1. Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study
- Author
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Kefei Dou, Na-Qiong Wu, Jie Qian, Qian Dong, Ming-Ming Liu, Cheng-Gang Zhu, Hui-Hui Liu, Jian-Jun Li, Jia Peng, and Yuan-Lin Guo
- Subjects
Prothrombin time ,medicine.medical_specialty ,Coagulation ,medicine.diagnostic_test ,business.industry ,Proportional hazards model ,Research ,PCSK9 ,PT ,Hematology ,Thrombin time ,Chest pain ,Atherosclerosis ,Gastroenterology ,Cardiovascular risks ,Internal medicine ,medicine ,Coagulation testing ,Diseases of the blood and blood-forming organs ,medicine.symptom ,RC633-647.5 ,business ,Prospective cohort study ,Partial thromboplastin time - Abstract
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is considered to have multiple roles in the development of atherosclerosis, which is recently reported to participate in the thrombotic process. We aimed to examine the relationship between PCSK9 concentration, coagulation indexes and cardiovascular events. Methods A total of 2293 consecutive patients with angina-like chest pain and without lipid-lowering drugs treatment were enrolled and followed up for major adverse cardiovascular events (MACEs). Circulating PCSK9 concentration was determined by ELISA. The routine coagulation tests including activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time were performed. The associations between PCSK9 concentration, routine coagulation indicators and MACEs were analyzed. Results Patients with high PCSK9 levels had lower PT and APTT levels (all p p Conclusions Our study firstly suggested that PCSK9 concentration was negatively correlated with plasma levels of PT. Furthermore, high PCSK9 and low PT were associated with MACEs and the combination of PCSK9 with PT had an addictive effect on predicting cardiovascular outcomes in patients with chest pain, which was useful for further subdivision of cardiovascular risks.
- Published
- 2021