1. Antagonists and inhibitors of lipid mediators in experimental inflammation of the cornea.
- Author
-
van Haeringen NJ, Verbey NL, and van Delft JL
- Subjects
- Animals, Chromones therapeutic use, Eicosapentaenoic Acid therapeutic use, Fluorometholone therapeutic use, Ginkgolides, Keratitis prevention & control, Lactones therapeutic use, Linolenic Acids therapeutic use, Lipoxygenase Inhibitors therapeutic use, Male, Platelet Activating Factor antagonists & inhibitors, Rabbits, SRS-A antagonists & inhibitors, Suprofen therapeutic use, Diterpenes, Keratitis metabolism, Lipids antagonists & inhibitors
- Abstract
In experimental immunogenic keratitis, provoked in rabbits by intracorneal injection of 20 microliters of human serum albumin (HSA), various anti-inflammatory agents were studied in their effects on corneal edema, neovascularisation and leukocyte infiltration. Prophylactic treatment with a corticosteroid completely prevented the occurrence of keratitis. Nonsteroidal anti-inflammatory drugs such as a cyclooxygenase inhibitor partly prevented neovascularisation and corneal edema, a lipoxygenase inhibitor, a leukotriene antagonist or platelet-activating factor (PAF)-antagonist BN 52021 partially prevented mainly leukocyte infiltration. Prophylactic topical treatment with the poly-unsaturated fatty acids eicosapentaenoic acid and columbinic acid or a dietary supplement with fish oil showed less symptoms of keratitis in all respects.
- Published
- 1993
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