122 results on '"G., Karthikeyan"'
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2. A hybrid deep learning approach to solve optimal power flow problem in hybrid renewable energy systems
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G. Gurumoorthi, S. Senthilkumar, G. Karthikeyan, and Faisal Alsaif
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Optimal power flow ,Hybrid renewable energy system ,Solar ,Wind energy ,Deep learning ,Deep reinforcement learning ,Medicine ,Science - Abstract
Abstract The reliable operation of power systems while integrating renewable energy systems depends on Optimal Power Flow (OPF). Power systems meet the operational demands by efficiently managing the OPF. Identifying the optimal solution for the OPF problem is essential to ensure voltage stability, and minimize power loss and fuel cost when the power system is integrated with renewable energy resources. The traditional procedure to find the optimal solution utilizes nature-inspired metaheuristic optimization algorithms which exhibit performance drop in terms of high convergence rate and local optimal solution while handling uncertainties and nonlinearities in Hybrid Renewable Energy Systems (HRES). Thus, a novel hybrid model is presented in this research work using Deep Reinforcement Learning (DRL) with Quantum Inspired Genetic Algorithm (DRL-QIGA). The DRL in the proposed model effectively combines the proximal policy network to optimize power generation in real-time. The ability to learn and adapt to the changes in a real-time environment makes DRL to be suitable for the proposed model. Meanwhile, the QIGA enhances the global search process through the quantum computing principle, and this improves the exploitation and exploration features while searching for optimal solutions for the OPF problem. The proposed model experimental evaluation utilizes a modified IEEE 30-bus system to validate the performance. Comparative analysis demonstrates the proposed model’s better performance in terms of reduced fuel cost of $620.45, minimized power loss of 1.85 MW, and voltage deviation of 0.065 compared with traditional optimization algorithms.
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- 2024
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3. The severe presentation and poor outcomes of rheumatic heart disease in Namibia: Lessons from the REMEDY study
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T Auala, L Zühlke, L Sikwaya, H du Toit, G Karthikeyan, K Teo, S Yusuf, M E Engels, B M Mayosi, and C T Hugo-Hamman
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Rheumatic Diseases ,Medicine ,Medicine (General) ,R5-920 - Abstract
Background. This paper reports the baseline characteristics and outcomes of 266 Namibian patients in the Global Registry of Rheumatic Heart Disease. Objective. To describe clinical findings and outcomes in a cohort of children and adults with rheumatic heart disease in Namibia. Methods. Prospective study of all patients with rheumatic heart disease at Windhoek Central Hospital between January 2010 and November 2012. Results. A total of 266 patients were enrolled; median age was 22 years, 72.6% were
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- 2023
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4. Co-existence of chlorosis inducing strain of Cucumber mosaic virus with tospoviruses on hot pepper (Capsicum annuum) in India
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J. Vinodhini, L. Rajendran, R. Abirami, and G. Karthikeyan
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Medicine ,Science - Abstract
Abstract Cucumo- and tospoviruses are the most destructive viruses infecting hot pepper (chilli). A diagnostic survey was conducted to assess the prevalence of cucumo and tospoviruses in chilli growing tracts of Tamil Nadu. Infected plants showing mosaic with chlorotic and necrotic rings, veinal necrosis, mosaic mottling, leaf filiformity and malformation were collected. Molecular indexing carried out through reverse transcription polymerase chain reaction (RT-PCR) with coat protein gene specific primer of Cucumber mosaic virus (CMV) and tospovirus degenerate primer corresponding to the L segment (RdRp). Ostensibly, amplifications were observed for both CMV and tospoviruses as sole as well for mixed infections. The sequence analysis indicated that the Capsicum chlorosis virus (CaCV) and Groundnut bud necrosis virus (GBNV) to be involved with CMV in causing combined infections. The co-infection of CMV with CaCV was detected in 10.41% of the symptomatic plant samples and combined infection of CMV with GBNV was recorded in around 6.25% of the symptomatic plants surveyed. The amino acid substitution of Ser129 over conserved Pro129 in coat protein of CMV implies that CMV strain involved in mixed infection as chlorosis inducing strain. Further, the electron microscopy of symptomatic plant samples explicated the presence of isometric particles of CMV and quasi spherical particles of tospoviruses. This is the first molecular evidence for the natural co-existence of chlorosis inducing CMV strain with CaCV and GBNV on hot pepper in India.
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- 2021
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5. Heart failure guidelines for India: Update 2017
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Sandeep Seth, S Ramakrishnan, Neeraj Parekh, G Karthikeyan, Sandeep Singh, and Gautam Sharma
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2017 ,heart failure guidelines ,India ,Medicine ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Heart failure (HF) is a major health problem in India with a postadmission mortality of 20%–30%. Medication adherence ranges from 25% to 50%, and the tolerance of guideline-based medication is low for Indian patients. We took out guidelines on HF in 2015, and this update covers the changes which have occurred in HF management in the past 2 years. As a number of new drugs such as angiotensin receptor-neprilysin inhibitor and ivabradine have been approved for use in India, devices such as implantable cardioverter-defibrillators and cardiac resynchronization therapy are becoming more accessible and more left ventricular assist devices and transplants are being done in India, there is need for clear guidelines for the use of each which are practical for India.
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- 2017
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6. Algorithms for cardiovascular disease prevention
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Sandeep Seth, S Ramakrishnan, Ambuj Roy, G Karthikeyan, Sunil K Verma, Balram Bhargava, and S K Maulik
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Algorithms ,CAD ,cardiovascular disease guidelines ,India ,prevention ,Medicine ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Prevention of coronary artery disease requires control of risk factors. It is not enough to take out guidelines, it is necessary to implement the guidelines. There are a number of studies which have shown that quite often guidelines are not followed.In this article, we have abstracted the essence of the guidelines into simple to follow algorithms so that they are easy to remember and also teach. For Cardiovascular risk reduction, general measures include stopping smoking, perform 150 minutes of moderate activity per week and take a low fat and low salt diet. For hypertension: All classes of drugs are suitable but generally (NICE 2011) Angiotensin receptor blockers or Angiotensin converting enzyme inhibitors for young (55 years, many with isolated systolic hypertension) Calcium channel blockers, diuretics if needed , are prefered. Combinations are used if monotherapy does not work. For dyslipidemia: Statin benefit groups are defined and manifest coronary artery disease and Diabetics above 40 years should get high dose statins. Lipid levels are only tested to look for compliance or further intensification of regime. Diabetes: Metformin is the drug of choice, Sulfonylureas can be used in combination. Glyptins are also safe and can be used. Other drugs should be used with the help of the endocrinologist.
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- 2016
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7. Initial Invasive or Conservative Strategy for Stable Coronary Disease
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Maron D. J., Hochman J. S., Reynolds H. R., Bangalore S., O'Brien S. M., Boden W. E., Chaitman B. R., Senior R., Lopez-Sendon J., Alexander K. P., Lopes R. D., Shaw L. J., Berger J. S., Newman J. D., Sidhu M. S., Goodman S. G., Ruzyllo W., Gosselin G., Maggioni A. P., White H. D., Bhargava B., Min J. K., John Mancini G. B., Berman D. S., Picard M. H., Kwong R. Y., Ali Z. A., Mark D. B., Spertus J. A., Krishnan M. N., Elghamaz A., Moorthy N., Hueb W. A., Demkow M., Mavromatis K., Bockeria O., Peteiro J., Miller T. D., Szwed H., Doerr R., Keltai M., Selvanayagam J. B., Gabriel Steg P., Held C., Kohsaka S., Mavromichalis S., Kirby R., Jeffries N. O., Harrell F. E., Rockhold F. W., Broderick S., Bruce Ferguson T., Williams D. O., Harrington R. A., Stone G. W., Rosenberg Y, ISCHEMIA Research Group: Joseph Ricci, A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Rabaça, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fernández Martínez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, André Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andrés García-Rincón, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej Łabyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Peñaranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel Åkerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezińska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Begoña Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard Jäger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Carísi A Polanczyk, Carita Krannila, Carla Vicente, Carl-Éric Gagné, Carlo Briguori, Carlos Peña Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Björklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cortés, Claudia Escobar, Cláudia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adrián Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elihú Durán-Cortés, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnación Alonso-Álvarez, Eric Nicollet, Eric Peterson, Erick Alexánderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eustáquio Ribeiro Silva, F Marin Ortuño, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Flávia Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely Ágoston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidović, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Lladó, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, Inês Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, João Reynaldo Abbud, João V Vitola, Joaquín V Peñafiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, José A Ortega-Ramírez, José Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Vieira, José M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padró, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio César Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna Łoboz-Grudzień, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kukuła, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura Keinaite, Laura Sarti, Laurel Kolakaluri, Lawrence M Phillips, Lawrence Friedman, Lawrence Phillips, Lazar Velicki, Leah Howell, Leandro C Maranan, Leanne Cox, Ledjalem Daba, Lei Zhang, Lekshmi Dharmarajan, Leo Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Leszek Sokalski, Li Hai Yan, Li Li, Lia Nijmeijer, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilia Schiavi, Lilian Mazza Barbosa, Lillian L Khor, Lina Felix-Stern, Linda L Hall, Linda M Hollenweger, Linda Arcand, Linda Davidson-Ray, Linda Schwarz, Lindsey N Sikora, Lingping Chi, Lino Patricio, Liping Zhang, Lisa Chaytor, Lisa Hatch, Lisa McCloy, Lisa Wong, Liselotte Persson, Lixin Jiang, Liz Low, Ljiljana Pupic, Loïc Bière, Lorenzo Monti, Lori Christensen, Lori Pritchard, Loriane Black, Lori-Ann Desimone, Lori-Ann Larmand, Lorraine McGregor, Louise Morby, Louise Thomson, Luc Harvey, Luciana de Pádua Baptista, Lucilla Garcia, Ludivine Eliahou, Ludmila Helmer, Luis F Smidt, Luis Bernanrdes, Luis Guzman, Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Valdés Chávarri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena Łanocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Małgorzta Celińska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Valério Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C 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George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely Ágoston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidović, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Lladó, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, Inês Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, João Reynaldo Abbud, João V Vitola, Joaquín V Peñafiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, José A Ortega-Ramírez, José Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Vieira, José M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padró, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio César Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima 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Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna Łoboz-Grudzień, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kukuła, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura Keinaite, Laura Sarti, Laurel Kolakaluri, Lawrence M Phillips, Lawrence Friedman, Lawrence Phillips, Lazar Velicki, Leah Howell, Leandro C Maranan, Leanne Cox, Ledjalem Daba, Lei Zhang, Lekshmi Dharmarajan, Leo Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Leszek Sokalski, Li Hai Yan, Li Li, Lia Nijmeijer, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilia Schiavi, Lilian Mazza Barbosa, Lillian L Khor, Lina Felix-Stern, Linda L Hall, Linda M Hollenweger, Linda 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Marija T Petrovic, Marija Zdravkovic, Marilyn Black, Marina Garcia, Mario J Garcia, Mariola Szulik, Marisa Orgera, Mark A de Belder, Mark Harbinson, Mark Hyun, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Marcinkiewicz-Siemion, Marta Swiderek, Martha Meyer, Martina Ceseri, Martina Tricoli, Marvin Kronenberg, Mary Williams, Mary Ann Champagne, Mary Colleen Rogge, Mary R Soltau, Mary Streif, Massimo Villella, Massoud Leesar, Matei Claudia, Mateusz Solecki, Matías Nicolás Mungo, Matthew Wall Jr, Matthew Budoff, Matthew Jezior, Matthew Luckie, Matthias Friedrich, Mauren P Haeffner, Maximilian Tscharre, Max-Paul Winter, Mayana Almeida, Mayil S Krishnam, Mayuri Patel, Meenakshi Mishra, Megan Manocchia, Meghana Kakade, Melanie J Munro, Melissa D Chaplin, Melissa LeFevre, Mervyn Andiapen, Michael A Gibson, Michael B Rubens, Michael C Turner, Michael D Shapiro, Michael W Lee, Michael Berlowitz, Michael Davidson, Michael Mack, Michael McDaniel, Michael Mumma, Michal Wlodarczyk, Michel G Khouri, Michel S Slama, Michele Rawlins, Michelle M Bonner, Michelle M Seib, Michelle Chang, Michelle Crowder, Michelle Dixon, Michelle Mayon, Michelle McEvoy, Michelle Yee, Miguel M Fernandes, Miguel Nobre Menezes, Miguel Souto Bayarri, Miguel Barrero, Mikhail T Torosoff, Milan R Dobric, Milan Dobric, Milica Nikola Dekleva, Milind Avdhoot Gadkari, Millie Gomez, Min Tun Kyaw, Miriam Brooks, Miroslav Stevo Martinovic, Mitchel B Lustre, Mohammad Tariq Vakani, Mohammad El-Hajjar, Mohammed Al-Amoodi, Mohammed Hussain, Mohammed Saleem, Moisés Blanco-Calvo, Moisés Jiménez-Santos, Mona Bhatia, Monica Rosca, Monika Laukyte, Montserrat Gracida Blanca, Montserrat Vila Perales, Mouaz H Al-Mallah, Moysés de Oliveira Filho, Mpiko Ntsekhe, Muhamed Saric, Mulei Chen, Myriam Brousseau, Myrthes Emy Takiuti, Nada Cemerlic-Adjic, Nadia Asif, Nadia Gakou, Nafisa Hussain, Nana O Katamadze, Nancy L Clapp, Nancy Aedy, Nandita Nataraj, Nanette K Wenger, Naomi Uchida, Nasrul Ismail, 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Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Julian, Pamela Ouyang, Pamela Sigel, Pamela Woodard, Panpan Zhou, Paola Emanuela Poggio, Paola Smanio, Paolo Calabro, Paramjit Jeetley, Pascal Goube, Patricia K Nguyen, Patricia Alarie, Patricia Arakelian, Patricia Arsenault, Patricia Blaise, Patricia Brito, Patricia Cowper, Patricia Endsley, Patricia Mieses, Patrick B Alexander, Patrick Donnelly, Patrick Wilmot, Patrycja Lebioda, Paul C Gordon, Paul Der Mesropian, Paul Galiwango, Paul Hauptman, Paul Kennedy, Paula Beardsley, Paula García-González, Paulo Cury Rezende, Paulo Ricardo Caramori, Pavel S Kozlov, Pedro Canas Silva, Pedro Gabriel Melo Barros E Silva, Pedro Píccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peeyush Jain, Peiyu He, Peter A McCullough, Peter H Stone, Peter M Pollak, Peter Douglass, Peter Henriksen, Peter OKane, Peter Ong, Philip Jones, Philip Rogal, Philippe Généreux, Philippe Menasche, Philippe Rheault, Phoebe Goold, Pierre Gervais, Pierre Michaud, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Piotr Slomka, Piyamitr Sritara, Poay-Huan Loh, Poonam Sonawane, Pouneh Samadi, Pragnesh P Parikh, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Precilia Vasquez, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puja K Mehta, Purvez Grant, Pushpa Naik, Qi Zhong, Qian Zhao, Qiang Zhou, Qianqian Yuan, Qin Yu, Qingxian Li, Qiulan Xie, Qiutang Zeng, R J Vindhya, R James Gerlach, Rachel King, Rada Vučić, Radmila Lyubarova, Radoslaw Pracon, Raewyn Fisher, Rafael Beyar, Rafael Diaz, Rafael Selgas, Raffaele Bugiardini, Raffaele Fanelli, Raisa Kavalakkat, V S Rajalekshmi, Rajat S Barua, Rajeev Menon, Rajesh Gopalan Nair, Rajesh Francis, Rajiv Narang, Rakesh Yadav, Ralph Alan Huston, T Ramakrishnan, Ramesh de Silva, Rami El Mahmoud, Ramiro Carvalho, Ramon de Jesús-Pérez, Ramona Stevens, Ran Leng, Ranjan Kachru, Ranjit Kumar Nath, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Raymond W Little, Raymundo Ocaranza Sanchez, Rebecca J Wimmer, Rebecca Bariciano, Rebecca Otis, Rebekah R Herrmann, Reem Yunis, Reinette Hampson, Renato Abdala Karam, Renee C Hessian, Renee Kaneshiro, Reshma Ravindran, Reto Andreas Gamma, Reyna Bhandari, Reza Arsanjani, Ricardo L Lopes, Ricardo Mendes Oliveira, Ricardo Costa, Richa Bhatt, Richard F Davies, Richard H J Trimlett, Richard Goldweit, Rik Hermanides, Rine Nakanishi, Rinu R Sidh, Risha Patel, Rita Coram, Rizwan A Siddiqui, Rob S Beanlands, Robert J Hamburger, Robert K Riezebos, Robert M Donnino, Robert Bojar, Robert Chilton, Robert Guyton, Robert Henderson, Robert Kornberg, Robert Leber, Robert Mao, Robert Stenberg, Roberta P Santos, Roberto René Favaloro, Roberto Amati, Rodolfo G S D Lima, Rodrigo J Cerci, Rogerio Tumelero, Rohit Tandon, Roma Tewari, Romalisa Miranda-Peats, Ron Wald, Ronald A Mastouri, Ronald G Morford, Ronald G Schwartz, Ronald P Pedalino, Rongrong Hu, Ronnell A Hansen, Ronny A Cohen, Rory Hachamovitch, Rosa Homem, Rosa Sandonato, Rosane Laimer, Rosann Gans, Roxanne Yost, Roy Mathew, Rubén Baleón-Espinosa, Ruben Ramos, Rubine Gevorgyan, Rui Ferreira, Rui Jing, Ruth Pérez-Fernández, S K Dwivedi, S Ramakrishnan, Saadat Khan, Sabahat Bokhari, Sabu Thomas, Sadath Lubna, Sajeeda Parveen Khan, Sajeev Chakanalil Govindan, Saket Girotra, Saleem Kassam, Sallie Canada, Salvador Cruz-Flores, Samaa Mohamed, Samantha Ly, Sameh El Kaffas, Samia Massalha, Sampoornima Setty, Samuel Nwosu, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandra M Rivest, Sandra S Zier, Sandra Ahoud, Sandy Carr, Sanjay Ganapathi, Sanjay Shetty, Sanjeev Sharma, Santa Jimenez, Santhosh Satheesh, Santiago A Garcia, Sara Fernandez, Sara Karlsson, Sara