1. Three-dimensional simultaneous T1 and T2* relaxation times and quantitative susceptibility mapping at 3 T: A multicenter validation study.
- Author
-
Fujita S, Hagiwara A, Kimura K, Taniguchi Y, Ito K, Nagao H, Takizawa M, Uchida W, Kamagata K, Tateishi U, and Aoki S
- Subjects
- Humans, Reproducibility of Results, Male, Female, Adult, Prospective Studies, Young Adult, Healthy Volunteers, Image Processing, Computer-Assisted methods, Algorithms, Linear Models, Magnetic Resonance Imaging methods, Imaging, Three-Dimensional methods, Brain diagnostic imaging
- Abstract
We aimed to determine the intra-site repeatability and cross-site reproducibility of T1 and T2* relaxation times and quantitative susceptibility (χ) values obtained through quantitative parameter mapping (QPM) at 3 T. This prospective study included three 3-T scanners with the same hardware and software platform at three sites. The brains of twelve healthy volunteers were scanned three times using QPM at three sites. Intra-site repeatability and cross-site reproducibility were evaluated based on voxel-wise and region-of-interest analyses. The within-subject coefficient of variation (wCV), within-subject standard deviation (wSD), linear regression, Bland-Altman plot, and intraclass correlation coefficient (ICC) were used for evaluation. The intra-site repeatability wCV was 11.9 ± 6.86% for T1 and 3.15 ± 0.03% for T2*, and wSD of χ at 3.35 ± 0.10 parts per billion (ppb). Intra-site ICC(1,k) values for T1, T2*, and χ were 0.878-0.904, 0.972-0.976, and 0.966-0.972, respectively, indicating high consistency within the same scanner. Linear regression analysis revealed a strong agreement between measurements from each site and the site-average measurement, with R-squared values ranging from 0.79 to 0.83 for T1, 0.94-0.95 for T2*, and 0.95-0.96 for χ. The cross-site wCV was 13.4 ± 5.47% for T1 and 3.69 ± 2.25% for T2*, and cross-site wSD of χ at 4.08 ± 3.22 ppb. The cross-site ICC(2,1) was 0.707, 0.913, and 0.902 for T1, T2*, and χ, respectively. QPM provides T1, T2*, and χ values with an intra-site repeatability of <12% and cross-site reproducibility of <14%. These findings may contribute to the development of multisite studies., Competing Interests: Declaration of competing interest YT is an employee of FUJIFILM Corporation. KI, HN, and MT are employees of FUJIFILM Healthcare Corporation. The remaining authors have no conflict of interest. This study was partially supported by the Juntendo Research Branding Project, the Sportology Center of Juntendo UniversityGraduate School of Medicine, Leading-edge Research Project for Sports Medicine and Science (LRP) of the Japan Sports Agency, the Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI; grant numbers JP19K17244, JP 23 K07189, JP19K17177), the Japan Agency for Medical Research and Development (AMED; grant numbers JP18dm0307004, JP19dm0307101 and JP21wm0425006), the Japan Radiological Society, and a Bayer Research Grant., (Copyright © 2024. Published by Elsevier Inc.)
- Published
- 2024
- Full Text
- View/download PDF