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A tandem formal [3+2] cycloaddition/cyclization reaction of aminochalcones with tosylmethyl isocyanide derivatives was developed for the practical and convenient synthesis of diverse tricyclic pyrrolo[3,4- c]quinolines in high to excellent yields. In this domino process, three new bonds and two rings are successively formed at ambient conditions. [ABSTRACT FROM AUTHOR]

A base-catalyzed tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition of ethyl isocyanoacetate and Michael acceptors with tethered carbonyl groups is described. This reaction leads to the formation of fused oxazolines in a highly diastereoselective manner under very mild conditions. [ABSTRACT FROM AUTHOR]

α-Acidic isocyanidesare versatile reagents in organicsynthesis, especially for the synthesis of five-membered heterocyclesvia [3 + 2]-cycloaddition reactions with activated multiplebonds. In this communication, the first [3 + 3]-cross-cycloadditionof α-acidic isocyanides with 1,3-dipolar azomethine iminesto generate a series of 1,2,4-triazine derivatives with significantregiochemical control under mild catalytic reaction conditionsis described. This new strategy shows that α-acidic isocyanidescan also be taken as potent reagents for the synthesis of six-memberedheterocycles through [3 + 3]-cross-cycloaddition reactionswith 1,3-dipoles. [ABSTRACT FROM AUTHOR]