17 results on '"G. Coffin"'
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2. Étude multicentrique sur les traitements conservateurs des tumeurs du greffon : vers les traitements ablatifs ?
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Rodolphe Thuret, M.O. Timsit, M. Devonec, Georges Karam, R. Codas, Nicolas Terrier, J.M. Boutin, Jacques Hubert, K. Guleryuz, F. Sallusto, E. Lechevallier, C. Sénéchal, Henri Bensadoun, Gregory Verhoest, Arnaud Doerfler, A. Erauso, Damien Chambade, G. Coffin, L. Salomon, L. Viart, Xavier Tillou, S Bouyé, Service d'Urologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Bordeaux [Bordeaux], Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Urologie [CHU Saint-Louis], Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'urologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Marseille, CHI Créteil, CHU Pointe-à-Pitre/Abymes [Guadeloupe], CHU Toulouse [Toulouse], Centre Hospitalier Universitaire [Grenoble] (CHU), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), CHU Pontchaillou [Rennes], CHU Amiens-Picardie, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), CHU Pitié-Salpêtrière [APHP], Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), and Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,030220 oncology & carcinogenesis ,Urology ,030232 urology & nephrology ,medicine ,business ,[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology ,ComputingMilieux_MISCELLANEOUS ,3. Good health - Abstract
Objectifs Decrire l’experience francaise des traitements conservateurs (nephrectomie partielle, radiofrequence et cryoablation) des tumeurs du greffon renal. Methodes Etude retrospective, nationale, multicentrique basee sur les donnees recueillies dans 32 centres de transplantation en France. De janvier 1988 a decembre 2013, les patients traites par traitements conservateurs pour tumeur d’un greffon fonctionnel ont ete inclus. Cent seize tumeurs du greffon ont ete diagnostiquees. Resultats Quarante-huit patients ont eu un traitement par nephrectomie partielle, 11 par radiofrequence et 3 par cryoablation. Les tumeurs traitees par nephrectomie elargie etaient plus souvent symptomatiques par rapport aux autres traitements ( p = 0,019). L’analyse anatomopathologique apres nephrectomie partielle retrouvait 27 carcinomes papillaires, 19 carcinomes a cellules claires, 1 tumeur mixte et 2 oncocytomes sans difference significative par rapport aux traitements ablatifs. La taille moyenne tumorale etait de 24,9 mm sans difference par rapport aux traitements ablatifs ( p = 0,3). Neuf patients ont eu des complications postoperatoires (20,9 %), quatre necessitant une reprise chirurgicale (Clavien IIIb). Aucun des patients traites par radiotherapie ou cryoablation n’ont eu de complications. La duree moyenne de suivi etait de 44,9 mois. Cinquante-neuf (95,1 %) patients avaient un greffon fonctionnel au long terme. La survie specifique etait de 100 %. Conclusion La nephrectomie partielle a prouve son efficacite dans le traitement des petites tumeurs de-novo du greffon renal avec des resultats oncologiques et fonctionnels a long terme satisfaisants. Chez des patients selectionnes, la cryoablation et la radiofrequence peuvent etre des alternatives therapeutiques avec egalement de bons resultats.
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- 2015
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3. Conversion of a French Electronic Medical Record (Emr) Database into the Observational Medical Outcomes Partnership Common Data Model
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S.-L. Jouaville, G. Coffin, M. Potdar, U. Shah, D. Chu, M. Van Zandt, T. Raoul, and M.-S. Schwalm
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medicine.medical_specialty ,Medical education ,business.industry ,Health Policy ,Family medicine ,General partnership ,Public Health, Environmental and Occupational Health ,Electronic medical record ,medicine ,Observational study ,business - Published
- 2017
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4. Transplantation rénale issue de donneurs décédés d’arrêt cardiaque de la catégorie III de Maastricht. Résultats après un an d’expérience
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P. Leprince, B. Riou, Jérôme Tourret, Benoit Barrou, N. Arzouk, G. Coffin, S. Ourahma, S. Drouin, J. Cohen, M. Raux, G. Lebreton, and J. Parra
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business.industry ,Urology ,Medicine ,business ,Humanities - Abstract
Objectifs L’extension du programme de don d’organes apres arret circulatoire aux donneurs de la categorie III de Maastricht (decedes dans le cadre d’une limitation ou d’un arret des therapeutiques [LATA]) a debute en France en 2015. Sept prelevements chez des donneurs Maastricht III ont ete realises dans notre centre aboutissant a sept transplantations renales. Methodes Nous avons collecte prospectivement les donnees des patients transplantes avec des greffons issus de donneurs de la categorie III de Maastricht. La LATA a ete realisee en reanimation, la circulation regionale normothermique (CRN) mise en place par une equipe specialisee sans desilet prealable et le patient transfere par ambulance secondairement au bloc operatoire. L’âge moyen des donneurs etait de 45 ± 11 ans, 5 etaient des hommes (71 %) et la creatininemie moyenne avant la LATA etait de 52 ± 23 μmol/L. Resultats La duree entre debut de la LATA et arret circulatoire etait de 17 ± 5 min, celle d’ischemie chaude fonctionnelle (PAM 45 mmHg) de 19 ± 2 min, celle entre pose de CRN et clampage de 135 ± 20 min. L’âge des receveurs etait de 45 ± 8 ans, la duree d’hemodialyse de 36 ± 24 mois et la duree d’attente sur liste de 32 ± 22 mois. Le taux de greffons incompatibles etait de 23 % ± 22. L’ischemie froide a ete de 9,6 ± 3 h. Apres transplantation, aucun patient n’a presente de reprise retardee de fonction. Un patient a necessite une seance d’hemodialyse en postoperatoire immediat pour hyperkaliemie. Les creatininemies moyennes etaient de 126, 124, 137 et 133 mol/L a j8, M1, M3 et M6 respectivement. Conclusion Le prelevement de reins chez des donneurs Maastricht III apparait etre une procedure sure et realisable par des equipes entrainees, plus facile a mettre en œuvre que la procedure en cas de Maastricht II. La transplantation renale donne a court terme des resultats tres satisfaisants comme retrouve dans la litterature. Une cohorte et un recul plus importants sont toutefois necessaires.
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- 2016
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5. L’emploi de la solution de préservation SCOT 15® pourrait réduire l’incidence des rejets aigus en transplantation rénale
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Jérôme Tourret, G. Coffin, J. Cohen, N. Arzouk, S. Drouin, Benoit Barrou, and J. Parra
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs La solution de preservation SCOT 15® a ete developpee sur le concept d’immunomasquage. Il a ete montre qu’elle pouvait prolonger la survie d’une allogreffe dans des modeles animaux. Le but de l’etude est le calcul de la survie sans rejet des greffons renaux a 6 mois apres preservation avec SCOT 15®. Methodes Nous avons realise une analyse retrospective monocentrique de 445 greffes renales entre 2009 et 2014 (12 % de donneurs vivants, 71 % DDME, 17 % de DDAC). Les reins ont ete preserves de maniere statique (59 %) ou sur Lifeport® (41 %). Nous avons analyse les differentes solutions de preservation et de rincage utilisees pour chaque greffon. Les rejets (humoraux ou cellulaires) ont tous ete prouves par biopsies et les biopsies realisees pour cause. Resultats Cinq groupes ont ete constitues : non S : greffons jamais perfuses avec SCOT 15® (n = 36) ; S : greffons perfuses d’emblee avec SCOT 15® + preservation statique (n = 155) ; SKS : greffons perfuses d’emblee avec SCOT 15® + preservation sur machine puis rincage avec SCOT 15® (n = 133) ; AS : greffons perfuses d’emblee avec une autre solution que SCOT 15® + preservation statique (n = 73) ; AKS : greffons perfuses d’emblee avec une autre solution que SCOT 15® + preserves sur machine, puis rinces avec SCOT 15® (n = 50) ; Les 4 derniers groupes sont reunis en groupe S (greffons rinces avec SCOT 15® avant implantation, quelles que soient les solutions anterieures utilisees.). La survie des greffons sans rejet a 6 mois a ete significativement meilleure dans le groupe S que dans le groupe Non S (p = 0,03) ( Fig. 1 ). Conclusion Cette etude suggere que les proprietes d’immunomasquage de la solution SCOT 15® pourraient jouer un role protecteur apres allogreffe renale chez l’homme. Ces resultats doivent etre confirmes sur des series plus grandes et multicentriques.
