Author: "Manzato, E." / Topic: medicine.disease - Searchworks@Jio Institute Digital Library Search Results

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77 results on '"Manzato, E."'

1. Consensus on: Screening and therapy of coronary heart disease in diabetic patients

Author: Rivellese AA1, Piatti PM, Italian Intersociety Consensus G.r.o.u.p. Collaborators Piatti PM, Avogaro A, Anfossi G, Ardigo D, de Kreutzenberg SV, Inchiostro S, Rivellese AA, Trovati M, Zambon S, Zavaroni I, Arcangeli A, Lettino M, Mafrici A, Uguccioni M, Bianchi A, Cavallaro V, Monducci I, Cadeddu C, De Luca G, Manzato E., GENTILE, Sandro, Rivellese, ANGELA ALBAROSA, P. M., Piatti, Rivellese, Aa1, Piatti, Pm, Collaborators Piatti PM, Italian Intersociety Consensus G. r. o. u. p., Avogaro, A, Anfossi, G, Ardigo, D, de Kreutzenberg, Sv, Inchiostro, S, Rivellese, Aa, Trovati, M, Zambon, S, Zavaroni, I, Arcangeli, A, Gentile, Sandro, Lettino, M, Mafrici, A, Uguccioni, M, Bianchi, A, Cavallaro, V, Monducci, I, Cadeddu, C, De Luca, G, and Manzato, E.
Subjects: medicine.medical_specialty, Diabetic Cardiomyopathies, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Cardiovascular risk factors, MEDLINE, Coronary heart disease, Diabetes, Cardiovascular risk factors, Medicine (miscellaneous), Coronary Disease, Revascularization, Electrocardiography, Risk Factors, Diabetes mellitus, Myocardial Revascularization, medicine, Humans, Hypoglycemic Agents, Intensive care medicine, Antihypertensive Agents, Hypolipidemic Agents, Nutrition and Dietetics, Framingham Risk Score, medicine.diagnostic_test, business.industry, Diabetes, Evidence-based medicine, medicine.disease, Coronary heart disease, Italy, Echocardiography, Physical therapy, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors
Abstract: The screening and best treatment for coronary heart disease in diabetic patients is still a matter of debate. For this reason the main Italian scientific societies dealing with diabetes and cardiovascular diseases have tried to finalize a document providing shared recommendations based on the available evidence on : 1) how and who to screen for coronary heart disease, 2) methodologies for the characterization of existing coronary heart disease 3) evaluation of the optimal treatment of cardiovascular risk factors and 4) appropriate revascularization procedures. For each of these points, the levels of evidence and strength of recommendations used in the Italian Standard of Care were adopted.
Published: 2011

2. Nonalcoholic fatty liver and metabolic syndrome in Italy: Results from a multicentric study of the Italian Arteriosclerosis society

Author: Soresi, M, Noto, D, Cefalù, Ab, Martini, S, Vigna, Gb, Fonda, M, Manzato, E, Cattin, L, Fellin, R, Averna, Mr, Notarbartolo, A, Metabolic Syndrome Study Group, Mannarino, Elmo, Pirro, Matteo, Soresi, M, Noto, D, Cefalù, A, Martini, S, Vigna, G, Fonda, M, Manzato, E, Cattin, L, Fellin, R, Averna, M, and Notarbartolo, A
Subjects: Male, Settore MED/09 - Medicina Interna, Endocrinology, Diabetes and Metabolism, Nonalcoholic fatty liver, Sex Factor, Settore MED/13 - Endocrinologia, Body Mass Index, Endocrinology, Non-alcoholic Fatty Liver Disease, Risk Factors, Nonalcoholic fatty liver disease, Atherosclerosis, Metabolic Syndrome X, Sex Factors, Humans, Lipids, Aged, Fatty Liver, Italy, Logistic Models, Liver, Middle Aged, Female, Ultrasonography, Multicentric study, Fatty liver, General Medicine, Arteriosclerosis, Lipid, Metabolic syndrome, Diabetes and Metabolism, Atherosclerosi, Human, medicine.medical_specialty, Logistic Model, Nonalcoholic fatty liver, Metabolic syndrome, Lipids, Multicentric study, Insulin resistance, Diabetes mellitus, Internal medicine, medicine, Internal Medicine, business.industry, Risk Factor, nutritional and metabolic diseases, Ambientale, medicine.disease, Steatosis, business, Body mass index
Abstract: Nonalcoholic fatty liver disease (NAFLD) is associated with all the components of metabolic syndrome (MS) and might to be considered an additional component of MS itself. The Italian Society for the Study of Atherosclerosis (SISA) in 2005 started a research project aimed to study the NAFLD, using ultrasound (US), in nondiabetic MS subjects matching at least one of the ATP III criteria for HDL-C or triglycerides [TG]. Prevalence of US-NAFLD and its associated risk factors and prevalence of hypertransaminasemia and its possible determinants were evaluated. NAFLD prevalence was 0.78. Men with steatosis compared to men without steatosis were younger (P < 0.05) with higher TG (P < 0.03), homeostasis model assessment insulin resistance (HOMA-R) (P < 0.003), and visceral fat thickness (VFT) (P < 0.0001). Women with steatosis showed higher TG (P < 0.05), HOMA-R (P < 0.04), VFT (P < 0.0001), and lower age (P < 0.05). At multivariate analyses, VFT (P < 0.0001), HOMA-R (P < 0.02), and TG/HDL (P < 0.05) were associated with severity of NAFLD. Age (P < 0.05), LogTG (P < 0.005), and VFT (P < 0.01) were associated with higher ALT. The US prevalence of steatosis in this study (0.78) is the highest reported in patients with MS. Considering the exclusion of severe obese and diabetic patients and the recruitment criteria, this finding highlights the prominent role played by the alterations of lipid metabolism in the pathogenesis of NAFLD. © 2012 Springer-Verlag.
Published: 2013

3. Cardiovascular prevention in subjects with impaired fasting glucose or impaired glucose tolerance

Author: Volpe, M, Borghi, C, Cavallo Perin, P, Chiariello, M, Manzato, E, Miccoli, R, Modena, Riccardi, G, Sesti, G, Tiengo, A, Trimarco, B, Vanuzzo, D, Verdecchia, P, Zaninelli, A, Del Prato, S, Volpe M, Borghi C, Cavallo Perin P, Chiariello M, manzato E, Miccoli R, Modena MG, Riccardi G, Sesti G, Tiengo A, Trimarco B, vannuzzo D, Verdecchia P, Zaninelli A, Del Prato S., Volpe, Massimo, Borghi, Claudio, Cavallo Perin, Paolo, Chiariello, Massimo, Manzato, Enzo, Miccoli, Roberto, Modena, Maria Grazia, Riccardi, Gabriele, Sesti, Giorgio, Tiengo, Antonio, Trimarco, Bruno, Vanuzzo, Diego, Verdecchia, Paolo, Zaninelli, Augusto, and Del Prato, Stefano
Subjects: medicine.medical_specialty, hypertension, Population, metabolic syndrome, Impaired glucose tolerance, impaired glucose tolerance insulin resistance abnormal glucose regulation metabolic syndrome diabetes mellitus hypertension cardiovascular prevention, insulin resistance, Epidemiology, medicine, Internal Medicine, Clinical significance, abnormal glucose regulation, cardiovascular prevention, diabetes mellitus, impaired glucose tolerance, Intensive care medicine, education, Socioeconomic status, education.field_of_study, business.industry, diabetes mellitu, Type 2 Diabetes Mellitus, medicine.disease, Impaired fasting glucose, Medical emergency, Metabolic syndrome, business, Cardiology and Cardiovascular Medicine
Abstract: Cardiovascular diseases still represent the leading cause of mortality and hospitalization, particularly in Western countries. As a consequence of the marked changes observed on the demographic characteristics of the general population, the improved survival rate after an acute cardiovascular event, and the progressive rise of costs (mostly due to technological and pharmacological innovations), the estimated burden of cardiovascular diseases will soon become insurmountable for national healthcare systems. In this view, an integrated approach aimed at improving strategies for cardiovascular disease prevention and, thus, limiting the negative outcomes, would probably be successful. Such an approach may not only achieve long-term benefits, but even significant advantages in the short to medium term, mostly in asymptomatic high-risk individuals. Indeed, this latter population of asymptomatic high-risk individuals would mostly benefit from extensive application and improvement of strategies for cardiovascular disease prevention with a favourable cost-benefit ratio. The Italian Society for Cardiovascular Disease Prevention — Società Italiana per la Prevenzione Cardiovascolare (SIPREC) — has recognized this strategic aim, focusing a vast majority of its institutional action on the effort for providing educational supports and consensus documents, which represent an overview of the scientific knowledge and personal clinical expertise by national and international key opinion leaders. Expert committees periodically generate ‘state-of-the-art’ documents on specific scientific topics with relevant socioeconomic implications and large clinical impact. The present article is dedicated to healthcare professionals, and is based on the available evidence, and provides useful information on diagnostic algorithms and therapeutic options. In 2006, the SIPREC Scientific Committee promoted a consensus document on the metabolic syndrome,[1] which is still widely used, frequently cited and updated, from which originated a broad educational programme throughout the Italian territory. This programme has certainly contributed to improving knowledge of a widespread clinical condition, such as the metabolic syndrome, which SIPREC interpreted not only as a theoretical pathophysiological concept or a nosographic entity, but rather as a real clinical tool for identifying and ‘intercepting’ those asymptomatic individuals at risk of cardiovascular events, before the estimated level of risk becomes high. This new article may be viewed in the same strategic line. The relationship between abnormalities in blood glucose metabolism (or dysglycaemia) and cardiovascular complications represents another important and relatively early target for cardiovascular disease prevention. SIPREC Scientific Committee identified even in this clinical setting an excellent group of scientific experts, in order to collect a multidisciplinary ‘task force’. This group has been asked to explain in a short, simple and effective fashion the epidemiological impact and the pathophysiological nature of the problem, its clinical features, potential diagnostic algorithms and therapeutic options, and its influence on the clinical practice of both specialist physicians and general practitioners. The work of this Task Force, which is reported in this article, is primarily a baseline for discussing novel future strategies for cardiovascular prevention. Also, this article is aimed at highlighting the importance of an emerging marker of cardiovascular risk, which is little recognized and often undervalued. Dysglycaemia, in turn, has a clinical significance, which is at least, in part, comparable with that of type 2 diabetes mellitus, both in terms of epidemiological prevalence and of long-term cardiovascular prognosis.
Published: 2010

4. Taste loss in hospitalized multimorbid elderly subjects

Author: Elena, Toffanello, Inelmen, E. M., Imoscopi, A., Perissinotto, E., Coin, A., Miotto, F., Donini, Lorenzo Maria, Cucinotta, D., Barbagallo, M., Manzato, E., Sergi, G., Donini, Inelmen, Imoscopi, Perissinotto, Coin, Miotto, Manzato, Sergi, Cuccinotta, Barbagallo, Toffanello, ED, Inelmen, EM, Imoscopi, A, Perissinotto, E, Coin, A, Miotto, F, Donini, LM, Cucinotta, D, Barbagallo, M, Manzato, E, and Sergi, G
Subjects: Male, Gerontology, medicine.medical_specialty, Taste, Settore MED/09 - Medicina Interna, taste thresholds, Health Status, malnutrition, Taste Disorders, Cognition, taste loss, hospitalized elderly, polypharmacy, sour stimuli, Internal medicine, medicine, Humans, Taste Threshold, Geriatric Assessment, Aged, Original Research, Aged, 80 and over, Polypharmacy, business.industry, RC952-954.6, Taste Perception, General Medicine, Odds ratio, medicine.disease, Confidence interval, taste thresholds, taste loss, hospitalized elderly, sour stimuli, polypharmacy, malnutrition, Hospitalization, Malnutrition, Nutrition Assessment, Taste disorder, Geriatrics, Clinical Interventions in Aging, Female, Observational study, Geriatrics and Gerontology, business
Abstract: ED Toffanello,1 EM Inelmen,1 A Imoscopi,1 E Perissinotto,2 A Coin,1 F Miotto,1 LM Donini,3 D Cucinotta,4 M Barbagallo,5 E Manzato,1 G Sergi11Department of Medical and Surgical Sciences, Geriatrics Division and University of Padova, Padova, 2Department of Environmental Medicine and Public Health, University of Padua, Padua, Italy; 3Department of Medical Physiopathology (Food Science Section), University of Roma, La Sapienza, Roma, 4S Orsola Malpighi Hospital, Bologna, 5Geriatric Unit, Department of Internal Medicine and Emerging Diseases, University of Palermo, Palermo, ItalyBackground: Loss of the sense of taste is common among older people. Morbidities and polypharmacy may contribute to the age-related decline in gustatory function. The aims of the present study were to investigate taste perception in elderly hospitalized patients by comparing their taste recognition thresholds with those of healthy, free-living elderly individuals and to identify potential determinants of taste loss.Methods: The participants in this observational study were 55 elderly patients hospitalized in the acute geriatric section of the Department of Medical and Surgical Sciences at Padova University and 41 free-living individuals aged older than 65 years, randomly recruited from elderly people attending mild fitness programs at public gymnasiums in Padova. Data were collected on nutrition, health, cognitive, and functional status for all participants. Gustatory capabilities were assessed using aqueous solutions of sucrose, sodium chloride, citric acid, and quinine hydrochloride (representing sweet, salty, sour, and bitter stimuli, respectively), and taste recognition thresholds were measured in both groups.Results: In comparison with the free-living elderly subjects, those in hospital were significantly less able to recognize the taste of citric acid (P < 0.05). Low citric acid sensitivity was independently associated with advanced age (≥75 years; odds ratio [OR] 3.01, 95% confidence interval [CI] 1.01–9.82), polypharmacy (number of prescribed drugs ≥ 4; OR 2.74, 95% CI 1.01–7.72), and poor nutritional status (as assessed by Mini Nutritional Assessment score < 23.5; OR 5.08, 95% CI 1.76–14.6).Conclusion: Because gustatory impairment may reduce a person's appetite and lead to inadequate dietary intake, compensatory nutritional measures, such as the use of flavor-enhanced foods, should be strongly encouraged, particularly in the hospital setting.Keywords: taste thresholds, taste loss, hospitalized elderly, sour stimuli, polypharmacy, malnutrition
Published: 2013

5. Cardiovascular risk factors and metabolic control in type 2 diabetic subjects attending outpatient clinics in Italy: the SFIDA (survey of risk factors in Italian diabetic subjects by AMD) study

