1. ICU Admission in Children With Acute Lymphoblastic Leukemia in Sweden: Prevalence, Outcome, and Risk Factors.
- Author
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Ranta S, Broman LM, Abrahamsson J, Berner J, Fläring U, Hed Myrberg I, Kalzén H, Karlsson L, Mellgren K, Nilsson A, Norén-Nyström U, Palle J, von Schewelov K, Svahn JE, Törnudd L, Heyman M, and Harila-Saari A
- Subjects
- Adolescent, Child, Child, Preschool, Humans, Infant, Infant, Newborn, Prevalence, Retrospective Studies, Risk Factors, Sweden epidemiology, Intensive Care Units, Precursor Cell Lymphoblastic Leukemia-Lymphoma epidemiology, Precursor Cell Lymphoblastic Leukemia-Lymphoma therapy
- Abstract
Objectives: Despite progress in the treatment of childhood acute lymphoblastic leukemia, severe complications are common, and the need of supportive care is high. We explored the cumulative prevalence, clinical risk factors, and outcomes of children with acute lymphoblastic leukemia, on first-line leukemia treatment in the ICUs in Sweden., Design: A nationwide prospective register and retrospective chart review study., Setting: Children with acute lymphoblastic leukemia were identified, and demographic and clinical data were obtained from the Swedish Childhood Cancer Registry. Data on intensive care were collected from the Swedish Intensive Care Registry. Data on patients with registered ICU admission in the Swedish Childhood Cancer Registry were supplemented through questionnaires to the pediatric oncology centers., Patients: All 637 children 0-17.9 years old with acute lymphoblastic leukemia diagnosed between June 2008 and December 2016 in Sweden were included., Interventions: None., Measurements and Main Results: Twenty-eight percent of the children (178/637) were admitted to an ICU at least once. The Swedish Intensive Care Registry data were available for 96% of admissions (241/252). An ICU admission was associated with poor overall survival (hazard ratio, 3.25; 95% CI, 1.97-5.36; p ≤ 0.0001). ICU admissions occurred often during early treatment; 48% (85/178) were admitted to the ICU before the end of the first month of acute lymphoblastic leukemia treatment (induction therapy). Children with T-cell acute lymphoblastic leukemia or CNS leukemia had a higher risk of being admitted to the ICU in multivariable analyses, both for early admissions before the end of induction therapy and for all admissions during the study period., Conclusions: The need for intensive care in children with acute lymphoblastic leukemia, especially for children with T cell acute lymphoblastic leukemia and CNS leukemia, is high with most admissions occurring during early treatment., Competing Interests: Dr. Ranta’s institution received funding from the Stockholm County Council, the Swedish Childhood Cancer Foundation, Swedish Orphan Biovitrum AB, and Pediatric Network on haemophilia management; she received support for article research from the Stockholm County Council (ALF project). Drs. Ranta and Heyman received support for article research from the Swedish Childhood Cancer Foundation. Dr. Broman received funding from Eurosets and Xenios. Dr. Abrahamsson received support for article research from the Children’s Cancer Foundation Sweden. Dr. Heyman’s institution received funding from Servier and Pfizer. The remaining authors have disclosed that they do not have any potential conflicts of interest., (Copyright © 2021 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.)
- Published
- 2021
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