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- 2016
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6. 722 Conservative treatments of de novo kidney graft tumours
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C. Sénéchal, K. Guleryuz, Henri Bensadoun, Georges Karam, Thomas Bessede, E. Lechevallier, A. Erauso, F. Sallusto, Rodolphe Thuret, Gregory Verhoest, Xavier Tillou, J-M. Boutin, S Bouyé, M. Devonec, L. Salomon, L. Viart, M.O. Timsit, Damien Chambade, G. Coffin, R. Codas, Nicolas Terrier, Arnaud Doerfler, and Jacques Hubert
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medicine.medical_specialty ,Kidney ,medicine.anatomical_structure ,business.industry ,Urology ,medicine ,business ,Surgery - Published
- 2016
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7. Predictive factors of chronic kidney disease stage V after partial nephrectomy in a solitary kidney: a multi-institutional study
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P. Laguna, J. Berger, M. Rouprêt, J-A. Long, Thomas Bessede, C. Maurin, Idir Ouzaid, E. Lechevallier, Emmanuel Oger, J-J. Patard, G. Coffin, Gregory Verhoest, Karim Bensalah, J-C. Bernhard, Roberto Bertini, Alejandro Rodriguez, Philippe Paparel, Benoit Peyronnet, Amnon Zisman, N. Rioux-Leclercq, K Barwari, L. Salomon, Börje Ljungberg, Axel Bex, Jean-Baptiste Rigaud, Roy Farfara, Cancer du rein : bases moléculaires de la tumorogenèse, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pontchaillou [Rennes], Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes], Université Pierre et Marie Curie - Paris 6 (UPMC), Applications des ultrasons à la thérapie, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Génétique moléculaire, neurophysiologie et comportement, Centre National de la Recherche Scientifique (CNRS), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)
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Nephrology ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,Urology ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Population ,Renal function ,urologic and male genital diseases ,Nephrectomy ,Body Mass Index ,Young Adult ,Postoperative Complications ,Renal cell carcinoma ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Stage (cooking) ,Renal Insufficiency, Chronic ,education ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,education.field_of_study ,business.industry ,Middle Aged ,medicine.disease ,Kidney Neoplasms ,3. Good health ,Oncology ,Surgical Procedures, Operative ,Female ,business ,Kidney cancer ,Kidney disease - Abstract
International audience; OBJECTIVE: Partial Nephrectomy (PN) in a solitary kidney is at risk of chronic kidney disease (CKD) stage V and/or haemodialysis (HD). Our objective was to determine predictive factors of CKD stage V in this population. MATERIAL & METHODS: Data from 300 patients were retrospectively collected from 16 tertiary centres. Clinical and operative parameters, tumor characteristics and renal function before surgery were analyzed. Patients with and without CKD stage V (defined as MDRD\textless1 5 ml/min) were compared using χ2 and Student-t tests for qualitative and quantitative variables, respectively. Predictive factors of CKD stage V were evaluated with a multivariable analysis using a Cox regression model. RESULTS: Median age and BMI were 63 years old and 26 kg/m², respectively. Most of the patients (65%) were male with an anatomic solitary kidney (88.3%). Median tumor size was 4 cm and 98% were malignant tumors. Median operative time, blood loss and clamping time were 180 min, 350 ml and 20 min respectively. Renal cooling was used in 19.3% and clamping of the pedicle was performed in 61.6%. Twenty five patients (8.5%) presented post operative CKD stage V at last follow-up and 18 underwent HD (6%) post-operatively because of acute renal insufficiency. There was no difference between CKD stage V and non CKD stage V patients concerning Charlson index, operative time (180 min vs 179 min, p = 0.39), blood loss (475 ml vs 350 ml, p = 0.51), use of renal cooling and type of clamping. Patients with CKD stage V were older (70 vs 63 years old, p = 0.005), had a lower baseline renal function (clearance MDRD 41 vs. 62 ml/min, p\textless0.0001) and an increased tumor size (p = 0.02). Complications occurred in 91 patients (30%) with 16% of minor (Clavien 1-2) and 14% of major (Clavien \textgreater 2) complications, respectively. In multivariable analysis, baseline MDRD, BMI, and the occurrence of a minor complication were independent predictive factors of post operative CKD stage V. CONCLUSION: PN in a solitary kidney is at risk of post-operative CKD stage V and HD. Pre-operative altered renal function and post operative complications are the main predictive factors of permanent CKD stage V.
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- 2012
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8. Validity And Limitations Of The Longitudinal Patient Database France For Use In Pharmacoepidemiological And Pharmacoeconomics Studies
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B. Sarfati, H. Miotti, G. Coffin, S.L. Jouaville, and A Meihoc
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Pediatrics ,medicine.medical_specialty ,Pharmacoeconomics ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,medicine ,Medical emergency ,Patient database ,medicine.disease ,business - Published
- 2015
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9. Comparaison d’un protocole standard de 12 carottes versus 2 à 3 carottes dirigées vers une cible IRM lors d’une première série de biopsies de prostate chez les patients présentant un PSA ≤ 10ng/mL
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Grégoire Chevreau, Pierre Mozer, M. Rouprêt, P. Conort, S. Drouin, Véronique Phé, G. Coffin, Eva Compérat, J. Parra, and Raphaëlle Renard-Penna
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Published
- 2013
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10. 794 Comparison between systematic and MRI targeted prostate biopsy for patients with no history of prostate cancer attending a first round of trans-rectal ultrasound biopsy procedure
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Pierre Conort, Eva Compérat, Raphaëlle Renard-Penna, M.A. Vitrani, G. Coffin, Grégoire Chevreau, C. Torterotot, M.-O. Bitker, and Pierre Mozer
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Oncology ,medicine.medical_specialty ,Prostate biopsy ,medicine.diagnostic_test ,business.industry ,Urology ,medicine.disease ,Rectal ultrasound ,Prostate cancer ,Internal medicine ,Medicine ,Radiology ,business ,Biopsy procedure - Published
- 2012
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11. 765 Does initial prostate functional MRI impact on treatment choice for patients on active surveillance?
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G. Coffin, A. Cortesse, Paul Meria, E. De Kerviller, A. Pluvinage, François Desgrandchamps, F Gaudez, Jérôme Verine, E. Tariel, Laurence Bastien, Pierre Mongiat-Artus, Guillaume Ploussard, and Francis Dubosq
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medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Prostate ,Urology ,Medicine ,Radiology ,business - Published
- 2012
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12. Lag vs noise in fluoroscopic imaging
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Robert M. Langdon, James G. Coffin, Gregory J. Murphy, and William Bitler
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Physics ,medicine.diagnostic_test ,business.industry ,Optical engineering ,Lag ,Quantum noise ,Image intensifier ,law.invention ,Noise ,Signal-to-noise ratio ,law ,Medical imaging ,medicine ,Fluoroscopy ,Computer vision ,Artificial intelligence ,business ,Simulation - Abstract
In a TV fluoroscopic system it is generally accepted that there exists somewhat of an inverse relationship between lag and noise integration. This paper will demonstrate techniques used to reduce the appearance of quantum noise while maintaining acceptable lag performance in systems utilizing PlumbiconTM camera tubes.© (1993) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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- 1993
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13. Importance of TV camera tube parameters in fluoroscopic imaging
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Robert M. Langdon, James G. Coffin, Walter Doesschate, Gregory J. Murphy, and William Bitler
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Engineering ,medicine.diagnostic_test ,business.industry ,Image intensifier ,law.invention ,law ,Professional video camera ,Medical imaging ,medicine ,Fluoroscopy ,Computer vision ,Tube (fluid conveyance) ,Artificial intelligence ,business ,Image resolution ,Fluoroscopic imaging - Abstract
In the search for better ftuoroscopic imaging, the TV camera tube performance has become more critical. Traditional camera tube test methods, which expose tubes to extreme conditions, have only marginal correlation to typical fluoroscopic usage. This paper compares these traditional measurements with test measurements made on a modern fluoroscopic digital system for two different types of TV camera tubes. The results obtained show how the x-ray system influences the importance of the TV camera tube parameters and which tube features are most relevant.
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- 1992
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14. Sorptive Composite Fabrics Containing Activated-Carbon Yarns
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Gilbert N. Arons, Laurance G. Coffin, and Richard N. Macnair
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Materials science ,Polymers and Plastics ,Composite number ,medicine ,Chemical Engineering (miscellaneous) ,Composite material ,Activated carbon ,medicine.drug - Abstract
Experimental woven and knit fabrics were prepared for potential use in protective clothing. Inherently weak activated-carbon yarns were incorporated in these fabrics with stronger yarns of other types, but in all cases Aramid warp yarns were used. In some fabrics carbon yams were covered with cotton yarns before the fabric was manufactured, which resulted in improved durability without any loss of sorptivity. Their strength, air permeability, thickness, weight, and abrasion resistance were greater than those of activated all-carbon fabrics. Thermal insulation was greater than that of a typical business-suit fabric and less than that of current impregnated protective fabrics.