Salkind, Sara Temiyasathit, Sarah Medina Rodriguez, Sarah Beaudry, Sarah Hadjih, Sarah Williams, Sarah Zahrani, Sarju Ralhan, Sasa Hinic, Sasko Kedev, Satinder Singh, Satoshi Yasuda, Satvic Cholenahally Manjunath, Sau Lee, Scott M Kaczkowski, Scott Kinlay, Sean W 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Stephanie M Lane, Stephanie Ferket, Stephanie Kelly, Stephanie Wasmiller, Stephen H McKellar, Stephen P Hoole, Stephen Fremes, Stephen Preston, Steve Leung, Steven A Fein, Steven J Lindsay, Steven P Sedlis, Steven Giovannone, Steven Michael, Steven Weitz, Stijn van Vugt, Subhash Banerjee, Sudhir Naik, Suellen Hosino, Sukie Desire, Sukit Yamwong, Suku T Thambar, Sulagna Mookherjee, Suman Singh, Sundeep Mishra, Sunil Kumar Verma, Supap Kulthawong, Supatchara Khwakhong, Surendra Naik, Suresh Babu, Surin Woragidpoonpol, Suryaprakash Narayanappa, Susan Derbyshire, Susan Gent, Susan Mathus, Susan Milbrandt, Susan Moore, Susan Regan, Susan Stinson, Susan Webber, Susana Silva, Susanna Stevens, Susanne Gruensfelder, Suthara Aramcharoen, Suvarna Kolhe, Suzana Tavares, Suzanne Arnold, Suzanne Welsh, Svetlana Apostolovic, Swapna Kunhunny, Ta-Chuan Hung, Taissa Zappernick, Tali Sharir, Talita Silva, Tamara Colaiácovo Soares, Tapan Umesh Pillay, Tarun K Mittal, Tatiana Trifonova, Tauane Bello Duarte, Tauqir Huk, Téodora Dutoiu, Terrance Chua, Terry Weyand, Thabitha Charles, Theodoros Kofidis, Theresa McCreary, Thierry Lefevre, Thippeekaa Arumairajah, Thitipong Tepsuwan, Thomas J Mulhearn, Thomas M Meyer, Thomas P Rocco, Thomas R Downes, Thomas Crain, Thomas Haldis, Thomas Mathew, Thomas Redick, Thounaojam Indira Devi, Thuraia Nageh, Tia Cauthren, Tiago Silva, Tiffany Little, Tijana Andric, Tina Harding, Titus Lau, Tiziana Formisano, Tiziano Moccetti, Tomasz Ciurus, Tomasz Mazurek, Tomasz Tarchalski, Toshiyuki Nagai, Tri Tran, Tricia Youn, Trish Tucker, Trudie Milner, Tuhina Bose, Tushar Kotecha, Udo Sechtem, Uma S Valeti, Umberto Cucchini, Umesh Badami, Upendra Kaul, V K Bahl, V S Narain, Valentina Casali, Valeria Godoy, Valerie Robesyn, Vamshi P Priya, Vandana Yadav, Vera McKinney, Veronica De Lenges, Veronica Tinnirello, Vicente Miro, Victor Navarro, Victoria Gumerova, Victoria Hernandez, Vidya Seeratan, Vijay Kumar, Vikentiy Y Kozulin, Viktoria Bulkley, Vilmar Veiga Jr, Vincent Setang, C P Vineeth, Virginai Pubull Nuñez, Virginia Fernández-Figares, Vitor Gomes, Viviana Gabriel, Viviane Dos Santos, Viviane Almeida, Vlad A Iliescu, Vladan Mudrenovic, Vladimir Dzavik, Vojislav L Giga, Walter Enrique Mogrovejo, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Warangkana Mekara, Wassim Nona, Wayne Old, Wayne Pennachi, Weerachai Nawarawong, Wei Chen, Wei Su, Weibing Xing, Wei-Ren Lan, Wenda Crawford, Wendy L Stewart, Wendy Drewes, Wenhua Lin, William B Abernethy, William D Salerno, William F Fearon, William Vergoni, William Weintraub, Winnie C Sia, Wlodzimierz J Musial, Xacobe Flores-Ríos, Xavier Garcia-Moll Marimon, Xi Su, Xiang Ma, Xiangqiong Gu, Xiao Wang, Xiaomei Li, Xiaowei Yao, Xin Fu, Xin Su, Xin Zeng, Xinchun Yang, Xiuhong Li, Xuehua Fang, Xutong Wang, Yaming Geng, Yan Yan, Yanek Pépin-Dubois, Yanfu Wang, Yang Wang, Yanmeng Tian, Yaping Huang, Yechen Han, Yesenia Zambrano, Yi-Hsuan Yang, Ying Tung Sia, Yining Yang, Yitong Ma, Yolayfi Peralta, Yongjian Wu, Yu Kunwu, Yu Zhao, Yudong Peng, Yueh-Hung Lin, Yulan Zhao, Yumei Dong, Yunhai Zhao, Yutthaphan Wannasopha, Yvonne Taul, Zakir Sahul, Zalina Kudzoeva, Zbigniew Kalarus, Zeljko Z Markovic, Zhen Huang, Zheng Ji, Zhenyu Liu, Zhou Yue, Zhulin Zhang, Zhuxi Li, Zile Singh Meharwal, Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits
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Male ,Cardiac Catheterization ,Computed Tomography Angiography ,medicine.medical_treatment ,Myocardial Ischemia ,Coronary Disease ,Coronary Artery Disease ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Coronary Angiography ,ISCHEMIA Research Group ,law.invention ,Angina ,Coronary artery disease ,0302 clinical medicine ,Randomized controlled trial ,law ,Cardiovascular Disease ,Myocardial Revascularization ,030212 general & internal medicine ,Coronary Artery Bypass ,11 Medical and Health Sciences ,Cardiac catheterization ,General Medicine ,Middle Aged ,humanities ,Cardiovascular Diseases ,Cardiology ,Female ,Human ,medicine.medical_specialty ,Ischemia ,Article ,03 medical and health sciences ,Geriatric cardiology ,Percutaneous Coronary Intervention ,General & Internal Medicine ,Internal medicine ,medicine ,Humans ,Angina, Unstable ,Aged ,business.industry ,Coronary Artery Bypa ,Percutaneous coronary intervention ,Bayes Theorem ,medicine.disease ,Heart failure ,Quality of Life ,business - Abstract
BACKGROUND: Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS: We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS: Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, -1.8 percentage points; 95% CI, -4.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS: Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used. (Funded by the National Heart, Lung, and Blood Institute and others; ISCHEMIA ClinicalTrials.gov number, NCT01471522.).
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- 2020
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8. Extraction, purification and characterization of phenazine from Pseudomonas aeruginosa isolate of wastewater sources: a panacea towards clinical pathogens
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C. Jeganathan, G. Karthikeyan, Arivalagan Pugazhendhi, Aswin Thacharodi, Akhila. P. Reghu, and R. Priyadharshini
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Materials Science (miscellaneous) ,Phenazine ,02 engineering and technology ,Bacillus subtilis ,Secondary metabolite ,010402 general chemistry ,medicine.disease_cause ,01 natural sciences ,chemistry.chemical_compound ,Column chromatography ,medicine ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,Candida albicans ,Chromatography ,biology ,Chemistry ,Pseudomonas aeruginosa ,Cell Biology ,021001 nanoscience & nanotechnology ,Antimicrobial ,biology.organism_classification ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,0210 nano-technology ,Antibacterial activity ,Biotechnology ,medicine.drug - Abstract
Today with the help of advancement in the biotechnological processes, researchers are concentrating more on economical and versatile ways to recover value-added products from natural resources such as waste waters. Pseudomonas aeruginosa is known to produce a broad range of secondary metabolites during its active growth phase. In this study, P aeruginosa was densely isolated from the waste dumping zone of the highly polluted Cooum River (CR), Tamil Nadu, India. The strain was identified through biochemical analysis and molecular characterization by 16S rRNA sequencing and named as JAAKPA. Enzyme profiling of the strain revealed that it had potential lipase and protease activities. Antibacterial and antifungal activities of the strain against ten clinical pathogens were tested. A significant antibacterial activity against Gram-positive strains such as methicillin-resistant Staphylococcus aureus (MRSA), Bacillus subtilis, and moderate antifungal activity against Candida albicans, were observed. The culture supernatant of JAAKPA was subjected to thin-layer chromatography and column chromatography to extract and purify the antimicrobial compound (Phenazine). The purified compound was further subjected to gas chromatography–mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FTIR), and nuclear magnetic resonance (NMR) studies. The results revealed phenazine to be the major secondary metabolite responsible for the antimicrobial activities.
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- 2021
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9. Phenotypic evaluation and utilization of tomato germplasm resistance for ToLCV and its vector Bemisia tabaci under natural condition
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M Murugan, A Beaulah, J Ramalingam, G Karthikeyan, C Chinniah, and MK Ponselvakumari
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Germplasm ,education.field_of_study ,Veterinary medicine ,Resistance (ecology) ,biology ,fungi ,Population ,Begomovirus ,Randomized block design ,food and beverages ,Whitefly ,biology.organism_classification ,medicine.disease_cause ,Vector (epidemiology) ,Infestation ,medicine ,education - Abstract
During May- June 2019, about 50 genotypes of tomato along with susceptible check, Arka Vikas were screened for resistance against the sweet potato whitefly, Bemisia tabaci and the begomovirus Tomato leaf curl virus (ToLCV) in a Randomized Block Design with two replications having a plot size of 5×4 m at Linga nayakan pati, Usilampatti Taluk, Madurai district. The population of whitefly was recorded on tomato at weekly interval from appearance of the whiteflies. The infestation found to be more at earlier weeks thereafter the population declined abruptly. The average minimum (0.24/plant) and maximum (3.41/plant) whitefly population during crop season was observed on EC-520078 andEC-165700. According to the mean of whitefly population the highest resistance was found in EC-520078 followed by EC-631364,EC-315477 and EC-620389. Among all the accessions observed for ToLCV resistance, the accession EC-520078 recorded only 7.88% disease incidence and found statistically significant as compared to other accessions while the maximum disease incidence was observed in EC-620372 (94.25%).
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- 2020
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10. A Walk with Lu-177 PSMA: How Close we Have Reached from Bench to Bedside?
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Vineet Talwar, G Karthikeyan, Pallabee Choudhury, Venkata Pradeep Babu Koyyala, Parveen Jain, Manish Sharma, Amitabh Singh, Sudhir Rawal, and Manoj Gupta
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Male ,0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Palliative treatment ,Disease ,Lutetium ,Translational Research, Biomedical ,Heterocyclic Compounds, 1-Ring ,03 medical and health sciences ,Prostate cancer ,Clinical Trials, Phase II as Topic ,0302 clinical medicine ,Quality of life ,Internal medicine ,Humans ,Medicine ,Randomized Controlled Trials as Topic ,Membrane antigen ,Radioisotopes ,business.industry ,Standard treatment ,Sequela ,Dipeptides ,General Medicine ,Prostate-Specific Antigen ,medicine.disease ,Bench to bedside ,Prostatic Neoplasms, Castration-Resistant ,030104 developmental biology ,030220 oncology & carcinogenesis ,Radiopharmaceuticals ,business - Abstract
Metastatic castration-resistant prostate cancer (mCRPC) is a natural sequela in advanced prostate cancer following resistance to standard treatment regimes, where patients develop with rising PSA, bone pains, and high disease volume. Further palliative treatment is the need of the hour for ensuring disease control and quality of life. In recent times, many novel methods have been evolved for these patients. Endo-radioligand therapy with Lutetium 177 prostate-specific membrane antigen 617 (Lu-177 PSMA) based on the Theranostic concept has emerged as a promising tool among these. We present here the current status of Lu177-PSMA for mCRPC patient and future directions.
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- 2020
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11. Socio-medical perspectives on leprosy in Indian religions
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G Karthikeyan, P. S. Sundar Rao, and M Solomon Raju
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Religion in India ,business.industry ,media_common.quotation_subject ,Stigma (botany) ,Indian culture ,Stigma reduction ,medicine.disease ,Hygiene ,Key informants ,medicine ,General Earth and Planetary Sciences ,Leprosy ,Social science ,business ,General Environmental Science ,media_common - Abstract
Religion plays an important role in Indian culture, and greatly influences thinking and behavior around issues of hygiene and health. This study explored the religious texts of six major religions in India, and interviewed key informants, in order to identify religious precepts and proscriptions that may underlie current levels of stigma and social restrictions placed on people affected by leprosy. The study found a historical basis for leprosy stigma in the scriptures of all six religions. Attitudes are changing, especially with the acceptance of modern treatment. It is essential to incorporate stigma reduction perspectives in religious preaching.
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- 2020
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12. An investigation into performance of electric discharge milling using slotted tools
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G. Karthikeyan, S. A. Mullya, and V. S. Ganachari
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0209 industrial biotechnology ,Materials science ,business.industry ,Mechanical Engineering ,Mechanical engineering ,02 engineering and technology ,Surface finish ,Computational fluid dynamics ,Rotation ,Debris ,020303 mechanical engineering & transports ,020901 industrial engineering & automation ,Electrical discharge machining ,0203 mechanical engineering ,Machining ,Mechanics of Materials ,medicine ,Flushing ,Electric discharge ,medicine.symptom ,business - Abstract
The flushing of by-products from the interelectrode gap (EG) of a few microns is the major concern in the electrical discharge machining (EDM). The inadequate removal of debris from the gap causes short-circuits and reduces machining efficiency. Researchers have explored different techniques to enhance debris flushing from the gap. In electrical discharge milling (ED milling), the rotation of the tool along with linear travel is the major driving force for the debris flushing. In this paper, the application of an improvised tool to enhance rotation induced debris flushing is proposed. The flow-fields of dielectric and debris were modeled using computational fluid dynamics (CFD). The simulations results were utilized to optimize the tool geometries. A comparative study of the cylindrical and improvised tool in terms of material removal rate (MRR), tool wear rate (TWR) and surface finish was calculated. Relative to conventional cylindrical tools, the improvised tool enhanced the MRR by 150 %.
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- 2020
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13. Analysis of Morphometry of Calyceal Pattern in Kidney Donors Using CT Angiogram Images
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Gunapriya Raghunath, G. Karthikeyan, Kumaresan M, Zareena Begum, Sangeetha A, Balaji Karunakaran, and Yuvaraj Maria Francis
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medicine.medical_specialty ,Kidney ,medicine.diagnostic_test ,business.industry ,Ct angiogram ,Infundibulum ,medicine.anatomical_structure ,medicine ,Statistical analysis ,Radiology ,General Pharmacology, Toxicology and Pharmaceutics ,business ,Renal pelvis ,Computed tomography angiography - Abstract
The advent of more conservative methods of treatment for renal pathologies has necessitated a precise knowledge of renal pelvicalyceal system. Knowledge on the patterns of pelvicalyceal system and its relation to the renal segmental arteries is of importance in procedures in kidney. The aim is to analyze the morphometry of calyceal system in kidney donors using 64- Slice Computed Tomography Angiography. The study was conducted in specialized scan center located in Chennai after getting appropriate permission from medical director of the center. The study group was drawn from kidney donors who approached the scan center who had no diseases related to kidney. In this study, a total of 99 kidney donors were included. This was a prospective cross-sectional study conducted from June 2014 to September 2017. The statistical analysis and plotting of graphs were carried out using Sigma stat 13.0 (Systat Software, USA). Various patterns of the pelvicalyceal system along with morphometric dimensions of the infundibulum, which leads from the major calyces to the renal pelvis were studied. The result was then correlated with clinically significant parameters.
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- 2020
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14. A study on sacral index and its uses in sex determination
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Yuvaraj M, Kumaresan M, Gunapriya Raghunath, J Vijayakumar, Vandana K, Balaji K, G. Karthikeyan, and Aishwarya
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musculoskeletal diseases ,Index (economics) ,business.industry ,Anatomy ,musculoskeletal system ,Sacrum ,body regions ,Sexual dimorphism ,medicine.anatomical_structure ,Age groups ,Calipers ,Medicine ,Racial differences ,General Pharmacology, Toxicology and Pharmaceutics ,Sacrum bone ,business ,Pelvis - Abstract
The human sacrum is a complex structure and provides accommodation for spinal nerves which stabilises the pelvis. Morphometric measurements of sacrum determine the sex of the individual. The measurement of sacral index using the sacrum bone is considered as one of the best methods for determination of sex. The aim of this study is to find out the importance of sacral index in sexual dimorphism and to compare the findings with various age groups. 100 fully ossified sacral bones were collected from department of Anatomy. Average sacral length and breadth were taken by using sliding Vernier caliper and sacral index was calculated. The obtained values were tabulated against their respective parameters and then interpreted for the study. Avergae sacral index in females (109) is significantly greater than males (94). As per present study sacral index can reliably identify 58% of male sacrum and 42% of female sacrum. It is therefore a quite reliable and significant criteria for sex determination of sacrum. Thus, regional and racial differences in sacrum along with sacral index can be used for anatomical, medico-legal and anthropological purposes.
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- 2020
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15. AMPA receptor localization in trigeminal ganglion and its upregulation in migraine
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Kumaresan M, G. Karthikeyan, Maria Francis Yuvaraj, Gunapriya R, A. Priyadharshini, Senthil Murugan, Siva T, and P. K. Sankaran
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Trigeminal ganglion ,nervous system ,Migraine ,Downregulation and upregulation ,business.industry ,musculoskeletal, neural, and ocular physiology ,Medicine ,AMPA receptor ,General Pharmacology, Toxicology and Pharmaceutics ,business ,medicine.disease ,Neuroscience - Abstract
Migraine is characterized by headache due to imbalance between excitation and inhibition of neurons disabling normal day to day activities. The excitations of neurons are done by excitatory neurotransmitter glutamate which plays the key role in creating any pathology related to neurons. This study was done to identify GluR1 a subunit of AMPA glutamate receptor in the cells of trigeminal ganglion after inducing migraine and compare it with control rats. The GluR1 subunits were localized in the cytoplasm of neurons, and these subunits were up-regulated following a migraine. The GluR1 was also localized in satellite glial cells and nerve fibers, indicating these subunits expressed in neurons and migrate during nociceptive sensitization. This GluR1 expression in the cells of trigeminal ganglion may be crucial in nociceptive sensitization leading to migraine and other painful conditions like trigeminal neuralgia.
