1. A higher De Ritis ratio (AST/ALT) is a risk factor for progression in high-risk non-muscle invasive bladder cancer
- Author
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Takashi Kawahara, Masahiro Yao, Yushi Araki, Nobuhiko Mizuno, Reona Nishimura, Kazuhiro Namura, Ichiro Ikeda, Hiroji Uemura, Sachi Fukui-Kawaura, and Koichi Uemura
- Subjects
medicine.medical_specialty ,Multivariate analysis ,Bladder cancer ,Receiver operating characteristic ,ALT ,business.industry ,Observation period ,Cancer ,medicine.disease ,Gastroenterology ,Oncology ,Internal medicine ,De Ritis ,Recurrent disease ,Medicine ,high risk NMIBC ,Risk factor ,business ,Non muscle invasive ,AST ,Research Paper - Abstract
Background: High-risk non-muscle invasive bladder cancer (NMIBC) is thought to be associated with a higher risk of recurrence and progression. A recent study revealed that a high De Ritis ratio was a risk factor in some solid malignancies. This study examined the importance of the De Ritis ratio as a prognostic marker in high-risk NMIBC. Materials and Methods: A total of 138 patients who were initially diagnosed with high-risk NMIBC between January 2012 to December 2016 were enrolled in this study. The criteria for the high-risk classification followed the EAU guidelines. The recurrence-free and progression-free survival of the higher and lower De Ritis ratio groups were compared. The cut-off value of the De Ritis ratio was set at 1.35, based on a receiver operator curve analysis. Results: The median observation period was 50.3 months. Among these patients, 32 (23.1%) patients developed recurrent disease and 15 (10.9%) patients showed progression. A multivariate analysis revealed that non-BCG treatment was an independent risk factor for recurrence, and a higher De Ritis ratio was an independent risk factor for cancer progression. Conclusions: The De Ritis ratio might be a risk factor for progression in high-risk NMIBC.
- Published
- 2021