Search

Your search keyword '"Anna Osipova"' showing total 5 results
Start Over Author "Anna Osipova" Topic medicine
5 results on '"Anna Osipova"'

1. Extracorporeal Photopheresis in Children with Chronic Graft-Versus-Host Disease

Author

Andrey Kozlov, Maria Estrina, Olesia Paina, Tatiana Bykova, Anna Osipova, Polina Kozhokar, Zhemal Rakhmanova, Irina Solodova, Elena Morozova, Alexander Alyansky, Irina Kulagina, Asmik Gevorgian, Anna Dotsenko, Ivan Moiseev, Alexey Chukhlovin, Alexander Kulagin, Sergey Bondarenko, Elena Semenova, and Ludmila Zubarovskaya

Subjects
children, chronic graft versus host disease, extracorporeal photopheresis, Medicine, Pharmacy and materia medica, RS1-441
Abstract

Chronic graft versus host disease (cGVHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). It significantly decreases survival and quality of life. The present study demonstrates retrospective data on extracorporeal photopheresis (ECP) in children with cGVHD. A total of 42 children with steroid-refractory cGVHD were enrolled in the study. The majority of patients had acute leukemia (n = 32, 76%). All patients received ECP as second (n = 18, 43%) or third (n = 24, 57%) line of therapy. Initial ECP schedule consisted of bimonthly regimen for two consecutive days with possibility of further tapering according to response. Any concurrent treatment administered before ECP could be continued if considered necessary. Complete response to ECP was registered in seven (17%) patients and partial response in 24 (57%). Overall response according to organ involvement was as follows: skin (n = 24, 75%), mucous membranes (n = 16, 73%), liver (n = 8, 80%), gut (n = 4, 80%), lungs (n = 2, 22%) and joints (n = 2, 67%). Five-year overall, progression-free and failure-free survival was 57%, 56% and 30%, respectively. Non-relapse mortality at 5 years was 14%. We didn’t observe any clinically significant complications in children that could be attributed to the procedure. ECP remains important and safe treatment option in children with cGVHD.

Published
2021
Full Text
View/download PDF

2. Assessment of a Possibility to Differentiate the Tumor Histological Type and Localization in Patients with Lung Cancer by the Composition of Exhaled Air

Author

Anna Osipova, V. A. Porkhanov, Dmitry Perunov, E. M. Gashimova, A. Z. Temerdashev, E. V. Dmitrieva, and Igor Polyakov

Subjects
Clinical Practice, Pathology, medicine.medical_specialty, Noninvasive sampling, Chemistry, Histological type, medicine, Cancer, In patient, Lung cancer, medicine.disease, Exhaled air, Analytical Chemistry
Abstract

In clinical practice, exhaled air analysis is a promising approach for diagnosing lung cancer due to a possibility of rapid and noninvasive sampling. We analyzed the exhaled air of 80 patients with lung cancer to identify differences in the profiles of volatile organic compounds in patients with different histological types and localization of cancer using gas chromatography–mass spectrometry. Some volatile organic compounds and their ratios have been identified, statistically signficant differences in concentrations of which have been found in samples with different localization and histological type.

Published
2021

3. Reading Comprehension Instruction for Students With Autism Spectrum Disorder

Author

Holly M. Menzies, Anna Osipova, and Ya-Chih Chang

Subjects
Pharmacology, Linguistics and Language, Teaching method, medicine.disease, Language and Linguistics, Developmental psychology, Comprehension, Reading comprehension, Autism spectrum disorder, medicine, Diagnostic assessment, Autism, Pharmacology (medical), Psychology, Inclusion (education)
Published
2020

4. Exhaled breath analysis using GC-MS and an electronic nose for lung cancer diagnostics

Author

E. M. Gashimova, V. A. Porkhanov, Dmitry Perunov, A. Z. Temerdashev, Igor Polyakov, Anna Osipova, and E. V. Dmitrieva

Subjects
Reproducibility, medicine.medical_specialty, Training set, Lung Neoplasms, Electronic nose, business.industry, General Chemical Engineering, General Engineering, Reproducibility of Results, medicine.disease, Gastroenterology, Gas Chromatography-Mass Spectrometry, Analytical Chemistry, Clinical Practice, Breath gas analysis, Breath Tests, Internal medicine, Healthy volunteers, Medicine, Humans, Gas chromatography–mass spectrometry, business, Lung cancer, Electronic Nose, Lung
Abstract

Exhaled breath analysis is an interesting and promising approach for the diagnostics of various diseases. Being non-invasive, convenient and simple, this approach has tremendous potential utility for further translation into clinical practice. In this study, gas chromatography-mass spectrometry (GC-MS) and quartz microbalance sensor-based "electronic nose" were applied for analysis of the exhaled breath of 40 lung cancer patients and 40 healthy individuals. It was found that the electronic nose was unable to distinguish the samples of different groups. However, the application of GC-MS allowed identifying statistically significant differences in compound peak areas and their ratios for investigated groups. Diagnostic models were created using random forest classifier based on peak areas and their ratios with the sensitivity and specificity of peak areas (ratios) of 85.7-96.5% (75.0-93.1%) and 73.3-85.1% (90.0-92.5%) on training data and 63.6-75.0% (72.7-100.0%) and 50.0-69.2% (76.9-84.6%) on test data, respectively. The exhaled breath samples of lung cancer patients and healthy volunteers could be distinguished by GC-MS with the use of individual compounds, but application of their ratios could help to determine specific differences between investigated groups and the level the influence of individual metabolism features alternating from one person to another as well as daily instrument reproducibility deviations. The electronic nose has to be significantly improved to apply it to lung cancer diagnostics of exhaled breath analysis and the influence of water vapour has to be lowered to increase the sensitivity of the sensors to detect lung cancer biomarkers.

Published
2021

5. Study of confounding factors influence on lung cancer diagnostics effectiveness using gas chromatography-mass spectrometry analysis of exhaled breath

Author

Anna Osipova, E. V. Dmitrieva, Igor Polyakov, A. Z. Temerdashev, E. M. Gashimova, Dmitry Perunov, and V. A. Porkhanov

Subjects
Disease status, medicine.medical_specialty, business.industry, 010401 analytical chemistry, Biochemistry (medical), Clinical Biochemistry, Confounding, medicine.disease, Logistic regression, 01 natural sciences, Gastroenterology, Gas Chromatography-Mass Spectrometry, 0104 chemical sciences, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Healthy individuals, Internal medicine, Drug Discovery, Healthy volunteers, medicine, Smoking status, Gas chromatography–mass spectrometry, Lung cancer, business
Abstract

Aim: The purpose of this study was to estimate volatile organic compounds (VOCs) ability to distinguish exhaled breath samples of lung cancer patients and healthy volunteers and to assess the effect of smoking status and gender on parameters. Patients & methods: Exhaled breath samples of 40 lung cancer patients and 40 healthy individuals were analyzed using gas chromatography–mass spectrometry. Influence of other factors on the exhaled breath VOCs profile was investigated. Results: Some parameters correlating with the disease status were affected by other factors. Excluding these parameters allows creating a logistic regression diagnostic model with 83% sensitivity and 81% specificity. Conclusion: Influence of other factors on the exhaled breath VOCs profile has to be taken into account to avoid misleading results.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results