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- 1977
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15. Sorptive Textile Systems Containing Activated Carbon Fibers
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Laurance G. Coffin, Hubkrtina D. Hogan, Richard N. Macnair, and Gilbert N. Arons
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010302 applied physics ,business.product_category ,Textile ,Materials science ,Polymers and Plastics ,business.industry ,chemistry.chemical_element ,Sorption ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Carton ,chemistry ,0103 physical sciences ,medicine ,Chemical Engineering (miscellaneous) ,Viscose ,Composite material ,0210 nano-technology ,business ,Carbon ,Lower activity ,Activated carbon ,medicine.drug - Abstract
Activated carton fabrics and yarns were shown to effectively sorb gases, vapors, and dissolved solids. Fabrics pre pared by Arons and Macnair (phenotic precursor) and Maggs (viscose precursor) were the most activated of all the materials studied. The yarns had a lower activity but probably can be improved to have comparahly high sorption capacity. Other materials studied included permeable textile systems made by mechanically reinforcing carbon fabrics and yarns with stronger materials. For example, selected fabrics were laminated or quilted between two other fabric layers while the yarns were knitted or woven with other yarns.
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- 1974
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16. Two Cases of Ruptured Uterus
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J G Coffin
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medicine.medical_specialty ,Text mining ,business.industry ,General surgery ,MEDLINE ,Medicine ,Ruptured uterus ,Articles ,General Medicine ,business - Abstract
n/a
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- 1814
17. Body mass index and complications following major gastrointestinal surgery
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Blanco-Colino R, Lee S, Kamarajah SK, Vasko P, Kuiper SZ, Farina V, Chapman SJ, Drake TM, Gavagna L, Pasquali S, Pata F, Pellino G, de la Rosa-Estadella M, Stellingwerf ME, Stijns RCH, Borrellas A, Golding D, Ngaage M, Van Tol RR, de Groof J, de Wilt H, Bemelman WA, McNamee L, Espin-Basany E, Emre Baki B, Gecim IE, Can Tatar O, Bach S, Bhangu A, Bresges K, Burke J, Claireaux HA, Fearnhead N, Fitzgerald JE, Gallagher S, Glasbey JC, Gundogan B, Harrison EM, Hernon J, Khatri C, Kong CY, Lyons A, Mohan M, Morton D, Pinkney TD, Arezzo A, Foppa C, Morino M, Rubbini M, Selvaggi F, Sensi B, Sica G, Orhalmi J, Naccari P, Sgrò A, Burger BHCM, Fares DA, Spijkerman R, van Elst TR, Wiersema R, Stassen LPS, Rodriguez Garcia R, Özkan BB, Tavuz AI, Demirci ZS, Baki BE, Choi PJ, O'Sullivan H, Salman M, Simioni A, Colombo F, Turati L, Cazzola FE, Gallo G, Perrotta G, Papandrea M, Naccari PM, Menduni N, Rossi E, Chetta N, Romeo F, Giordano F, Randisi B, Curletti G, Kuiper J, Costa A, Marcos Rodrigo A, Sanchez A, Varo Muñoz A, Martinez Rios CE, Aliseda-Jover D, Fernandez Nieto D, Alvarez Reyes I, Dominguez Rodriguez LM, Hernandez Ros MI, Esteban Sinovas O, Bartrina Soler P, Villarejo Campos P, Laguna Román S, Fontanet-Soler S, Raurich-Leandro J, Dominguez-Prieto V, Segura-Sampedro JJ, Alconchel-Gago F, Salazar-García C, Gezen AE, Sahin A, Atasoy H, Yuksek B, Arslan E, Ozmen BB, Sen AY, Erol HI, Ucar E, Aktas MK, Yurdaor SS, Mermer S, Seyhan U, Tosun V, Gunaydin Y, Ekinci ZB, Yazkan Z, Choi J, Yeoh TSL, Jones CS, Venturini S, Saat MI, Loo J, Pike G, Davies SC, Kabariti R, Olivier J, Hurný M, Žebrák R, Machačová A, Schulzová M, Smolák P, Široká M, Palyzová H, Jaroš J, Dušek T, Šimáčková B, Bartoš M, Sotona O, Pös M, Karásek D, Higgins P, Hacking S, Arora E, Coughlan G, Palanivail N, Quill S, Zhang AA, Malak M, Maan DS, Cheema J, Goh AWJ, Shamsul Badrin AK, Guinness F, Howard James N, Neary A, Sebaoui S, Gilroy D, Petrov G, Craven K, MacDonald A, Redmond A, Brennan D, Roche D, O'Dwyer M, Collins P, Edwards S, Doyle J, Tiedt L, Arthurs B, O'Byrne L, Kiely A, Glynn M, Sproule L, Heaney A, Li Hi Shing S, Goh W, Al-Nasser Z, Al-Nasser A, Teh JW, De Boni D, Goldin E, Ciccioli E, Vendramin E, Marchese N, Bruno M, Vinci A, Harder G, Morandi V, Magnoli M, Suppa A, Palmieri A, Martorana M, Sette M, Balagna P, Cruciani C, Corte M, Ciano P, Bagaglini G, Montuori M, Di Benedetto L, Arcudi C, Pezzuto R, Saraceno F, Milana F, Franceschilli M, Rizzi A, Sampietro G, Rampulla V, Bianco F, Boschetti ME, Ghignone F, Bianchini S, Esposto R, Riva L, Riva M, Cannavò M, Arrigo A, Giavarini L, Colombo EM, Trompetto M, Clerico G, Catalano M, Dosa T, El Mabruk M, Barone V, Pallara E, Pasqualoni M, Caudullo G, Mastandrea Bonaviri GN, Muro M, Pistola I, Verardi L, Ferrara D, Gerardi S, Remore LM, Belia F, Del Coco F, Larotonda C, Botrugno EM, Cammarota A, Di Girolami L, Laterza V, Laurino A, Paolo G, Santocchi P, Puccioni C, Truma A, Giardino FR, Giuffrida A, Ripa M, Cautiero R, Patturelli M, 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Bookless LR, McLean RC, Stone EJ, Wright EV, Abdikadir HR, Roberts C, Spence O, Srikantharajah M, Ruiz EM, Matthews JH, Gardner E, Hester E, Naran P, Simpson R, Minhas M, Cornish E, Semnani SA, Rojoa D, Radotra A, Eraifej J, Eparh K, Smith DNE, Mistry BD, Hickling SL, Din W, Liu C, Mithrakumar P, Mirdavoudi V, Rashid M, Mcgenity C, Hussain O, Kadicheeni M, Gardner H, Anim-Addo N, Pearce J, Aslanyan A, Ntala C, Sorah T, Parkin J, Alizadeh M, White A, Edozie F, Johnston J, Kahar A, Navayogaarajah V, Carter D, Khonsari P, Burgess A, Patel B, Kong C, Ponweera A, Cody A, Tan Y, Ng AYL, Croall A, Allan C, Ng S, Raghuvir V, Telfer R, Greenhalgh AD, McKerr CN, Edison MA, Patel BA, Dear K, Hardy MR, Williams P, Hassan S, Sajjad