1. Impact of Kidney Transplantation on Male Sexual Function: Results from a Ten-Year Retrospective Study
- Author
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Fabrizio Salemi, Rosa Carrano, Vincenzo Mirone, Alberto Trinchieri, Paolo Verze, Lorenzo Spirito, Carmine Sciorio, Celeste Manfredi, Spirito, L, Manfredi, C, Carrano, R, Trinchieri, A, Salemi, F, Sciorio, C, Mirone, V, Verze, P, Spirito, L., Manfredi, C., Carrano, R., Trinchieri, A., Salemi, F., Sciorio, C., Mirone, V., and Verze, P.
- Subjects
Male ,medicine.medical_specialty ,Ejaculatory Function ,Erectile Function ,Kidney Transplantation ,Sexual Dysfunction ,Sexual Function ,Ejaculation ,Humans ,Penile Erection ,Retrospective Studies ,Surveys and Questionnaires ,Erectile Dysfunction ,Prostatic Hyperplasia ,Urology ,Endocrinology, Diabetes and Metabolism ,030232 urology & nephrology ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Internal medicine ,Diabetes mellitus ,medicine ,Kidney transplantation ,030219 obstetrics & reproductive medicine ,business.industry ,Testosterone (patch) ,Retrospective cohort study ,medicine.disease ,Transplantation ,Psychiatry and Mental health ,Sexual dysfunction ,Reproductive Medicine ,medicine.symptom ,Sexual function ,business - Abstract
Background The effects of kidney transplantation on male sexual function are controversial. Aim To evaluate the impact of kidney transplantation on erectile and ejaculatory function and to assess a possible correlation between some selected characteristics of patients and their erectile and ejaculatory function after renal transplantation. Methods An observational retrospective analysis was conducted on male patients who had undergone kidney transplantation from January 2009 to April 2019. A prospectively maintained database was used to collect all data. Patients were evaluated before kidney transplant and 6 and 12 months after kidney transplant. Male patients undergoing renal transplantation for any cause who were sexually active with a stable partner were included in the study. Outcomes The main outcome measures included the International Index of Erectile Function (IIEF-15) and the 4-item version of Male Sexual Health Quality–Ejaculation Disorders (MSHQ-EjD Short Form) questionnaires. The first 3 questions of the MSHQ-EjD Short Form were used to assess the ejaculatory function, whereas the fourth question was used to evaluate the ejaculation bother. Results A total of 95 patients were eligible in the study. The evaluation of sexual function was available in 56 patients (58.9%). Mean IIEF-15 significantly decreased at 6 months (P Clinical Implications Improvement of knowledge regarding the effects of kidney transplantation on sexual function and about the patient characteristics related to sexual health after transplantation. Strength & Limitations This is the first article that analyzes in depth the ejaculatory function in patients who had undergone kidney transplantation assessing ejaculation with a validated questionnaire. The main limitation is the retrospective design of the study. Conclusion Kidney transplantation appears to have a negative impact on sexual health, significantly worsening both erectile and ejaculatory functions. Age, diabetes, hypertension, smoking, pretransplantation testosterone levels, time for transplantation, as well as erectile and ejaculatory function before transplant were significantly related to erectile and ejaculatory functions after renal transplantation.
- Published
- 2020