1. Cytotoxic garcimultiflorones K–Q, lavandulyl benzophenones from Garcinia multiflora branches.
- Author
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Wang, Zhao-Quan, Li, Xing-Yu, Hu, Dong-Bao, and Long, Chun-Lin
- Subjects
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GARCINIA , *BENZOPHENONES , *NUCLEAR magnetic resonance spectroscopy , *MASS spectrometry , *CANCER cells - Abstract
Seven undescribed lavandulyl benzophenones garcimultiflorones K – Q, and fourteen known compounds were isolated from the CHCl 3 soluble fraction of 95% EtOH extract of Garcinia multiflora branches. Their structures and absolute configurations were determined by spectroscopic techniques including NMR spectroscopy, MS analysis, and ECD calculations. Seven isolated compounds expect for garcimultiflorone L and garcimultiflorone O exhibited cytotoxic activities in vitro against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7, and SW480). It is worth mentioning that garcimultiflorone Q exhibited most significant cytotoxicities against five cancer cell lines with IC 50 values ranging from 3.07–12.56 μM. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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