U, O'Neill EM, Lopes S, Healy L, Jamal N, Tan S, Lazenby D, Husnoo SB, Beecroft S, Sarvanandan T, Weston C, Bassam N, Rabinthiran S, Hayat U, Ng L, Varma D, Sukkari M, Mian A, Omar A, Kim JW, Sellathurai J, Mahmood J, O'Connell C, Bose R, Heneghan H, Lalor P, Matheson J, Doherty C, Cullen C, Cooper D, Angelov S, Drislane C, Smith ACD, Kreibich A, Palkhi E, Durr A, Lotfallah A, Gold D, Mckean E, Dhanji A, Anilkumar A, Thacoor A, Siddiqui ZH, Lim S, Piquet A, Anderson SM, McCormack DR, Gulati J, Ibrahim A, Murray SE, Walsh SL, McGrath A, Ziprin P, Chua EY, Lou CN, Bloomer J, Paine HR, Osei-Kuffour D, White CJ, Szczap A, Gokani S, Patel K, Malys MK, Reed A, Torlot GE, Cumber EM, Charania A, Ahmad S, Varma N, Cheema H, Austreng L, Petra H, Chaudhary M, Zegeye MI, Cheung F, Coffey D, Heer RS, Singh S, Seager E, Cumming S, Suresh RS, Verma S, Ptacek IB, Gwozdz AM, Yang T, Khetarpal AA, Shumon S, Fung TMP, Leung W, Kwang P, Chew L, Loke W, Curran A, Chan C, McGarrigle C, Mohan K, Cullen S, Wong E, Toale C, Collins D, Keane N, Traynor BP, Shanahan D, Yan A, Jafree DJ, Topham C, Mitrasinovic S, Omara S, Bingham G, Lykoudis PM, Miranda BH, Whitehurst K, Kumaran G, Devabalan Y, Aziz H, Shoa M, Dindyal S, Yates JA, Bernstein I, Rattan G, Coulson R, Stezaker S, Isaac A, Salem M, McBride A, McFarlane H, Yow L, MacDonald J, Bartlett RD, Turaga S, White U, Liew W, Yim N, Ang A, Simpson A, McAuley D, Craig E, Murphy L, Shepherd P, Kee JY, Abdulmajid A, Chung A, Warwick HL, Livesey A, Holton P, Theodoreson MD, Jenkin SL, Turner J, Entwisle JH, Marchal ST, O'Connor S, Blege HK, Aithie JM, Sabine LM, Stewart GE, Jackson S, Kishore A, Lankage CM, Acquaah F, Joyce HL, McKevitt KL, Coffey CJ, Fawaz AS, Dolbec KS, O'Sullivan DA, Geraghty JM, Lim E, Bolton L, FitzPatrick D, Robinson C, Ramtoola T, Collinson S, Grundy L, McEnhill PM, Harbhajan Singh GS, Loughran D, Golding DM, Keeling RE, Williams RP, Whitham RDJ, Yoganathan S, Nachiappan R, Egan RJ, Owasil R, Kwan ML, He A, Goh RW, Bhome R, Wilson H, Teoh PJ, Raji K, Jayakody N, Matthams J, Chong J, Luk CY, Greig RJ, Trail M, Charalambous G, Rocke AS, Gardiner N, Bulley F, Warren N, Brennan E, Fergurson P, Wilson R, Whittingham H, Brown EJ, Khanijau R, Gandhi K, Morris S, Boulton AJ, Chandan N, Barthorpe AE, Maamari R, Sandhu S, McCann M, Higgs L, Balian V, Reeder C, Diaper C, Sale T, Ali H, Archer CH, Clarke AK, Heskin J, Hurst PC, Farmer JD, O'Flynn LD, Doan L, Shuker BA, Stott GD, Vithanage NA, Hoban KA, Nesargikar PN, Kennedy HR, Grossart CM, Tan ESM, Roy CSD, Sim P, Leslie KE, Sim D, Abul MH, Cody N, Tay AY, Woon E, Sng S, Mah J, Robson J, Shakweh E, Wing VC, Mills H, Li MM, Barrow TR, Balaji S, Jordan HEM, Phillips C, Naveed H, Hirani S, Tai A, Ratnakumaran R, Sahathevan A, Shafi AMA, Seedat M, Weaver R, Batho A, Punj R, Selvachandran H, Bhatt N, Botchey S, Khonat Z, Brennan K, Morrison CJ, Devlin E, Linton A, Galloway E, McGarvie S, Ramsay N, McRobbie HD, Whewell H, Dean W, Nelaj S, Eragat M, Mishra A, Kane T, Zuhair M, Wells M, Wilkinson D, Woodcock N, Sun E, Aziz N, Abd Ghaffar MK, Bath MF, Nepogodiev D., Blanco-Colino, R, Lee, S, Kamarajah, Sk, Vasko, P, Kuiper, Sz, Farina, V, Chapman, Sj, Drake, Tm, Gavagna, L, Pasquali, S, Pata, F, Pellino, G, de la Rosa-Estadella, M, Stellingwerf, Me, Stijns, Rch, Borrellas, A, Golding, D, Ngaage, M, Van Tol, Rr, de Groof, J, de Wilt, H, Bemelman, Wa, Mcnamee, L, Espin-Basany, E, Emre Baki, B, Gecim, Ie, Can Tatar, O, Bach, S, Bhangu, A, Bresges, K, Burke, J, Claireaux, Ha, Fearnhead, N, Fitzgerald, Je, Gallagher, S, Glasbey, Jc, Gundogan, B, Harrison, Em, Hernon, J, Khatri, C, Kong, Cy, Lyons, A, Mohan, M, Morton, D, Pinkney, Td, Arezzo, A, Foppa, C, Morino, M, Rubbini, M, Selvaggi, F, Sensi, B, Sica, G, Orhalmi, J, Naccari, P, Sgrò, A, Burger, Bhcm, Fares, Da, Spijkerman, R, van Elst, Tr, Wiersema, R, Stassen, Lp, Rodriguez Garcia, R, Özkan, Bb, Tavuz, Ai, Demirci, Z, Baki, Be, Choi, Pj, O'Sullivan, H, Salman, M, Simioni, A, Colombo, F, Turati, L, Cazzola, Fe, Gallo, G, Perrotta, G, Papandrea, M, Naccari, Pm, Menduni, N, Rossi, E, Chetta, N, Romeo, F, Giordano, F, Randisi, B, Curletti, G, Kuiper, J, Costa, A, Marcos Rodrigo, A, Sanchez, A, Varo Muñoz, A, Martinez Rios, Ce, Aliseda-Jover, D, Fernandez Nieto, D, Alvarez Reyes, I, Dominguez Rodriguez, Lm, Hernandez Ros, Mi, Esteban Sinovas, O, Bartrina Soler, P, Villarejo Campos, P, Laguna Román, S, Fontanet-Soler, S, Raurich-Leandro, J, Dominguez-Prieto, V, Segura-Sampedro, Jj, Alconchel-Gago, F, Salazar-García, C, Gezen, Ae, Sahin, A, Atasoy, H, Yuksek, B, Arslan, E, Ozmen, Bb, Sen, Ay, Erol, Hi, Ucar, E, Aktas, Mk, Yurdaor, S, Mermer, S, Seyhan, U, Tosun, V, Gunaydin, Y, Ekinci, Zb, Yazkan, Z, Choi, J, Yeoh, Tsl, Jones, C, Venturini, S, Saat, Mi, Loo, J, Pike, G, Davies, Sc, Kabariti, R, Olivier, J, Hurný, M, Žebrák, R, Machačová, A, Schulzová, M, Smolák, P, Široká, M, Palyzová, H, Jaroš, J, Dušek, T, Šimáčková, B, Bartoš, M, Sotona, O, Pös, M, Karásek, D, Higgins, P, Hacking, S, Arora, E, Coughlan, G, Palanivail, N, Quill, S, Zhang, Aa, Malak, M, Maan, D, Cheema, J, Goh, Awj, Shamsul Badrin, Ak, Guinness, F, Howard James, N, Neary, A, Sebaoui, S, Gilroy, D, Petrov, G, Craven, K, Macdonald, A, Redmond, A, Brennan, D, Roche, D, O'Dwyer, M, 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Abdulrahman, N, de Roy van Zuidewijn, D, de Groof, Ej, Zijlmans, Jl, van Dalen, Ashm, Bos, K, Musters, Gd, Looijen, Rc, Fliers, Jm, Oostendorp, Se, Mosterd, Cm, Blonk, L, Jurgens, J, Ribbink, Me, Boom, M, Boersma, Am, Hidding, E, Schmidt, Pa, Mensink, G, Graus, Sa, Gastel, Mda, Veenker, Cgh, Van Heumen, Tm, Slieker, Fjb, Sedee, Wja, Löwensteyn, Yn, Amelung, Fj, de Guerre, Levm, Nota, Clma, Van Dijck, Wpm, van Wijnbergen, Jwm, Pronk, A, Kip, M, van der Zee, C, Heiloo, S, Muller, S, Verboeket, B, Oudman, T, Zope, S, Gilissen, V, Gommers, J, Cremers, D, Van