Author: Comaschi, M, Coscelli, C, Cucinotta, Domenico Maria, Malini, P, Manzato, E, Nicolucci, A, and SFIDA Study Group Italian Association of Diabetologists
Subjects: Adult, Blood Glucose, Male, medicine.medical_specialty, Waist, Endocrinology, Diabetes and Metabolism, Population, Medicine (miscellaneous), Type 2 diabetes, Body Mass Index, Sex Factors, Risk Factors, Internal medicine, Diabetes mellitus, medicine, Outpatient clinic, Humans, Obesity, education, Aged, Glycated Hemoglobin, education.field_of_study, Nutrition and Dietetics, business.industry, Middle Aged, medicine.disease, Surgery, Blood pressure, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Italy, Cardiovascular Diseases, Hypertension, Population study, Microalbuminuria, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Summary Background and aim To perform an observational, cross-sectional study aiming to assess multiple cardiovascular risk factors and metabolic control in a very large and representative sample of type 2 diabetic subjects attending diabetes outpatient clinics (DOCs) in Italy. Methods and results Two hundred and sixty-one clinics were involved, representing about one-third of the whole number of DOCs in the Country. Each clinic recruited on a random basis from 50 to 100 type 2 diabetic patients aged 35–70 years, diagnosed more than six months before the start of the study. Demographic and clinical data were collected and blood pressure, lipids, HbA 1c , fasting blood glucose (FBG), and microalbuminuria were measured. Overall, 12,222 type 2 diabetic patients were recruited in 253 DOCs. Female subjects showed higher FBG, HbA 1c , blood pressure, lipid levels, and a longer duration of disease. The proportion of patients with BMI≥30 was 33.3% among males and 45.9% among females; 40.9% of male patients had a waist circumference greater than 102cm, while 79% of female patients had a waist circumference over 88cm. More than two-third of the patients (74.4%) had systolic blood pressure values of ≥130mmHg, and one-third (33.2%) had diastolic values≥85mmHg. The mean value of HbA 1c was 7.6±1.6, and 23.7% of the observed population had an HbA 1c level>8.5%. More than half of the study population had total cholesterol levels≥5.2mmol/l, 47% had LDL cholesterol values of 3.3mmol/l or greater and 9.6% had HDL cholesterol level lower than 0.90mmol/l. The presence of multiple lipid alterations was associated with markedly higher HbA 1c levels, in both subjects treated with lipid lowering drugs and untreated subjects. Finally, even moderate increases in HbA 1c levels (i.e. HbA 1c >7.5%) were associated with a statistically significant greater risk of systolic blood pressure levels≥160mmHg in women (OR=1.40; 95% CI 1.09–1.80) but not in men (OR=1.21; 95% CI 0.96–1.54). Conclusions The SFIDA study provides a clear indication of the need to orient diabetes care towards the control of global cardiovascular risk. Only a stricter adherence to the existing guidelines and a much stronger attention to the attainment of the desired therapeutic goals will allow a decrease in morbidity and mortality as well as in the costs related to diabetes.
Published: 2004

6. Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Author: Rodriguez-Martinez, Andrea, Zhou, Bin, Sophiea, Marisa K, Bentham, James, Paciorek, Christopher J, Iurilli, Maria LC, Carrillo-Larco, Rodrigo M, Bennett, James E, Di Cesare, Mariachiara, Taddei, Cristina, Bixby, Honor, Stevens, Gretchen A, Riley, Leanne M, Cowan, Melanie J, Savin, Stefan, Danaei, Goodarz, Chirita-Emandi, Adela, Kengne, Andre P, Khang, Young-Ho, Laxmaiah, Avula, Malekzadeh, Reza, Miranda, J Jaime, Moon, Jin Soo, Popovic, Stevo R, Sorensen, Thorkild IA, Soric, Maroje, Starc, Gregor, Zainuddin, Ahmad A, Gregg, Edward W, Bhutta, Zulfiqar A, Black, Robert, Ezzati, Majid, Abarca-Gomez, Leandra, Abdeen, Ziad A, Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Rahim, Hanan F Abdul, Abu-Rmeileh, Niveen M, Garba, Jamila Abubakar, Acosta-Cazares, Benjamin, Adams, Robert J, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Aguilar-Salinas, Carlos A, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Othman, Amani Rashed, Al-Raddadi, Rajaa, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M, Alkandari, Abdullah, Alkerwi, Ala'a, Allin, Kristine, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amiri, Parisa, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Angquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Aounallah-Skhiri, Hajer, Araujo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Aspelund, Thor, Assah, Felix K, Assuncao, Maria Cecilia F, Aung, May Soe, Auvinen, Juha, Avdicova, Maria, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha V, Jorgensen, Maja Baeksgaard, Baharudin, Azli, Bahijri, Suhad, Baker, Jennifer L, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, Jose R, Baran, Joanna, Barbagallo, Carlo M, Barcelo, Alberto, Barkat, Amina, Barros, Aluisio JD, Barros, Mauro Virgilio Gomes, Basit, Abdul, Bastos, Joao Luiz D, Bata, Iqbal, Batieha, Anwar M, Batista, Rosangela L, Battakova, Zhamilya, Batyrbek, Assembekov, Baur, Louise A, Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedics, Judith, Benet, Mikhail, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Lele, Elysee Claude Bika, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Bjorkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boeing, Heiner, Boggia, Jose G, Bogova, Elena, Boissonnet, Carlos P, Bojesen, Stig E, Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Bovet, Pascal, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn CE, Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Breda, Joao, Brenner, Hermann, Brewster, Lizzy M, Brian, Garry R, Brinduse, Lacramioara, Brophy, Sinead, Bruno, Graziella, Bueno-de-Mesquita, H Bas, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, de Leon, Antonio Cabrera, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, Jose, Can, Gunay, Candido, Ana Paula C, Canete, Felicia, Capanzana, Mario V, Capkova, Nadezda, Capuano, Eduardo, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C, Carlsson, Axel C, Carmuega, Esteban, Carvalho, Joana, Casajus, Jose A, Casanueva, Felipe F, Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A, Chamukuttan, Snehalatha, Chan, Angelique W, Chan, Queenie, Chaturvedi, Himanshu K, Chaturvedi, Nish, Rahim, Norsyamlina Che Abdul, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chiolero, Arnaud, Chiou, Shu-Ti, Chirlaque, Maria-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Claessens, Frank, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Concin, Hans, Confortin, Susana C, Cooper, Cyrus, Coppinger, Tara C, Corpeleijn, Eva, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L, Crampin, Amelia C, Crujeiras, Ana B, Csilla, Semanova, Cucu, Alexandra M, Cui, Liufu, Cureau, Felipe V, D'Arrigo, Graziella, d'Orsi, Eleonora, Dacica, Liliana, Saavedra, Maria Angeles Dal Re, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T, Dankner, Rachel, Dantoft, Thomas M, Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, De Backer, Guy, De Bacquer, Dirk, de Gaetano, Giovanni, De Henauw, Stefaan, de Oliveira, Paula Duarte, De Ridder, David, De Ridder, Karin, de Rooij, Susanne R, De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D, DeGennaro, Vincent, Dehghan, Abbas, Delisle, Helene, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Deren, Katarzyna, Deschamps, Valerie, Dhana, Klodian, Dhimal, Meghnath, Di Castelnuovo, Augusto F, Dias-da-Costa, Juvenal Soares, Diaz-Sanchez, Maria Elena, Diaz, Alejandro, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha TP, Dobson, Annette J, Donati, Maria Benedetta, Donfrancesco, Chiara, Donoso, Silvana P, Doring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Doua, Kouamelan, Drygas, Wojciech, Duan, Jia Li, Duante, Charmaine A, Duboz, Priscilla, Duda, Rosemary B, Duleva, Vesselka, Dulskiene, Virginija, Dumith, Samuel C, Dushpanova, Anar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Eddie, Ricky, Eftekhar, Ebrahim, Egbagbe, Eruke E, Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ati, Jalila, Eldemire-Shearer, Denise, Eliasen, Marie, Elliott, Paul, Engle-Stone, Reina, Enguerran, Macia, Erasmus, Rajiv T, Erbel, Raimund, Erem, Cihangir, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Pena, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Faeh, David, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Sant'Angelo, Victoria Farrugia, Farzadfar, Farshad, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernandez-Berges, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Marika, Ferrario, Marco M, Ferreccio, Catterina, Ferrer, Eldridge, Ferrieres, Jean, Figueiro, Thamara Hubler, Fijalkowska, Anna, Fink, Gunther, Fischer, Krista, Foger, Bernhard, Foo, Leng Huat, Forsner, Maria, Fouad, Heba M, Francis, Damian K, Franco, Maria do Carmo, Franco, Oscar H, Frikke-Schmidt, Ruth, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujiati, Isti I, Fujita, Yuki, Fumihiko, Matsuda, Furusawa, Takuro, Gaciong, Zbigniew, Gafencu, Mihai, Galbarczyk, Andrzej, Galenkamp, Henrike, Galeone, Daniela, Galfo, Myriam, Galvano, Fabio, Gao, Jingli, Garcia-de-la-Hera, Manoli, Garcia-Solano, Marta, Gareta, Dickman, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gaya, Adroaldo Cesar Araujo, Gaya, Anelise Reis, Gazzinelli, Andrea, Gehring, Ulrike, Geiger, Harald, Geleijnse, Johanna M, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Giampaoli, Simona, Gianfagna, Francesco, Gill, Tiffany K, Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Godos, Justyna, Gogen, Sibel, Goldsmith, Rebecca A, Goltzman, David, Gomez, Santiago F, Gomula, Aleksandra, da Silva, Bruna Goncalves Cordeiro, Goncalves, Helen, Gonzalez-Chica, David A, Gonzalez-Gross, Marcela, Gonzalez-Leon, Margot, Gonzalez-Rivas, Juan P, Gonzalez-Villalpando, Clicerio, Gonzalez-Villalpando, Maria-Elena, Gonzalez, Angel R, Gottrand, Frederic, Graca, Antonio Pedro, Graff-Iversen, Sidsel, Grafnetter, Dusan, Grajda, Aneta, Grammatikopoulou, Maria G, Gregor, Ronald D, Grodzicki, Tomasz, Groholt, Else Karin, Grontved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Gualdi-Russo, Emanuela, Guallar-Castillon, Pilar, Gualtieri, Andrea, Gudmundsson, Elias F, Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L, Gulliford, Martin C, Gunnlaugsdottir, Johanna, Gunter, Marc J, Guo, Xiu-Hua, Guo, Yin, Gupta, Prakash C, Gupta, Rajeev, Gureje, Oye, Gurzkowska, Beata, Gutierrez-Gonzalez, Enrique, Gutierrez, Laura, Gutzwiller, Felix, Ha, Seongjun, Hadaegh, Farzad, Hadjigeorgiou, Charalambos A, Haghshenas, Rosa, Hakimi, Hamid, Halkjaer, Jytte, Hambleton, Ian R, Hamzeh, Behrooz, Hange, Dominique, Hanif, Abu AM, Hantunen, Sari, Kumar, Rachakulla Hari, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, Hayes, Alison J, He, Jiang, He, Yuan, He, Yuna, Heidinger-Felso, Regina, Heinen, Mirjam, Hejgaard, Tatjana, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, 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Zampelas, Antonis, Zamrazilova, Hana, Zapata, Maria Elisa, Zargar, Abdul Hamid, Zaw, Ko Ko, Zdrojewski, Tomasz, Vrkic, Tajana Zeljkovic, Zeng, Yi, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhao, Wenhua, Zhen, Shiqi, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zocalo, Yanina, Cisneros, Julio Zuniga, Zuziak, Monika, Faculdade de Ciências da Nutrição e Alimentação, Instituto de Saúde Pública da Universidade do Porto, Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Environnement, Santé, Sociétés (ESS), Centre National de la Recherche Scientifique (CNRS), European Project: 774548, Reproductive Origins of Adult Health and Disease (ROAHD), Rodriguez-Martinez A, Zhou B, Sophiea MK, Bentham J, Paciorek CJ, Iurilli ML, Carrillo-Larco RM, Bennett JE, Di Cesare M, Taddei C, Bixby H, Stevens GA, Riley LM, Cowan MJ, Savin S, 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Baharudin A, Bahijri S, Baker JL, Balakrishna N, Bamoshmoosh M, Banach M, Bandosz P, Banegas JR, Baran J, Barbagallo CM, Barceló A, Barkat A, Barros AJ, Barros MVG, Basit A, Bastos JLD, Bata I, Batieha AM, Batista RL, Battakova Z, Batyrbek A, Baur LA, Beaglehole R, Bel-Serrat S, Belavendra A, Ben Romdhane H, Benedics J, Benet M, Berkinbayev S, Bernabe-Ortiz A, Bernotiene G, Bettiol H, Bezerra J, Bhagyalaxmi A, Bharadwaj S, Bhargava SK, Bi H, Bi Y, Bia D, Bika Lele EC, Bikbov MM, Bista B, Bjelica DJ, Bjerregaard P, Bjertness E, Bjertness MB, Björkelund C, Bloch KV, Blokstra A, Bo S, Bobak M, Boddy LM, Boehm BO, Boeing H, Boggia JG, Bogova E, Boissonnet CP, Bojesen SE, Bonaccio M, Bongard V, Bonilla-Vargas A, Bopp M, Borghs H, Bovet P, Braeckevelt L, Braeckman L, Bragt MC, Brajkovich I, Branca F, Breckenkamp J, Breda J, Brenner H, Brewster LM, Brian GR, Brinduse L, Brophy S, Bruno G, Bueno-de-Mesquita HB, Bugge A, Buoncristiano M, Burazeri G, Burns C, Cabrera de León A, Cacciottolo J, Cai H, Cama T, Cameron C, Camolas J, Can G, Cândido APC, Cañete F, Capanzana MV, Capková N, Capuano E, Capuano V, Cardol M, Cardoso VC, Carlsson AC, Carmuega E, Carvalho J, Casajús JA, Casanueva FF, Celikcan E, Censi L, Cervantes-Loaiza M, Cesar JA, Chamukuttan S, Chan AW, Chan Q, Chaturvedi HK, Chaturvedi N, Che Abdul Rahim N, Chen C-J, Chen F, Chen H, Chen S, Chen Z, Cheng C-Y, Cheraghian B, Chetrit A, Chikova-Iscener E, Chiolero A, Chiou S-T, Chirlaque M-D, Cho B, Christensen K, Christofaro DG, Chudek J, Cifkova R, Cilia M, Cinteza E, Claessens F, Clarke J, Clays E, Cohen E, Concin H, Confortin SC, Cooper C, Coppinger TC, Corpeleijn E, Costanzo S, Cottel D, Cowell C, Craig CL, Crampin AC, Crujeiras AB, Csilla S, Cucu AM, Cui L, Cureau FV, D'Arrigo G, d'Orsi E, Dacica L, Dal Re Saavedra MÁ, Dallongeville J, Damasceno A, Damsgaard CT, Dankner R, Dantoft TM, Dasgupta P, Dastgiri S, Dauchet L, Davletov K, De Backer G, De Bacquer D, de Gaetano G, De Henauw S, de Oliveira PD, De Ridder D, De Ridder K, de Rooij SR, De Smedt D, Deepa M, Deev AD, DeGennaro V, Jr, Dehghan A, Delisle H, Delpeuch F, Demarest S, Dennison E, Deren K, Deschamps V, Dhana K, Dhimal M, Di Castelnuovo AF, Dias-da-Costa JS, Díaz-Sánchez ME, Diaz A, Dika Z, Djalalinia S, Djordjic V, Do HT, Dobson AJ, Donati MB, Donfrancesco C, Donoso SP, Döring A, Dorobantu M, Dorosty AR, Doua K, Drygas W, Duan JL, Duante CA, Duboz P, Duda RB, Duleva V, Dulskiene V, Dumith SC, Dushpanova A, Dzerve V, Dziankowska-Zaborszczyk E, Eddie R, Eftekhar E, Egbagbe EE, Eggertsen R, Eghtesad S, Eiben G, Ekelund U, El-Khateeb M, El Ati J, Eldemire-Shearer D, Eliasen M, Elliott P, Engle-Stone R, Enguerran M, Erasmus RT, Erbel R, Erem C, Eriksen L, Eriksson JG, Escobedo-de la Peña J, Eslami S, Esmaeili A, Evans A, Faeh D, Fakhretdinova AA, Fall CH, Faramarzi E, Farjam M, Farrugia Sant'Angelo V, Farzadfar F, Fattahi MR, Fawwad A, Felix-Redondo FJ, Ferguson TS, Fernandes RA, Fernández-Bergés D, Ferrante D, Ferrao T, Ferrari M, Ferrario MM, Ferreccio C, Ferrer E, Ferrieres J, Figueiró TH, Fijalkowska A, Fink G, Fischer K, Föger B, Foo LH, Forsner M, Fouad HM, Francis DK, Franco MDC, Franco OH, Frikke-Schmidt R, Frontera G, Fuchs FD, Fuchs SC, Fujiati II, Fujita Y, Fumihiko M, Furusawa T, Gaciong Z, Gafencu M, Galbarczyk A, Galenkamp H, Galeone D, Galfo M, Galvano F, Gao J, Garcia-de-la-Hera M, García-Solano M, Gareta D, Garnett SP, Gaspoz J-M, Gasull M, Gaya ACA, Gaya AR, Gazzinelli A, Gehring U, Geiger H, Geleijnse JM, Ghanbari A, Ghasemi E, Gheorghe-Fronea O-F, Giampaoli S, Gianfagna F, Gill TK, Giovannelli J, Gironella G, Giwercman A, Gkiouras K, Godos J, Gogen S, Goldsmith RA, Goltzman D, Gómez SF, Gomula A, Goncalves Cordeiro da Silva B, Gonçalves H, Gonzalez-Chica DA, Gonzalez-Gross M, González-Leon M, González-Rivas JP, González-Villalpando C, González-Villalpando M-E, Gonzalez AR, Gottrand F, Graça AP, Graff-Iversen S, Grafnetter D, Grajda A, Grammatikopoulou MG, Gregor RD, Grodzicki T, Grøholt EK, Grøntved A, Grosso G, Gruden G, Gu D, Gualdi-Russo E, Guallar-Castillón P, Gualtieri A, Gudmundsson EF, Gudnason V, Guerrero R, Guessous I, Guimaraes AL, Gulliford MC, Gunnlaugsdottir J, Gunter MJ, Guo X-H, Guo Y, Gupta PC, Gupta R, Gureje O, Gurzkowska B, Gutiérrez-González E, Gutierrez L, Gutzwiller F, Ha S, Hadaegh F, Hadjigeorgiou CA, Haghshenas R, Hakimi H, Halkjær J, Hambleton IR, Hamzeh B, Hange D, Hanif AA, Hantunen S, Hari Kumar R, Hashemi-Shahri SM, Hassapidou M, Hata J, Haugsgjerd T, Hayes AJ, He J, He Y, He