titers after influenza vaccination. We collected blood samples in a randomized controlled trial of influenza vaccination in children and tested them with hemagglutination inhibition assays for influenza A(H3N2) and influenza B/Victoria lineage. Using piecewise log-linear mixed-effects models, we found evidence for a faster initial waning of antibody titers for the first 1-2 years after vaccination and then slower longer-term declines. Children with higher postvaccination titers had faster antibody decay. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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