1. Relation of renal dysfunction with incident atrial fibrillation and cardiovascular morbidity and mortality: The PREVEND study.
- Author
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Marcos EG, Geelhoed B, Van Der Harst P, Bakker SJL, Gansevoort RT, Hillege HL, Van Gelder IC, and Rienstra M
- Subjects
- Adult, Albuminuria diagnosis, Albuminuria mortality, Albuminuria physiopathology, Atrial Fibrillation diagnosis, Atrial Fibrillation mortality, Atrial Fibrillation physiopathology, Biomarkers blood, Creatinine blood, Cystatin C blood, Female, Follow-Up Studies, Humans, Incidence, Kaplan-Meier Estimate, Kidney Diseases diagnosis, Kidney Diseases mortality, Kidney Diseases physiopathology, Male, Middle Aged, Multivariate Analysis, Netherlands epidemiology, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Risk Assessment, Risk Factors, Time Factors, Albuminuria epidemiology, Atrial Fibrillation epidemiology, Glomerular Filtration Rate, Kidney physiopathology, Kidney Diseases epidemiology
- Abstract
Aims: Renal dysfunction is a risk factor for cardiovascular disease, including atrial fibrillation (AF) and mortality. However, the exact pathobiology linking different renal dysfunction measures, such as albumin excretion or glomerular filtration rate (GFR), to cardiovascular- and AF risk are unclear. In this study, we investigated the association of several renal function measures and incident AF, and whether the relation between renal measures and outcomes is modified by AF., Methods and Results: We examined 8265 individuals (age 49 ± 13 years, 50% women) included in the PREVEND study. We used albumin excretion (morning void and 24-h urine samples), serum creatinine, cystatin C, and Cystatin C-based, creatinine-based, and creatinine-cystatin C-based GFR as renal function measures; results: During a follow-up of 9.8 ± 2.3 years, 267 participants (3.2%) developed AF. In the multivariate-adjusted model, GFR, estimated by creatinine, cystatin C, or the combination was not associated with incident AF. However, increased albumin excretion was strongly associated with incident AF; urine albumin concentration and excretion (HRmorning void 1.10, P = 0.005 and HR24-hr collection 1.05, P = 0.033) and albumin creatinine ratio (HRmorning void 1.05, P = 0.010 and HR24-hr collection 1.06, P < 0.001). Interaction terms of incident AF and renal measures were not significant for incident cerebrovascular events, peripheral vascular events, ischemic heart disease, heart failure, and mortality., Conclusion: In this community-based cohort, increased albumin excretion, and not GFR, was associated with incident AF, independent of established cardiovascular risk factors. Incidence of AF did not largely alter the association of renal dysfunction and cardiovascular outcomes., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2017
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