Y, Heidinger-Felso R, Heinen M, Hejgaard T, Hendriks ME, Henrique RDS, Henriques A, Hernandez Cadena L, Herrala S, Herrera VM, Herter-Aeberli I, Heshmat R, Hill AG, Ho SY, Ho SC, Hobbs M, Hofman A, Holden Bergh I, Holdsworth M, Homayounfar R, Homs C, Hopman WM, Horimoto AR, Hormiga CM, Horta BL, Houti L, Howitt C, Htay TT, Htet AS, Htike MMT, Hu Y, Huerta JM, Huhtaniemi IT, Huidumac Petrescu C, Husseini A, Huu CN, Huybrechts I, Hwalla N, Hyska J, Iacoviello L, Ibarluzea JM, Ibrahim MM, Ibrahim Wong N, Ikeda N, Ikram MA, Iotova V, Irazola VE, Ishida T, Islam M, Islam SMS, Iwasaki M, Jackson RT, Jacobs JM, Jaddou HY, Jafar T, James K, Jamil KM, Jamrozik K, Janszky I, Janus E, Jarani J, Jarvelin M-R, Jasienska G, Jelakovic A, Jelakovic B, Jennings G, Jha AK, Jiang CQ, Jimenez RO, Jöckel K-H, Joffres M, Johansson M, Jokelainen JJ, Jonas JB, Jørgensen T, Joshi P, Joukar F, Jovic DP, Józwiak JJ, Juolevi A, Jurak G, Jurca Simina I, Juresa V, Kaaks R, Kaducu FO, Kafatos A, Kajantie EO, Kalmatayeva Z, Kalter-Leibovici O, Kameli Y, Kanala KR, Kannan S, Kapantais E, Karki KB, Katibeh M, Katz J, Katzmarzyk PT, Kauhanen J, Kaur P, Kavousi M, Kazakbaeva GM, Keil U, Keinan Boker L, Keinänen-Kiukaanniemi S, Kelishadi R, Kelleher C, Kemper HC, Keramati M, Kerimkulova A, Kersting M, Key T, Khader YS, Khalili D, Khaw K-T, Kheiri B, Kheradmand M, Khosravi A, Khouw IM, Kiechl-Kohlendorfer U, Kiechl S, Killewo J, Kim DW, Kim HC, Kim J, Kindblom JM, Klakk H, Klimek M, Klimont J, Klumbiene J, Knoflach M, Koirala B, Kolle E, Kolsteren P, König J, Korpelainen R, Korrovits P, Korzycka M, Kos J, Koskinen S, Kouda K, Kovacs VA, Kowlessur S, Koziel S, Kratzer W, Kriemler S, Kristensen PL, Krokstad S, Kromhout D, Krtalic B, Kruger HS, Kubinova R, Kuciene R, Kujala UM, Kujundzic E, Kulaga Z, Kumar RK, Kunešová M, Kurjata P, Kusuma YS, Kuulasmaa K, Kyobutungi C, La QN, Laamiri FZ, Laatikainen T, Lachat C, Laid Y, Lam TH, Lambrinou C-P, Landais E, Lanska V, Lappas G, Larijani B, Latt TS, Lauria L, Lazo-Porras M, Le Nguyen Bao K, Le Port A, Le TD, Lee J, Lee J, Lee PH, Lehmann N, Lehtimäki T, Lemogoum D, Levitt NS, Li Y, Liivak M, Lilly CL, Lim W-Y, Lima-Costa MF, Lin H-H, Lin X, Lin Y-T, Lind L, Linneberg A, Lissner L, Litwin M, Liu J, Liu L, Lo W-C, Loit H-M, Long KQ, Lopes L, Lopes O, Lopez-Garcia E, Lopez T, Lotufo PA, Lozano JE, Lukrafka JL, Luksiene D, Lundqvist A, Lundqvist R, Lunet N, Lunogelo C, Lustigová M, Luszczki E, Ma G, Ma J, Ma X, Machado-Coelho GL, Machado-Rodrigues AM, Machi S, Macieira LM, Madar AA, Maggi S, Magliano DJ, Magnacca S, Magriplis E, Mahasampath G, Maire B, Majer M, Makdisse M, Mäki P, Malekzadeh F, Malhotra R, Mallikharjuna Rao K, Malyutina SK, Maniego LV, Manios Y, Mann JI, Mansour-Ghanaei F, Manzato E, Margozzini P, Markaki A, Markey O, Markidou Ioannidou E, Marques-Vidal P, Marques LP, Marrugat J, Martin-Prevel Y, Martin R, Martorell R, Martos E, Marventano S, Mascarenhas LP, Masoodi SR, Mathiesen EB, Mathur P, Matijasevich A, Matsha TE, Mavrogianni C, Mazur A, Mbanya JCN, McFarlane SR, McGarvey ST, McKee M, McLachlan S, McLean RM, McLean SB, McNulty BA, Mediene-Benchekor S, Medzioniene J, Mehdipour P, Mehlig K, Mehrparvar AH, Meirhaeghe A, Meisfjord J, Meisinger C, Menezes AMB, Menon GR, Mensink GB, Menzano MT, Mereke A, Meshram II, Metspalu A, Mi J, Michaelsen KF, Michels N, Mikkel K, Milkowska K, Miller JC, Minderico CS, Mini GK, Miquel JF, Mirjalili MR, Mirkopoulou D, Mirrakhimov E, Mišigoj-Durakovic M, Mistretta A, Mocanu V, Modesti PA, Moghaddam SS, Mohajer B, Mohamed MK, Mohamed SF, Mohammad K, Mohammadi Z, Mohammadifard N, Mohammadpourhodki R, Mohan V, Mohanna S, Mohd Yusoff MF, Mohebbi I, Mohebi F, Moitry M, Molbo D, Møllehave LT, Møller NC, Molnár D, Momenan A, Mondo CK, Monroy-Valle M, Monterrubio-Flores E, Monyeki KDK, Moosazadeh M, Moreira LB, Morejon A, Moreno LA, Morgan K, Morin SN, Mortensen EL, Moschonis G, Mossakowska M, Mostafa A, Mota-Pinto A, Mota J, Motlagh ME, Motta J, Moura-dos-Santos MA, Mridha MK, Msyamboza KP, Mu TT, Muc M, Mugoša B, Muiesan ML, Mukhtorova P, Müller-Nurasyid M, Murphy N, Mursu J, Murtagh EM, Musa KI, Music Milanovic S, Musil V, Mustafa N, Nabipour I, Naderimagham S, Nagel G, Naidu BM, Najafi F, Nakamura H, Námešná J, Nang EEK, Nangia VB, Nankap M, Narake S, Nardone P, Nauck M, Neal WA, Nejatizadeh A, Nelis K, Nelis L, Nenko I, Neovius M, Nervi F, Nguyen CT, Nguyen D, Nguyen QN, Nieto-Martínez RE, Nikitin YP, Ning G, Ninomiya T, Nishtar S, Noale M, Noboa OA, Nogueira H, Norat T, Nordendahl M, Nordestgaard BG, Noto D, Nowak-Szczepanska N, Nsour MA, Nuhoglu I, Nurk E, O'Neill TW, O'Reilly D, Obreja G, Ochimana C, Ochoa-Avilés AM, Oda E, Oh K, Ohara K, Ohlsson C, Ohtsuka R, Olafsson Ö, Olinto MTA, Oliveira IO, Omar MA, Onat A, Ong SK, Ono LM, Ordunez P, Ornelas R, Ortiz AP, Ortiz PJ, Osler M, Osmond C, Ostojic SM, Ostovar A, Otero JA, Overvad K, Owusu-Dabo E, Paccaud FM, Padez C, Pagkalos I, Pahomova E, Paiva KMD, Pajak A, Palli D, Palloni A, Palmieri L, Pan W-H, Panda-Jonas S, Pandey A, Panza F, Papandreou D, Park S-W, Park S, Parnell WR, Parsaeian M, Pascanu IM, Pasquet P, Patel ND, Pednekar MS, Peer N, Peixoto SV, Peltonen M, Pereira AC, Peres MA, Pérez-Farinós N, Pérez CM, Peterkova V, Peters A, Petersmann A, Petkeviciene J, Petrauskiene A, Pettenuzzo E, Peykari N, Pham ST, Pichardo RN, Pierannunzio D, Pigeot I, Pikhart H, Pilav A, Pilotto L, Pistelli F, Pitakaka F, Piwonska A, Pizarro AN, Plans-Rubió P, Poh BK, Pohlabeln H, Pop RM, Porta M, Posch G, Poudyal A, Poulimeneas D, Pouraram H, Pourfarzi F, Pourshams A, Poustchi H, Pradeepa R, Price AJ, Price JF, Providencia R, Puder JJ, Pudule I, Puhakka SE, Puiu M, Punab M, Qasrawi RF, Qorbani M, Quoc Bao T, Radic I, Radisauskas R, Rahimikazerooni S, Rahman M, Rahman M, Raitakari O, Raj M, Rakhimova E, Rakhmatulloev S, Rakovac I, Ramachandra Rao S, Ramachandran A, Ramke J, Ramos E, Ramos R, Rampal L, Rampal S, Rarra V, Rascon-Pacheco RA, Rasmussen M, Rech CR, Redon J, Reganit PFM, Regecová V, Revilla L, Rezaianzadeh A, Ribas-Barba L, Ribeiro R, Riboli E, Richter A, Rigo F, Rinaldo N, Rinke de Wit TF, Rito A, Ritti-Dias RM, Rivera JA, Robitaille C, Roccaldo R, Rodrigues D, Rodríguez-Artalejo F, Rodriguez-Perez MDC, Rodríguez-Villamizar LA, Roggenbuck U, Rojas-Martinez R, Rojroongwasinkul N, Romaguera D, Romeo EL, Rosario RV, Rosengren A, Rouse I, Roy JG, Rubinstein A, Rühli FJ, Ruidavets J-B, Ruiz-Betancourt BS, Ruiz Moreno E, Rusakova IA, Russell Jonsson K, 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Shrestha N, Si-Ramlee K, Siani A, Siantar R, Sibai AM, Silva AM, Silva DAS, Simon M, Simons J, Simons LA, Sjöberg A, Sjöström M, Skodje G, Slowikowska-Hilczer J, Slusarczyk P, Smeeth L, So H-K, Soares FC, Sobek G, Sobngwi E, Sodemann M, Söderberg S, Soekatri MY, Soemantri A, Sofat R, Solfrizzi V, Somi MH, Sonestedt E, Song Y, Sørgjerd EP, Sossa Jérome C, Soto-Rojas VE, Soumaré A, Sovic S, Sparboe-Nilsen B, Sparrenberger K, Spinelli A, Spiroski I, Staessen JA, Stamm H, Stathopoulou MG, Staub K, Stavreski B, Steene-Johannessen J, Stehle P, Stein AD, Stergiou GS, Stessman J, Stevanovic R, Stieber J, Stöckl D, Stocks T, Stokwiszewski J, Stoyanova E, Stratton G, Stronks K, Strufaldi MW, Sturua L, Suárez-Medina R, Suka M, Sun C-A, Sundström J, Sung Y-T, Sunyer J, Suriyawongpaisal P, Swinburn BA, Sy RG, Syddall HE, Sylva RC, Szklo M, Szponar L, Tai ES, Tammesoo M-L, Tamosiunas A, Tan EJ, Tang X, Tanser F, Tao Y, Tarawneh MR, Tarp J, Tarqui-Mamani CB, Taxová Braunerová R, Taylor A, Taylor J, 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Vladulescu M, Vlasoff T, Vocanec D, Völzke H, Voutilainen A, Voutilainen S, Vrijheid M, Vrijkotte TG, Wade AN, Wagner A, Waldhör T, Walton J, Wambiya EO, Wan Bebakar WM, Wan Mohamud WN, Wanderley Júnior RDS, Wang M-D, Wang N, Wang Q, Wang X, Wang YX, Wang Y-W, Wannamethee SG, Wareham N, Weber A, Wedderkopp N, Weerasekera D, Weghuber D, Wei W, Weres A, Werner B, Whincup PH, Widhalm K, Widyahening IS, Wiecek A, Wilks RJ, Willeit J, Willeit P, Williams J, Wilsgaard T, Wojtyniak B, Wong-McClure RA, Wong A, Wong JE, Wong TY, Woo J, Woodward M, Wu FC, Wu J, Wu LJ, Wu S, Xu H, Xu L, Yaacob NA, Yamborisut U, Yan W, Yang L, Yang X, Yang Y, Yardim N, Yaseri M, Yasuharu T, Ye X, Yiallouros PK, Yoosefi M, Yoshihara A, You QS, You S-L, Younger-Coleman NO, Yusof SM, Yusoff AF, Zaccagni L, Zafiropulos V, Zakavi SR, Zamani F, Zambon S, Zampelas A, Zamrazilová H, Zapata ME, Zargar AH, Zaw KK, Zdrojewski T, Zeljkovic Vrkic T, Zeng Y, Zhang L, Zhang Z-Y, Zhao D, Zhao M-H, Zhao W, Zhen S, Zheng W, Zheng Y, Zholdin B, Zhou M, Zhu D, Zocalo Y, Zuñiga Cisneros J, Zuziak M, Ezzati M, Tampere University, Clinical Medicine, Department of Clinical Chemistry, Eye Centre, NCD Risk Factor Collaboration (NCD-RisC), ACS - Diabetes & metabolism, APH - Global Health, APH - Personalized Medicine, Public and occupational health, Epidemiology and Data Science, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, ARD - Amsterdam Reproduction and Development, Adult Psychiatry, Global Health, APH - Methodology, APH - Quality of Care, ACS - Atherosclerosis & ischemic syndromes, ACS - Heart failure & arrhythmias, Rodriguez-Martinez A., Zhou B., Sophiea M.K., Bentham J., Paciorek C.J., Iurilli M.L., Carrillo-Larco R.M., Bennett J.E., Di Cesare M., Taddei C., Bixby H., Stevens G.A., Riley L.M., Cowan M.J., Savin S., Danaei G., Chirita-Emandi A., Kengne A.P., Khang Y.-H., Laxmaiah A., Malekzadeh R., Miranda J.J., Moon J.S., Popovic S.R., Sorensen T.I., Soric M., Starc G., Zainuddin A.A., Gregg 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Wojtyniak B., Wong-McClure R.A., Wong A., Wong J.E., Wong T.Y., Woo J., Woodward M., Wu F.C., Wu J., Wu L.J., Wu S., Xu H., Xu L., Yaacob N.A., Yamborisut U., Yan W., Yang L., Yang X., Yang Y., Yardim N., Yaseri M., Yasuharu T., Ye X., Yiallouros P.K., Yoosefi M., Yoshihara A., You Q.S., You S.-L., Younger-Coleman N.O., Yusof S.M., Yusoff A.F., Zaccagni L., Zafiropulos V., Zakavi S.R., Zamani F., Zambon S., Zampelas A., Zamrazilova H., Zapata M.E., Zargar A.H., Zaw K.K., Zdrojewski T., Zeljkovic Vrkic T., Zeng Y., Zhang L., Zhang Z.-Y., Zhao D., Zhao M.-H., Zhao W., Zhen S., Zheng W., Zheng Y., Zholdin B., Zhou M., Zhu D., Zocalo Y., Zuniga Cisneros J., Zuziak M., and Ezzati M.
Subjects: Male, body-mass index, ADULTHOOD, Adolescents, pituuskasvu, Pediatrics, Body Mass Index, 0302 clinical medicine, Child Development, nuoret, Public health surveillance, Medicine, Health Status Indicators, 10. No inequality, Child, 11 Medical and Health Sciences, Body mass index, ComputingMilieux_MISCELLANEOUS, education.field_of_study, VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801, General Medicine, Body mass indexes, kansainvälinen vertailu, 3. Good health, Geography, Health, 030220 oncology & carcinogenesis, Child, Preschool, Medical and Health sciences, purl.org/becyt/ford/3 [https], medicine.medical_specialty, School-aged adolescents, Socio-culturale, lapset (ikäryhmät), Nursing, territories, ravinto, purl.org/becyt/ford/3.3 [https], 03 medical and health sciences, School Children, SDG 3 - Good Health and Well-being, SYSTEMATIC ANALYSIS, Humans, school-aged children and adolescents, Montenegro, education, Science & Technology, Omvårdnad, Health sciences, Medical and Health sciences, Ciências médicas e da saúde, Bayes Theorem, Anthropometry, Adolescent Development, medicine.disease, TRENDS, Height and Body-mass Index, Faculdade de Ciências Sociais, UNDERNUTRITION, Height index trajectories, Height, body mass index, children , epidemiology, risk factors, growth, Stature, Demography, Settore MED/09 - Medicina Interna, Internationality, [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, Body-mass index trajectories, Epidemiology, Medicine and Health Sciences, risk factors, countries, EPIDEMIOLOGY, height, children, adolescents, BMI, 030212 general & internal medicine, painoindeksi, Child development, 2. Zero hunger, Medicine(all), School age child, obestity children cardiovascular, Population Health, 1. No poverty, Pediatrik, Public Health, Global Health, Social Medicine and Epidemiology, 3142 Public health care science, environmental and occupational health, Pooled analysis, NUTRITION, Female, medicine.symptom, pooled analysis, Life Sciences & Biomedicine, terveys, height, BMI, nutrition, health, children, adolescents, Adolescent, growth, Population, body-mass, Population based, Body-mass index, Young Adult, Medicine, General & Internal, Meta-Analysis as Topic, General & Internal Medicine, parasitic diseases, Weight gain, School-aged childrens, Age trajectories, business.industry, Height, Weight, Body Height, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Malnutrition, ONSET, Ciências da Saúde, Ciências médicas e da saúde, School-aged children, VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801, business, terveysriskit, Estilos de Vida e Impacto na Saúde
Abstract: BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents., METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence., FINDINGS: We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls., INTERPRETATION: The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks., Wellcome Trust, AstraZeneca Young Health Programme, EU., peer-reviewed
Published: 2020

7. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants

Author: Cesare, Mariachiara Di, Bentham, James, Stevens, Gretchen A., Zhou, Bin, Danaei, Goodarz, Lu, Yuan, Bixby, Honor, Cowan, Melanie J., Riley, Leanne M., Hajifathalian, Kaveh, Fortunato, Lea, Taddei, C., Bennett, James E., Ikeda, Nayu, Khang, Young-Ho, Kyobutungi, Catherine, Laxmaiah, Avula, Li, Yanping, Lin, Hsien-Ho, Miranda, J. Jaime, Mostafa, Aya, Turley, Maria L., Paciorek, Christopher J., Gunter, Marc, Ezzati, Majid, Abdeen, Ziad A., Hamid, Zargar Abdul, Abu-Rmeileh, Niveen M., Acosta-Cazares, Benjamin, Adams, Robert, Aekplakorn, Wichai, Aguilar-Salinas, Carlos A., Agyemang, Charles, Ahrens, Wolfgang, Ali, Farhan, Alkerwi, Ala'a, Alvarez-Pedrerol, Mar, Aly, Eman, Amouyel, Philippe, Amuzu, Antoinette, Andersen, Lars Bo, Anderssen, Sigmund A., Andrade, Dolores S., Anjana, Ranjit Mohan, Aounallah-Skhiri, Hajer, Ariansen, Inger, Aris, Tahir, Arlappa, Nimmathota, Arveiler, Dominique, Assah, Felix K., Avdicova, Maria, Azizi, Fereidoun, Babu, Bontha V., Balakrishna, Nagalla, Bandosz, Piotr, Banegas, Jose R., Barbagallo, Carlo M., Barcelo, Alberto, Barkat, Amina, Barros, Mauro V., Bata, Iqbal, Batieha, Anwar M., Batista, Rosangela L., Baur, Louise A., Beaglehole, Robert, Romdhane, H. B., Benet, Mikhail, Bernabe-Ortiz, Antonio, Bernotine, Gailute, Bettiol, Heloisa, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K., Bhatti, Zaid, Bhutta, Zulfiqar A., Bi, HongSheng, Bi, Yufang, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B., Bjorkelund, Cecilia, Blake, Margaret, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M., Boehm, Bernhard O., Boeing, Heiner, Boissonnet, Carlos P., Bongard, Vanina, Bovet, Pascal, Bradbury, Mark, Bragt, Marjolijn C. E., Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Brenner, Hermann, Brewster, Lizzy M., Brian, Garry R., Bruno, Graziella, Bueno-de-Mesquita, H. B., Bugge, Anna, Burns, C., Leon, Antonio Cabrera de, Cacciottolo, Joseph, Cama, Tilema, Cameron, Christine, Camolas, Jose, Can, Gunay, Candido, Ana Paula C., Capuano, Vincenzo, Cardoso, Viviane C., Carvalho, Maria J., Casanueva, Felipe F., Casas, Juan-Pablo, Caserta, Carmelo A., Castetbon, Katia, Chamukuttan, Snehalatha, Chan, Angelique W., Chan, Queenie, Chaturvedi, Himanshu K., Chaturvedi, Nishi, Chen, Chien-Jen, Chen, Fangfang, Chen, Shuohua, Chen, Y. Z., Cheng, Ching-Yu, Chetrit, Angela, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Cho, Yumi, Christensen, Kaare, Chudek, Jerzy, Cifkova, Renata, Claessens, Frank, Clays, Els, Concin, Hans, Cooper, Cyrus, Cooper, Rachel, Coppinger, Tara C., Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L., Crujeiras, Ana B., D'Arrigo, Graziella, d'Orsi, Eleonora, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T., Dankner, Rachel, Dauchet, Luc, Backer, Guy De, Bacquer, Dirk De, Gaetano, Giovanni de, Hanauw, Stefaan De, Smedt, Delphine De, Deepa, Mohan, Deev, Alexander D., Dehghan, Abbas, Delisle, Helene, Delpeuch, Francis, Dhana, Klodian, Castelnuovo, Augusto F. Di, Dias-da-Costa, Juvenal Soares, Diaz, Alejandro, Djalalinia, Shirin, Do, Ha T. P., Dobson, Annette J., Donfrancesco, Chiara, Döring, A., Doua, Kouamelan, Drygas, Wojciech, Egbagbe, Eruke E., Eggertsen, Robert, Ekelund, Ulf, Ati, Jalila El, Elliott, Paul, Engle-Stone, Reina, Erasmus, Rajiv T., Erem, Cihangir, Eriksen, Louise, Peña, J. E. De La, Evans, Alun, Faeh, David, Fall, Caroline H., Farzadfar, Farshad, Felix-Redondo, Francisco J., Ferguson, Trevor S., Fernandez-Berges, Daniel, Ferrante, Daniel, Ferrari, Marika, Ferreccio, Catterina, Ferrieres, Jean, Finn, Joseph D., Fischer, Krista, Flores, E. M., Foeger, Bernhard, Foo, Leng Huat, Forslund, Ann-Sofie, Fortmann, Stephen P., Fouad, Heba M., Francis, Damian K., Franco, M. Do Carmo, Franco, Oscar H., Frontera, Guillermo, Fuchs, Flavio D., Fuchs, Sandra C., Fujita, Yuki, Furusawa, Takuro, Gaciong, Zbigniew, Gafencu, Mihai, Gareta, Dickman, Garnett, Sarah P., Gaspoz, Jean-Michel, Gasull, Magda, Gates, Louise, Geleijnse, Johanna M., Ghasemian, Anoosheh, Giampaoli, Simona, Gianfagna, Francesco, Giovannelli, Jonathan, Giwercman, Aleksander, Goldsmith, Rebecca A., Gross, M. G., Rivas, J. P. G., Gorbea, M. B., Gottrand, Frederic, Graff-Iversen, Sidsel, Grafnetter, Dusan, Grajda, Aneta, Grammatikopoulou, Maria G., Gregor, Ronald D., Grodzicki, Tomasz, Grontved, Anders, Gruden, Grabriella, Grujic, Vera, Gu, Dongfeng, Guan, Ong Peng, Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L., Gulliford, Martin C., Gunnlaugsdottir, Johanna, Guo, Xiu H., Guo, Yin, Gupta, Prakash C., Gureje, Oye, Gurzkowska, Beata, Gutierrez, Laura, Gutzwiller, Felix, Halkjaer, Jytte, Hardy, Rebecca, Kumar, Rachakulla Hari, Hayes, Alison J., He, Jiang, Hendriks, Marleen Elisabeth, Cadena, L. H., Heshmat, Ramin, Hihtaniemi, Ilpo Tapani, Ho, Sai Yin, Ho, Suzanne C., Hobbs, Michael, Hofman, Albert, Hormiga, Claudia M., Horta, Bernardo L., Houti, Leila, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Hu, Yonghua, Hussieni, Abdullatif S., Huu, C. N., Huybrechts, Inge, Hwalla, Nahla, Iacoviello, Licia, Iannone, Anna G., Ibrahim, Mohsen M., Ikram, M. Arfan, Irazola, Vilma E., Islam, Muhammad, Iwasaki, Masanori, Jackson, Rod T., Jacobs, Jeremy M., Jafar, Tazeen, Jamil, Kazi M., Jamrozik, Konrad, Jasienska, Grazyna, Jiang, Chao Qiang, Joffres, Michel, Johansson, Mattias, Jonas, Jost B., Jorgensen, Torben, Joshi, Pradeep, Juolevi, Anne, Jurak, Gregor, Juresa, Vesna, Kaaks, Rudolf, Kafatos, Anthony, Kalter-Leibovici, Ofra, Kapantais, Efthymios, Kasaeian, Amir, Katz, Joanne, Kaur, Prabhdeep, Kavousi, Maryam, Keil, Ulrich, Boker, Lital Keinan, Kelishadi, Roya, Kemper, Han C. G., Kengne, Andre Pascal, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khalili, Davood, Khaw, Kay-Tee H., Khouw, Ilse M. S. L., Kiechl, Stefan, Killewo, Japhet, Kim, Jeongseon, Kiyohara, Yutaka, Klimont, Jeannette, Kolle, Elin, Kolsteren, Patrick, Korrovits, Paul, Koskinen, Seppo, Kouda, Katsuyasu, Koziel, Slawomir, Kratzer, Wolfgang, Krokstad, Steinar, Kromhout, Daan, Kruger, Herculina S., Kula, Krzysztof, Kulaga, Zbigniew, Kumar, R. Krishna, Kusuma, Yadlapalli S., Kuulasmaa, Kari, Laamiri, Fatima Zahra, Laatikainen, Tiina, Lachat, Carl, Laid, Youcef, Lam, Tai Hing, Landrove, Orlando, Lanska, Vera, Lappas, Georg, Laugsand, Lars E., Bao, K. Le Nguyen, Le, Tuyen D., Leclercq, Catherine, Lee, Jeannette, Lehtimaki, Terho, Lekhraj, Rampal, Leon-Munoz, Luz M., Lim, Wei-Yen, Lima-Costa, M. F., Lin, Xu, Linneberg, Allan, Lissner, Lauren, Litwin, Mieczyslaw, Liu, Jing, Lorbeer, Roberto, Lotufo, Paulo A., Lozano, J. E., Luksiene, Dalia, Lundqvist, Annamari, Lunet, Nuno, Lytsy, Per, Ma, Guansheng, Machi, Suka, Maggi, Stefania, Magliano, Dianna J., Makdisse, Marcia, Malekzadeh, Reza, Malhotra, Rahul, Rao, Kodavanti Mallikharjuna, Manios, Yannis, Mann, Jim I., Manzato, Enzo, Margozzini, Paula, Markey, Oonagh, Marques-Vidal, Pedro, Marrugat, Jaume, Martin-Prevel, Yves, Martorell, Reynaldo, Masoodi, Shariq R., Matsha, Tandi E., Mazur, Artur, Mbanya, Jean Claude N., McFarlane, Shelly R., McGarvey, Stephen T., McKee, Martin, McLachlan, Stela, McLean, Rachael M., McNulty, Breige A., Yusof, S. Md, Mediene-Benchekor, Sounnia, Meirhaeghe, Aline, Meisinger, Christa, Mendes, Larissa L., Menezes, Ana Maria B., Mensink, Gert B. M., Meshram, Indrapal I., Metspalu, Andres, Mi, Jie, Michaelsen, Kim F., Mikkel, Kairit, Miller, Jody C., Miquel, J. F., Misigoj-Durakovic, Marjeta, Mohamed, Mostafa K., Mohammad, Kazem, Mohammadifard, Noushin, Mohan, Viswanathan, Yusoff, Muhammad Fadhli Mohd, Molbo, Drude, Moller, Niels C., Molnar, Denes, Mondo, Charles K., Monterrubio, Eric A., Monyeki, Kotsedi Daniel K., Moreira, Leila B., Morejon, Alain, Moreno, Luis A., Morgan, Karen, Mortensen, Erik Lykke, Moschonis, George, Mossakowska, Malgorzata, Mota, Jorge, Motlagh, Mohammad Esmaeel, Motta, Jorge, Mu, Thet Thet, Muiesan, Maria Lorenza, Mueller-Nurasyid, Martina, Murphy, Neil, Mursu, Jaakko, Murtagh, Elaine M., Musa, Kamarul Imran, Musil, Vera, Nagel, Gabriele, Nakamura, Harunobu, Namesna, Jana, Nang, E. E. K., Nangia, Vinay B., Nankap, Martin, Narake, Sameer, Navarrete-Muñoz, E. M., Nenko, Ilona, Neovius, Martin, Nervi, Flavio, Neuhauser, Hannelore K., Nguyen, Nguyen D., Nieto-Martinez, Ramfis E., Ning, Guang, Ninomiya, Toshiharu, Nishtar, Sania, Noale, Marianna, Norat, Teresa, Noto, Davide, Nsour, Mohannad Al, O'Reilly, Dermot, Ochoa-Avilés, A. M., Oh, Kyungwon, Olayan, Iman H., Olinto, M. T. A., Oltarzewski, Maciej, Omar, Mohd A., Onat, Altan, Ordunez, Pedro, Ortiz, Ana P., Osler, Merete, Osmond, Clive, Ostojic, Sergej M., Otero, Johanna A., Overvad, Kim, Paccaud, Fred Michel, Padez, Cristina, Pajak, Andrzej, Palli, Domenico, Palloni, Alberto, Palmieri, Luigi, Panda-Jonas, Songhomitra, Panza, Francesco, Parnell, Winsome R., Parsaeian, Mahboubeh, Pednekar, Mangesh S., Peeters, Petra H., Peixoto, Sergio Viana, Pereira, Alexandre C., Perez, Cynthia M., Peters, Annette, Peykari, Niloofar, Pham, S. T., Pigeot, Iris, Pikhart, Hynek, Pilav, Aida, Pilotto, Lorenza, Pistelli, Francesco, Pitakaka, Freda, Piwonska, Aleksandra, Piwonski, J., Plans-Rubio, Pedro, Poh, Bee Koon, Porta, Miquel, Portegies, Marileen L. P., Poulimeneas, Dimitrios, Pradeepa, Rajendra, Prashant, Mathur, Price, Jacqueline F., Puiu, Maria, Punab, Margus, Qasrawi, Radwan F., Qorbani, Mostafa, Bao, T. Q., Radic, Ivana, Radisauskas, Ricardas, Rahman, Mahmudur, Raitakari, Olli, Raj, Manu, Rao, Sudha Ramachandra, Ramachandran, Ambady, Ramke, Jacqueline, Ramos, Rafel, Rampal, Sanjay, Rasmussen, Finn, Redon, Josep, Reganit, Paul Ferdinand M., Ribeiro, Robespierre, Riboli, Elio, Rigo, Fernando, Wit, Tobias Floris Rinke de, Ritti-Dias, Raphael M., Rivera, Juan A., Robinson, Sian M., Robitaille, Cynthia, Rodriguez-Artalejo, Fernando, Rodriguez-Perez, Maria del Cristo, Rodriguez-Villamizar, Laura A., Rojas-Martinez, Rosalba, Rojroongwasinkul, Nipa, Romaguera, Dora, Ronkainen, Kimmo, Rosengren, Annika, Rouse, Ian, Rubinstein, Adolfo, Ruhli, Frank J., Rui, Ornelas, Ruiz-Betancourt, B. S., Horimoto, Andrea R. V. Russo, Rutkowski, Marcin, Sabanayagam, Charumathi, Sachdev, Harshpal S., Saidi, Olfa, Salanave, Benoit, Martinez, E. S., Salomaa, Veikko, Salonen, Jukka T., Salvetti, Massimo, Sanchez-Abanto, Jose, Sandjaja, Sans, Susana, Santos, Diana A., Santos, Osvaldo, Santos, Renata Nunes dos, Santos, Rute, Sardinha, Luis B., Sarrafzadegan, Nizal, Saum, Kai-Uwe, Savva, Savvas C., Scazufca, Marcia, Rosario, Angelika Schaffrath, Schargrodsky, Herman, Schienkiewitz, Anja, Schmidt, Ida Maria, Schneider, Ione J., Schultsz, Constance, Schutte, Aletta E., Sein, Aye Aye, Sen, Abhijit, Senbanjo, Idowu O., Sepanlou, Sadaf G., Shalnova, Svetlana A., Shaw, Jonathan E., Shibuya, Kenji, Shin, Youchan, Shiri, Rahman, Siantar, Rosalynn, Sibai, Abla M., Silva, Antonio M., Silva, D. A. S., Simon, Mary, Simons, Judith, Simons, Leon A., Sjostrom, Michael, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, Smith, Margaret C., Snijder, Marieke B., So, Hung-Kwan, Sobngwi, Eugene, Soderberg, Stefan, Soekatri, Moesijanti Y. E., Solfrizzi, Vincenzo, Sonestedt, Emily, Sorensen, Thorkild I. 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H., Trivedi, Atul, Tshepo, Lechaba, Tulloch-Reid, Marshall K., Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Tynelius, Per, Tzotzas, Themistoklis, Tzourio, Christophe, Ueda, Peter, Ukoli, Flora A. M., Ulmer, Hanno, Unal, Belgin, Valdivia, Gonzalo, Vale, Susana, Valvi, Damaskini, Schouw, Yvonne T. van der, Herck, Koen Van, Minh, H. Van, Valkengoed, Irene G. M. van, Vanderschueren, Dirk, Vanuzzo, Diego, Vatten, Lars, Vega, Tomas, Velasquez-Melendez, Gustavo, Veronesi, Giovanni, Verschuren, W. M. Monique, Viegi, Giovanni, Viet, Lucie, Viikari-Juntura, Eira, Vineis, Paolo, Vioque, Jesus, Virtanen, Jyrki K., Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vollenweider, Peter, Voutilainen, Sari, Vrijheid, Martine, Wade, Alisha N., Wagner, A. Fink, Walton, Janette, Mohamud, Wan Nazaimoon Wan, Wang, Ming-Dong, Wang, Qian, Wang, Ya Xing, Wannamethee, S. Goya, Wareham, Nicholas, Weerasekera, Deepa, Whincup, Peter H., Widhalm, Kurt, Widyahening, Indah S., Wiecek, Andrzej, Wilks, Rainford J., Willeit, Johann, Wojtyniak, Bogdan, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C., Wu, Jianfeng, Wu, Shou Ling, Xu, Haiquan, Xu, Liang, Yamborisut, Uruwan, Yan, Weili, Yang, Xiaoguang, Yardim, Nazan, Ye, Xingwang, Yiallouros, Panayiotis K., Yoshihara, Akihiro, You, Qi Sheng, Younger-Coleman, Novie O., Yusoff, Ahmad F., Zainuddin, Ahmad A., Zambon, Sabina, Zdrojewski, Tomasz, Zeng, Yi, Zhao, Dong, Zhao, Wenhua, Zheng, Yingfeng, Zhou, Maigeng, Zhu, Dan, Zimmermann, Esther, Cisneros, Julio Zuniga, NCD Risk Factor Collaboration (NCD-RisC), Di Cesare, M., Bentham, J., Stevens, G.A., Zhou, B., Danaei, G., Lu, Y., Bixby, H., Cowan, M.J., Riley, L.M., Hajifathalian, K., Fortunato, L., Taddei, C., Bennett, J.E., Ikeda, N., Khang, Y.H., Kyobutungi, C., Laxmaiah, A., Li, Y., Lin, H.H., Miranda, J.J., Mostafa, A., Turley, M.L., 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Keinan Boker L, Kelishadi R, Kemper HHCG, Kengne AP, Kersting M, Key T, Khader YS, Khalili D, Khang Y-H, Kay-Tee H Khaw K-TH, Khouw LMSL, Kiechl S, Killewo J, Kim J, Kiyohara Y, Klimont J, Kolle E, Kolsteren P, Korrovits P, Koskinen S, Kouda K, Koziel S, Kratzer W, Krokstad S, Kromhout D, Kruger HS, Kula K, Kulaga Z, Kumar RK, Kusuma YS, Kuulasmaa K, Laamiri FZ, Laatikainen T, Lachat C, Laid Y, Lam TH, Landrove O, Lanska V, Lappas G, Laugsand LE, Nguyen Bao KL, Le TD, Leclercq C, Lee J, Jeonghee Lee J, Lehtimäki T, Lekhraj R, León-Muñoz LM, Lim W-Y, M Fernanda Lima-Costa MF, Lin H-H, Lin X, Linneberg A, Lissner L, Litwin M, Liu J, Lorbeer R, Lotufo PA, Lozano JE, Luksiene D, Lundqvist A, Lunet N, Lytsy P, Ma G, Machi S, Maggi S, Magliano DJ, Makdisse M, Malekzadeh R, Malhotra R, Mallikharjuna Rao K, Manios Y, Mann JI, Manzato E, Margozzini P, Markey O, Marques-Vidal P, Marrugat P, Martin-Prevel Y, Martorell R, Masoodi SR, Matsha TE, Mazur A, Mbanya JCN, McFarlane SR, McGarvey ST, McKee M, McLachlan S, McLean RM, McNulty BA, Md Yusof S, Mediene-Benchekor S, Meirhaeghe A, Meisinger A, Mendes LL, Menezes AMB, Mensink GBM, Meshram II, Metspalu A, Mi JM, Michaelsen KF, Miller JC, Miquel JF, Mišigoj-Duraković M, Mohamed MK, Mohammad K, Mohammadifard N, Mohan V, Mohd Yusoff MF, Molbo D, Møller NC, Molnár D, Mondo CK, Monterrubio EA, Monyeki KDK, Leila B Moreira LB, Morejon A, Moreno LA, Morgan K, Mortensen EL, Moschonis G, Mossakowska M, Mota J, Motlagh ME, Motta J, Mu TT, Muiesan ML, Müller-Nurasyid M, Murphy N, Mursu J, Murtagh EM, Musa KI, Musil V, Nagel G, Nakamura H, Námešná J, Nang EEK, Nangia VB, Nankap M, Narake S, Navarrete-Muñoz EM, Nenko I, Neovius M, Nervi F, Neuhauser HK, Nguyen ND, Ngoc Nguyen Q, Nieto-Martínez RE, Ning G, Ninomiya T, Nishtar S, Noale M, Norat T, Noto D, Al Nsour M, O'Reilly D, Ochoa-Avilés AM, Oh K, Olayan IH, Olinto MTA, Oltarzewski M, Omar MA, Onat A, Ordunez P, Ortiz AP, Osler M, Osmond C, Ostojic AM, Otero JA, Overvad K, Paccaud F, Padez C, Pajak A, Palli D, Palloni A, Palmieri L, Panda-Jonas S, Panza F, Parnell WR, Parsaeian M, Pednekar MS, Peeters PH, Peixoto SV, Pereira AC, Pérez CM, Peters A, Peykari N, Pham ST, Pigeot I, Pikhart H, Pilav A, Pilotto L, Pistelli F, Pitakaka F, Piwonska A, Piwonski J, Pedro Plans-Rubió P, Poh BK, Porta M, Portegies MLP, Poulimeneas D, Pradeepa R, Prashant M, Price JF, Puiu M, Punab M, Qasrawi RF, Qorbani M, Quoc Bao T, Radic I, Ricardas Radisauskas R, Rahman M, Raitakari O, Raj M, Ramachandra Rao S, Ramachandran A, Ramke J, Ramos R, Rampal S, Rasmussen F, Redon J, Reganit PFM, Robespierre Ribeiro R, Riboli E, Rigo F, Rinke de Wit TF, Ritti-Dias RM, Juan A Rivera JA, Robinson SM, Robitaille C, Rodríguez-Artalejo F, Rodriguez-Perez MdC, Rodríguez-Villamizar LA, Rojas-Martinez R, Rojroongwasinkul N, Romaguera D, Ronkainen K, Rosengren A, Rouse I, Rubinstein A, Rühli FJ, Rui O, Ruiz-Betancourt BS, Russo Horimoto ARV, Rutkowski M, Sabanayagam C, Sachdev HS, Saidi O, Salanave B, Salazar Martinez E, Salomaa V, Salonen JT, Salvetti M, Sánchez-Abanto J, Sandjaja A, Sans S, Santos DA, Santos O, dos Santos RN, Santos R, Sardinha LB, Sarrafzadegan N, Saum K-U, Savva SC, Scazufca M, Schaffrath Rosario A, Schargrodsky H, Schienkiewitz A, Schmidt IM, Schneider IJ, Schultsz C, Schutte AE, Sein AA, Sen A, Senbanjo IO, Sepanlou SG, Shalnova SA, Shaw JE, Shibuya K, Shin Y, Shiri R, Siantar R, Sibai AM, Silva AM, Simon M, Simons J, Simons LA, Sjostrom M, Slowikowska-Hilczer J, Slusarczyk P, Smeeth L, Smith MC, Snijder MB, So H-K, Sobngwi E, Söderberg S, Soekatri MYE, Solfrizzi V, Sonestedt E, Sørensen TIA, Sorić M, Sossa Jérome C, Soumare A, Staessen JA, Starc G, Stathopoulou MG, Staub K, Stavreski B, Steene-Johannessen J, Stehle P, Stein AD, Stergiou GS, Stessman J, Stieber J, Stöckl D, Stocks T, Stokwiszewski J, Stratton G, Strufaldi MW, Chien-An Sun C-A, Sundström J, Sung Y-T, Sunyer J, Suriyawongpaisal P, Swinburn BA, Sy RG, Szponar L, E Shyong Tai E, Tammesoo M-L, Tamosiunas A, Tang L, Tang X, Tanser F, Tao Y, Tarawneh M, Jakob Tarp J, Tarqui-Mamani CB, Taylor A, Félicité Tchibindat F, Thijs L, Thuesen BH, Tjonneland A, Tolonen HK, Janne S Tolstrup JS, Topbas M, Topór-Madry R, Torrent M, Traissac P, Trichopoulos D, Trinh OTH, Trivedi A, Tshepo L, Tulloch-Reid MK, Tuomainen T-P, Tuomilehto J, Tynelius P, Tzotzas T, Tzourio C, Ueda P, Ukoli FAM, Ulmer H, Unal B, Valdivia G, Susana Va S, Valvi D, van der Schouw YT, Van Herck K, Van Minh H, van Valkengoed IGM, Vanderschueren D, Vanuzzo D, Vatten L, Vega T, Velasquez-Melendez G, Veronesi G, Verschuren WMM, Viegi G, Viet L, Viikari-Juntura E, Vineis P, Vioque P, Virtanen JK, Visvikis-Siest S, Viswanathan B, Vollenweider P, Voutilainen S, Vrijheid M, Wade AN, Wagner A, Walton J, Wan Mohamud WN, Wang M-D, Wang Q, Wang YX, Wannamethee SG, Wareham N, Deepa Weerasekera D, Whincup PH, Widhalm K, Widyahening IS, Wiecek A, Wilks RJ, Willeit J, Wojtyniak B, Wong, Wong TY, Woo J, Woodward M, Wu FC, JianFeng Wu JF, Wu SL, Xu H, Xu L, Yamborisut U, Yan W, Yang X, Yardim N, Ye X, Yiallouros PK, Yoshihara A, Qi Sheng You QS, Younger-Coleman NO, Yusoff AF, Ahmad A Zainuddin AA, Zambon S, Zdrojewski T, Zeng Y, Zhao D, Zhao W, Zheng Y, Zhou M, Zhu D, Zimmermann E, Zuñiga Cisneros J, General Internal Medicine, AII - Amsterdam institute for Infection and Immunity, Public and occupational health, Global Health, and APH - Amsterdam Public Health
Subjects: Male, Obesidad, CHILDREN, Salud, Review, países desarrollados, Global Health, Body Mass Index, Body mass index, population study, 0302 clinical medicine, Models, Factores de riesgo cardiovascular, Medicine, body mass index, underweight, overweight, obesity, Young adult, Human Nutrition & Health, education.field_of_study, Humane Voeding & Gezondheid, General Medicine, ASSOCIATION, 11 Medical And Health Sciences, adulto, predicción, adulto joven, CARDIOVASCULAR-DISEASE, thinness/epidemiology, NONCOMMUNICABLE DISEASES, NCD Risk Factor Collaboration (NCD-RisC), Enfermedades cardiovasculares, Developed country, teorema de Bayes, Medical sciences, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Thinness, Humans, education, Developing Countries, obesidad, VLAG, Science & Technology, Models, Statistical, CAUSE-SPECIFIC MORTALITY, Bayes Theorem, medicine.disease, QP, Obesity, adult body-mass, Indice de masa corporal (IMC), RISK-FACTORS, Adolescent, Adult, Developed Countries, Female, Forecasting, Obesity/epidemiology, Prevalence, Thinness/epidemiology, Young Adult, RA, Body mass index, Demography, Meta-Analysis, Gerontology, Settore MED/09 - Medicina Interna, Nutrition and Disease, humanos, adolescente, Overweight, países en desarrollo, Voeding en Ziekte, Medicine and Health Sciences, Global health, 030212 general & internal medicine, Non-U.S. Gov't, Medicine (all), Research Support, Non-U.S. Gov't, prevalencia, Public Health, Global Health, Social Medicine and Epidemiology, Statistical, Underweight, medicine.symptom, pooled analysis, Life Sciences & Biomedicine, obesity/*epidemiology, Population, 030209 endocrinology & metabolism, Research Support, Medicine, General & Internal, EPIDEMIC, General & Internal Medicine, Journal Article, Life Science, ddc:610, Obesidad morbida, OBESITY PREVENTION, OVERWEIGHT, business.industry, índice de masa corporal, COHORTS, purl.org/pe-repo/ocde/ford#3.02.00 [https], Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Ciencias socio biomédicas, business, delgadez
Abstract: Copyright © NCD Risk Factor Collaboration. Open Access article distributed under the terms of CC BY., Background: Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its population distribution, and in the prevalences of a complete set of BMI categories for adults in all countries. Methods: We analysed, with use of a consistent protocol, population-based studies that had measured height and weight in adults aged 18 years and older. We applied a Bayesian hierarchical model to these data to estimate trends from 1975 to 2014 in mean BMI and in the prevalences of BMI categories (, Wellcome Trust, Grand Challenges Canada
Published: 2016

