1. Acute Adrenal Insufficiency Precipitated by the Discontinuation of a Betamethasone and Dextrochlorpheniramine Combination: The Diagnostic Utility of an Echocardiographic Assessment of Systemic Vascular Resistance
- Author
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Ken-ichi Hirata, Ryo Takeshige, Hiroyuki Shimoura, Hiroshi Imada, Jun Mukai, Shumpei Mori, Yutaka Takahashi, Tokiko Tabata, Hachidai Takahashi, and Yukiko Katsumori-Yoshimura
- Subjects
medicine.medical_specialty ,Chlorpheniramine ,Hydrocortisone ,Perforation (oil well) ,systemic vascular resistance ,Shock, Cardiogenic ,Case Report ,030204 cardiovascular system & hematology ,betamethasone ,Medication Adherence ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Internal Medicine ,medicine ,Adrenal insufficiency ,Humans ,Aged ,Heart Failure ,Ejection fraction ,business.industry ,primary biliary cholangitis ,Cardiogenic shock ,Hemodynamics ,General Medicine ,medicine.disease ,acute adrenal insufficiency ,Discontinuation ,celestamine ,medicine.anatomical_structure ,Treatment Outcome ,Echocardiography ,Heart failure ,Cardiology ,Vascular resistance ,Betamethasone ,030211 gastroenterology & hepatology ,Female ,Vascular Resistance ,business ,medicine.drug ,Adrenal Insufficiency - Abstract
A 72-year-old woman with primary biliary cholangitis was admitted to our hospital with heart failure with a preserved ejection fraction. An accidental right ventricular perforation that occurred during an endomyocardial biopsy precipitated cardiogenic shock. Despite successful surgical treatment, she demonstrated progressive hemodynamic deterioration, which was resistant to the administration of high-dose catecholamines. She was diagnosed with acute adrenal insufficiency, which was attributed to the discontinuation of Celestamine® (betamethasone/dextrochlorpheniramine combination) just after the perforation. Prompt intravenous administration of hydrocortisone (150 mg/day) led to hemodynamic stabilization. The serial noninvasive assessment of systemic vascular resistance using transthoracic echocardiography was instrumental in detecting acute adrenal insufficiency in this case.
- Published
- 2019