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- 2019
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16. Functional characterization of Candida albicans Hos2 histone deacetylase [v3; ref status: indexed, http://f1000r.es/3xh]
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G Karthikeyan, Maneesh Paul-Satyaseela, Nachiappan Dhatchana Moorthy, Radha Gopalaswamy, and Shridhar Narayanan
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Medical Microbiology ,Microbial Evolution & Genomics ,Medicine ,Science - Abstract
Candida albicans is a mucosal commensal organism capable of causing superficial (oral and vaginal thrush) infections in immune normal hosts, but is a major pathogen causing systemic and mucosal infections in immunocompromised individuals. Azoles have been very effective anti-fungal agents and the mainstay in treating opportunistic mold and yeast infections. Azole resistant strains have emerged compromising the utility of this class of drugs. It has been shown that azole resistance can be reversed by the co-administration of a histone deacetylase (HDAC) inhibitor, suggesting that resistance is mediated by epigenetic mechanisms possibly involving Hos2, a fungal deacetylase. We report here the cloning and functional characterization of HOS2 (HighOsmolarity Sensitive), a gene coding for fungal histone deacetylase from C. albicans. Inhibition studies showed that Hos2 is susceptible to pan inhibitors such as trichostatin A (TSA) and suberoylanilide hydroxamic acid (SAHA), but is not inhibited by class I inhibitors such as MS-275. This in vitro enzymatic assay, which is amenable to high throughput could be used for screening potent fungal Hos2 inhibitors that could be a potential anti-fungal adjuvant. Purified Hos2 protein consistently deacetylated tubulins, rather than histones from TSA-treated cells. Hos2 has been reported to be a putative NAD+ dependent histone deacetylase, a feature of sirtuins. We assayed for sirtuin activation with resveratrol and purified Hos2 protein and did not find any sirtuin activity.
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- 2014
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17. Co-existence of chlorosis inducing strain of Cucumber mosaic virus with tospoviruses on hot pepper (Capsicum annuum) in India
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L. Rajendran, J. Vinodhini, G. Karthikeyan, and R. Abirami
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0106 biological sciences ,0301 basic medicine ,Sequence analysis ,Science ,India ,Biology ,01 natural sciences ,Microbiology ,Cucumovirus ,Virus ,Article ,Cucumber mosaic virus ,03 medical and health sciences ,Tospovirus ,Pepper ,Anemia, Hypochromic ,Multidisciplinary ,Chlorosis ,Strain (chemistry) ,food and beverages ,biology.organism_classification ,Virology ,Reverse transcription polymerase chain reaction ,Plant Leaves ,030104 developmental biology ,Medicine ,Plant sciences ,Capsicum ,010606 plant biology & botany - Abstract
Cucumo- and tospoviruses are the most destructive viruses infecting hot pepper (chilli). A diagnostic survey was conducted to assess the prevalence of cucumo and tospoviruses in chilli growing tracts of Tamil Nadu. Infected plants showing mosaic with chlorotic and necrotic rings, veinal necrosis, mosaic mottling, leaf filiformity and malformation were collected. Molecular indexing carried out through reverse transcription polymerase chain reaction (RT-PCR) with coat protein gene specific primer of Cucumber mosaic virus (CMV) and tospovirus degenerate primer corresponding to the L segment (RdRp). Ostensibly, amplifications were observed for both CMV and tospoviruses as sole as well for mixed infections. The sequence analysis indicated that the Capsicum chlorosis virus (CaCV) and Groundnut bud necrosis virus (GBNV) to be involved with CMV in causing combined infections. The co-infection of CMV with CaCV was detected in 10.41% of the symptomatic plant samples and combined infection of CMV with GBNV was recorded in around 6.25% of the symptomatic plants surveyed. The amino acid substitution of Ser129 over conserved Pro129 in coat protein of CMV implies that CMV strain involved in mixed infection as chlorosis inducing strain. Further, the electron microscopy of symptomatic plant samples explicated the presence of isometric particles of CMV and quasi spherical particles of tospoviruses. This is the first molecular evidence for the natural co-existence of chlorosis inducing CMV strain with CaCV and GBNV on hot pepper in India.
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- 2021
18. Health status after invasive or conservative care in coronary and advanced kidney disease
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Spertus J. A., Jones P. G., Maron D. J., Mark D. B., O'Brien S. M., Fleg J. L., Reynolds H. R., Stone G. W., Sidhu M. S., Chaitman B. R., Chertow G. M., Hochman J. S., Bangalore S, ISCHEMIA-CKD Research Group: Abdallah M Abdallah, Abel E Moreyra, Abhay A Laddu, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Adedayo Adeboye, Agne Juceviciene, Agne Urboniene, Agnieszka Szramowska, Ahmed Abdel-Latif, Ahmed Ayoub, Ahmed Elghamaz, Ahmed Kamal, Ahmed Talaat, Ajay Sharma, Ajit Singh Narula, Akshay Bagai, Akvile Smigelskaite, Alain Raymond, Alain Rheault, Alaine Melanie Loehr, Albert Varga, Aldo P Maggioni, Alec Moorman, Alejandro Chevaile Ramos, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alexander M Chernyavskiy, Alexander Sergeevich Borisov, Alexandra Craft, Alexandra Hunter, Alexandre Ciappina Hueb, Alexandre Schaan de Quadros, Alice Manica Muller, Aline Peixoto Deiro, Allegra Stone, Almudena Castro, Amar Uxa, Amaryllis Van Craenenbroeck, Ambuj Roy, Amit Kakkar, Amy Flowers, Amy Iskandrian, Ana D Djordjevic-Dikic, Ana Gomes Almeida, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anandaroop Lahiri, Anastasia M Kuzmina-Krutetskaya, Anastasia Vamvakidou, Andras Vertes, Andre Gabriel, Andrea Bartykowszki, Andrea Lorimer, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andrés García-Rincón, Andrew Starovoytov, Andrzej Łabyk, Anelise Kawakami, Angela Hoye, Angelo Nobre, Anjali Acharya, Anjali Anand, Anjana Rishmawi, Ann Banfield, Ann Luyten, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Teresinska, Anne Marie Webb, Anne Heath, Anoop Mathew, Antonia Vega, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anu Tharini, Anupama Rao, Aquiles Valdespino-Estrada, Ariel Diaz, Arif Asif, Arnold H Seto, Arturo S Campos-Santaolalla, Asim N Cheema, Asker Ahmed, Atul Mathur, Audrey W Leong, Axel Åkerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Balaji Srinivasan, Baljeet Kaur, Balram Bhargava, Bandula Guruge, Barbara Wicklund, Bartosz Czarniak, Bebek Singh, Begoña Igual, Bela Merkely, Benoy N Shah, Bernard de Bruyne, Beth Abramson, Beth Stefanchik, Bethany Harvey, Bharati Shivalkar, Bilal Malik, Binoy Mannekkattukudy Kurian, Bougrida Hammouche, Branko D Beleslin, Bruce Ferguson, Bruce McManus, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Carl-Éric Gagné, Carly Ohmart, Carol M Kartje, Caroline Alsweiler, Caroline Rodgers, Caroline Spindler, Carolyn J Gruber, Catherine Albert, Catherine Bone, Catherine Lemay, Cezary Kepka, Chandini Suvarna, Chantale Mercure, Charlene Wiyarand, Chetan Patel, Chiara Attanasio, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Buller, Christel Vassaliere, Christiaan Vrints, Christian Witzke, Christie Ballantyne, Christina Björklund, Christine Roraff, Christophe Laure, Christophe Thuaire, Christopher Chan, Christopher Fordyce, Christopher Kinsey, Chunli Xia, Cidney Schultz, Claes Held, Claudia Cortés, Claudia Escobar, Cláudia Freixo, Clemens T Kadalie, Corine Thobois, Courtney Page, Cristina Bare, Dalisa Espinosa, Dan Gao, Dana Rizk, Daniela Puzhevsky, Data Analyst, David M Charytan, David O Williams, David Booth, David Charytan, David Cohen, David DeMets, David Foo, David Goldfarb, David Schlichting, David Sisson, David Taggart, David Waters, David Wheeler, David Williams, Davis Vo, Dawid Teodorczyk, Dawn D Shelstad, Dean Kereiakes, Deborah Yip, Deepa Ramaswamy, Deirdre Mattina, Deirdre Murphy, Dengke Jiang, Derek Cyr, Diana Cukali, Diane Camara, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Doreen Reimann, Doron Schwartz, Duarte Cacela, Dwayne S G Conway, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Eduardo Gomes Lima, Eduardo Hernandez-Rangel, Edward D Nicol, Edyta Kaczmarska, Elena Refoyo Salicio, Eli Feen, Elihú Durán-Cortés, Elisabeth M Janzen, Elise van Dongen, Elissa Restelli Piloto, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizaveta V Zbyshevskaya, Ellie Fridell, Ellis W Lader, Elvira Gosmanova, Emilie Tachot, Emma Howard, Emmanuel Sorbets, Encarnación Alonso-Álvarez, Eric Daugas, Erick Alexánderson Rosas, Estelle Montpetit, Eugene Passamani, Evgeny Shutov, Ewa Szczerba, Ewelina Wojtala, Expedito Eustáquio Ribeiro Silva, Fabio Fimiani, Fadi Hage, Fahim Haider Jafary, Fang Feng, Fatima Ranjbaran, Fausto J Pinto, Fernando Caeiro, Fernando Nolasco, Filipa Silva, Filippo Ottani, Firas Al Solaiman, Flávia Egydio, Florina Chereches, Francesca De Micco, Francesca Bianchini, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francisca Patuleia Figueiras, François Madore, Frank Harrell, Frank Rockhold, Frans Van de Werf, Franziska Guenther, Fred Mohr, G Karthikeyan, Gabriel Galeote, Gabriel Grossmann, Gabriel Steg, Gabriela Guzman, Gabriele Gabrielli, Gang Chen, Gautam Sharma, Gaylin Petty, Gelmina Mikolaitiene, Gennie Yee, Gerard Patrick Devlin, Gerard Esposito, Gergely Ágoston, Gervasio Lamas, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Girish Mishra, Gonzalo Barge-Caballero, Grace M Young, Graciela Scaro, Graham Wong, Gregg Pressman, Gregor Simonis, Gudrun Steinmaurer, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillermo Garcia-Garcia, Guoqin Wang, Gurpreet S Wander, Gurpreet Gulati, Haibo Zhang, Halina Marciniak, Hao Dai, Haojian Dong, Harold Franch, Harvey White, Hatem Elabd, Hayley Pomeroy, Heather Golden, Heidi Wilson, Helene Abergel, Hemalata Siddaram, Hemant Shakhar Mahapatra, Henry C Stokes, Hermine Osseni, Herwig Schuchlenz, Hicham Skali, Holly Mattix-Kramer, Hong Cheng, Hossam Mahrous, Hristo Pejkov, Hugo Marques, Hui Zhong, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ikraam Hassan, Ileana L Pina, Ilona Tamasauskiene, Inês Zimbarra Cabrita, Ines Rodrigues, Inga Soveri, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Isabelle Roy, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, Jacek Kusmierek, Jackie Chow, Jaekyeong Heo, Jakub Maksym, James E Davies, James J Jang, James Hirsch, James Tatoulis, Jan Henzel, Janaina Oliveira, Janani Rangaswami, Jane Eckstein, Janitha Raj, Jaqueline Pozzibon, Jaroslaw Drozdz, Jason Loh Kwok Kong, Jason T Call, Jason Linefsky, Javier J Garcia, Jay Meisner, Jayne Scales, Jean Michel Juliard, Jean Diodati, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeff Leimberger, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Stojkovic, Jenne M Jose, Jennifer L Stanford, Jennifer Hogan, Jennifer Horst, Jennifer Isaacs, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jerry Yee, Jessica Berg, Jesus Peteiro, Jesús Peteiro, Jia Li, Jiamin Liu, Jianxin Zhang, Jill Marcus, Jim Blankenship, Jing Dong, Jiyan Chen, Jo Evans, Joaquín V Peñafiel, Joe Sabik, Johann Christopher, John B Kostis, John Joseph Graham, John Doan, John Jose, John Kotter, John Lehman, John Middleton, John Pownall, Jonathan M Gleadle, Jonathan S Chavez-Iñiguez, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Lebowitz, Jonean Thorsen, Jorge Carrillo Calvillo, Jorge Escobedo, José A Ortega-Ramírez, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Costa Vieira, José M Flores-Palacios, Jose Fragata, Jose Lopes, Jose Lopez-Sendon, José Lopez-Sendon, Jose Rueda, Joseph B Selvanayagam, Joseph Sacco, Joshua P Loh, Joy Burkhardt, Juan Manuel López Quijano, Juan Gaztanaga, Judit Sebo, Judith Wright, Juergen Stumpf, Julia de Aveiro Morata, Julio César Figal, Julio Hernandez Jaras, Junqing Yang, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Karen Calfas, Karen Petrosyan, Karen Servilla, Karen Swan, Karin Ploetze, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Katharina Knaut, Katherine Martin, Kathleen Claes, Kathryn Mason, Ken Mahaffey, Kenneth Gin, Kerry Lee, Kerstin Bonin, Kerstin Mikes, Kevin R Bainey, Kevin T Harley, Kevin Marzo, Kevin McMahon, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khrystyna Kushniriuk, Kian-Keong Poh, Kim Holland, Kimberly E Halverson, Kinnari Murphy, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kreton Mavromatis, Krishnakumar Hongalgi, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristine Arges, Kristine Teoh, Krzysztof Drzymalski, Lalathaksha Kumbar, Laszlone Matics, LaTonya J Hickson, Laura Keinaite, Laura Sarti, Laura True, Lawrence M Phillips, Lawrence Friedman, Leandro C Maranan, Leda Lotaif, Lekshmi Dharmarajan, Leo A Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Li Hai Yan, Li Li, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilian Mazza Barbosa, Liljana Tozija, Linda Arcand, Lino Patricio, Liping Zhang, Lisa Hatch, Lixin Jiang, Liz Low, Loay Salman, Lorena Lopez, Lori Pritchard, Luis Bernanrdes, Luis Guzman, Lynette L Teo, M Sowjanya Reddy, Maarten Simoons, Maayan Konigstein, Mafalda Selas, Magdalena Madero, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdy Abdelhamid, Magid Fahim, Mahevamma Mylarappa, Majo X Joseph, Malgorzata Frach, Manjula Rani, Marcello Galvani, Marcin Demkow, Marcin Szkopiak, Marco De Fabritis, Marco Magnoni, Marco Marini, Marco Sicuro, Marek Roik, Maria A Alfonso, Maria Antonieta Pereira de Moraes, María Dolores Martínez-Ruíz, Maria Eugenia Canziani, Maria Eugenia Martin, Maria Inês Caetano, Maria P Corral, Maria Pérez García, Maria Andreasson, Maria Posada, Marianna D A Dracoulakis, Mariano Rubio, Marija T Petrovic, Marina Vieira, Mario J Garcia, Mario D'arezzo, Maris Orgera, Marius Miglinas, Mark Garand, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Swiderek, Martha Meyer, Martina Ceseri, Martinia Tricoli, Mary Wiilliams, Mary Ann Champagne, Mary Streif, Massoud Leesar, Matei Claudia, Mateusz Solecki, Matías Nicolás Mungo, Matthew Shinseki, Matthew Weir, Maura Carina Nédio, Max-Paul Winter, Mayil S Krishnam, Meenakshi Mishra, Mei Hwang, Melemadathil Srilatha, Melissa LeFevre, Mengistu Simegn, Michael A Gibson, Michael B Rubens, Michael D Shapiro, Michael Chobanian, Michael Davidson, Michael Farkouh, Michael Mack, Michal Wlodarczyk, Michel G Khouri, Michelle Crowder, Michelle Ratliff, Miguel Borges Santos, Miguel Nobre Menezes, Miguel Perez Fontan, Miguel Barrero, Mihaly Tapolyai, Mikhail T Torosoff, Milan R Dobric, Milind Avdhoot Gadkari, Min Tun Kyaw, Miri Revivo, Mitchel B Lustre, Mohamed Adel, Mohamed Hassan, Mohammad El-Hajjar, Mohammed Hussain, Mohammed Saleem, Moisés Blanco-Calvo, Moisés Jiménez-Santos, Monika Laukyte, Muhamed Saric, Myrthes Emy Takiuti, Nadia Asif, Nagaraja Moorthy, Naima L Ogletree, Nana O Katamadze, Nandita Nataraj, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Nathalie Brosens, Naved Aslam, Naveed Akhtar, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Neesh Pannu, Neill Duncan, Nevena Garcevic, Ngaire Meadows, Nicholas Danchin, Nicole Deming, Nikola N Boskovic, Nikolaos Karogiannis, Ning Zhang, Nirmal Kumar, Niruta Sharma, Nitika Chadha, Nitish Naik, Noelle M Durfee, Nora M Cosgrove, Norbert Urbanski, Norma Hogg, Olga Walesiak, Olga Zdończyk, Olga Zhdanova, Olivia Anaya, Olugbenga Bello, Omar Almousalli, Omar Thompson, Orit Kliuk, Oscar Méndiz, Óscar Prada-Delgado, Oz Shapira, Pablo Raffaele, Page Salanger, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Ouyang, Pamela Woodard, Paola Emanuela Poggio Smanio, Paola Smanio, Paolo Calabro, Patricia K Nguyen, Patricia Alarie, Patricia Carrilho, Patricia Endsley, Patricia Pellikka, Patrycja Lebioda, Paul Der Mesropian, Paul Hauptman, Paula García-González, Paula Wilson, Paulo Cury Rezende, Paulo Novis Rocha, Pedro Canas Silva, Pedro Farto E Abreu, Pedro Píccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peiyu He, Peter A McCullough, Peter H Stone, Peter Douglass, Peter Sizeland, Peter Voros, Philippe Gabriel Steg, Philippe Genereux, Philippe Généreux, Philippe Menasche, Philippe Rheault, Piero Tassinario, Pierre Gervais, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Poay-Huan Loh, Pouneh Samadi, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puneet Sodhi, Pushpa Naik, Qi Zhong, Qian Zhao, Qianqian Yuan, Qiulan Xie, Rachel Murphy, Radmila Lyubarova, Radmilar Lyubarova, Raewyn Fisher, Rafael Diaz, Rafael Maldonado, Rafael Selgas, Raffaele Bugiardini, Rafia Chaudhry, Raisa Kavalakkat, Rajalekshmi Vs, Rajesh Gopalan Nair, Rajiv Narang, Rakesh Yadav, Ramiro Carvalho, Ramon de Jesús-Pérez, Ran Leng, Ranjan Kachru, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Reinette Hampson, Renato Abdala Karam Kalil, Renato D Lopes, Renato George Eick, Renato Lopes, Reshma Ravindran, Reto Andreas Gamma, Ricardo Costa, Richa Bhatt, Richard H J Trimlett, Risha Patel, Rita Coram, Robert K Riezebos, Robert M Donnino, Robert Guyton, Robert Harrington, Robert Malecki, Roberto René Favaloro, Robyn Elliott, Rodolfo G S D Lima, Rohit Tandon, Rolf Doerr, Roma Tewari, Ron Wald, Rongrong Hu, Rory Collins, Roxana Mehran, Roxy Senior, Rubén Baleón-Espinosa, Ruben Ramos, Rui Ferreira, Ruth Kirby, Ruth Pérez-Fernández, S Ramakrishnan, S K Dwivedi, Sadath Lubna, Sadiq Ahmed, Sajeev Chakanalil Govindan, Salamah Alfalahi, Salvador Cruz-Flores, Salvatore P Costa, Sampoornima Setty, Samuel Nwosu, Sandeep Mahajan, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandy Carr, Sanja Simic Ogrizovic, Sanja Ogrizovic, Sanjeev Gulati, Sanjeev Sharma, Sara Fernandez, Sarah Williams, Sarju Ralhan, Sasko Kedev, Satinder Singh, Satish Sankaranarayanan, Satvic Cholenahally Manjunath, Sau Lee, Schawana Thaxton, Sean M O'Brien, Sebastian Sobczak, Seema Nour, Sergey A Sayganov, Sérgio Bravo Baptista, Sergio Draibe, Seth Sokol, Sharad Chandra, Shari Mackedanz, Shaun Goodman, Shayan Shirazian, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shruti Pandey, Shuyang Zhang, 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Wong, Gregg Pressman, Gregor Simonis, Gudrun Steinmaurer, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillermo Garcia-Garcia, Guoqin Wang, Gurpreet S Wander, Gurpreet Gulati, Haibo Zhang, Halina Marciniak, Hao Dai, Haojian Dong, Harold Franch, Harvey White, Hatem Elabd, Hayley Pomeroy, Heather Golden, Heidi Wilson, Helene Abergel, Hemalata Siddaram, Hemant Shakhar Mahapatra, Henry C Stokes, Hermine Osseni, Herwig Schuchlenz, Hicham Skali, Holly Mattix-Kramer, Hong Cheng, Hossam Mahrous, Hristo Pejkov, Hugo Marques, Hui Zhong, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ikraam Hassan, Ileana L Pina, Ilona Tamasauskiene, Inês Zimbarra Cabrita, Ines Rodrigues, Inga Soveri, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Isabelle Roy, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, Jacek Kusmierek, Jackie Chow, Jaekyeong Heo, Jakub Maksym, James E Davies, James J Jang, James Hirsch, James Tatoulis, 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Jonathan Lebowitz, Jonean Thorsen, Jorge Carrillo Calvillo, Jorge Escobedo, José A Ortega-Ramírez, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Costa Vieira, José M Flores-Palacios, Jose Fragata, Jose Lopes, Jose Lopez-Sendon, José Lopez-Sendon, Jose Rueda, Joseph B Selvanayagam, Joseph Sacco, Joshua P Loh, Joy Burkhardt, Juan Manuel López Quijano, Juan Gaztanaga, Judit Sebo, Judith Wright, Juergen Stumpf, Julia de Aveiro Morata, Julio César Figal, Julio Hernandez Jaras, Junqing Yang, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Karen Calfas, Karen Petrosyan, Karen Servilla, Karen Swan, Karin Ploetze, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Katharina Knaut, Katherine Martin, Kathleen Claes, Kathryn Mason, Ken Mahaffey, Kenneth Gin, Kerry Lee, Kerstin Bonin, Kerstin Mikes, Kevin R Bainey, Kevin T Harley, Kevin Marzo, Kevin McMahon, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khrystyna Kushniriuk, Kian-Keong Poh, Kim Holland, Kimberly E Halverson, Kinnari Murphy, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kreton Mavromatis, Krishnakumar Hongalgi, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristine Arges, Kristine Teoh, Krzysztof Drzymalski, Lalathaksha Kumbar, Laszlone Matics, LaTonya J Hickson, Laura Keinaite, Laura Sarti, Laura True, Lawrence M Phillips, Lawrence Friedman, Leandro C Maranan, Leda Lotaif, Lekshmi Dharmarajan, Leo A Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Li Hai Yan, Li Li, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilian Mazza Barbosa, Liljana Tozija, Linda Arcand, Lino Patricio, Liping Zhang, Lisa Hatch, Lixin Jiang, Liz Low, Loay Salman, Lorena Lopez, Lori Pritchard, Luis Bernanrdes, Luis Guzman, Lynette L Teo, M Sowjanya Reddy, Maarten Simoons, Maayan Konigstein, Mafalda Selas, Magdalena Madero, Magdalena Miller, 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Melissa LeFevre, Mengistu Simegn, Michael A Gibson, Michael B Rubens, Michael D Shapiro, Michael Chobanian, Michael Davidson, Michael Farkouh, Michael Mack, Michal Wlodarczyk, Michel G Khouri, Michelle Crowder, Michelle Ratliff, Miguel Borges Santos, Miguel Nobre Menezes, Miguel Perez Fontan, Miguel Barrero, Mihaly Tapolyai, Mikhail T Torosoff, Milan R Dobric, Milind Avdhoot Gadkari, Min Tun Kyaw, Miri Revivo, Mitchel B Lustre, Mohamed Adel, Mohamed Hassan, Mohammad El-Hajjar, Mohammed Hussain, Mohammed Saleem, Moisés Blanco-Calvo, Moisés Jiménez-Santos, Monika Laukyte, Muhamed Saric, Myrthes Emy Takiuti, Nadia Asif, Nagaraja Moorthy, Naima L Ogletree, Nana O Katamadze, Nandita Nataraj, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Nathalie Brosens, Naved Aslam, Naveed Akhtar, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Neesh Pannu, Neill Duncan, Nevena Garcevic, Ngaire Meadows, Nicholas Danchin, Nicole Deming, Nikola N Boskovic, Nikolaos Karogiannis, Ning Zhang, Nirmal Kumar, Niruta Sharma, Nitika Chadha, Nitish Naik, Noelle M Durfee, Nora M Cosgrove, Norbert Urbanski, Norma Hogg, Olga Walesiak, Olga Zdończyk, Olga Zhdanova, Olivia Anaya, Olugbenga Bello, Omar Almousalli, Omar Thompson, Orit Kliuk, Oscar Méndiz, Óscar Prada-Delgado, Oz Shapira, Pablo Raffaele, Page Salanger, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Ouyang, Pamela Woodard, Paola Emanuela Poggio Smanio, Paola Smanio, Paolo Calabro, Patricia K Nguyen, Patricia Alarie, Patricia Carrilho, Patricia Endsley, Patricia Pellikka, Patrycja Lebioda, Paul Der Mesropian, Paul Hauptman, Paula García-González, Paula Wilson, Paulo Cury Rezende, Paulo Novis Rocha, Pedro Canas Silva, Pedro Farto E Abreu, Pedro Píccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peiyu He, Peter A McCullough, Peter H Stone, Peter Douglass, Peter Sizeland, Peter Voros, Philippe Gabriel Steg, Philippe Genereux, Philippe Généreux, Philippe Menasche, Philippe Rheault, Piero Tassinario, Pierre Gervais, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Poay-Huan Loh, Pouneh Samadi, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puneet Sodhi, Pushpa Naik, Qi Zhong, Qian Zhao, Qianqian Yuan, Qiulan Xie, Rachel Murphy, Radmila Lyubarova, Radmilar Lyubarova, Raewyn Fisher, Rafael Diaz, Rafael Maldonado, Rafael Selgas, Raffaele Bugiardini, Rafia Chaudhry, Raisa Kavalakkat, Rajalekshmi Vs, Rajesh Gopalan Nair, Rajiv Narang, Rakesh Yadav, Ramiro Carvalho, Ramon de Jesús-Pérez, Ran Leng, Ranjan Kachru, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Reinette Hampson, Renato Abdala Karam Kalil, Renato D Lopes, Renato George Eick, Renato Lopes, Reshma Ravindran, Reto Andreas Gamma, Ricardo Costa, Richa Bhatt, Richard H J Trimlett, Risha Patel, Rita Coram, Robert K Riezebos, Robert M Donnino, Robert Guyton, Robert Harrington, Robert Malecki, Roberto René Favaloro, Robyn Elliott, Rodolfo G S D Lima, Rohit Tandon, Rolf Doerr, Roma Tewari, Ron Wald, Rongrong Hu, Rory Collins, Roxana Mehran, Roxy Senior, Rubén Baleón-Espinosa, Ruben Ramos, Rui Ferreira, Ruth Kirby, Ruth Pérez-Fernández, S Ramakrishnan, S K Dwivedi, Sadath Lubna, Sadiq Ahmed, Sajeev Chakanalil Govindan, Salamah Alfalahi, Salvador Cruz-Flores, Salvatore P Costa, Sampoornima Setty, Samuel Nwosu, Sandeep Mahajan, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandy Carr, Sanja Simic Ogrizovic, Sanja Ogrizovic, Sanjeev Gulati, Sanjeev Sharma, Sara Fernandez, Sarah Williams, Sarju Ralhan, Sasko Kedev, Satinder Singh, Satish Sankaranarayanan, Satvic Cholenahally Manjunath, Sau Lee, Schawana Thaxton, Sean M O'Brien, Sebastian Sobczak, Seema Nour, Sergey A Sayganov, Sérgio Bravo Baptista, Sergio Draibe, Seth Sokol, Sharad Chandra, Shari Mackedanz, Shaun Goodman, Shayan Shirazian, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shruti Pandey, Shuyang Zhang, Siddharth Gadage, Sik-Yin V Tan, Sílvia Zottis Poletti, Silvia Valbuena, Simone Savaris, Solomon Yakubov, Songlin Zhu, Sonika Gupta, Sorin Brener, Sothinathan Gurunathan, Soundarya Nayak, Sowjanya Reddy, Stanley E Cobos, Stefan Weikl, Stephanie M Lane, Stephanie Ferket, Stephanie Mavromichalis, Stephen Fremes, Steven A Fein, Steven P Sedlis, Steven Giovannone, Steven Weitz, Subhash Banerjee, Sudhanva S Hegde, Suellen Hosino, Sulagna Mookherjee, Suman Singh, Sumith Abeygunasekara, Sundeep Mishra, Sunil Kumar Verma, Suresh Kumar, Suryaprakash Narayanappa, Susan K Milbrandt, Susana Silva, Susanna Stevens, Suvarna Kolhe, Suzana Tavares, Suzanne Welsh, T A Kishore, Tamara Colaiácovo Soares, Tapan Umesh Pillay, Tarek Rashid, Tarun K Mittal, Tauane Bello Duarte, Téodora Dutoiu, Teresa Delgadillo, Terrance Chua, Terrance Welch, Theodoros Kofidis, Thierry Lefevre, Tiago Silva, Timea Boros, Titus Lau, Tiziana Formisano, Tomasz Ciurus, Tomasz Tarchalski, Tracy Tan, Umesh Lingaraj, V K Bahl, V S Narain, Valentina Pellu, Valentine Lobo, Valerie Robesyn, Vandana Yadav, Veerabhadra Gupta, Verghese Mathew, Vicente Miro, Victoria Gumerova, Victoria Hernandez, Vijay Kher, Vijay Kumar, Vikas Makkar, Vikranth Reddy, Viktoria Bulkley, Vinoi George David, Virendra Misra, Virginia Fernández-Figares, Vladimir Ryasniansky, Vojislav L Giga, Wael A Almahmeed, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Wayne Pennachi, Wei Ling Lau, Weibing Xing, Weijing Bian, Wendy L Stewart, Wendy Drewes, Whady Hueb, William Weintraub, Winnie C Sia, Xacobe Flores-Ríos, Xiang Ma, Xiangqiong Gu, Xiaomei Li, Xiaoyi Xu, Xin Fu, Xuemei Li, Xutong Wang, Yanek Pépin-Dubois, Yaron Arbel, Yechen Han, Yiming Lit, Ying Tung Sia, Ying Wang, Yining Yang, Yitong Ma, Yolayfi Peralta, Yves Smets, Yvonne Taul, Zalina Kudzoeva, Zeljko Z Markovic, Zhangsuo Liu, Zhenyu Liu, Zhiming Ye, Zixiang Yu, Zoltan Davidovits, Zvezdana Petronijevic
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Male ,Intention to Treat Analysi ,medicine.medical_treatment ,Health Status ,Myocardial Ischemia ,030204 cardiovascular system & hematology ,Coronary Angiography ,law.invention ,Health Statu ,0302 clinical medicine ,Randomized controlled trial ,law ,Surveys and Questionnaires ,Odds Ratio ,Surveys and Questionnaire ,030212 general & internal medicine ,Myocardial infarction ,Coronary Artery Bypass ,medicine.diagnostic_test ,General Medicine ,Middle Aged ,Intention to Treat Analysis ,Cardiology ,Female ,Human ,medicine.medical_specialty ,Revascularization ,Follow-Up Studie ,03 medical and health sciences ,Percutaneous Coronary Intervention ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Healthy Lifestyle ,Renal Insufficiency, Chronic ,Proportional Hazards Models ,Aged ,Intention-to-treat analysis ,business.industry ,Coronary Artery Bypa ,Percutaneous coronary intervention ,Odds ratio ,medicine.disease ,Angiography ,Exercise Test ,Proportional Hazards Model ,business ,Kidney disease ,Follow-Up Studies - Abstract
BACKGROUND In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy alone (conservative strategy) in participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease (an estimated glomerular filtration rate of
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- 2020
19. Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging
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Cole B. Hirschfeld, Maurizio Dondi, Thomas N.B. Pascual, Mathew Mercuri, Joao Vitola, Ganesan Karthikeyan, Nathan Better, John J. Mahmarian, Salah E. Bouyoucef, Henry Hee-Seung Bom, Vikram Lele, Vincent Peter C. Magboo, Erick Alexánderson, Adel H. Allam, Mouaz H. Al-Mallah, Albert Flotats, Scott Jerome, Philipp A. Kaufmann, Osnat Luxenburg, S. Richard Underwood, Madan M. Rehani, Jenia Vassileva, Diana Paez, Andrew J. Einstein, A.J. Einstein, T.N.B. Pascual, D. Paez, M. Dondi, N. Better, S.E. Bouyoucef, G. Karthikeyan, R. Kashyap, V. Lele, V.P.C. Magboo, J.J. Mahmarian, J.B. Meeks, M. Mercuri, F. Mut, M.M. Rehani, J.V. Vitola, E. Alexanderson, A. Allam, M.H. Al-Mallah, H. Bom, A. Flotats, S. Jerome, P.A. Kaufmann, O. Luxenburg, J. Mahmarian, L.J. Shaw, S.R. Underwood, J. Vitola, W. Amouri, H. Essabbah, S.S. Gassama, K.B. Makhdomi, G.I.E. El Mustapha, N. El Ouchdi, N. Qaïs, N. Soni, W. Vangu, R.M. Abazid, B. Adams, V. Agarwal, M.A. Alfeeli, N. Alnafisi, L. Bernabe, G.G. Bural, T. Chaiwatanarat, J.M. Chandraguptha, G.J. Cheon, I. Cho, A.S. Dogan, M. Eftekhari, A. Frenkel, I. Garty, S. George, P. Geramifar, H. Golan, S. Habib, R. Hussain, H. Im, H.-J. Jeon, T. Kalawat, W.J. Kang, F. Keng, A. Klaipetch, P.G. Kumar, J. Lee, W.W. Lee, I. Lim, C.M.M. Macaisa, G. Malhotra, B.R. Mittal, M.H. Mohammad, P. Mohan, I.D. Mulyanto, D. Nariman, U.N. Nayak, K. Niaz, G. Nikolov, J.M. Obaldo, E. Ozturk, J.M. Park, S. Park, C.D. Patel, H.K. Phuong, A.P. Quinon, T.R. Rajini, Y. Saengsuda, J. Santiago, H.B. Sayman, A.S. Shinto, V. Sivasubramaniyan, M.H. Son, P. Sudhakar, G.M.S. Syed, N. Tamaki, K. Thamnirat, T. Thientunyakit, S. Thongmak, D.N. Velasco, A. Verma, U. Vutrapongwatana, Y. Wang, K.S. Won, Z. Yao, T. Yingsa-nga, R. Yudistiro, K.T. Yue, N. Zafrir, S.C. Adrian, D. Agostini, S. Aguadé, G. Armitage, M. Backlund, M. Backman, M. Baker, M.T. Balducci, C. Bavelaar, M. Berovic, F. Bertagna, R. Beuchel, A. Biggi, G. Bisi, R. Bonini, A. Bradley, L. Brudin, I. Bruno, E. Busnardo, R. Casoni, A. Choudhri, C. Cittanti, R. Clauss, D.C. Costa, M. Costa, K. Dixon, M. Dziuk, N. Egelic, I. Eriksson, G. Fagioli, D.B. de Faria, L. Florimonte, A. Francini, M. French, E. Gallagher, I. Garai, O. Geatti, D. Genovesi, L. Gianolli, A. Gimelli, E. del Giudice, S. Halliwell, M.J. Hansson, C. Harrison, F. Homans, F. Horton, D. Jędrzejuk, J. Jogi, A. Johansen, H. Johansson, M. Kalnina, M. Kaminek, A. Kiss, M. Kobylecka, M. Kostkiewicz, J. Kropp, R. Kullenberg, T. Lahoutte, O. Lang, Y.H. Larsson, M. Lázár, L. Leccisotti, N. Leners, O. Lindner, R.W. Lipp, A. Maenhout, L. Maffioli, C. Marcassa, B. Martins, P. Marzullo, G. Medolago, C.G. Mendiguchía, S. Mirzaei, M. Mori, B. Nardi, S. Nazarenko, K. Nikoletic, R. Oleksa, T. Parviainen, J. Patrina, R. Peace, C. Pirich, H. Piwowarska-Bilska, S. Popa, V. Prakash, V. Pubul, L. Puklavec, S. Rac, M. Ratniece, S.A. Rogan, A. Romeo, M. Rossi, D. Ruiz, N. Sabharwal, B.G. Salobir, A.I. Santos, S. Saranovic, A. Sarkozi, R.P. Schneider, R. Sciagra, S. Scotti, Z. Servini, L.R. Setti, S.-Å. Starck, D. Vajauskas, J. Veselý, A. Vieni, A. Vignati, I.M. Vito, K. Weiss, D. Wild, M. Zdraveska-Kochovska, R.N. Agüro, N. Alvarado, C.M. Barral, M. Beretta, I. Berrocal, J.F. Batista Cuellar, T-M. Cabral Chang, L.O. Cabrera Rodríguez, J. Canessa, G. Castro Mora, A.C. Claudia, G.F. Clavelo, A.F. Cruz Júnior, F.F. Faccio, K.M. Fernández, J.R. Gomez Garibo, U. Gonzalez, P. González E, M.A. Guzzo, J. Jofre, M. Kapitán, G. Kempfer, J.L. Lopez, T. Massardo V, I. Medeiros Colaco, C.T. Mesquita, M. Montecinos, S. Neubauer, L.M. Pabon, A. Puente, L.M. Rochela Vazquez, J.A. Serna Macias, A.G. Silva Pino, F.Z. Tártari Huber, A.P. Tovar, L. Vargas, C. Wiefels, A. Aljizeeri, R.J. Alvarez, D. Barger, W. Beardwood, J. Behrens, L. Brann, D. Brown, H. Carr, K. Churchwell, G.A. Comingore, J. Corbett, M. Costello, F. Cruz, T. Depinet, S. Dorbala, M. Earles, F.P. Esteves, E. Etherton, R.J. Fanning, J. Fornace, L. Franks, H. Gewirtz, K. Gulanchyn, C.-L. Hannah, J. Hays, J. Hendrickson, J. Hester, K. Holmes, A. Johnson, C. Jopek, H. Lewin, J. Lyons, C. Manley, J. Meden, S. Moore, W.H. Moore, V. Murthy, R. Nace, D. Neely, L. Nelson, O. Niedermaier, D. Rice, R. Rigs, K. Schiffer, E. Schockling, T. Schultz, T. Schumacker, B. Sheesley, A. Sheikh, B. Siegel, A.M. Slim, J. Smith, M. Szulc, N. Tanskersley, P. Tilkemeier, G.D. Valdez, R. Vrooman, D. Wawrowicz, D.E. Winchester, A. Alcheikh, B. Allen, E. Atkins, J. Bevan, C. Bonomini, J. Christiansen, L. Clack, E. Craig, H. Dixson, I. Duncan, S. Fredericks, S. Gales, R. Hampson, T. Hanley, K. Hartcher, J. Hassall, B. Kelley, S. Kelly, T. Kidd, T. de Kort, G. Larcos, W. Macdonald, C. McGrath, E. Murdoch, S. O'Malley, M. O'Rourke, M. Pack, R. Pearce, R. Praehofer, S. Ramsay, L. Scarlett, K. Smidt, F. Souvannavong, K. Taubman, G. Taylor, K. Tse, S. Unger, J. Weale, Columbia University Irving Medical Center (CUIMC), New York Presbyterian Hospital, International Atomic Energy Agency [Vienna] (IAEA), McMaster University [Hamilton, Ontario], University of Toronto, All India Institute of Medical Sciences [New Delhi], The Royal Melbourne Hospital, University of Melbourne, Methodist Debakey Heart and Vascular Center [Houston, TX, USA], Houston Methodist Hospital [Houston, TX, USA], Centre Hospitalier Universitaire de Bab-el-Oued, Alger, Algérie., Chonnam National University [Gwangju], Jaslok Hospital & Research Centre, University of the Philippines (UP System), University of Santo Tomas Hospital, Instituto Nacional de Cardiologia Ignacio Chavez, Universidad Nacional Autónoma de México (UNAM), Al-Azhar University [Cairo, Egypt], Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona (UAB), University of Maryland [Baltimore], University hospital of Zurich [Zurich], The Gertner Institute for Epidemiology and Health Policy Research, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Massachusetts General Hospital [Boston], and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