der Lubbe, M, Smet, M, Ter Weele, K, de Bruin, M, Geerlings, M, Ter Horst, L, Kerimova, N, Pesser, N, Heesakkers, H, de Mees, T, de Gooyer, Jm, Willems, L, Gawria, L, Bonouvrie, D, Harms, J, Eggen, Y, Hengeveld, E, Smeets, Hj, Hoffman, Rpc, Detmers Blom, Fpn, Van Bruggen, D, Steup, Wh, Gooiker, Ga, Willems, Yr, van der Hoeven, Ac, Vallve-Bernal, M, Perez-Gandara, B, Perez, Jl, Caballero Rodriguez, E, Perez Febles, M, Protti Ruiz, Gp, Hidalgo Pujol, M, Alberti Delgado, P, Gil Barrionuevo, E, Anabitarte, O, Caballero, L, Poyato Nuñez, Fj, Prado Perez, R, de la Portilla de Juan, F, Fulgencio Barbarin, J, Elorza Echaniz, G, Mitxelena Elosegi, L, Delgado, At, Marti Gelonch, L, Gonzalez Arribas, M, De Serra Tejada, I, Alberdi San Roman, I, de Andres Olabarria, U, Fernández-Domper, L, Perez Costoya, C, Perez Arias, H, Fa Binefa, M, Becerra Nieves, M, Escalona Canal, Mg, Aldrey, I, Vazquez-Gonzalez, I, Falcon Cazas, A, Amarelo Garcia, M, Gonzalez Ruiz, Aa, Garcia Garrido, M, Simon Frapolli, V, Martinez Diaz, Jm, De la Torre Conde, C, Rodrigues Silva, K, Hernandez Kakauridze, S, Lopez Garcia, Mc, Flores Funes, D, Gómez-López de San Román, C, San Martín Bragado, M, Tejero Pintor, Fj, Pando Ruiz, B, Sánchez Estébanez, E, Roquet Puigneró, E, Pla Seró, S, Vela Polanco, Ff, Mirallas Viñas, O, Caro Gonzalez, Mp, Bertelli Puche, Jl, Gonzalez-Martinez, A, Sanchez Cambronero, M, Garcia Torres, A, Dominguez Jimenez, M, de Jesus Rodriguez Perdomo, M, Echazarreta-Gallego, E, Sánchez-Blasco, L, Del Mar López-Cuevas, M, Latras-Cortés, I, López-Vendrell, L, Díaz Padillo, A, Mestres Petit, N, Cruz Reyes, Ja, Fernandez, C, Posada, M, Moratilla Lapeña, L, Martin Morales, E, Mate-Mate, P, Garcia Cruz, G, Gorini, L, Rubio-Perez, I, Soldevila-Verdeguer, C, Jiménez-Viñas, C, Luehrman, A, Sena-Ruiz, F, Garcia-Perez, Jm, Plomer-Sanchez, M, Pujol-Cano, N, Jimenez-Segovia, M, Diaz-Jover, P, Pineño-Flores, C, Ambrona-Zafra, D, Gonzalez-Argente, Xf, Jiménez-Morillas, P, López-Mármol, R, Durán-Martínez, M, González-Crespo, A, Checa Guillen, M, Valderrama Pérez, A, Claramonte Bellmunt, O, Martí Fernández, Rm, Kasap, S, Soylemez, Zobb, Bolat, Ab, Aydar, Seyi, Birgin, Bz, Coskun, O, Cakir, Sg, Belibagli, Zo, Herken, M, Erdem, S, Kayacan, S, Kelesoglu, Y, Moran, D, Atalay, H, Kucukdiler, E, Demirci, A, Buyukkasap, C, Kuzey, A, Emral, C, Dogan, H, Cok, H, Durmaz, H, Asma, A, Ergul, B, Kaya, A, Bilicen, G, Gunay, M, Senturk, E, 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Aljbour, A, Aljbour, I, Akcaoglu, T, Kakil, E, Taskin, O, Taskin, Rb, Topal, U, Huzmeli, E, Caliskan, T, Unal, Ag, Yurekli, Am, Sari, V, Tutam, Dn, Celen, D, Posteki, G, Demirtas, B, Yildiz, S, Kilic, E, Yalcin, Y, Kurt, A, Gozubuyuk, Y, Huseynova, S, Cinar, S, Calar, Sn, Kurklu, O, Binbuga, M, Ceylan, C, Yavuz, G, Alim, Ye, Yildirim, N, Yilmaz, S, Onar, D, Aray, E, Ozsipahi, Ac, Koc, Ge, Yetiskin, E, Kocer, Md, Ozgencil, B, Bahcecioglu, B, Hacioglu, Ad, Bilici, O, Cin, S, Uzunoglu, Ec, Cumen, Ec, Aslan, L, Erozgur, B, Zengin, T, Kullac, S, Mizan, Sr, Baykan, B, Kopac, O, Karabacak, U, Aytekin, A, Deliktas, T, Buyukkarabacak, Y, Uzun, O, Karahan, B, Turkmen, M, Akdogan, A, Uctepe, F, Bandirmali, O, Erdogan, P, Demir, F, Bozkurt, Gk, Yilmaz, T, Sheikh, Imi, Orhan, K, Balci, B, Keyif, Mf, Bilgin, S, Cantimer, E, Yaman, S, Akkaya, E, Atesavci, Sn, Arslan, U, Asik, M, Koksal, S, Murtaza, Mi, Mustafa, S, Oun, H, Sam, Zh, Brogan, A, Zaidi, R, Quinn, K, Taylor, F, Pang, G, Heath, H, Smart, Nj, Home, J, Mauro, D, Noone, Tm, Fenn, J, Sinha, A, Lowe, R, Hutchings, I, Longstaff, L, Smith, Ag, Edwards, Ja, Alcocer, Bp, Oakley, T, Thomas-Davies, M, Hourston, Gjm, Kankam, Hkn, Ramana, A, Baker, C, Endo, Y, Wong, C, Anderson, Rgj, Badran, A, Ali, A, Myers, L, Tippins, F, Stanley, S, Sandison, L, Schofield, E, Delf, J, Rees, S, Anyan-Brown, J, Long, K, Archer, M, Anakwenze, V, Goel, S, Sharma Khatiwada, A, Khan, S, Leafe, O, Lee, J, Embury-Young, Y, Edwards, L, Hazenberg, P, Agrawal, M, Guerero, D, Britton, F, Rejayee, M, Mahesh, S, Khaing, Ph, Baldwin, A, Iyer, S, Gaskell, P, Adlan, A, Cuckow, L, Barmayehvar, B, Rob, T, Ciurleo, C, Mural-Krishnan, S, Jong, N, Carlson, S, Abdelgalil, R, Goble, M, Doshi, A, Ogunleye, O, Marsh, L, Bagley, J, Poacher, A, Cantelo, J, Wylie, J, Govil, S, Hill, F, Beaver, D, Urquhart, A, Rakhimov, I, Raina, V, Clifford, T, Iorga, R, Cartwright, E, Harris, Aj, Shurovi, B, Wadanamby, S, Brown, E, Bradley, C, Ahmad, A, Jeyabraba, S, Hardaman, B, Truss, A, 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AII - Infectious diseases, AII - Inflammatory diseases, ANS - Neuroinfection & -inflammation, APH - Quality of Care, AII - Amsterdam institute for Infection and Immunity, Paediatric Infectious Diseases / Rheumatology / Immunology, ACS - Pulmonary hypertension & thrombosis, ACS - Heart failure & arrhythmias, Blanco-Colino R, Lee S, Kamarajah SK, Vasko P, Kuiper SZ, Farina V, Chapman SJ, Drake TM, Gavagna L, Pasquali S, Pata F, Pellino G, de la Rosa-Estadella M, Stellingwerf ME, Stijns RCH, Borrellas A, Golding D, Ngaage M, Van Tol RR, de Groof J, de Wilt H, Bemelman WA, McNamee L, Espin-Basany E, Emre Baki B, Gecim IE, Can Tatar O, Bach S, Bhangu A, Bresges K, Burke J, Claireaux HA, Fearnhead N, Fitzgerald JE, Gallagher S, Glasbey JC, Gundogan B, Harrison EM, Hernon J, Khatri C, Kong CY, Lyons A, Mohan M, Morton D, Pinkney TD, Arezzo A, Foppa C, Morino M, Rubbini M, Selvaggi F, Sensi B, Sica G, Orhalmi J, Naccari P, Sgrò A, Burger BHCM, Fares DA, Spijkerman R, van Elst TR, Wiersema R, Stassen LPS, Rodriguez Garcia R, Özkan BB, Tavuz AI, Demirci ZS, Baki BE, Choi PJ, O'Sullivan H, Salman M, Simioni A, Colombo F, Turati L, Cazzola FE, Gallo G, Perrotta G, Papandrea M, Naccari PM, Menduni N, Rossi E, Chetta N, Romeo F, Giordano F, Randisi B, Curletti