8. Prevalence of sarcopenia and associated factors in the healthy older adults of the Peruvian Andes

Author: Alessandra Tramontano, Valter Giantin, Francesca De Zaiacomo, Stefania Maggi, Giuseppe Sergi, Caterina Trevisan, Diana Rodríguez-Hurtado, Enzo Manzato, Nicola Veronese, Tramontano, A., Veronese, N., Sergi, G., Manzato, E., Rodriguez-Hurtado, D., Maggi, S., Trevisan, C., De Zaiacomo, F., and Giantin, V.
Subjects: Male, Gerontology, Sarcopenia, Aging, Health (social science), Activities of daily living, Sarcopenia/epidemiology, Population, Nutritional Status, Walk Test, 030209 endocrinology & metabolism, Motor activity, Body Mass Index, NO, Disability Evaluation, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Peru, Prevalence, Instrumental activities of daily living, Humans, Medicine, Activities of daily living, Body mass index, Instrumental activities of daily living, Motor activity, Sarcopenia, 030212 general & internal medicine, education, Exercise, Body mass index, Aged, education.field_of_study, business.industry, Confounding, Age Factors, Odds ratio, medicine.disease, Physical activity level, Confidence interval, Female, Geriatrics and Gerontology, purl.org/pe-repo/ocde/ford#3.02.26 [https], business, Peru/epidemiology, human activities
Abstract: Aim To assess the prevalence of sarcopenia and associated factors in a population of older people living in a rural area of the Peruvian Andes. Materials and methods The study concerned 222 people aged ≥65 years. Sarcopenia was diagnosed on the basis of skeletal muscle mass, measured using bioimpedance analysis, and gait speed, measured with the 4-m walking test, as recommended by the International Working Group on sarcopenia. Self-reported physical activity, the Short Physical Performance Battery, and the Six-Minute Walking Test also contributed information on participants’ physical performance status. Disabilities were investigated by assessing participants’ self-reported difficulties in performing one or more basic or instrumental activities of daily living. Results The prevalence of sarcopenia was 17.6%. Compared with participants without sarcopenia, individuals who were found sarcopenic were significantly older, female and were less frequently farmers, had fewer children, had a worse nutritional status, a significantly lower physical performance, and higher levels of disability in the instrumental activities of daily living. After adjusting for potential confounders, age, female sex, a low body mass index, a self-reported low physical activity level, a worse Six-Minute Walking Test scores, and a low number of children were significantly associated with sarcopenia. Conclusion The prevalence of sarcopenia seems to be quite high among community-dwelling older subjects in the Peruvian Andes. Age, female sex, a low body mass index, little physical activity, a poor Six-Minute Walking Test scores, and a low number of children could be associated with this condition. © 2016 Elsevier Ireland Ltd
Published: 2017

9. Weight loss is associated with improvements in cognitive function among overweight and obese people: A systematic review and meta-analysis

Author: Nicola Veronese, Enzo Manzato, Brendon Stubbs, Giuseppe Sergi, Silvia Facchini, Stefania Maggi, Theodore D. Cosco, Claudio Luchini, Luigi Fontana, Marco Solmi, Veronese, N., Facchini, S., Stubbs, B., Luchini, C., Solmi, M., Manzato, E., Sergi, G., Maggi, S., Cosco, T., and Fontana, L.
Subjects: Weight loss, medicine.medical_specialty, Cognitive Neuroscience, Physical activity, 030209 endocrinology & metabolism, Overweight, law.invention, 03 medical and health sciences, Behavioral Neuroscience, Cognition, 0302 clinical medicine, Randomized controlled trial, Memory, law, medicine, Humans, Attention, Obesity, Exercise, Nutrition, Meta-analysis, Weight Loss, Cognition, Memory, Attention, Weight loss, Obesity, Meta-analysis, Physical activity, Nutrition, Executive functions, medicine.disease, Neuropsychology and Physiological Psychology, Physical therapy, medicine.symptom, Psychology, 030217 neurology & neurosurgery
Abstract: Whilst obesity is associated with a higher risk of cognitive impairment, the influence of weight loss on cognitive function in obese/overweight people is equivocal. We conducted a meta-analysis of randomized controlled trials (RCTs) and longitudinal studies evaluating the influence of voluntary weight loss on cognitive function in obese/overweight individuals. Articles were acquired from a systematic search of major databases from inception till 01/2016. A random effect meta-analysis of weight loss interventions (diet, physical activity, bariatric surgery) on different cognitive domains (memory, attention, executive functions, language and motor speed) was conducted. Twenty studies (13 longitudinal studies = 551 participants; 7 RCTs = 328 treated vs. 140 controls) were included. Weight loss was associated with a significant improvement in attention and memory in both longitudinal studies and RCTs, whereas executive function and language improved in longitudinal and RCT studies, respectively. In conclusion, intentional weight loss in obese/overweight people is associated with improvements in performance across various cognitive domains. Future adequately powered RCTs are required to confirm/refute these findings. © 2016 Elsevier Ltd
Published: 2017

10. Extra-nodal extension of sentinel lymph node metastasis is a marker of poor prognosis in breast cancer patients: A systematic review and an exploratory meta-analysis