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medicine.medical_specialty ,MESH: Radiation Dosage ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,030204 cardiovascular system & hematology ,Single-photon emission computed tomography ,MESH: Tomography, Emission-Computed, Single-Photon ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Myocardial perfusion imaging ,0302 clinical medicine ,MESH: Cross-Sectional Studies ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,MESH: Diagnostic Reference Levels ,Medical imaging ,medicine ,administered activity ,Radiology, Nuclear Medicine and imaging ,Medical physics ,SPECT myocardial perfusion imaging ,Protocol (science) ,MESH: Humans ,medicine.diagnostic_test ,business.industry ,radiation dose reduction ,diagnostic reference level ,MESH: Predictive Value of Tests ,3. Good health ,Predictive value of tests ,Regional studies ,Dose reduction ,Cardiology and Cardiovascular Medicine ,business ,Emission computed tomography ,MESH: Perfusion - Abstract
Objectives This study sought to establish worldwide and regional diagnostic reference levels (DRLs) and achievable administered activities (AAAs) for single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). Background Reference levels serve as radiation dose benchmarks to compare individual laboratories against aggregated data, helping to identify sites in greatest need of dose reduction interventions. DRLs for SPECT MPI have previously been derived from national or regional registries. To date there have been no multiregional reports of DRLs for SPECT MPI from a single standardized dataset. Methods Data were submitted voluntarily to the INCAPS (International Atomic Energy Agency Nuclear Cardiology Protocols Study), a cross-sectional, multinational registry of MPI protocols. A total of 7,103 studies were included. DRLs and AAAs were calculated by protocol for each world region and for aggregated worldwide data. Results The aggregated worldwide DRLs for rest-stress or stress-rest studies employing technetium Tc 99m–labeled radiopharmaceuticals were 11.2 mCi (first dose) and 32.0 mCi (second dose) for 1-day protocols, and 23.0 mCi (first dose) and 24.0 mCi (second dose) for multiday protocols. Corresponding AAAs were 10.1 mCi (first dose) and 28.0 mCi (second dose) for 1-day protocols, and 17.8 mCi (first dose) and 18.7 mCi (second dose) for multiday protocols. For stress-only technetium Tc 99m studies, the worldwide DRL and AAA were 18.0 mCi and 12.5 mCi, respectively. Stress-first imaging was used in 26% to 92% of regional studies except in North America where it was used in just 7% of cases. Significant differences in DRLs and AAAs were observed between regions. Conclusions This study reports reference levels for SPECT MPI for each major world region from one of the largest international registries of clinical MPI studies. Regional DRLs may be useful in establishing or revising guidelines or simply comparing individual laboratory protocols to regional trends. Organizations should continue to focus on establishing standardized reporting methods to improve the validity and comparability of regional DRLs.
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- 2021
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20. Characterisation Of Phytochemical Constituents, Antioxidant And Anti Bacterial Properties Of Red Strawberry Against Klebsiella And Streptococcus
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G. Karthikeyan
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Klebsiella ,Antioxidant ,Traditional medicine ,biology ,Phytochemical ,Streptococcus ,Chemistry ,medicine.medical_treatment ,medicine ,Anti bacterial ,biology.organism_classification ,medicine.disease_cause - Published
- 2020
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21. Worldwide Variation in the Use of Nuclear Cardiology Camera Technology, Reconstruction Software, and Imaging Protocols
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Cole B. Hirschfeld, Mathew Mercuri, Thomas N.B. Pascual, Ganesan Karthikeyan, João V. Vitola, John J. Mahmarian, Nathan Better, Salah E. Bouyoucef, Henry Hee-Seung Bom, Vikram Lele, V. Peter C. Magboo, Erick Alexánderson, Adel H. Allam, Mouaz H. Al-Mallah, Sharmila Dorbala, Albert Flotats, Scott Jerome, Philipp A. Kaufmann, Osnat Luxenburg, Leslee J. Shaw, S. Richard Underwood, Madan M. Rehani, Diana Paez, Maurizio Dondi, Andrew J. Einstein, A.J. Einstein, T.N.B. Pascual, D. Paez, M. Dondi, N. Better, S.E. Bouyoucef, G. Karthikeyan, R. Kashyap, V. Lele, V.P.C. Magboo, J.J. Mahmarian, J.B. Meeks, M. Mercuri, F. Mut, M.M. Rehani, J.V. Vitola, E. Alexanderson, A. Allam, M.H. Al-Mallah, H. Bom, A. Flotats, S. Jerome, P.A. Kaufmann, O. Luxenburg, J. Mahmarian, L.J. Shaw, S.R. Underwood, J. Vitola, W. Amouri, H. Essabbah, S.S. Gassama, K.B. Makhdomi, G.I.E. El Mustapha, N. El Ouchdi, N. Qaïs, N. Soni, W. Vangu, R.M. Abazid, B. Adams, V. Agarwal, M.A. Alfeeli, N. Alnafisi, L. Bernabe, G.G. Bural, T. Chaiwatanarat, J.M. Chandraguptha, G.J. Cheon, I. Cho, A.S. Dogan, M. Eftekhari, A. Frenkel, I. Garty, S. George, P. Geramifar, H. Golan, S. Habib, R. Hussain, H. Im, H.-J. Jeon, T. Kalawat, W.J. Kang, F. Keng, A. Klaipetch, P.G. Kumar, J. Lee, W.W. Lee, I. Lim, C.M.M. Macaisa, G. Malhotra, B.R. Mittal, M.H. Mohammad, P. Mohan, I.D. Mulyanto, D. Nariman, U.N. Nayak, K. Niaz, G. Nikolov, J.M. Obaldo, E. Ozturk, J.M. Park, S. Park, C.D. Patel, H.K. Phuong, A.P. Quinon, T.R. Rajini, Y. Saengsuda, J. Santiago, H.B. Sayman, A.S. Shinto, V. Sivasubramaniyan, M.H. Son, P. Sudhakar, G.M.S. Syed, N. Tamaki, K. Thamnirat, T. Thientunyakit, S. Thongmak, D.N. Velasco, A. Verma, U. Vutrapongwatana, Y. Wang, K.S. Won, Z. Yao, T. Yingsa-nga, R. Yudistiro, K.T. Yue, N. Zafrir, S.C. Adrian, D. Agostini, S. Aguadé, G. Armitage, M. Backlund, M. Backman, M. Baker, M.T. Balducci, C. Bavelaar, M. Berovic, F. Bertagna, R. Beuchel, A. Biggi, G. Bisi, R. Bonini, A. Bradley, L. Brudin, I. Bruno, E. Busnardo, R. Casoni, A. Choudhri, C. Cittanti, R. Clauss, D.C. Costa, M. Costa, K. Dixon, M. Dziuk, N. Egelic, I. Eriksson, G. Fagioli, D.B. de Faria, L. Florimonte, A. Francini, M. French, E. Gallagher, I. Garai, O. Geatti, D. Genovesi, L. Gianolli, A. Gimelli, E. del Giudice, S. Halliwell, M.J. Hansson, C. Harrison, F. Homans, F. Horton, D. Jędrzejuk, J. Jogi, A. Johansen, H. Johansson, M. Kalnina, M. Kaminek, A. Kiss, M. Kobylecka, M. Kostkiewicz, J. Kropp, R. Kullenberg, T. Lahoutte, O. Lang, Y.H. Larsson, M. Lázár, L. Leccisotti, N. Leners, O. Lindner, R.W. Lipp, A. Maenhout, L. Maffioli, C. Marcassa, B. Martins, P. Marzullo, G. Medolago, C.G. Mendiguchía, S. Mirzaei, M. Mori, B. Nardi, S. Nazarenko, K. Nikoletic, R. Oleksa, T. Parviainen, J. Patrina, R. Peace, C. Pirich, H. Piwowarska-Bilska, S. Popa, V. Prakash, V. Pubul, L. Puklavec, S. Rac, M. Ratniece, S.A. Rogan, A. Romeo, M. Rossi, D. Ruiz, N. Sabharwal, B.G. Salobir, A.I. Santos, S. Saranovic, A. Sarkozi, R.P. Schneider, R. Sciagra, S. Scotti, Z. Servini, L.R. Setti, S.-Å. Starck, D. Vajauskas, J. Veselý, A. Vieni, A. Vignati, I.M. Vito, K. Weiss, D. Wild, M. Zdraveska-Kochovska, R.N. Agüro, N. Alvarado, C.M. Barral, M. Beretta, I. Berrocal, J.F. Batista Cuellar, T.-M. Cabral Chang, L.O. Cabrera Rodríguez, J. Canessa, G. Castro Mora, A.C. Claudia, G.F. Clavelo, A.F. Cruz Júnior, F.F. Faccio, K.M. Fernández, J.R. Gomez Garibo, U. Gonzalez, P. González E, M.A. Guzzo, J. Jofre, M. Kapitán, G. Kempfer, J.L. Lopez, T. Massardo V, I. Medeiros Colaco, C.T. Mesquita, M. Montecinos, S. Neubauer, L.M. Pabon, A. Puente, L.M. Rochela Vazquez, J.A. Serna Macias, A.G. Silva Pino, F.Z. Tártari Huber, A.P. Tovar, L. Vargas, C. Wiefels, A. Aljizeeri, R.J. Alvarez, D. Barger, W. Beardwood, J. Behrens, L. Brann, D. Brown, H. Carr, K. Churchwell, G.A. Comingore, J. Corbett, M. Costello, F. Cruz, T. Depinet, S. Dorbala, M. Earles, F.P. Esteves, E. Etherton, R.J. Fanning, J. Fornace, L. Franks, H. Gewirtz, K. Gulanchyn, C.-L. Hannah, J. Hays, J. Hendrickson, J. Hester, K. Holmes, A. Johnson, C. Jopek, H. Lewin, J. Lyons, C. Manley, J. Meden, S. Moore, W.H. Moore, V. Murthy, R. Nace, D. Neely, L. Nelson, O. Niedermaier, D. Rice, R. Rigs, K. Schiffer, E. Schockling, T. Schultz, T. Schumacker, B. Sheesley, A. Sheikh, B. Siegel, A.M. Slim, J. Smith, M. Szulc, N. Tanskersley, P. Tilkemeier, G.D. Valdez, R. Vrooman, D. Wawrowicz, D.E. Winchester, A. Alcheikh, B. Allen, E. Atkins, J. Bevan, C. Bonomini, J. Christiansen, L. Clack, E. Craig, H. Dixson, I. Duncan, S. Fredericks, S. Gales, R. Hampson, T. Hanley, K. Hartcher, J. Hassall, B. Kelley, S. Kelly, T. Kidd, T. de Kort, G. Larcos, W. Macdonald, C. McGrath, E. Murdoch, S. O'Malley, M. O'Rourke, M. Pack, R. Pearce, R. Praehofer, S. Ramsay, L. Scarlett, K. Smidt, F. Souvannavong, K. Taubman, G. Taylor, K. Tse, S. Unger, and J. Weale
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medicine.medical_specialty ,Technology ,camera technology ,myocardial perfusion scintigraphy ,nuclear cardiology protocols ,radiation dose reduction ,SPECT ,INCAPS Investigators Group ,Cardiology ,030204 cardiovascular system & hematology ,Radiation Dosage ,030218 nuclear medicine & medical imaging ,NO ,03 medical and health sciences ,Myocardial perfusion imaging ,0302 clinical medicine ,Software ,Predictive Value of Tests ,Internal medicine ,Myocardial perfusion scintigraphy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,1102 Cardiorespiratory Medicine and Haematology ,Protocol (science) ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,business.industry ,Myocardial Perfusion Imaging ,1103 Clinical Sciences ,Cross-Sectional Studies ,Cardiovascular System & Hematology ,Positron emission tomography ,Dose reduction ,Cardiology and Cardiovascular Medicine ,business ,Tomography, X-Ray Computed ,Correction for attenuation ,Emission computed tomography - Abstract
Objectives This study sought to describe worldwide variations in the use of myocardial perfusion imaging hardware, software, and imaging protocols and their impact on radiation effective dose (ED). Background Concerns about long-term effects of ionizing radiation have prompted efforts to identify strategies for dose optimization in myocardial perfusion scintigraphy. Studies have increasingly shown opportunities for dose reduction using newer technologies and optimized protocols. Methods Data were submitted voluntarily to the INCAPS (International Atomic Energy Agency Nuclear Cardiology Protocols Study) registry, a multinational, cross-sectional study comprising 7,911 imaging studies from 308 labs in 65 countries. The study compared regional use of camera technologies, advanced post-processing software, and protocol characteristics and analyzed the influence of each factor on ED. Results Cadmium-zinc-telluride and positron emission tomography (PET) cameras were used in 10% (regional range 0% to 26%) and 6% (regional range 0% to 17%) of studies worldwide. Attenuation correction was used in 26% of cases (range 10% to 57%), and advanced post-processing software was used in 38% of cases (range 26% to 64%). Stress-first single-photon emission computed tomography (SPECT) imaging comprised nearly 20% of cases from all world regions, except North America, where it was used in just 7% of cases. Factors associated with lower ED and odds ratio for achieving radiation dose ≤9 mSv included use of cadmium-zinc-telluride, PET, advanced post-processing software, and stress- or rest-only imaging. Overall, 39% of all studies (97% PET and 35% SPECT) were ≤9 mSv, while just 6% of all studies (32% PET and 4% SPECT) achieved a dose ≤3 mSv. Conclusions Newer-technology cameras, advanced software, and stress-only protocols were associated with reduced ED, but worldwide adoption of these practices was generally low and varied significantly between regions. The implementation of dose-optimizing technologies and protocols offers an opportunity to reduce patient radiation exposure across all world regions.
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- 2020
22. Effects of Binary Mixtures and Transpiration on Accumulation of Pharmaceuticals by Spinach
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Elizabeth L. Miller, Joel A. Pedersen, Sara L. Nason, and Krishnapuram G. Karthikeyan
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Crops, Agricultural ,Metabolite ,Wastewater ,010501 environmental sciences ,01 natural sciences ,chemistry.chemical_compound ,Spinacia oleracea ,medicine ,Soil Pollutants ,Environmental Chemistry ,0105 earth and related environmental sciences ,Transpiration ,biology ,food and beverages ,Plant physiology ,General Chemistry ,Carbamazepine ,Metabolism ,biology.organism_classification ,chemistry ,Environmental chemistry ,Spinach ,Water Pollutants, Chemical ,medicine.drug - Abstract
Many pharmaceuticals are present in reclaimed wastewater and effluent-dominated water bodies used to irrigate edible crops. Previous research has shown that plants irrigated with reclaimed wastewater can accumulate pharmaceuticals. However, plant-driven processes that contribute to differences in accumulation among compounds are not well understood. Here, we tested the effects of exposure to mixtures on spinach accumulation and metabolism of four psychoactive pharmaceuticals found in reclaimed wastewater: carbamazepine, fluoxetine, amitriptyline, and lamotrigine. Coexposure of plants to carbamazepine and fluoxetine or amitriptyline decreased accumulation of the toxic carbamazepine metabolite 10,11-epoxycarbamazepine. Furthermore, we tested a simple transpiration-based accumulation model and found that transpiration is a strong predictor for accumulation of the studied compounds. Amitriptyline accumulated to a larger extent than predicted from transpiration alone, and we suggest the possibility that a transporter protein may be involved in its uptake. Our findings highlight the need to consider plant physiology and mixture effects in studying accumulation of polar and ionizable organic contaminants and their metabolites.