G, Kuiper J, Costa A, Marcos Rodrigo A, Sanchez A, Varo Muñoz A, Martinez Rios CE, Aliseda-Jover D, Fernandez Nieto D, Alvarez Reyes I, Dominguez Rodriguez LM, Hernandez Ros MI, Esteban Sinovas O, Bartrina Soler P, Villarejo Campos P, Laguna Román S, Fontanet-Soler S, Raurich-Leandro J, Dominguez-Prieto V, Segura-Sampedro JJ, Alconchel-Gago F, Salazar-García C, Gezen AE, Sahin A, Atasoy H, Yuksek B, Arslan E, Ozmen BB, Sen AY, Erol HI, Ucar E, Aktas MK, Yurdaor SS, Mermer S, Seyhan U, Tosun V, Gunaydin Y, Ekinci ZB, Yazkan Z, Choi J, Yeoh TSL, Jones CS, Venturini S, Saat MI, Loo J, Pike G, Davies SC, Kabariti R, Olivier J, Hurný M, Žebrák R, Machačová A, Schulzová M, Smolák P, Široká M, Palyzová H, Jaroš J, Dušek T, Šimáčková B, Bartoš M, Sotona O, Pös M, Karásek D, Higgins P, Hacking S, Arora E, Coughlan G, Palanivail N, Quill S, Zhang AA, Malak M, Maan DS, Cheema J, Goh AWJ, Shamsul Badrin AK, Guinness F, Howard James N, Neary A, Sebaoui S, Gilroy D, Petrov G, Craven K, MacDonald A, Redmond A, Brennan D, Roche D, O'Dwyer M, Collins P, Edwards S, Doyle J, Tiedt L, Arthurs B, O'Byrne L, Kiely A, Glynn M, Sproule L, Heaney A, Li Hi Shing S, Goh W, Al-Nasser Z, Al-Nasser A, Teh JW, De Boni D, Goldin E, Ciccioli E, Vendramin E, Marchese N, Bruno M, Vinci A, Harder G, Morandi V, Magnoli M, Suppa A, Palmieri A, Martorana M, Sette M, Balagna P, Cruciani C, Corte M, Ciano P, Bagaglini G, Montuori M, Di Benedetto L, Arcudi C, Pezzuto R, Saraceno F, Milana F, Franceschilli M, Rizzi A, Sampietro G, Rampulla V, Bianco F, Boschetti ME, Ghignone F, Bianchini S, Esposto R, Riva L, Riva M, Cannavò M, Arrigo A, Giavarini L, Colombo EM, Trompetto M, Clerico G, Catalano M, Dosa T, El Mabruk M, Barone V, Pallara E, Pasqualoni M, Caudullo G, Mastandrea Bonaviri GN, Muro M, Pistola I, Verardi L, Ferrara D, Gerardi S, Remore LM, Belia F, Del Coco F, Larotonda C, Botrugno EM, Cammarota A, Di Girolami L, Laterza V, Laurino A, Paolo G, Santocchi P, Puccioni C, Truma A, Giardino FR, Giuffrida A, Ripa M, Cautiero R, Patturelli M, Capozzolo A, Selvaggi L, Facchiano A, Milazzo LF, Papazachariou SK, Pattapola V, Anania G, Feo C, Bellinato M, Priani P, Zigiotto D, Troia A, Vable T, Piran G, Targa S, Pulpito S, Tagariello F, Fasano A, Anconelli D, Castiglione F, Tognolo L, Lopez G, Campion A, Tarantino M, Sacco R, Sammarco G, Palmisano S, Giacca M, Rocco I, Bellio G, Favero A, Raimondi P, Pantalone MR, De Nardi P, Notarnicola M, Picciariello A, Licari L, Parinisi Z, Fazzotta S, Ciciliot M, Reggiani L, Mariani F, Aonzo P, Checcacci P, Montanelli P, Guerra F, Skalamera I, Staderini F, Grandi S, Nelli T, de Boer DV, van der Pool AEM, Janssen TL, El-Atmani S, van Verschuer VMT, Poelman M, Dronkers WJ, van Steensel L, Toorenvliet BR, Duinhouwer LE, Vermaas M, Ter Bruggen FFJA, Hogendoorn W, van der Harst E, van Rijckevorsel VAJIM, Bayoumy AB, Lap CR, Gooszen JAH, Abdulrahman N, de Roy van Zuidewijn D, de Groof EJ, Zijlmans JL, van Dalen ASHM, Bos K, Musters GD, Looijen RC, Fliers JM, Oostendorp SE, Mosterd CM, Blonk L, Jurgens J, Ribbink ME, Boom MS, Boersma AM, Hidding E, Schmidt PA, Mensink G, Graus SA, Gastel MDA, Veenker CGH, Van Heumen TM, Slieker FJB, Sedee WJA, Löwensteyn YN, Amelung FJ, de Guerre LEVM, Nota CLMA, Van Dijck WPM, van Wijnbergen JWM, Pronk A, Kip M, van der Zee C, Heiloo S, Muller S, Verboeket B, Oudman TS, Zope S, Gilissen V, Gommers J, Cremers D, Van der Lubbe M, Smet M, Ter Weele K, de Bruin M, Geerlings M, Ter Horst L, Kerimova N, Pesser N, Heesakkers H, de Mees T, de Gooyer JM, Willems L, Gawria L, Bonouvrie D, Harms J, Eggen Y, Hengeveld E, Smeets HJ, Hoffman RPC, Detmers Blom FPN, Van Bruggen D, Steup WH, Gooiker GA, Willems YR, van der Hoeven AC, Vallve-Bernal M, Perez-Gandara B, Perez JL, Caballero Rodriguez E, Perez Febles M, Protti Ruiz GP, Hidalgo Pujol M, Alberti Delgado P, Gil Barrionuevo E, Anabitarte O, Caballero L, Poyato Nuñez FJ, Prado Perez R, de la Portilla de Juan F, Fulgencio Barbarin J, Elorza Echaniz G, Mitxelena Elosegi L, Delgado AT, Marti Gelonch L, Gonzalez Arribas M, De Serra Tejada I, Alberdi San Roman I, de Andres Olabarria U, Fernández-Domper L, Perez Costoya C, Perez Arias H, Fa Binefa M, Becerra Nieves M, Escalona Canal MG, Aldrey I, Vazquez-Gonzalez I, Falcon Cazas A, Amarelo Garcia M, Gonzalez Ruiz AA, Garcia Garrido M, Simon Frapolli V, Martinez Diaz JM, De la Torre Conde C, Rodrigues Silva K, Hernandez Kakauridze S, Lopez Garcia MC, Flores Funes D, Gómez-López de San Román C, San Martín Bragado M, Tejero Pintor FJ, Pando Ruiz B, Sánchez Estébanez E, Roquet Puigneró E, Pla Seró S, Vela Polanco FF, Mirallas Viñas O, Caro Gonzalez MP, Bertelli Puche JL, Gonzalez-Martinez A, Sanchez Cambronero M, Garcia Torres A, Dominguez Jimenez M, de Jesus Rodriguez Perdomo M, Echazarreta-Gallego E, Sánchez-Blasco L, Del Mar López-Cuevas M, Latras-Cortés I, López-Vendrell L, Díaz Padillo A, Mestres Petit N, Cruz Reyes JA, Fernandez C, Posada M, Moratilla Lapeña L, Martin Morales E, Mate-Mate P, Garcia Cruz G, Gorini L, Rubio-Perez I, Soldevila-Verdeguer C, Jiménez-Viñas C, Luehrman A, Sena-Ruiz F, Garcia-Perez JM, Plomer-Sanchez M, Pujol-Cano N, Jimenez-Segovia M, Diaz-Jover P, Pineño-Flores C, Ambrona-Zafra D, Gonzalez-Argente XF, Jiménez-Morillas P, López-Mármol R, Durán-Martínez M, González-Crespo A, Checa Guillen M, Valderrama Pérez A, Claramonte Bellmunt O, Martí Fernández RM, Kasap S, Soylemez ZOBB, Bolat AB, Aydar SEYI, Birgin BZ, Coskun O, Cakir SG, Belibagli ZO, Herken M, Erdem S, Kayacan S, Kelesoglu Y, Moran D, Atalay H, Kucukdiler E, Demirci A, Buyukkasap C, Kuzey A, Emral C, Dogan H, Cok H, Durmaz H, Asma A, Ergul B, Kaya A, Bilicen G, Gunay M, Senturk E, Baskoy L, Besısık HM, Topalan K, Piraliyev E, Danalıoglu AN, Ilbak A, Yıgman S, Kara C, Guzel M, Inci ET, Onsal U, Erel T, Cetin SK, Yekenkurul E, Kasar