Author: Paola Capelli, Mehmet Akif Eryılmaz, Franco Bonetti, Audrey H. Choi, Antonio Pea, Mehmet Koç, Luisa Carbognin, Marco Solmi, Giuseppe Sergi, Fabio Bagante, Rudi M. H. Roumen, Emilio Bria, Mattia Barbareschi, Brendon Stubbs, Enzo Manzato, Maheswari Senthil, Alessia Nottegar, Matteo Fassan, Nicola Veronese, Marco Maruzzo, Claudio Luchini, N. C. Verheuvel, Nottegar, A., Veronese, N., Senthil, M., Roumen, R.M., Stubbs, B., Choi, A.H., Verheuvel, N.C., Solmi, M., Pea, A., Capelli, P., Fassan, M., Sergi, G., Manzato, E., Maruzzo, M., Bagante, F., Koç, M., Eryilmaz, M.A., Bria, E., Carbognin, L., Bonetti, F., Barbareschi, M., Luchini, C., RS: FHML non-thematic output, RS: GROW - School for Oncology and Reproduction, Surgery, Promovendi ODB, Interne Geneeskunde, and RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy
Subjects: Breast cancer, ENE, Extra-nodal, Extracapsular, Extranodal, Sentinel, Oncology, Surgery, 0301 basic medicine, Metastasis, 0302 clinical medicine, sentinel, Lymph node, extracapsular, medicine.diagnostic_test, extra-nodal, General Medicine, Prognosis, medicine.anatomical_structure, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Female, Sentinel Lymph Node, medicine.medical_specialty, Sentinel lymph node, Breast Neoplasms, Malignancy, Disease-Free Survival, 03 medical and health sciences, breast cancer, Internal medicine, Biopsy, medicine, Humans, Survival analysis, Neoplasm Staging, Sentinel Lymph Node Biopsy, business.industry, medicine.disease, Survival Analysis, Axilla, 030104 developmental biology, Lymph Node Excision, business, Follow-Up Studies
Abstract: Invasive breast cancer is the most common malignancy in women. Its most common site of metastasis is represented by the lymph nodes of axilla, and the sentinel lymph node (SLN) is the first station of nodal metastasis. Axillary SLN biopsy accurately predicts axillary lymph node status and has been accepted as standard of care for nodal staging in breast cancer. To date, the morphologic aspects of SLN metastasis have not been considered by the oncologic staging system. Extranodal extension (ENE) of nodal metastasis, defined as extension of neoplastic cells through the nodal capsule into the peri-nodal adipose tissue, has recently emerged as an important prognostic factor in several types of malignancies. It has also been considered as a possible predictor of non-sentinel node tumor burden in SLN-positive breast cancer patients. We sought out to clarify the prognostic role of ENE in SLN-positive breast cancer patients in terms of overall and disease-free survival by conducting a systematic review and meta-analysis. Among 172 screened articles, 5 were eligible for the meta-analysis; they globally include 624 patients (163 ENE+ and 461 ENE−) with a median follow-up of 58 months. ENE was associated with a higher risk of both mortality (RR=2.51; 95% CI: 1.66–3.79, p&nbsp
Published: 2016

11. Factors influencing serum 25-hydroxivitamin D levels and other bone metabolism parameters in healthy older women

Author: Emine Meral Inelmen, Giuseppe Sergi, Alessandra Coin, Egle Perissinotto, Nicola Veronese, M. De Rui, Francesco Bolzetta, Enzo Manzato, Linda Berton, S. Carraro, F. Miotto, Caterina Trevisan, Trevisan, C., Veronese, N., Berton, L., Carraro, S., Bolzetta, F., de Rui, M., Miotto, F., Inelmen, E.M., Coin, A., Perissinotto, E., Manzato, E., and Sergi, G.
Subjects: 0301 basic medicine, medicine.medical_specialty, Bone density, Medicine (miscellaneous), 030209 endocrinology & metabolism, 25-hydroxyvitamin D, bone metabolism, dietary vitamin D intake, elderly, fat mass, Nutrition and Dietetics, Geriatrics and Gerontology, NO, Bone remodeling, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Vitamin D and neurology, Femoral neck, Bone mineral, Hyperparathyroidism, 030109 nutrition & dietetics, business.industry, medicine.disease, medicine.anatomical_structure, Endocrinology, chemistry, 25-hydroxyvitamin D, dietary vitamin D intake, fat mass, bone metabolism, elderly, Calcifediol, Secondary hyperparathyroidism, business
Abstract: Objective: Older women have frequently low serum 25-hydroxivitamin D (25[OH]D) concentrations, high parathormone (PTH) levels and low bone mineral density (BMD) values. Endogenous synthesis, dietary habits, sunlight exposure and fat-mass-mediated storage may influence 25(OH)D levels and bone metabolism, but the relevance of these factors in the elderly has yet to be fully elucidated. We aimed to investigate the influence of dietary vitamin D intake and fat mass on serum 25(OH)D levels and bone metabolism in older women. Design: Cross-sectional. Setting: Community. Participants: 218 fit older women attending a biweekly mild fitness program. Measurements: Dietary habits was investigated through a 3-day record questionnaire. Serum 25(OH)D and intact parathormone (PTH) concentrations were measured by radioimmunoassay and by a 2-step immunoradiometric assay, respectively. BMD and body composition were estimated using dualenergy X-ray absorptiometry with fan-beam technology. Results: Only fat mass showed a significant negative association with 25(OH)D (β=-3.76, p
Published: 2016

12. Serum Dehydroepiandrosterone Sulfate and Risk for Type 2 Diabetes in Older Men and Women: The Pro.V.A Study

Author: Giuseppe Sergi, Egle Perissinotto, Marina De Rui, Sabina Zambon, Maria Chiara Corti, Giovannella Baggio, Gaetano Crepaldi, Stefania Maggi, Caterina Trevisan, Nicola Veronese, Enzo Manzato, Francesco Bolzetta, Veronese, N., Trevisan, C., De Rui, M., Bolzetta, F., Maggi, S., Zambon, S., Corti, M.C., Baggio, G., Perissinotto, E., Crepaldi, G., Manzato, E., and Sergi, G.
Subjects: Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, DHEAS, Endocrinology, Diabetes and Metabolism, Blood sugar, Physiology, 030209 endocrinology & metabolism, Type 2 diabetes, NO, sex hormones in the pathogenesis of diabete, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, Elderly, 0302 clinical medicine, Endocrinology, Dehydroepiandrosterone sulfate, Risk Factors, Internal medicine, Diabetes mellitus, Internal Medicine, Humans, Medicine, Aged, Glycated Hemoglobin, Dehydroepiandrosterone Sulfate, business.industry, Incidence (epidemiology), General Medicine, Prognosis, medicine.disease, Community-dwelling adults, Diabetes and Metabolism, 030104 developmental biology, Diabetes Mellitus, Type 2, chemistry, dehydroepiandrosterone sulfate (DHEAS), Cohort, Female, Glycated hemoglobin, business, Biomarkers, Follow-Up Studies, Cohort study
Abstract: Objective: A large body of clinical data suggests the importance of endogenous sex hormones in the pathogenesis of diabetes, but very little is known about the possible relationship between dehydroepiandrosterone sulfate (DHEAS) and diabetes, particularly in the elderly. We aimed, therefore, to examine whether high serum levels of DHEAS have any protective effects on the incidence of type 2 diabetes and to elucidate the possible role of gender in a cohort of older subjects. Methods: We followed 1258 community-dwelling subjects aged ≥65 years without type 2 diabetes who belonged to the Progetto Veneto Anziani (Pro.V.A.) for 4.4±1.2 years. DHEAS were measured at baseline and categorized into gender-specific tertiles. The incidence of type 2 diabetes was diagnosed in cases of fasting plasma glucose above 7.0 nmol/L, glycated hemoglobin ≥6.5%, use of glucose-lowering drugs or a 2-hour postload blood sugar level ≥11.1 nmol/L during the follow-up period. Results: Although no significant differences in potential risk factors for diabetes were apparent across DHEAS tertiles at the baseline in either gender, when those with lower DHEAS were taken for reference, Cox regression analysis showed that males in the highest DHEAS tertile had lower risks for being diagnosed with diabetes during the follow up (HR = 0.23; 95% CI: 0.11-0.51; p < 0.0001), whereas no significant differences emerged across DHEAS tertiles for females or for the sample as a whole. Conclusions: Higher serum DHEAS levels revealed a significant protective effect against the onset of type 2 diabetes in older men but not in older women, confirming different sensitivities of type 2 diabetes to DHEAS between genders. Objectif: Méthodes: Résultats: Conclusions: © 2016 Canadian Diabetes Association.
Published: 2016

13. Acute decompensated heart failure: Decision pathways for older people

Author: M. De Rui, Enzo Manzato, S. Carraro, Giuseppe Sergi, Nicola Veronese, Carraro, S., Veronese, N., De Rui, M., Manzato, E., and Sergi, G.
Subjects: medicine.medical_specialty, education.field_of_study, Acute decompensated heart failure, acute heart failure, business.industry, Mortality rate, Population, Emergency department, comprehensive geriatric assessment, medicine.disease, Multidisciplinary approach, Heart failure, Intensive care, medicine, Geriatrics and Gerontology, Disease management (health), Intensive care medicine, business, education, Gerontology
Abstract: Introduction: Acute decompensated heart failure (ADHF) is a common condition in older people, but little research has been conducted on the appropriate decision pathways for this population. The aim of this review was to explore ADHF management in older people, paying particular attention to the comprehensive geriatric assessment (CGA). Material and methods: A search was run in the PubMed literature database, combining the term "acute heart failure" with "management", "geriatric" "multidisciplinary", "co-management", "co-care", "approach", and "comprehensive geriatric assessment", from the databases inception to 1st January 2015. A manual check was also conducted on the reference lists in the articles and reviews identified as relevant to check for any additional sources of information. Results: The management of older patients with ADHF depends on the setting. After being assessed at the emergency department, unstable patients could be addressed to intensive care or coronary care units, while the in-hospital solutions for stable patients could be an observation unit or a cardiology or internal medicine ward. For end-stage patients, the hospital at home with telemonitoring and the hospice are worthwhile options. In all these settings, a CGA could improve the management of patients with ADHF. Conclusions: The most appropriate pathway for elderly ADHF patient management depends on several factors, including hemodynamic stability, social and family networks. CGA seems to be relevant because it enables a global assessment of this complex patient. Future trials are needed, however, to test whether a multidimensional approach to these patients could reduce their mortality rate and other negative outcomes. © 2015 Elsevier Masson SAS and European Union Geriatric Medicine Society.
Published: 2015

14. Effects of acetyl-l-carnitine in diabetic neuropathy and other geriatric disorders

Author: S. Pizzato, G. Sergi, Francesca Piovesan, Nicola Veronese, Caterina Trevisan, Enzo Manzato, Sergi, G., Pizzato, S., Piovesan, F., Trevisan, C., Veronese, N., and Manzato, E.
Subjects: 0301 basic medicine, Nervous system, Aging, medicine.medical_specialty, Diabetic neuropathy, Pain, Neurotrophic effect, Acetyl-l-carnitine, Analgesia, Geriatrics and Gerontology, NO, 03 medical and health sciences, 0302 clinical medicine, Diabetic Neuropathies, Alzheimer Disease, Internal medicine, Diabetes mellitus, medicine, Humans, Carnitine, Acetylcarnitine, Acetyl-l-carnitine, Diabetic neuropathy, Analgesia, Neurotrophic effect, Aged, Analgesics, business.industry, Glutamate receptor, medicine.disease, Mitochondria, 030104 developmental biology, Nerve growth factor, Endocrinology, medicine.anatomical_structure, Alzheimer's disease, business, 030217 neurology & neurosurgery, medicine.drug
Abstract: A long history of diabetes mellitus and increasing age are associated with the onset of diabetic neuropathy, a painful and highly disabling complication with a prevalence peaking at 50% among elderly diabetic patients. Acetyl-l-carnitine (ALC) is a molecule derived from the acetylation of carnitine in the mitochondria that has an essential role in energy production. It has recently been proposed as a therapy to improve the symptoms of diabetic neuropathy. ALC is widely distributed in mammalian tissues, including the brain, blood–brain barrier, brain neurons, and astrocytes. Aside from its metabolic activity, ALC has demonstrated cytoprotective, antioxidant, and antiapoptotic effects in the nervous system. It exerts an analgesic action by reducing the concentration of glutamate in the synapses. It facilitates nerve regeneration and damage repair after primary trauma: its positive effects on metabolism promote the synthesis, fluidity, and functionality of neuronal membranes, increase protein synthesis, and improve the axonal transport of neurofilament proteins and tubulin. It also amplifies nerve growth factor responsiveness, an effect that is believed to enhance overall neurite growth. ALC has been proposed for the treatment of various neurological and psychiatric diseases, such as mood disorders and depression, dementias, Alzheimer’s disease, and Parkinson’s disease, because synaptic energy states and mitochondrial dysfunction are core factors in their pathogenesis. © 2017, Springer International Publishing Switzerland.
Published: 2018

15. Assessing appendicular skeletal muscle mass with bioelectrical impedance analysis in free-living Caucasian older adults

Author: Egle Perissinotto, Alessandra Coin, Marina De Rui, Enzo Manzato, Francesco Bolzetta, Nicola Veronese, Giuseppe Sergi, Linda Berton, S. Carraro, Giulia Bano, Sergi, G., De Rui, M., Veronese, N., Bolzetta, F., Berton, L., Carraro, S., Bano, G., Coin, A., Manzato, E., and Perissinotto, E.
Subjects: Male, medicine.medical_specialty, Critical Care and Intensive Care Medicine, White People, Body Mass Index, Absorptiometry, Photon, Internal medicine, Electric Impedance, Humans, Medicine, Dual x-ray absorptiometry, Muscle, Skeletal, Aged, Aged, 80 and over, Multiple regression equation, Nutrition and Dietetics, business.industry, Body Weight, Reproducibility of Results, Middle Aged, SarcopeniaBody compositionPrediction equationLimbs lean massOlder adults, medicine.disease, Skeletal muscle mass, Resistive index, Surgery, Cross-Sectional Studies, Sarcopenia, Body Composition, Linear Models, Lean body mass, Cardiology, Female, business, Bioelectrical impedance analysis
Abstract: Background & aims: Aging is characterized by a loss of appendicular skeletal muscle mass (ASMM) leading to physical disability and death. Bioelectrical impedance analysis (BIA) is reliable in estimating ASMM but no prediction equations are available for elderly Caucasian subjects. The aim of the study was to develop and validate an equation derived from bioelectrical impedance analysis (BIA) to predict appendicular skeletal muscle mass (ASMM) in healthy Caucasian elderly subjects, taking dual X-ray absorptiometry (DXA) as the reference method, and comparing the reliability of the new equation with another BIA-based model developed by Kyle etal. (Kyle UG, Genton L, Hans D, Pichard C, 2003). Methods: With a cross-sectional design, 296 free-living, healthy Caucasian subjects (117 men, 179 women) over 60 years of age were enrolled. Lean mass of limbs was measured with DXA to ascertain ASMM (ASMMDxA). Whole-body tetrapolar BIA was performed to measure resistance (Rz), resistance normalized for stature (RI), and reactance (Xc). The BIA multiple regression equation for predicting ASMM was developed using a double cross-validation technique. The predicted ASMM values were compared with ASMMKyle, i.e. ASMM estimates derived from the model developed by Kyle etal. (Kyle etal., 2003). Results: Cross-validation resulted in a unique equation using the whole sample: ASMM (kg)=-3.964+(0.227*RI)+(0.095*weight)+(1.384*sex)+(0.064*Xc) [R2=0.92 and SEE=1.14kg]. In our sample, ASMMKyle differed significantly from the ASMMDxA (p
Published: 2015