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- 2019
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23. Plant-Induced Changes to Rhizosphere pH Impact Leaf Accumulation of Lamotrigine but Not Carbamazepine
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Sara L. Nason, Elizabeth L. Miller, Joel A. Pedersen, and Krishnapuram G. Karthikeyan
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Rhizosphere ,010504 meteorology & atmospheric sciences ,Ecology ,Chemistry ,Health, Toxicology and Mutagenesis ,fungi ,food and beverages ,Carbamazepine ,010501 environmental sciences ,Contamination ,Lamotrigine ,01 natural sciences ,Pollution ,chemistry.chemical_compound ,Nutrient ,Nitrate ,Wastewater ,Environmental chemistry ,medicine ,Environmental Chemistry ,Ammonium ,Waste Management and Disposal ,0105 earth and related environmental sciences ,Water Science and Technology ,medicine.drug - Abstract
Many ionizable organic contaminants (IOCs) are present in treated wastewater used to irrigate edible crops and accumulate in plants under field conditions. Phytoavailability of IOCs with pKa values between 4 and 9 may be affected by the pH of the rhizosphere (the water and soil within 2–3 mm of the root surface). Plants can alter rhizosphere pH by 2–3 units in either direction in response to nutrient availability. The effects of plant modulation of rhizosphere pH on IOC accumulation have not been previously reported. Here we provide direct evidence that plant-driven changes in rhizosphere pH impact accumulation of an IOC in plant leaves. Using a modified hydroponic system, we found that rhizosphere pH was higher by 1.5–2.4 units when plants received only nitrate rather than a combination of nitrate and ammonium. Plant-driven changes to rhizosphere pH altered accumulation of lamotrigine (pKa = 5.7) but not carbamazepine, a non-ionizable contaminant. Lamotrigine accumulation in leaves correlated strongly wi...
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- 2018
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24. An Incomplete Ectrodactyly Ectodermal Cleft Syndrome – A Case Report
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G Karthikeyan and Sudakshina Chakrabarti
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medicine.medical_specialty ,Ectrodactyly ,business.industry ,Medicine ,General Medicine ,business ,medicine.disease ,Dermatology - Published
- 2017
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25. PROLONGED JAUNDICE IN AN APPARENTLY HEALTHY BABY: A REVIEW
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G K Monish, G Karthikeyan, and M Geethanjali
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medicine.medical_specialty ,Pediatrics ,Extrahepatic Biliary Atresia ,business.industry ,Incidence (epidemiology) ,Urinary system ,030232 urology & nephrology ,Breast Milk Jaundice ,General Medicine ,Jaundice ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Etiology ,medicine ,medicine.symptom ,business - Abstract
Jaundice persisting beyond 14 days of life is a commonly encountered problem in the neonatal follow-up clinic. Although by far the most common underlying etiology is breast milk jaundice, clinician should not miss out an important surgical condition the extrahepatic biliary atresia (an incidence of about 1 in 10000 live births) whose outcome without a surgical intervention before 8 weeks is dismal. Eminently treatable entities such as hypothyroidism and urinary tract infection also can present as prolonged jaundice. This article will synthesize the available literature on this topic and present an algorithm for evaluation of neonates presenting with prolonged jaundice useful to pediatricians in outpatient practice.
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- 2017
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26. Bioactive Components (Polyphenols, Flavonoids, Total Carotenoids, Antioxidant Activity) and Proximate Chemical Composition of Selected Food Processing Industry By - Products
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G. Hemalatha, G. Karthikeyan, M. L. Mini, S. Amutha, and C. Sivananth
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chemistry.chemical_classification ,Antioxidant ,business.industry ,medicine.medical_treatment ,010401 analytical chemistry ,04 agricultural and veterinary sciences ,Proximate ,040401 food science ,01 natural sciences ,0104 chemical sciences ,0404 agricultural biotechnology ,chemistry ,Polyphenol ,medicine ,Food processing ,Food science ,business ,Carotenoid ,Chemical composition - Published
- 2017
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27. Correspondence
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G. Karthikeyan, G. K. Monish, Aashima Dabas, Piyush Gupta, Mani Ram Krishna, Usha Nandhini Sennaiyan, Tapas Bandyopadhyay, Manish Kumar Gaur, Sanjay Gupta, Aniruddha Ghosh, and Pavel Kundu
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03 medical and health sciences ,0302 clinical medicine ,business.industry ,030225 pediatrics ,Pediatrics, Perinatology and Child Health ,MEDLINE ,Medicine ,030204 cardiovascular system & hematology ,business ,Data science - Published
- 2017
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28. Safety Profile and Therapeutic Efficacy of One Cycle of Lu177-PSMA in End-Stage Metastatic Castration-Resistant Prostate Cancer Patients with Low Performance Status
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G Karthikeyan, Vineet Talwar, Partha Sarathi Choudhury, Kumar Deep Dutta, Manoj Gupta, Amitabh Singh, and Sudhir Rawal
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medicine.medical_specialty ,Performance status ,business.industry ,Visual analogue scale ,Urology ,Correction ,urologic and male genital diseases ,medicine.disease ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Prostate-specific antigen ,Prostate cancer ,0302 clinical medicine ,medicine.anatomical_structure ,Docetaxel ,Leukocytopenia ,Prostate ,030220 oncology & carcinogenesis ,Medicine ,Radiology, Nuclear Medicine and imaging ,Original Article ,business ,Progressive disease ,medicine.drug - Abstract
PURPOSE: The aim of this study was to evaluate safety and therapeutic efficacy of lutetium 177 prostate-specific membrane antigen (Lu-177-PSMA) in metastatic castration-resistant prostate cancer (mCRPC) patients with low performance status. METHODS: Twenty-two patients already treated with anti-androgens and docetaxel were enrolled for one cycle of Lu-177-PSMA therapy. Haemoglobin, total leukocyte counts, platelets and serum creatinine for toxicity profile while prostate specific antigen (PSA), Eastern Cooperative Oncology Group (ECOG) performance status, visual analogue scale (VAS) and analgesic quantification scale (AQS) for therapeutic efficacy were recorded pre and 8 weeks post therapy. Wilcoxon signed-rank and ANOVA tests were used for statistical analysis. RESULTS: Partial response (PR), stable disease (SD) and progressive disease (PD) for PSA were seen in 5 (22.7%), 13 (59.1%) and 4 (18.2%) patients respectively treated with mean 6.88 GBq dose of Lu-177-PSMA. 8/22 (36.4%) patients showed ≥ 30% drop in PSA. Grade 3 haemoglobin toxicity was seen in 5/22 (22.7%) patients. No patient developed grade 4 haemoglobin toxicity. No patients had grade 3 or 4 leukocytopenia or thrombocytopenia. Wilcoxon signed-rank test showed statistical significant (P
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- 2019
29. Antioxidant role of Nymphaea alba flower extract against alloxan induced experimental diabetes condition
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G Karthikeyan, S Rajaram, and S Arulraja
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Nymphaea alba flower extract ,Antioxidant ,Traditional medicine ,medicine.medical_treatment ,Cell Biology ,Biology ,Biochemistry ,chemistry.chemical_compound ,chemistry ,Alloxan ,medicine ,Molecular Biology ,Biotechnology ,Experimental diabetes - Published
- 2019
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30. Dysbiosis Disrupts Gut Immune Homeostasis and Promotes Gastric Diseases
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Chhavi Goel, Prashant Kumar, Hridayesh Prakash, Anil Kumar, Sandhya Singh, Devinder Toor, G Karthikeyan, Mishi Kaushal Wsson, and Naveen Kumar Kaushik
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0301 basic medicine ,Antibiotics ,Review ,Gut flora ,lcsh:Chemistry ,0302 clinical medicine ,immune epigenetics ,Homeostasis ,Receptor ,Hypoxia ,lcsh:QH301-705.5 ,Spectroscopy ,education.field_of_study ,biology ,Toll-Like Receptors ,General Medicine ,Gastric Diseases ,Computer Science Applications ,Anti-Bacterial Agents ,030220 oncology & carcinogenesis ,medicine.drug_class ,Population ,TLR mimicry ,Stomach Diseases ,Antineoplastic Agents ,Catalysis ,Autoimmune Diseases ,Inorganic Chemistry ,03 medical and health sciences ,Immune system ,medicine ,Animals ,Humans ,Epigenetics ,Physical and Theoretical Chemistry ,education ,Molecular Biology ,Inflammation ,gut microbiota ,Host Microbial Interactions ,Macrophages ,Organic Chemistry ,medicine.disease ,biology.organism_classification ,Diet ,Gastrointestinal Microbiome ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,sterile inflammation ,Immunology ,Dysbiosis ,metabolism - Abstract
Perturbation in the microbial population/colony index has harmful consequences on human health. Both biological and social factors influence the composition of the gut microbiota and also promote gastric diseases. Changes in the gut microbiota manifest in disease progression owing to epigenetic modification in the host, which in turn influences differentiation and function of immune cells adversely. Uncontrolled use of antibiotics, chemotherapeutic drugs, and any change in the diet pattern usually contribute to the changes in the colony index of sensitive strains known to release microbial content in the tissue micromilieu. Ligands released from dying microbes induce Toll-like receptor (TLR) mimicry, skew hypoxia, and cause sterile inflammation, which further contributes to the severity of inflammatory, autoimmune, and tumorous diseases. The major aim and scope of this review is both to discuss various modalities/interventions across the globe and to utilize microbiota-based therapeutic approaches for mitigating the disease burden.
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- 2019
31. Correspondence
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Venkateswari Ramesh, Janani Sankar, Podhini Jegadeesan, Thirunavukkarasu Arun Babu, Teng-Fu Tsao, Yu-Hua Chao, Ira Shah, Suresh Kumar Angurana, Savita Verma Attri, Satish K. Shah, Rakesh Lodha, G. Karthikeyan, B. Vishnu Bhat, Hasmukh Chapsi Gala, Amol Madave, Shiv Sajan Saini, Vidushi Mahajan, Manju Kumari, Sriram Krishnamurthy, and Anbazhagan Jagadeesh
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Hyperostosis ,Infantile cortical hyperostosis ,business.industry ,Osteomyelitis ,030206 dentistry ,Anatomy ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Scapula ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,medicine ,business - Published
- 2017
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32. Molecular characterization and genetic diversity of Tobacco streak virus infecting soybean (Glycine max L.)
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G. Karthikeyan, S. Rajamanickam, and K. Ganesamurthy
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0106 biological sciences ,0301 basic medicine ,Genetic diversity ,Mutation ,Sequence analysis ,Inoculation ,food and beverages ,Plant Science ,Biology ,medicine.disease_cause ,biology.organism_classification ,01 natural sciences ,Microbiology ,Virology ,Virus ,03 medical and health sciences ,030104 developmental biology ,Infectious Diseases ,medicine ,Blight ,Gene ,Tobacco streak virus ,010606 plant biology & botany - Abstract
Soybean (Glycine max L.), the most popular oil seed crop, grown in the experimental fields of Tamil Nadu Agricultural University and adjoining areas exhibited symptoms of necrosis and stunting. The symptoms were similar to bud blight of soybean caused by the Tobacco streak virus (TSV) and the disease is most prevalent throughout the country. To study the nature of infection, sap inoculation of the soybean strain induced local as well systemic infection on cowpea plants cv. C 152 and resulted in the production of circular necrotic lesions and death of plants. The samples were also serologically positive in DAC-ELISA and it has also yielded a protein band of approximately 29 kDa corresponding to coat protein of TSV in Western blot assay. For the characterization of virus, RT-PCR was carried out with a newly designed coat protein gene specific primer, which resulted in amplification of the expected 929 bp size. Sequence analysis of the CP gene had nucleotide similarity of 80.6 to 99.3% with known isolates of TSV. The multiple sequence alignment revealed that CP gene showed single unique variation and some of deletion and addition mutation was found in nucleotide and amino acid sequences against the isolates of other soybean Brazil and USA isolates and produced single unique variation at position 344 where adenine was substituted with guanine. There was no deletion and addition between nucleotide sequences in the group of Indian isolates, further confirms the placement of the soybean isolate of TSV in a single subgroup. Key words: Soybean, Tobacco streak virus, coat protein gene, diversity analysis.
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- 2016
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33. Gender Differences in Radiation Dose From Nuclear Cardiology Studies Across the World
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Lynn Shi, Sharmila Dorbala, Diana Paez, Leslee J. Shaw, Katherine A. Zukotynski, Thomas N.B. Pascual, Ganesan Karthikeyan, João V. Vitola, Nathan Better, Nadia Bokhari, Madan M. Rehani, Ravi Kashyap, Maurizio Dondi, Mathew Mercuri, Andrew J. Einstein, A.J. Einstein, T.N.B. Pascual, D. Paez, M. Dondi, N. Better, S.E. Bouyoucef, G. Karthikeyan, R. Kashyap, V. Lele, V.P.C. Magboo, J.J. Mahmarian, J.B. Meeks, M. Mercuri, F. Mut, M.M. Rehani, J.V. Vitola, E. Alexanderson, A. Allam, M.H. Al-Mallah, H. Bom, A. Flotats, S. Jerome, P.A. Kaufmann, O. Luxenburg, J. Mahmarian, L.J. Shaw, S.R. Underwood, J. Vitola, W. Amouri, H. Essabbah, S.S. Gassama, K.B. Makhdomi, G.I.E. El Mustapha, N. El Ouchdi, N. Qaïs, N. Soni, W. Vangu, R.M. Abazid, B. Adams, V. Agarwal, M.A. Alfeeli, N. Alnafisi, L. Bernabe, G.G. Bural, T. Chaiwatanarat, J.M. Chandraguptha, G.J. Cheon, I. Cho, A.S. Dogan, M. Eftekhari, A. Frenkel, I. Garty, S. George, P. Geramifar, H. Golan, S. Habib, R. Hussain, H. Im, H.-J. Jeon, T. Kalawat, W.J. Kang, F. Keng, A. Klaipetch, P.G. Kumar, J. Lee, W.W. Lee, I. Lim, C.M.M. Macaisa, G. Malhotra, B.R. Mittal, M.H. Mohammad, P. Mohan, I.D. Mulyanto, D. Nariman, U.N. Nayak, K. Niaz, G. Nikolov, J.M. Obaldo, E. Ozturk, J.M. Park, S. Park, C.D. Patel, H.K. Phuong, A.P. Quinon, T.R. Rajini, Y. Saengsuda, J. Santiago, H.B. Sayman, A.S. Shinto, V. Sivasubramaniyan, M.H. Son, P. Sudhakar, G.M.S. Syed, N. Tamaki, K. Thamnirat, T. Thientunyakit, S. Thongmak, D.N. Velasco, A. Verma, U. Vutrapongwatana, Y. Wang, K.S. Won, Z. Yao, T. Yingsa-nga, R. Yudistiro, K.T. Yue, N. Zafrir, S.C. Adrian, D. Agostini, S. Aguadé, G. Armitage, M. Backlund, M. Backman, M. Baker, M.T. Balducci, C. Bavelaar, M. Berovic, F. Bertagna, R. Beuchel, A. Biggi, G. Bisi, R. Bonini, A. Bradley, L. Brudin, I. Bruno, E. Busnardo, R. Casoni, A. Choudhri, C. Cittanti, R. Clauss, D.C. Costa, M. Costa, K. Dixon, M. Dziuk, N. Egelic, I. Eriksson, G. Fagioli, D.B. de Faria, L. Florimonte, A. Francini, M. French, E. Gallagher, I. Garai, O. Geatti, D. Genovesi, L. Gianolli, A. Gimelli, E. del Giudice, S. Halliwell, M.J. Hansson, C. Harrison, F. Homans, F. Horton, D. Jędrzejuk, J. Jogi, A. Johansen, H. Johansson, M. Kalnina, M. Kaminek, A. Kiss, M. Kobylecka, M. Kostkiewicz, J. Kropp, R. Kullenberg, T. Lahoutte, O. Lang, Y.H. Larsson, M. Lázár, L. Leccisotti, N. Leners, O. Lindner, R.W. Lipp, A. Maenhout, L. Maffioli, C. Marcassa, B. Martins, P. Marzullo, G. Medolago, C.G. Mendiguchía, S. Mirzaei, M. Mori, B. Nardi, S. Nazarenko, K. Nikoletic, R. Oleksa, T. Parviainen, J. Patrina, R. Peace, C. Pirich, H. Piwowarska-Bilska, S. Popa, V. Prakash, V. Pubul, L. Puklavec, S. Rac, M. Ratniece, S.A. Rogan, A. Romeo, M. Rossi, D. Ruiz, N. Sabharwal, B.G. Salobir, A.I. Santos, S. Saranovic, A. Sarkozi, R.P. Schneider, R. Sciagra, S. Scotti, Z. Servini, L.R. Setti, S.-Å. Starck, D. Vajauskas, J. Veselý, A. Vieni, A. Vignati, I.M. Vito, K. Weiss, D. Wild, M. Zdraveska-Kochovska, R.N. Agüro, N. Alvarado, C.M. Barral, M. Beretta, I. Berrocal, J.F. Batista Cuellar, T.-M. Cabral Chang, L.O. Cabrera Rodríguez, J. Canessa, G. Castro Mora, A.C. Claudia, G.F. Clavelo, A.F. Cruz Júnior, F.F. Faccio, K.M. Fernández, J.R. Gomez Garibo, U. Gonzalez, P. González E., M.A. Guzzo, J. Jofre, M. Kapitán, G. Kempfer, J.L. Lopez, T. Massardo V., I. Medeiros Colaco, C.T. Mesquita, M. Montecinos, S. Neubauer, L.M. Pabon, A. Puente, L.M. Rochela Vazquez, J.A. Serna Macias, A.G. Silva Pino, F.Z. Tártari Huber, A.P. Tovar, L. Vargas, C. Wiefels, A. Aljizeeri, R.J. Alvarez, D. Barger, W. Beardwood, J. Behrens, L. Brann, D. Brown, H. Carr, K. Churchwell, G.A. Comingore, J. Corbett, M. Costello, F. Cruz, T. Depinet, S. Dorbala, M. Earles, F.P. Esteves, E. Etherton, R.J. Fanning, J. Fornace, L. Franks, H. Gewirtz, K. Gulanchyn, C.-L. Hannah, J. Hays, J. Hendrickson, J. Hester, K. Holmes, A. Johnson, C. Jopek, H. Lewin, J. Lyons, C. Manley, J. Meden, S. Moore, W.H. Moore, V. Murthy, R. Nace, D. Neely, L. Nelson, O. Niedermaier, D. Rice, R. Rigs, K. Schiffer, E. Schockling, T. Schultz, T. Schumacker, B. Sheesley, A. Sheikh, B. Siegel, A.M. Slim, J. Smith, M. Szulc, N. Tanskersley, P. Tilkemeier, G.D. Valdez, R. Vrooman, D. Wawrowicz, D.E. Winchester, A. Alcheikh, B. Allen, E. Atkins, J. Bevan, C. Bonomini, J. Christiansen, L. Clack, E. Craig, H. Dixson, I. Duncan, S. Fredericks, S. Gales, R. Hampson, T. Hanley, K. Hartcher, J. Hassall, B. Kelley, S. Kelly, T. Kidd, T. de Kort, G. Larcos, W. Macdonald, C. McGrath, E. Murdoch, S. O'Malley, M. O'Rourke, M. Pack, R. Pearce, R. Praehofer, S. Ramsay, L. Scarlett, K. Smidt, F. Souvannavong, K. Taubman, G. Taylor, K. Tse, S. Unger, and J. Weale
- Subjects
medicine.medical_specialty ,Multivariate analysis ,medicine.diagnostic_test ,business.industry ,Cross-sectional study ,Gender Inequality Index ,Odds ratio ,030204 cardiovascular system & hematology ,Effective dose (radiation) ,030218 nuclear medicine & medical imaging ,3. Good health ,03 medical and health sciences ,Myocardial perfusion imaging ,0302 clinical medicine ,Radiology Nuclear Medicine and imaging ,Internal medicine ,Cardiology ,Medicine ,Radiology, Nuclear Medicine and imaging ,Observational study ,Cardiology and Cardiovascular Medicine ,business ,Chi-squared distribution - Abstract
Objectives The aim of this study was to investigate gender-based differences in nuclear cardiology practice globally, with a particular focus on laboratory volume, radiation dose, protocols, and best practices. Background It is unclear whether gender-based differences exist in radiation exposure for nuclear cardiology procedures. Methods In a large, multicenter, observational, cross-sectional study encompassing 7,911 patients in 65 countries, radiation effective dose was estimated for each examination. Patient-level best practices relating to radiation exposure were compared between genders. Analysis of covariance was used to determine any difference in radiation exposure according to gender, region, and the interaction between gender and region. Linear, logistic, and hierarchical regression models were developed to evaluate gender-based differences in radiation exposure and laboratory adherence to best practices. The study also included the United Nations Gender Inequality Index and Human Development Index as covariates in multivariable models. Results The proportion of myocardial perfusion imaging studies performed in women varied among countries; however, there was no significant correlation with the Gender Inequality Index. Globally, mean effective dose for nuclear cardiology procedures was only slightly lower in women (9.6 ± 4.5 mSv) than in men (10.3 ± 4.5 mSv; p Conclusions Despite significant worldwide variation in best practice use and radiation doses from nuclear cardiology procedures, only small differences were observed between genders worldwide. Regional variations noted in myocardial perfusion imaging use and radiation dose offer potential opportunities to address gender-related differences in delivery of nuclear cardiology care.