P, Saglam ZA, Gursoy F, Cetinkaya M, Aktekin H, Bober DN, Mugurtay YS, Koksal G, Celik S, Bektur G, Yildirim R, Ankarali T, Güven H, Yuksel A, Semiz A, Cise S, Tomas K, Ulusahin M, Akbulut F, Tulum H, Bodur S, Isler VC, Pektas AM, Mutlu D, Mericliler M, Tansoker I, Polat ZP, Seyrek N, Beyatli S, Toto OF, Cakaloglu HC, Sapci I, Akpunarli B, Adiyaman C, Kobal BB, Gok Z, Benli S, Turpan M, Kocapinar S, Parimli H, Acar S, Eger M, Yilmaz I, Cengiz U, Yoruk I, Mutlu B, Ulkucu A, Arukan C, Kara B, Gokce K, Calisgan B, Demirci K, Elkatroushi T, Ayaz B, Uzun B, Sivrikaya T, Goksoy B, Eroz E, Celik B, Canbay Torun B, Ekin B, Senay BB, Temiz C, Yilmaz M, Yasar C, Cakir E, Subasi A, Celik K, Aksoy K, Karabulut E, Altintas O, Bali AN, Ciftci E, Babaoglu H, Aljbour A, Aljbour I, Akcaoglu T, Kakil E, Taskin O, Taskin RB, Topal U, Huzmeli E, Caliskan T, Unal AG, Yurekli AM, Sari V, Tutam DN, Celen D, Posteki G, Demirtas B, Yildiz S, Kilic E, Yalcin Y, Kurt A, Gozubuyuk Y, Huseynova S, Cinar S, Calar SN, Kurklu O, Binbuga M, Ceylan C, Yavuz G, Alim YE, Yildirim N, Yilmaz S, Onar D, Aray E, Ozsipahi AC, Koc GE, Yetiskin E, Kocer MD, Ozgencil B, Bahcecioglu B, Hacioglu AD, Bilici O, Cin S, Uzunoglu EC, Cumen EC, Aslan L, Erozgur B, Yildiz SS, Zengin T, Kullac S, Mizan SR, Baykan B, Kopac O, Karabacak U, Aytekin A, Deliktas TS, Buyukkarabacak Y, Uzun O, Karahan B, Turkmen M, Akdogan A, Uctepe F, Bandirmali O, Erdogan P, Demir F, Bozkurt GK, Yilmaz T, Sheikh IMI, Orhan K, Balci B, Keyif MF, Bilgin S, Cantimer E, Yaman S, Akkaya E, Atesavci SN, Arslan U, Asik M, Koksal S, Murtaza MI, Mustafa S, Oun H, Sam ZH, Brogan A, Zaidi R, Quinn K, Taylor F, Pang G, Heath H, Smart NJ, Home J, Mauro D, Noone TM, Fenn J, Sinha A, Lowe R, Hutchings I, Longstaff L, Smith AG, Edwards JA, Alcocer BP, Oakley T, Thomas-Davies M, Hourston GJM, Kankam HKN, Ramana A, Baker C, Endo Y, Wong C, Anderson RGJ, Badran A, Ali A, Myers L, Tippins F, Stanley S, Sandison L, Schofield E, Delf J, Rees S, Anyan-Brown J, Long K, Archer M, Anakwenze V, Goel S, Sharma Khatiwada A, Khan S, Leafe O, Lee J, Embury-Young Y, Edwards L, Hazenberg P, Agrawal M, Guerero D, Britton F, Rejayee M, Mahesh S, Khaing PH, Baldwin A, Iyer S, Gaskell P, Adlan A, Cuckow L, Barmayehvar B, Rob T, Ciurleo C, Mural-Krishnan S, Jong N, Carlson S, Abdelgalil R, Goble M, Doshi A, Ogunleye O, Marsh L, Bagley J, Poacher A, Cantelo J, Wylie J, Govil S, Hill F, Beaver D, Urquhart A, Rakhimov I, Raina V, Clifford T, Iorga R, Cartwright E, Harris AJ, Shurovi B, Wadanamby S, Brown E, Bradley C, Ahmad A, Jeyabraba S, Hardaman B, Truss A, Mohamed US, Örhalmi J, Kerin MJ, Reynolds J, Ridgway P, Pietrabissa A, Foschi D, Sgroi G, Rosati G, Benevento A, Coco C, Persiani R, Vasquez G, Messina F, De Manzini N, Innocenti P, Rosati R, Altomare DF, Sartori A, Salamone G, Galleano R, Cianchi F, Wijnhoven BPL, van de Ven AWH, de Vos Tot Nederveen Cappel RJ, de Castro SMM, Meijerink WJHJ, Mulder IM, Acherman YIZ, van Leeuwen BL, Schasfoort RA, Kloppenberg FWH, Wiezer R, Consten ECJ, Van Grevenstein WMU, Schiphorst A, Wijffels N, Uittenbogaart M, Klinkert M, Koppe M, de Hingh I, Konsten J, Polat F, Berends F, Langenhoff B, Zimmerman D, van Engelenburg T, Vries JJM, Baeten CIM, Bastiaansen AJNM, van Geloven A, Khan I, Girones J, Barrera Gomez M, Sanz Ortega G, Duran Muñoz-Cruzado VM, Ruiz Montesinos I, Enriquez-Navascues JM, Portugal Porras V, Baixauli J, Garcia Florez LJ, Alonso Gonçalves S, Parajo A, Sanchez-Guillen L, Lujan Mompean JA, Soria Aledo V, Arenal JJ, Blanco Antona F, Badia JM, Roura J, Garcia Garcia J, Elía-Guedea M, Millan M, Viñas-Salas J, Garcia-Olmo D, Prieto-Nieto MI, Medina-Fernández FJ, Romero-Simó M, Frasson M, Espí Macías A, Tirnaksiz MB, Leventoglu S, Kara E, Taşçı Y, Pehlivan M, Guner A, Ozben V, Agalar C, Albayrak D, Ertekin C, Oncel M, Sakman G, Guler SA, Firat O, Akkucuk S, Ozbalci GS, Sozuer EM, Sengul N, Schizas A, Horgan PG, Singh B, Harikrishnan A, Stechman M, Hayat J, Coyne P, Wilson T, Arun C, Manvydas V, Moroni P, Lo Secco G, Argenti F, Romano F, Calcagno P, Steccanella F, Cisternino G, Bottini C, Realis Luc A, Apicella M, Candilio G, Gubbiotti F, De Luca E, Casagranda B, Decorato A, Aquilino F, Badii B, Rahmee CNS, Kleine E, Yauw S, de Zeeuw S, Aarts E, Teixeira da Silva M, Brueren L, Bokkerink G, Schok T, Graafland M, Fliers JM, Gonzalez de Chaves PE, Jimenez-Gomez LM, García Galocha JL, Palos Campos MC, Jimenez Escovar F, Hernandez-Lizoáin JL, Monzonis Hernandez X, Dominguez Sanchez JM, Vives-Rodriguez E, Abrisqueta Carrion J, Beltrán de Heredia J, Padilla Valverde D, Alcazar Montero JA, Córdoba-Díaz de Laspra E, Franco Chacón M, Muriel P, Pastor-Riquelme P, Peinado Iribar B, Alonso Hernandez N, Costa-Navarro D, Martínez Chillarón E, Secilmis E, Bamac E, Koç F, Kayaci Durak M, Bayram S, Ekrem M, Uzun S, Gok AFK, Gorguner F, Yildiz T, Dalci K, Kilinc C, Koç M, Yuksek MA, Ersoy T, Celik E, Parmar E, Abuhussein N, Metcalf P, Atif M, Heywood E, Mayes JW, Kelly M, Mitchell H, Antoniou I, Dean R, Davies N, Trecarten S, Henderson I, Holmes C, Shuttleworth RH, Jindal A, Hughes F, Gouda P, Fleck R, Hanrahan M, Karunakaran P, Chen JH, Sykes MC, Sethi RK, Suresh S, Patel P, Patel M, Varma RK, Mushtaq J, Bolton W, Khan T, Morley R, Favero N, Adams R, Thirumal V, Kennedy ED, Ong KK, Tan YH, Gabriel J, Bakhsh A, Low JYL, Yener A, Paraoan V, Preece R, Tilston TW, Cumber E, Dean S, Ross T, McCance E, Amin H, Satterthwaite L, Clement KD, Gratton R, Mills ED, Chiu SM, Hung G, Rafiq NM, Hayes JDB, Robertson KL, Dynes K, Huang HC, Assadullah S, Duncumb JW, Moon RDC, Poo SX, Mehta JK, Joshi KR, Callan R, Norris JM, Chilvers NJ, Keevil H, Jull P, Mallick S, Elf D, Carr L, Player C, Barton EC, Martin AL, Ratu SG, Roberts EJ, Phan PN, Dyal AR, Rogers JE, Henson AD, Reid NB, Burke D, Culleton G, Lynne S, Mansoor