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Your search keyword '"deWolf-Peeters, C"' showing total 4 results
Start Over Author "deWolf-Peeters, C" Topic lymphoma, b-cell
4 results on '"deWolf-Peeters, C"'

1. Analysis of VH genes in 49 marginal zone lymphoma cases reveals marked heterogeneity between splenic and nodal tumors and suggests the existence of clonal selection.

Author

Dewolf Peeters C

Subjects
Animals, Antibody-Producing Cells physiology, Clonal Anergy genetics, Genes, Immunoglobulin physiology, Humans, Lymph Nodes, Lymphatic Diseases blood, Lymphoma, B-Cell blood, Lymphoma, B-Cell immunology, Mice, Mutation drug effects, Neoplasms, Splenic Neoplasms blood, T-Lymphocytes immunology, Immunoglobulin Heavy Chains genetics, Immunoglobulin Variable Region genetics, Lymphatic Diseases genetics, Lymphoma, B-Cell genetics, Splenic Neoplasms genetics
Published
2005

2. Mutation analysis of the rearranged immunoglobulin heavy chain genes of marginal zone cell lymphomas indicates an origin from different marginal zone B lymphocyte subsets.

Author

Tierens A, Delabie J, Pittaluga S, Driessen A, and DeWolf-Peeters C

Subjects
Aged, Aged, 80 and over, Amino Acid Sequence, Cell Lineage genetics, DNA Mutational Analysis, Female, Humans, Lymph Nodes immunology, Lymph Nodes pathology, Lymphoma, B-Cell pathology, Male, Middle Aged, Molecular Sequence Data, Spleen immunology, Spleen pathology, Gene Rearrangement, Genes, Immunoglobulin, Immunoglobulin Heavy Chains genetics, Lymphocyte Subsets immunology, Lymphoma, B-Cell genetics, Lymphoma, B-Cell immunology
Abstract

Marginal zone cell lymphoma is a recently described entity among the non-Hodgkin's lymphomas. It likely originates from the marginal zone B cells in the spleen and equivalent cells in the lymph node and extranodal tissues. Recent evidence indicates that marginal zone B cells are functionally heterogeneous and may differ with respect to the pattern of somatic hypermutation in their Ig variable genes. To test whether marginal zone lymphomas may originate from different subsets of marginal zone B cells, we performed a sequence and mutation analysis of the rearranged Ig heavy chain (IgH) variable genes (VH) of a series of 14 cases of marginal zone lymphoma, occurring in the spleen (4), the lymph node (4), the stomach (2), the orbit (2), the tongue (1), and the skin (1). Our data show that marginal zone cell lymphomas preferentially rearrange the VH4, VH3, and VH1 family genes, without preference for any particular VH gene. Somatic mutations are present in 13 cases; one case of marginal zone cell lymphoma of the skin showed a germline configuration of the rearranged VH gene. Mutation analysis shows evidence of antigen selection in three cases of marginal zone cell lymphoma, one of the spleen, stomach, and orbit, respectively. No evidence of antigen selection was present in the other cases. These data indicate that marginal zone cell lymphomas may arise from different subsets of marginal zone B cells. In addition, lymphomagenesis may not be triggered by antigen in all cases of marginal zone cell lymphoma.

Published
1998

3. Workshop report on Hodgkin's disease and related diseases ('grey zone' lymphoma).

Author

Rüdiger T, Jaffe ES, Delsol G, deWolf-Peeters C, Gascoyne RD, Georgii A, Harris NL, Kadin ME, MacLennan KA, Poppema S, Stein H, Weiss LE, and Müller-Hermelink HK

Subjects
Diagnosis, Differential, Hodgkin Disease immunology, Hodgkin Disease pathology, Humans, Immunohistochemistry, Lymphoma, B-Cell immunology, Lymphoma, B-Cell pathology, Lymphoma, Large B-Cell, Diffuse immunology, Lymphoma, Large B-Cell, Diffuse pathology, Mediastinal Neoplasms immunology, T-Lymphocytes immunology, Hodgkin Disease diagnosis, Lymphoma, B-Cell diagnosis, Lymphoma, Large B-Cell, Diffuse diagnosis
Abstract

Despite advances in immunohistochemistry and molecular biology, the distinction between classical Hodgkin's lymphoma and related diseases such as nodular lymphocyte-predominant Hodgkin's disease, T-cell rich large B-cell lymphoma or anaplastic large cell lymphoma has remained difficult in rare cases. Lack of clear-cut diagnostic criteria represents a problem for both the pathologist and the clinician. To delineate this 'grey zone' between classical Hodgkin's lymphoma and non-Hodgkin's lymphoma (NHL) and to develop criteria for classification of such cases, 12 expert hematopathologists each submitted one to five borderline cases to a workshop. Cases were reviewed and classified at a multiheaded microscope and criteria were established for the diagnosis of questionable cases. Well established entities such as classical Hodgkin's lymphoma, anaplastic large-cell lymphoma and TCRBCL were defined more strictly and cases with unusual morphology or antigen expression could be identified. A distinctive subset of cases representing mediastinal large B-cell lymphomas with features of Hodgkin's lymphoma was identified.

Published
1998
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4. Gastric lymphoma and Helicobacter pylori--diagnostic criteria.

Author

Ectors N, Driessen A, DeWolf-Peeters C, and Geboes K

Subjects
Antigens, CD analysis, Antigens, Neoplasm analysis, Biopsy, Gastroscopy, Helicobacter Infections diagnosis, Helicobacter pylori isolation & purification, Humans, Immunohistochemistry, Neoplasm Staging, Polymerase Chain Reaction, Sensitivity and Specificity, Lymphoma, B-Cell diagnosis, Stomach Neoplasms diagnosis
Published
1997

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