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- 2016
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34. Streptokinase versus recombinant tissue-type plasminogen activator for thrombolysis of mechanical prosthetic heart valve thrombosis
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Nilkanth Chandrakant Patil, Vinay K. Bahl, Sandeep Singh, G Karthikeyan, and Shrenik Doshi
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medicine.medical_specialty ,thrombolysis ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_treatment ,Streptokinase ,lcsh:Surgery ,Hemodynamics ,lcsh:Medicine ,Prosthetic heart valve thrombosis ,Internal medicine ,medicine ,Thrombolytic Agent ,streptokinase ,Stroke ,Urokinase ,business.industry ,lcsh:R ,Atrial fibrillation ,Thrombolysis ,lcsh:RD1-811 ,medicine.disease ,Surgery ,recombinant tissue-type plasminogen activator ,lcsh:RC666-701 ,Cardiology ,business ,Plasminogen activator ,medicine.drug - Abstract
Aims and Objectives: This study was designed to compare streptokinase (STK) versus recombinant tissue-type plasminogen activator (rt-PA) for thrombolysis in patients with prosthetic heart valve thrombosis (PHVT). Background: Optimal management of PHVT remains controversial. Thrombolytic therapy is a reasonable alternative to surgery. Numerous thrombolytic protocols with STK, urokinase, and rt-PA have been used over the past 40 years. So far there is a lack of consensus on the ideal thrombolytic agent for PHVT. There are no major studies comparing efficacy of STK versus rt-PA. Methods and Results: Sixty patients who underwent thrombolysis for PHVT over 1 year were studied. Forty-eight patients were thrombolysed with STK, whereas 12 patients received rt-PA. Overall 68.33% (41/60) patients showed complete response (CR), whereas 85% (51/60) showed some improvement in hemodynamics, with no significant difference in efficacy according to age, sex, duration from surgery, New York Heart Association Class III–IV, presence of atrial fibrillation, type of valve, or history of stroke. Overall 10% patients developed major complications with mortality of 5%. CR to thrombolytic therapy was numerically better with STK (72.9% vs. 50%; P = 0.12) and mortality was significantly higher in rt-PA (16.6% vs. 2%, P = 0.038). Mean duration of successful thrombolysis was significantly longer with STK as compared to rt-PA (22.96 ± 19.2 vs. 3 h). Conclusion: STK use as compared to rt-PA was associated with numerically more successful thrombolysis and significant lower mortality, hence may be optimal for elective thrombolysis.
- Published
- 2016
35. RHINOSPORIDIOMA: PRIMARY CUTANEOUS RHINOSPORIDIOSIS - A RARE CASE REPORT
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G Karthikeyan, A Prabakar, and R Syed
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Rhinosporidium seeberi ,medicine.medical_specialty ,Pathology ,Conjunctiva ,biology ,Genitourinary system ,business.industry ,Mucocutaneous zone ,biology.organism_classification ,medicine.disease ,Cutaneous rhinosporidiosis ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Chronic granulomatous disease ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Rhinosporidiosis ,Medicine ,business ,Nose - Abstract
Rhinosporidiosis is a chronic granulomatous disease caused by Rhinosporidium seeberi. Rhinosporidium seeberi causes granulomatous inflammation of mucocutaneous sites, presenting most frequently as polypoidal lesions in the nose. Sites like the conjunctiva, trachea, nasopharnyx, skin, and genitourinary tract are less frequently involved. Primary cutaneous lesion is extremely rare and it is often mistaken for soft-tissue tumour. We present a case of 55 years male patient from Thanjavur, Tamilnadu, with primary cutaneous rhinosporidiosis without mucosal involvement.
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- 2016
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36. Energy Consumption and Recovery in Capacitive Deionization Using Nanoporous Activated Carbon Electrodes
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Krishnapuram G. Karthikeyan, Linchen Han, and Kelvin B. Gregory
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Materials science ,Renewable Energy, Sustainability and the Environment ,Capacitive deionization ,Nanoporous ,Energy consumption ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Chemical engineering ,Electrode ,Materials Chemistry ,Electrochemistry ,medicine ,Activated carbon ,medicine.drug - Published
- 2015
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37. Translation and validation of the questionnaire on current status of physiotherapy practice in the cancer rehabilitation
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Udayakumar Manoor, G Karthikeyan, and Sanjay S. Supe
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medicine.medical_specialty ,medicine.medical_treatment ,Regional language ,lcsh:RC254-282 ,law.invention ,law ,Neoplasms ,Surveys and Questionnaires ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Physical Therapy Modalities ,physiotherapy ,Face validity ,validation ,Rehabilitation ,Cancer rehabilitation ,business.industry ,Debriefing ,Reproducibility of Results ,questionnaire translation ,Cognition ,General Medicine ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,language.human_language ,Treatment Outcome ,Oncology ,Tamil ,CLARITY ,language ,Physical therapy ,Malayalam ,business - Abstract
Background: The translation and cultural adaptation of psychometrically tested tools is an essential component of effective evaluation of the intended purpose. The English questionnaire had been designed to measure current status of physiotherapy practice in cancer rehabilitation. Aim: The aim of this study was to culturally adapt, including translation and preliminary validation of the questionnaire for the cancer patients. Materials and Methods: A custom-made, validated version of the English self-administered questionnaire consisting of 30 items was translated into Tamil, Kannada and Malayalam languages. The process of translation included recommended methodology, mandating forward translation, backward translation, reconciliation and pretesting steps, was followed. Tool validation included assessing content accuracy and clarity. Process involved 13 jurors for the translation and content validation and 30 cancer patients for the face validity. All subjects were asked to complete the translated versions of the questionnaire, which was previously validated. Analysis and Results: The psychometric properties of the three regional language versions of the questionnaire for cancer patients employed during rehabilitation were good. Cognitive debriefing showed the regional language versions to be clear, relevant and comprehensive. Conclusion: The translated and adapted versions are comparable with the original English instrument in terms of content and accuracy and it is suitable to assess the current physiotherapy practice pattern in cancer rehabilitation settings.
- Published
- 2015
38. Clinical Study to Analyze the Intramuscular Anatomy of Musculocutaneous Perforators of Anterolateral Thigh Flaps
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G. Karthikeyan, S.K. Singh, Gurusamy Vishwanath, Gopi Renganathan, and R. Venkatnaryanan
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Vascular anatomy ,Vastus lateralis muscle ,030230 surgery ,Thigh ,Clinical anatomy ,Surgical Flaps ,Veins ,Clinical study ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Medicine ,Humans ,Prospective Studies ,Child ,Aged ,Thigh surgery ,business.industry ,Graft Survival ,Anatomic Variation ,Anatomy ,Skin Transplantation ,Anterolateral thigh ,Middle Aged ,Plastic Surgery Procedures ,Surgery ,Femoral Artery ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Tissue and Organ Harvesting ,Female ,business ,Perforator Flap ,Artery - Abstract
Background Anterolateral thigh (ALT) flap is a common flap used for many microsurgical reconstructive procedures. Majority of these flaps are based on the musculocutaneous perforators, which, after arising from source artery, course through the bulk of the vastus lateralis muscle. The vascular anatomy of the ALT flap has been often decried as its limiting factor. Methods In this prospective study conducted over 3 years, 207 cases of ALT flap were evaluated. During the harvest of ALT flap, musculocutaneous perforators were laid open through the vastus lateralis, and its variations and pattern were studied for clinical anatomy as well as impact of anatomy on the viability of the flap postoperatively. Results The perforators were recognized to be grouped into three broadly distinguishable anatomical patterns: linear (I), branching (Y), or tortuous (S). While the majority of perforators (51%) were linear “I” perforators, serpentine “S” and branching “Y” perforators were 28 and 21%, respectively. The clinical outcomes were also related to the simplicity of these perforators course as linear “I” perforators had 100% flap viability. Conclusion During the harvest of 207 ALT flaps through 3 years, it could be deciphered that the musculocutaneous perforators traverse through the bulk of vastus lateralis muscle in only three types of patterns (IYS pattern). This identification of pattern could help in prevention of injury while delineating the perforators. Identification and typing of anatomical variation of the musculocutaneous perforator within the vastus muscle could lead to a predictable and safer harvest of the ALT flap.
- Published
- 2017
39. Melon thrips Thrips palmi karny association with bud necrosis disease in water melon
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P. Aishwarya, T R Usharani, I Rabeena, D Rajabaskar, J.S. Kennedy, and G Karthikeyan
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Horticulture ,Necrosis ,Ecology ,Thrips ,biology ,Melon ,Insect Science ,medicine ,Thrips palmi ,medicine.symptom ,biology.organism_classification ,Agronomy and Crop Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2020
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40. Analysis of challenging reconstruction of soft tissue defects around the knee joint and evolving a treatment algorithm
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G Karthikeyan, J J Lankaram, U. Rasheedha Begum, and V Ramadevi
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musculoskeletal diseases ,Reconstructive surgery ,medicine.medical_specialty ,Rotation flap ,business.industry ,Soft tissue ,Pedicled Flap ,Knee Joint ,Thigh ,Tendon ,medicine.anatomical_structure ,medicine ,Contracture ,medicine.symptom ,business ,Algorithm - Abstract
Background: The soft tissue defects around knee joint give a challenging experience to reconstruct. There are various ways to reconstruct soft tissue defects around knee joint. In this study, a reconstructive algorithm is formed for soft tissue defect around knee joint using pedicled flaps.Methods: Reconstructive procedures were done for 15 cases of soft tissue defects around knee joints following different etiologies during the tenure of January 2017 to December 2018 in the Department of Burns, Plastic and Reconstructive Surgery, Kilpauk Medical College, Chennai.Results: Soft tissue defects around knee joint need flap to have a durable cover, to protect the underlying structures – bones, vessels, tendon, and to enable ease of free movement of knee joint without producing contracture. There are various etiologies for soft tissue defects around knee joint-post traumatic injuries, post total knee replacement, post electric burn injuries, post burn scar contracture release of knee joint. 15 cases of soft tissue defects around knee joint were reconstructed using various pedicled flaps-medial thigh rotation flap, gastrocnemius muscle and myocutaneous flap, reverse anterolateral thigh flap, propeller flap. In this retrospective study, reconstructive algorithm for soft tissue defects around knee joint is provided.Conclusions: The reconstruction of soft tissue defects around knee joint is difficult one. In this study, a simple reconstructive algorithm is provided based on the experience in Department of Burns, Plastic, and Reconstructive Surgery, Kilpauk Medical College, Chennai.
- Published
- 2019
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41. STROKE RISK PREDICTION IN PATIENTS WITH ATRIAL FIBRILLATION AND RHEUMATIC HEART DISEASE: RESULTS FROM THE RE-LY AF REGISTRY
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S H Hohnloser, Jonas Oldgren, Salim Yusuf, Alexander P. Benz, T. Marsden, Lars Wallentin, Michael D. Ezekowitz, Jeff S. Healey, Stuart J. Connolly, and G. Karthikeyan
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Stroke risk ,medicine.medical_specialty ,Heart disease ,business.industry ,Internal medicine ,medicine ,Cardiology ,Atrial fibrillation ,In patient ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business - Published
- 2019
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42. Microalbuminuria among obese and non-obese individuals: a case control study
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M. Nataraj and G. Karthikeyan
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medicine.medical_specialty ,business.industry ,Case-control study ,Renal function ,Odds ratio ,medicine.disease ,Obesity ,Non obese ,Internal medicine ,medicine ,Outpatient clinic ,Microalbuminuria ,Statistical analysis ,business - Abstract
Background: Microalbuminuria among obesity cases reflects specific glomerular damage or is the marker of generalized endothelial cell dysfunction is still debatable. Thus, this study aimed to assess the presence of microalbuminuria among obese persons and non-obese individuals, who were euglycemic and normotensive.Methods: A case control study was conducted among patients attending outpatient department of general medicine in Govt Thiruvarur Medical College, Thiruvarur, for their illnesses from June 2017 to December 2017. A total of hundred participants with fifty obese cases and fifty non obese controls were included in this study. Detailed history and examination were done by the principal investigator and the same was documented in a proforma. Data entry was done using Microsoft excel and the statistical analysis includes odds ratio were calculated using Statistical Package for Social Sciences (SPSS) software version 17.Results: Among the study participants, 32% and 4% had microalbuminuria in obese and non-obese group, respectively. Also, obese participants were 11.29 times at higher chances of having microalbuminuria when compared to the non-obese patients with significant p value (p=0.002).Conclusions: Microalbuminuria can be used to predict the risk of complications in obese subjects in order to bring down the overall morbidity and mortality related to renal function.