S, Brennan C, Blessed R, Holloway C, Hill A, Goldsmith T, Mackin S, Kim S, Woin E, Brent G, Coffin J, Ziff O, Momoh Z, Debenham R, Ahmed M, Yong CS, Wan JC, Copley HC, Raut P, Chaudhry FI, Nixon G, Dorman C, Tan R, Kanabar S, Canning N, Dolaghan M, Bell N, McMenamin M, Chhabra A, Duke K, Turner L, Patel T, Chew LS, Mirza M, Lunawat S, Oremule B, Ward N, Khan M, Tan ET, Maclennan D, McGregor RJ, Chisholm EG, Griffin EJ, Bell L, Hughes BA, Davies J, Haq H, Ahmed H, Ungcharoen N, Whacha C, Thethi R, Markham RM, Lee AHY, Batt E, Bullock NP, Francescon CT, Davies JE, Shafiq NM, Zhao J, Vivekanantham S, Barai I, Allen JLY, Marshall DC, McIntyre CJ, Wilson HCP, Ashton AJ, Lek C, Behar N, Davis-Hall M, Seneviratne N, Esteve L, Sirakaya M, Ali S, Pope S, Ahn JS, Craig-McQuaide A, Gatfield WA, Leong S, Demetri AM, Kerr AL, Rees C, Loveday J, Liu S, Wijesekera M, Maru D, Attalla M, Smith N, Brown D, Sritharan P, Shah A, Charavanamuttu V, Heppenstall-Harris G, Ng K, Raghvani T, Rajan N, Hulley K, Moody N, Williams M, Cotton A, Sharifpour M, Lwin KN, Bright M, Chitnis AR, Abdelhadi M, Semana AD, Morgan F, Reid R, Dickson J, Anderson L, McMullan R, Ahern N, Asmadi A, Anderson LB, Lua Boon Xuan J, Crozier L, McAleer S, Lees DM, Adebayo AA, Das M, Amphlett AH, Al-Robeye A, Valli A, Khangura J, Winarski A, Woodward H, Gouldthrope C, Turner M, Sasapu K, Tonkins M, Wild JRL, Robinson M, Hardie J, Heminway R, Narramore R, Ramjeeawon N, Hibberd A, Winslow F, Ho W, Chong BF, Lim K, Ho S, Crewdson JA, Singagireson S, Kalra N, Koumpa F, Jhala H, Soon WC, Karia M, Rasiah MG, Xylas D, Gilbert H, Sundar-Singh M, Wills J, Akhtar S, Patel S, Hu L, Brathwaite-Shirley C, Nayee H, Amin O, Rangan T, Turner EJH, McCrann C, Shepherd R, Patel N, Prest-Smith J, Auyoung E, Murtaza A, Coates A, Prys-Jones O, King M, Gaffney S, Dewdney CJ, Nehikhare I, Lavery J, Bassett J, Davies K, Ahmad K, Collins A, Acres M, Egerton C, Cheng K, Chen X, Chan N, Sheldon A, Empey J, Ingram E, Malik A, Johnstone M, Goodier R, Shah JP, Giles JE, Sanders JA, McLure SW, Pal S, Rangedara A, Baker AN, Asbjoernsen CA, Girling C, Gray L, Gauntlett L, Joyner C, Qureshi S, Mogan YP, Ng JCK, Kumar AN, Park JH, Tan D, Choo KP, Raman KP, Buakuma P, Xiao C, Govinden S, Thompson OD, Charalambos MA, Karsan RB, Dogra T, Bullman LM, Dawson PM, Frank AL, Abid H, Tung L, Qureshi U, Tahmina A, Matthews BW, Harris RT, O'Connor A, Mazan K, Iqbal S, Stanger SA, Thompson JD, Sullivan JAL, Uppal E, MacAskill A, Bamgbose FA, Neophytou C, Carroll AF, Rookes CW, Datta U, Dhutia AJ, Rashid S, Ahmed N, Lo T, Bhanderi S, Blore CD, Ahmed S, Shaheen H, Abburu S, Majid S, Abbas Z, Talukdar SS, Burney LJ, Patel JB, Al-Obaedi O, Roberts AW, Mahboob S, Sheth S, Karia P, Prabhudesai A, Kow K, Koysombat K, Wang S, Morrison P, Maheswaran Y, Keane P, Copley PC, Brewster O, Xu GX, Harries P, Wall C, Al-Mousawi A, Bonsu S, Cunha P, Ward T, Paul J, Nadanakumaran K, Tayeh S, Holyoak H, Remedios J, Theodoropoulou K, Luhishi A, Jacob L, Long F, Atayi A, Sarwar S, Parker O, Harvey J, Ross H, Rampal R, Thomas G, Vanmali P, McGowan C, Stein J, Robertson V, Carthew L, Teng V, Fong J, Street AN, Thakker CE, O'Reilly D, Bravo M, Pizzolato A, Khokhar HA, Ryan M, Cheskes L, Carr R, Salih AE, Bassiony S, Yuen R, Chrastek D, Rosen O'Sullivan H, Amajuoyi A, Wang A, Sitta O, Wye J, Qamar MA, Major C, Kaushal A, Morgan C, Petrarca M, Allot R, Verma K, Dutt S, Chilima CP, Peroos S, Kosasih SR, Chin H, Ashken L, Pearse RJ, O'Loughlin RA, Menon A, Singh K, Norton J, Sagar R, Jathanna N, Rothwell L, Watson N, Harding F, Dube P, Khalid H, Punjabi N, Sagmeister M, Gill P, Shahid S, Hudson-Phillips S, George D, Ashwood J, Lewis T, Dhar M, Sangal P, Rhema IA, Kotecha D, Afzal Z, Syeed JA, Prakash E, Jalota P, Herron J, Kimani L, Delport A, Shukla A, Agarwal V, Parthiban S, Thakur H, Cymes W, Rinkoff S, Turnbull JA, Hayat M, Darr S, Khan U, Lim J, Higgins A, Lakshmipathy G, Forte B, Canning E, Jaitley A, Lamont J, Toner E, Ghaffar A, McDowell M, Salmon D, O'Carroll O, Khan A, Kelly 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HD, Whewell H, Dean W, Nelaj S, Eragat M, Mishra A, Kane T, Zuhair M, Wells M, Wilkinson D, Woodcock N, Sun E, Aziz N, Abd Ghaffar MK., Nepogodiev, Dmitri, Rosati, Riccardo, Nepogodiev, D., and Robotics and image-guided minimally-invasive surgery (ROBOTICS)
- Subjects
Male ,obesity ,Multivariate analysis ,Gastrointestinal Diseases ,IMPACT ,Settore MED/18 - CHIRURGIA GENERALE ,Body mass index ,Body weight ,Digestive tract ,Gastrointestinal tract ,Obesity ,Postoperative complications ,Gastroenterology ,digestive tract ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,0302 clinical medicine ,Risk Factors ,Medicine ,Prospective Studies ,Prospective cohort study ,Aged ,Europe ,Female ,Gastrointestinal Neoplasms ,Humans ,Middle Aged ,Postoperative Complications ,Body Mass Index ,OUTCOMES ,body mass index ,body weight ,gastrointestinal tract ,030220 oncology & carcinogenesis ,Meta-analysis ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,Cohort ,030211 gastroenterology & hepatology ,Cohort study ,medicine.medical_specialty ,Malignancy ,NO ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,business.industry ,postoperative complications ,MORTALITY ,medicine.disease ,Settore MED/18 ,Surgery ,Postoperative complication ,Postoperative Complications, Obesity, Digestive Tract, Gastrointestinal Tract, Body Mass Index, Body Weight ,business - Abstract
Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data.Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results.Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery for malignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49-2.96, P Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease.
- Published
- 2018
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