- Published
- 2019
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43. Mechanical Heart Valves and Pregnancy
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G Karthikeyan
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Mechanical heart ,Pregnancy ,medicine.medical_specialty ,business.industry ,Internal medicine ,Cardiology ,Medicine ,business ,medicine.disease - Published
- 2017
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44. Poster Session Wednesday 5 December all day Display * Determinants of left ventricular performance
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J. Skranes, I. Andreadou, A. Germain, A. Alghamdi, C. Santoro, Z. Markovic, G. Jones, N. Lousada, K. Shahgaldi, A. Iqbal, L. Carpinteiro, O. Dzikowska-Diduch, J. Khoo, H. Vago, Y. Juilliere, M. L. Del Pino, M. Lisi, J. Choi, Y. Yotov, M. Monaghan, P. Seferovic, R. Beanlands, K. Dima, J. Suarez De Lezo Herreros De Tejada, I. D-Angeli, S. Veioglanis, A. Magalhaes, R. Esposito, D. Damaskos, L. Faber, M. Centeno, A. Sahlen, A. Stoylen, K. Adamyan, R. Gao, C. Zito, M. Gomez-Rubin, A. Simon, N. Markovic Nikolic, J. Gibbs, J. Dahl, S. Gati, A. Omran, K. Aonuma, B. Michalski, B. Zweig, V. Katsi, S. Giannitsi, S. Wrideier, D. Marcadet, S. Malm, S. Rahman Haley, B. Rybus-Kalinowska, S. Yurdakul, N. Haas, C. Katseli, M. Caplin, D. Haghi, L. Drvol, S. Bosi, M. M. Gurzun, B. Merkely, T. Alvarez, L. Capotosto, G. Draganic, C. Lowery, D. J. Cuthbertson, T. Kovats, S. Gherardi, F. Elmkies, H.-J. Trappe, S. Backovic, A. Koumoulidis, W. Sheng, S. G. Da Silva, M. Alam, I. Felekos, L. Badano, A. Manouras, W. Burchert, H. Direskeneli, M. Alraies, B. Natali, L. Weinert, A. Scullion, Y. Noguchi, K. Chun, M. Borggrefe, A. Barbieri, S. Hassantash, M. Banovic, M. Takeuchi, E. Sfendouraki, D. Horstkotte, W. Gin-Sing, K. Gatzoulis, W. Choi, K. Grudzka, G. Luzza, J. Sellal, M. Galderisi, C. Halley, O. Hallioglu, T. Sueselbeck, A. Nagy, S. Eroglu, N. Mansencal, H. Seggewiss, V. Kuznetsov, M. Anastasiou-Nana, M. Lourenco, W. Jaber, L. Howard, S. Piret, P. Palczewski, A. Mohamed, R. Dekemp, S. Habash, L. Videbaek, B. Kilicaslan, E. Nestaas, C. Marin, C. Selton-Suty, I. Ikonomidis, G. Sjoberg, L. Stefanczyk, S. Goliszek, A. Charalampopoulos, A. Travlou, V. Pipitone, N. Matveeva, T. G. Alujas, K. Ananthasubramaniam, M. Karvandi, D. Ermacora, A. Rodriguez-Ogando, J. Silva Marques, J. Kim, L. Michalis, M. Prull, O. Wendler, J. Chattahi, M. Baldelli, J.-L. Philip, A. Squeri, D. Jiminez, I. Tzoulaki, J. Hallberg, G. Truscelli, P. Zinzius, L. Santos, D. Tousoulis, I. B. Surribas, B. Stojcevski, C. Reverberi, S. Ghani, F. Toledano Delgado, D. Han, M. Hedger, I. Ilic-Djordjevic, S. Berthier, B. Tasdelen, G. Pushkarev, P. Maccarthy, M. Cikes, L. Arnold, M. Ostojic, A. Massoni, D. Fugelseth, K. Szymczyk, F. Caranci, Y. Seo, O. Kunchev, E. Picano, A. Nunes Diogo, V. Vukcevic, S. Martins, C. Doesch, M. Chiavarelli, M. Petrovic, O. Enescu, H. Al-Shehri, D. Cini, M. Kalinowski, A. Zaidi, T. Song, Z. Cosic, S. Lupu, I. Koutagiar, J. Stabryla, S. Rangamani, M. Ciurzynski, C. Medrano, L. Tong, A. Ylitalo, J. Sanderson, B. Prendergast, L. R. Tumasyan, E. Gunyeli, F. Castillo Bernal, A. Vershinina, M. Krupa, A. Madaffari, D. Ledoux, M. Ozeren, A. Baltabaeva, A. Mladenovic, T. Christophersen, T. Papavassiliu, C. Yu, P. Lipiec, M. Fischer, D. Bacic, A. Padiyath, I. Paraskevaidis, T. Kukulski, M. Stamatelatou, H. Houle, S. Sideris, G. Kolunin, S. Boedeker, K.-L. Ang, G. A. Derumeaux, L. Agoston-Coldea, M. Baeza Garzon, B. Buyukakilli, S. Antoniou, A. Buno, G. Roussakis, L. Sargento, A. Ouss, M. Losito, O. Azevedo, M. M. Urdaniz, G. Arpesella, B. Lichodziejewska, B. Vujisic-Tesic, T. Butz, J. Davar, M. Poulsen, A. Grasso, G. Gkiouras, J. Moller, A. Apor, O. Dettori, T. Ruddy, W. Aljaroudi, G. Saifullina, C. Mabbet, N. Sheikh, M. De Maio, R. Sharma, G. Sutherland, J. Sun, M. Frenneaux, A. Saitta, D. Mahadevan, A. Angelov, F. Maffessanti, C. Gouva, A. Almeida, W. Serra, G. Tamborini, R. Winter, R. Medeiros, R. Ionasec, L. Gapon, P. Carrilho Ferreira, E. Ramirez, D. Roberson, A. Sadykov, R. P. Dos Reis, M. Burgess, P. Bruno, J. Hamilton, A. E. Masip, F. Oner, A. Erraki, M. Naldi, M. Massetti, C. Calisto, J. Lopez-Sendon, S. Gao, E. Kartsagoulis, J. Lof, D. Muraru, J. Kwong, V. Muthurangu, F. Degener, B. Bijnens, R. Arunkumar, S. Ranjbar, S. Longo, M. Pietila, W. Streb, T. Bombardini, H. Zemir, D. Silva, Q. Zhang, S. Lee, K. Naka, F. Vecchio, F. Schaefer, C. Marcos, A. Kottam, L. Brunvand, A. Burghardt, M. Satendra, I. Machado, M. Toth, J. Nowak, G. Gnanavelu, S. Stojkovic, E. Maroto, Y. Park, S. Coulibaly, N. Ozgunes, O. Oldenburg, S. Gurgul, M. Canales, T. Rudbaek, T. Lopez-Fernandez, P. Katsimbri, M. Dekleva, F. Liu, J. Thomas, L. Garcia Cuenllas, P. Meimoun, K. Egstrup, T. Mocan, J. Coghlan, R. Bader, B. Loegstrup, F. Barilla, S. Ribeiro, S. Akhunova, F. Sibellas, C. Aggeli, N. Swaminathan, I. Zyrianov, D. Citirik, J. Suzic Lazic, A. Lourenco, A. Cox, S. Tzortzis, G. Makavos, M. Szulik, P. Massion, R. Sicari, B. Wozniakowski, B. Bahlay, A. Rosner, S. Kutty, J. Lekakis, R. Tripodi, D. Hofsten, M. Pepi, J. Davies, D. Trifunovic, B. Sasko, A. Bircan, M. Camino, J. Stepanovic, A. Bernardes, P. Marie, S. H. Kim, R. Dulgheru, S. Aytekin, B. Pencic, I. Papadakis, G. Dwivedi, D. Danford, J. Sousa, R. Klein, P. Pruszczyk, M. Altman, J. Schwartz, F. De Torres, A. Sahinarslan, A. Moysich, A. Chilingaryan, P. Goktas, N. Cortez-Dias, M. Maccherini, M. Mpougialkli, K. Kurnicka, L.-A. Mohlkert, M D Mesa Rubio, E. Imbalzano, O. Huttin, T. Kiviniemi, P. Wiesen, M. Norman, A. Sezgin, B. Pirat, M. Mercy, N. Shurkevich, J. Clerc, A. Pereira, K. Katopodis, P. Dilaveris, A. Saraste, A. Kisheva, B. Chow, S. Sahin, A. Ionescu, C. Toumpanakis, A. Rudd, J. Srinivasan, S. Chachalos, T. Kuehne, X. Liu, S. Mihaila, A. Aydinalp, T. Ishizu, M. Cameli, G. Pavlidis, A. Aussoleil, M. Hussein, F. Streitner, H. Schirmer, J.-C. Eicher, C. Bergerot, L. A. Pierard, A. Chernjavskiy, H. Raju, S. Mondillo, A. Taylor, S. Carerj, T. Lehtinen, C. Stefanadis, D. Chin, C. Barreiros, R. Davies, M. Schumann, R. Riezebos, D. Gemma, R. Capoulade, B. Montalvan, A. Ciobanu, J. D'hooge, D. I. Del Valle, J. Feliu, D. Duman, D. Donato, D. G. Dorado, V. Bistola, J. B. Rius, M. Kleut, T. Myrmel, M. Bessonova, F. Ballesteros, M. Delgado Ortega, I. Grapsa, C. Papadopoulos, P. Pellikka, D. Muthukumar, A. Flyvbjerg, H. Triantafyllidi, M. Al-Mallah, L. Mircheva, I. Quelhas, R. Rimbas, M. Boricic, J. F. R. Palomares, J. Kasprzak, M. Ravi, Y. Harimura, F. Sargin, V. Dhandapani, D. Knight, J.-L. Canivet, N. Kouris, A. Sljivic, R. A. Dobson, G. Nartsissova, G. T. Tura, P. Trivilou, C. Sousa, I. Ali, C. Jorge, S. Chidambaram, A. Rotkiewicz, R. Grimm, K. Yun, E. Yaroslavskaya, E. Poulidakis, O. Dubourg, P. Lancellotti, D. Dedovic, H. Muderrisoglu, P. Pibarot, A. Rodriguez, A. Vitarelli, D. Kececioglu, R. Placido, P. T. Mas, C. Halvorsen, F. Fang, M. van Bracht, M. Galinanes, A. Toth, Z. Kalarus, M. Ruiz Ortiz, M. Bjerre, J.-E. Wolf, A. Majstorovic, G. Karthikeyan, N. D. Papamichael, E. Szymczyk, I. Kallikazaros, S. Singh, S. Venkatesan, A. Chan, A. Stevanovic, L. Sade, L. G. Garcia-Moreno, B. Lorcerie, A. Tsantes, M. Loudon, C. Olympios, B. K. Avci, K. Laser, Y. Feng, H. Koerperich, L. Rodriguez, I. Schilling, A. Avgeropoulou, S. Goncalves, J. Guardado, R. Reynolds, V. De Cicco, V. Kostopoulos, D. Karassavidou, R. Lang, S. Stankovic, S. Granja, H. Thibault, L. Rasmussen, C. Prinz, N. Banner, F. Mazuelos, E. Bonnefoy-Cudraz, R. Jasaityte, B. Popovic, L. Li, R. Del Bene, P. Karjalainen, W. Tsang, I. Vlasseros, P. Gripari, S. Binno, K. Airaksinen, V. Celic, J. Magne, D. Krinochkin, E. Ferdenzi, D. Avenarius, K. Meenakshi, D. Vinereanu, Z. Elhonsali, S. Sharma, J. D'arcy, D. Dawson, M. Cusma-Piccione, A. Inan, A. Rodriguez Lopez, G. M. Nasr, M. Kostrubiec, D. Iaccarino, H. Botker, M. Morenate Navio, V. Cui, and A. Luycx-Bore
- Subjects
medicine.medical_specialty ,business.industry ,Physical therapy ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Session (computer science) ,Cardiology and Cardiovascular Medicine ,business - Published
- 2012
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45. Evaluation of wound healing activity of Acacia leucophloea bark in rats
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Kalidass Subramaniam, G Karthikeyan, Sembian Suriyamoorthy, and Femina Wahab
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Skin repair ,histopathological ,medicine.medical_specialty ,Traditional medicine ,integumentary system ,Incision wound ,business.industry ,biochemical ,skin ointment ,lcsh:RS1-441 ,wound healing ,Histopathological examination ,Surgery ,lcsh:Pharmacy and materia medica ,Human health ,Acacia leucophloea ,Male rats ,Contraction rate ,medicine ,General Pharmacology, Toxicology and Pharmaceutics ,Wound healing ,business - Abstract
Wound healing activity of the bark extracts of Acacia leucophloea Willd., Fabaceae, was investigated by excision and incision wound healing models in Wistar male rats. Ethanolic extract based ointment of A. leucophloea bark (2 and 5% (w/w)) was formulated and evaluated for its wound healing in Wistar male rats. In comparision with a standard wound healing ointment betadine. A. leucophloea ethanolic extract ointment exhibited marked wound healing activity and significantly enhanced the wound contraction and the period of epithelialization as assessed by wound contraction rate, tensile strength, increasing of DNA, collagen and protein synthesis and histopathological examination. The formulated ointment might well find use as skin repair agent without hazard to human health based on these results.
- Published
- 2012
46. Degloving injuries of the hand
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R Krishnamoorthy and G Karthikeyan
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medicine.medical_specialty ,Degloving ,Reconstructive Surgeon ,reconstruction ,Hand injury ,integumentary system ,business.industry ,medicine.medical_treatment ,Degloving injury ,lcsh:Surgery ,Poison control ,Hand surgery ,Review Article ,lcsh:RD1-811 ,medicine.disease ,Surgery ,Avulsion ,hand surgery ,Injury prevention ,medicine ,Skin grafting ,hand injury ,business ,flap - Abstract
Avulsion of skin from the hand or fingers is an injury that has a dramatic presentation. The entire musculo-skeletal unit of the finger is intact, and the patient can often move the parts of his naked hand quite normally. The challenge for the reconstructive surgeon lies in resurfacing the hand or finger with a good quality pliable sensate skin cover while preserving the movements and function of the hand. Traditionally, skin grafting has been the standard method of reconstruction in such injuries. However, skin grafting does have many disadvantages, too. This article deals with the features of such injuries, management protocols and other reconstructive options available in the armamentarium of the hand surgeon.
- Published
- 2011
47. Depression, anxiety, stress and its correlates among urban school going adolescents in Tamilnadu, India
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G Karthikeyan and A Praveena Daya
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business.industry ,education ,05 social sciences ,050301 education ,Medicine ,0501 psychology and cognitive sciences ,Anxiety stress ,business ,0503 education ,Depression (differential diagnoses) ,050104 developmental & child psychology ,Clinical psychology - Abstract
Background: Undetected and untreated mental disorders can impair a person’s ability to perform at school or work place, cope with daily activities of life and can lead to severe psychiatric disorders and consequences later in their life. Study objective was to determine the prevalence and patterns of depression, anxiety and stress among 400 school going adolescents belonging to classes 10th to 12th of Tirunelveli district, Tamilnadu, India.Methods: Burden of Depression, anxiety and stress was assessed using DASS21 questionnaire. Chi-square test was done using SPSS software version 21 to test for statistical significance.Results: Overall prevalence of depression, anxiety and stress was 73.6%, 86.5% and 24.7% respectively. Depression (p value=0.01), Anxiety (p value = 0.005) and stress (p value = 0.007) were significantly observed more among 10th class students when compared with other classes.Conclusions: The present study has identified a higher prevalence of depression, anxiety and stress among students. This warrants immediate action of creating awareness among teachers and parents in early identification and treatment to prevent serious consequences in later life.
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- 2018
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48. Knowledge and practice about contraception among married women in reproductive age group in a rural area of Tirunelveli district, Tamil Nadu, India: a cross-sectional study
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A Praveena Daya, G Karthikeyan, and G Prema Priya
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Cross-sectional study ,business.industry ,Tamil ,language ,Medicine ,Reproductive age ,Rural area ,Socioeconomics ,business ,language.human_language - Abstract
Background: Unmet need for contraception is still high in developing countries because of various reasons and poses a great challenge to the success of family welfare programme Assessing the knowledge and filling the gap is essential for successful functioning of the programme and for reducing the unmet need.Methods: A cross-sectional study was conducted to assess the knowledge and practices on contraception among 100 married women in reproductive age group (15-49 years) residing in a Rural Health centre area of Tirunelveli district, Tamil Nadu, South India.Results: Among the 100 participants, common known methods of contraception were IUD (56%), permanent sterilization (38%), Pills (21%) and Condoms (14%). Out of 100 participants, only 38 were using contraception. Among the 62 who are not using any method of contraception, 30 are willing to practice contraception after motivation and among them 27 prefer to use temporary methods. Fear of side effects was most common reason stated for not using contraception.Conclusions: Knowledge and practice related to contraception among the participants were observed to be less. Health education campaigns emphasizing the need of family planning and about the services available in the government health facilities has to be organized regularly.
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- 2018
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49. Sorption of the Antibiotic Tetracycline to Humic-Mineral Complexes
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Krishnapuram G. Karthikeyan and Cheng Gu
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Environmental Engineering ,Tetracycline ,Inorganic chemistry ,Management, Monitoring, Policy and Law ,complex mixtures ,symbols.namesake ,Aluminum Oxide ,medicine ,Soil Pollutants ,Humic acid ,Surface charge ,Waste Management and Disposal ,Dissolution ,Humic Substances ,Water Science and Technology ,chemistry.chemical_classification ,Langmuir adsorption model ,Sorption ,Hydrogen-Ion Concentration ,Pollution ,Anti-Bacterial Agents ,chemistry ,Ionic strength ,symbols ,Adsorption ,Clay minerals ,medicine.drug - Abstract
Humic substances, by altering the surface properties and/ or competing for available reaction sites, can either suppress or promote sorption of organic compounds to mineral surfaces. Limited literature evidence points to the reduction in sorption of the antibiotic tetracycline to clay minerals in the presence of humic substances. We investigated the surface interaction of Elliott soil humic acid (ESHA) with hydrous Al oxide (HAO) and the effect of this association on tetracycline sorption. Strong interaction between ESHA and HAO led to ESHA-promoted dissolution of HAO and surface charge reversal. The ESHA-HAO sorption-desorption isotherms were successfully described using a modified Langmuir model that accounted for the heterogeneity of HAO surface and ESHA Ligand exchange was proposed as the major interaction mechanism, and the edge Al atoms on HAO surface were considered as the sorption sites for ESHA macromolecules. ESHA was coated onto HAO to achieve two different organic content (f oc ) levels of 0.81 and 1.52%. Sorption results were compared for the binary ESHA-tetracycline and HAO-tetracycline systems, and the ternary ESHA-HAO-tecracycline system. The coating of ESHA on HAO significantly suppressed tetracycline sorption levels, attributable to altered HAO surface charge characteristics and/or direct competition between ESHA and tetracycline for potential sorption sites. Higher f oc level, besides increasing the extent of sorption suppression, also resulted in greater ionic strength dependence and increased nonlinearity of sorption behavior. It, therefore, appears that the presence of humic substances, in both dissolved and mineral-bound forms, is likely to increase the environmental mobility of tetracycline compounds.
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- 2008
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50. Complexation of the antibiotic tetracycline with humic acid
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Joel A. Pedersen, Krishnapuram G. Karthikeyan, Samuel D. Sibley, and Cheng Gu
- Subjects
Environmental Engineering ,Tetracycline ,Health, Toxicology and Mutagenesis ,Inorganic chemistry ,complex mixtures ,Soil ,Adsorption ,Desorption ,medicine ,Environmental Chemistry ,Humic acid ,Freundlich equation ,Ternary complex ,Humic Substances ,chemistry.chemical_classification ,Public Health, Environmental and Occupational Health ,Sorption ,General Medicine ,General Chemistry ,Hydrogen-Ion Concentration ,Pollution ,Models, Chemical ,chemistry ,Thermodynamics ,Chemical equilibrium ,medicine.drug - Abstract
The effect of solution chemistry and sorbate-to-sorbent ratio on the interaction of the antibiotic tetracycline with Elliott soil humic acid (ESHA) was investigated using equilibrium dialysis and FITEQL modeling. Tetracycline speciation strongly influenced its sorption to ESHA. Sorption was strongly pH-dependent with a maximum around pH 4.3, and competition with H+ and electrolyte cation (Na+) was evident. The pH-dependent trend was consistent with complexation between the cationic/zwitterionic tetracycline species and deprotonated sites in ESHA (mainly carboxylic functional groups). Modification of ESHA by Ca2+ addition increased tetracycline sorption suggesting that ternary complex formation (ESHA-metal-tetracycline) may be important at higher concentrations of multivalent metal cations. The macroscopic data (pH-envelope and sorption isotherms) were successfully modeled using a discrete logK function with the FITEQL 4.0 chemical equilibrium program indicating that ESHA-tetracycline interaction could be reasonably represented as complex formation of a monoacid with discrete sites in humic acid. Sorption-desorption hysteresis was observed; both sorption and desorption isotherms were well described by the Freundlich equation.
- Published
- 2007
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