16. Effect of acetyl-l-carnitine in the treatment of diabetic peripheral neuropathy : A systematic review and meta-analysis

Author: Gaetano Crepaldi, Daniel Tessier, Cornel C. Sieber, Giuseppe Sergi, Mario Barbagallo, Nicola Veronese, Brendon Stubbs, Sophie Gillain, Isabelle Bourdel-Marchasson, Stefania Maggi, Timo E. Strandberg, Enzo Manzato, Clinicum, Department of Medicine, Timo Strandberg / Principal Investigator, Geriatrian yksikkö, HUS Internal Medicine and Rehabilitation, Veronese, N., Sergi, G., Stubbs, B., Bourdel-Marchasson, I., Tessier, D., Sieber, C., Strandberg, T., Gillain, S., Barbagallo, M., Crepaldi, G., Maggi, S., and Manzato, E.
Subjects: medicine.medical_specialty, Diabetic neuropathy, Diabete, Placebo, Nerve conduction velocity, law.invention, RATS, 03 medical and health sciences, GLUTAMATE, 0302 clinical medicine, Randomized controlled trial, law, Diabetes mellitus, Medicine, QUALITY, Meta-analysi, 030212 general & internal medicine, Ulnar nerve, Adverse effect, business.industry, Diabetes, NERVE GROWTH-FACTOR, PAIN, medicine.disease, Acetyl-L-carnitine, 3. Good health, Surgery, Neuropathy, Meta-analysis, Gerontology, Geriatrics and Gerontology, Peripheral neuropathy, Anesthesia, 3121 General medicine, internal medicine and other clinical medicine, business, 030217 neurology & neurosurgery, CLINICAL-TRIALS
Abstract: Background/aim: Deficiency of acetyl-L-carnitine (ALC) and L-carnitine (LC) appears to play a role in peripheral diabetic neuropathy, although the evidence in humans is still limited. We conducted a systematic review and meta-analysis investigating the effect of ALC on pain and electromyographic parameters in people with diabetic neuropathy. Methods: A literature search in major databases, without language restriction, was undertaken. Eligible studies were randomized controlled trials (RCTs) or pre-and post-test studies. The effect of ALC supplementation on pain perception and electromyographic parameters in patients with diabetic neuropathy was compared vs. a control group (RCTs). The effect of ALC/LC on electromyographic parameters were also calculated vs. baseline values. Standardized mean differences (SMD) and 95% confidence intervals (CIs) were used for summarizing outcomes. Results: Six articles, with a total of 711 diabetic participants, were included. Three RCTs (340 treated with ALC vs. 203 placebo and 115 with methylcobalamine) showed that ALC reduces pain perception (SMD = -0.45; 95% CI: -0.86 to -0.04; P = 0.03; I-2 = 85%). Compared to controls, ALC supplementation improved nerve conduction velocity and amplitude response for ulnar nerve (both sensory and motor component). Compared to baseline values, ALC/LC supplementation improved nerve conduction velocity for all the sensory and motor nerves (except ulnar and peroneal) investigated and the amplitude of all nerves. The onset of adverse events was generally limited to minor side effects. Conclusion: ALC appears to be effective in reducing pain due to diabetic neuropathy compared to active or placebo controls and improving electromyographic parameters in these patients. (C) 2017 Elsevier Masson SAS and European Union Geriatric Medicine Society. All rights reserved.
Published: 2017

17. Low vitamin D levels increase the risk of type 2 diabetes in older adults: A systematic review and meta-analysis

Author: Giuseppe Sergi, Nicola Veronese, Brendon Stubbs, Youssef Kouidrat, Marco Solmi, Giulia Bano, Enzo Manzato, Patricia Schofield, Anna Bertocco, Caterina Trevisan, Paola Lucato, Stefania Maggi, Lucato, P., Solmi, M., Maggi, S., Bertocco, A., Bano, G., Trevisan, C., Manzato, E., Sergi, G., Schofield, P., Kouidrat, Y., Veronese, N., and Stubbs, B.
Subjects: Genetics and Molecular Biology (all), Adult, Risk, medicine.medical_specialty, 030209 endocrinology & metabolism, vitamin D, Type 2 diabetes, Biochemistry, General Biochemistry, Genetics and Molecular Biology, vitamin D deficiency, NO, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Vitamin D and neurology, Humans, Medicine, Cumulative incidence, 030212 general & internal medicine, Vitamin D, Prospective cohort study, Aged, diabetes, business.industry, Diabetes, Confounding, Hypovitaminosis D, Obstetrics and Gynecology, Vitamins, Vitamin D Deficiency, medicine.disease, Meta-analysis, Biochemistry, Genetics and Molecular Biology (all), meta-analysis, aged, Diabetes Mellitus, Type 2, hypovitaminosis D, Physical therapy, business, Vitamin D, Hypovitaminosis D, Diabetes,Aged, Meta-analysis
Abstract: Low serum levels of 25 hydroxyvitamin D (25OHD) (hypovitaminosis D) is common in older adults and associated with several negative outcomes. The association between hypovitaminosis D and diabetes in older adults is equivocal, however. We conducted a meta-analysis investigating if hypovitaminosis D is associated with diabetes in prospective studies among older participants. Two investigators systematically searched major electronic databases, from inception until 10/07/2016. The cumulative incidence of diabetes among groups was estimated according to baseline serum 25OHD levels. Random effect models were used to assess the association between hypovitaminosis D and diabetes at follow-up. From 4268 non-duplicate hits, 9 studies were included; these followed 28,258 participants with a mean age of 67.7 years for a median of 7.7 years. Compared with higher levels of 25OHD, lower levels of 25OHD were associated with a higher risk of developing diabetes (6 studies; n=13,563; RR=1.31; 95% CI: 1.11–1.54; I2=37%). The findings remained significant after adjusting for a median of 11 potential confounders in all the studies available (9 studies; n=28,258; RR=1.17; 95% CI: 1.03–1.33; p=0.02; I2=0%). In conclusion, our data suggest that hypovitaminosis D is associated with an elevated risk of future diabetes in older people. Future longitudinal studies are required and should seek to confirm these findings and explore potential pathophysiological underpinnings. © 2017 Elsevier B.V.
Published: 2017

18. Geriatric Insights on Elderly Women and Heart Disease

Author: Giuseppe Sergi, Enzo Manzato, Stefania Maggi, Caterina Trevisan, Nicola Veronese, Trevisan, C., Maggi, S., Manzato, E., Sergi, G., and Veronese, N.
Subjects: Elderly, Heart diseases, Sex differences, Pharmacology, Gerontology, Heart disease, business.industry, media_common.quotation_subject, Longevity, 030204 cardiovascular system & hematology, medicine.disease, NO, Heart diseases, Sex differences, Elderly, Clinical Practice, 03 medical and health sciences, 0302 clinical medicine, Elderly population, Medicine, Pharmacology (medical), Lack of knowledge, Potential source, 030212 general & internal medicine, business, media_common
Abstract: Purpose of Review: The prevalence of heart diseases is growing in recent years and will further rise because of the increased longevity of elderly population, mainly reported for the female gender. Recent Findings: Several studies have demonstrated the presence of a large sex-specific variability on physiopathology, presentation, and overall prognosis of cardiovascular diseases (CVD). Women, in particular, tend to present heart diseases generally later than men, have a higher number of comorbidities, and report worse outcomes. Moreover, atypical symptomatology of heart diseases in older women constitutes a potential source of delay in the identification of such pathologies, influencing the management of CVDs that is still characterized by a lesser access to invasive procedures for the female gender compared with the male one. The lack of knowledge in the field of sex-specific disparities in CVDs is probably due to the underrepresentation of women in the first large cardiovascular trials, with the processing of guidelines for the prevention, identification, and treatment of CVDs that do not consider gender variability. Summary: Although growing attention has been recently dedicated to this topic, further investigations are needed to fully analyze heart diseases in elderly women with the aim of developing new and targeted recommendations for clinical practice. © 2017, Springer Science+Business Media New York.
Published: 2017

19. Pain increases the risk of developing frailty in older adults with osteoarthritis

Author: Gaetano Crepaldi, Brendon Stubbs, Marina De Rui, Francesco Bolzetta, Stefania Maggi, Caterina Trevisan, Leonardo Sartori, Sabina Zambon, Egle Perissinotto, Marianna Noale, Estella Musacchio, Giuseppe Sergi, Nicola Veronese, Enzo Manzato, Veronese, N., Maggi, S., Trevisan, C., Noale, M., De Rui, M., Bolzetta, F., Zambon, S., Musacchio, E., Sartori, L., Perissinotto, E., Stubbs, B., Crepaldi, G., Manzato, E., and Sergi, G.
Subjects: Male, medicine.medical_specialty, Frail Elderly, Poison control, Pain, Osteoarthritis, Logistic regression, NO, Cohort Studies, 03 medical and health sciences, Frailty and Elderly, 0302 clinical medicine, Injury prevention, medicine, Humans, 030212 general & internal medicine, Prospective cohort study, Aged, Aged, 80 and over, business.industry, Medical record, Confounding, General Medicine, Anthropometry, medicine.disease, Anesthesiology and Pain Medicine, Cross-Sectional Studies, Physical therapy, Female, Osteoarthriti, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract: OBJECTIVE.: While osteoarthritis (OA)-related pain increases the risk of physical inactivity, disability, and falls, less is known about whether pain increases the risk of frailty. We investigated if people with OA reporting pain are more likely to develop frailty than people with OA without pain. DESIGN.: Population-based prospective cohort study with a follow-up of 4.4 years. SETTING.: Community. SUBJECTS.: The subjects were 1,775 older men and women with osteoarthritis, enrolled in the Progetto Veneto Anziani. METHODS.: Pain was ascertained according to medical records, symptoms/signs, and use of analgesics. Participants were considered frail if they met three out of five criteria of Fried’s Index. RESULTS.: Cross-sectional analysis at baseline demonstrated that after adjusting for potential confounders (age, gender, anthropometric and demographic data, comorbidities), people with OA and pain (n = 568) were significantly more likely to have frailty compared with those with OA without pain (n = 1,207; hand OA, OR = 1.86, 95% CI = 1.65-2.09; hip OA, OR = 1.62, 95% CI = 1.44-1.83; knee OA, OR = 1.42, 95% CI = 1.26-1.60; all p
Published: 2017

20. Inflammation and sarcopenia: A systematic review and meta-analysis

Author: Brendon Stubbs, Nicola Veronese, Claudio Luchini, Marco Solmi, Giulia Bano, Enzo Manzato, Giuseppe Sergi, S. Carraro, Caterina Trevisan, Bano, G., Trevisan, C., Carraro, S., Solmi, M., Luchini, C., Stubbs, B., Manzato, E., Sergi, G., and Veronese, N.
Subjects: Sarcopenia, Inflammation, Meta-analysis, C reactive protein, medicine.medical_specialty, Sarcopenia, Inflammation, Gastroenterology, General Biochemistry, Genetics and Molecular Biology, Proinflammatory cytokine, NO, sarcopenia, 03 medical and health sciences, 0302 clinical medicine, C reactive protein, Meta-analysis, Biomarkers, C-Reactive Protein, Case-Control Studies, Cross-Sectional Studies, Humans, Interleukin-6, Tumor Necrosis Factor-alpha, Internal medicine, medicine, 030212 general & internal medicine, Wasting, biology, business.industry, C-reactive protein, Obstetrics and Gynecology, medicine.disease, Confidence interval, meta-analysis, Protein catabolism, Endocrinology, inflammation, biology.protein, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: Inflammatory cytokines have been shown to prompt muscle wasting, ultimately stimulating protein catabolism and suppressing muscle synthesis. However, the possible association between inflammatory parameters and sarcopenia is poorly understood. We therefore aimed to summarize the current evidence about this topic with a meta-analysis of studies reporting serum inflammatory parameters in patients with sarcopenia vs. people without sarcopenia (controls). An electronic PubMed and Scopus search through to 09/01/2016 and meta-analysis of cross-sectional studies comparing serum levels of inflammatory cytokines between patients with sarcopenia and controls was made, calculating random-effects standardized mean differences (SMDs) ±95% confidence intervals (CIs) as the effect size. Out of 1370 initial hits, 17 studies with a total of 11249 participants (3072 with sarcopenia and 8177 without) were meta-analyzed. Sarcopenic participants had significantly higher levels of CRP (SMD = 0.51; 95%CI 0.26, 0.77; p < 0.0001; I2 = 96%) than controls. Conversely, serum IL6 levels were not significantly different (SMD = 0.35; 95%CI: −0.19, 0.89; p = 0.21; I2 = 97%) in people with sarcopenia versus controls. Sarcopenic people did not have higher levels of TNF-α than controls (SMD = 0.28; 95%CI −0.26, 0.83; p = 0.31; I2 = 97%). In conclusion, sarcopenia seems to be associated with elevated serum CRP levels; future longitudinal studies are needed to clarify this relationship. © 2016 Elsevier Ireland Ltd
Published: 2017

21. Hyperuricemia, cardiovascular profile, and comorbidity in older men and women: The Pro.V.A. Study

Author: Sabina Zambon, Leonardo Punzi, Egle Perissinotto, Nicola Veronese, Leonardo Sartori, Roberta Ramonda, Giovannella Baggio, Gaetano Crepaldi, Maria Chiara Corti, Estella Musacchio, Enzo Manzato, Musacchio, E., Perissinotto, E., Sartori, L., Veronese, N., Punzi, L., Zambon, S., Manzato, E., Baggio, G., Corti, M.-C., Crepaldi, G., and Ramonda, R.
Subjects: Male, Aging, medicine.medical_specialty, Prevalence, Comorbidity, Hyperuricemia, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Epidemiology, medicine, Odds Ratio, Humans, Life Style, Aged, 030203 arthritis & rheumatology, Anthropometry, business.industry, Case-control study, Odds ratio, medicine.disease, Uric Acid, Logistic Models, Italy, Cardiovascular Diseases, Case-Control Studies, Physical therapy, Female, cardiovascular diseases, comorbidity, elderly, gender, hypertension, hyperuricemia, Geriatrics and Gerontology, business, Body mass index
Abstract: Hyperuricemia (HU) is growing worldwide and associates with several medical conditions in the elderly. However, data about older people and possible gender differences are sparse. The aim of this study was to compare HU prevalence rates and association with relevant medical disorders in elderly subjects of both sexes. Pro.V.A. is a survey of 3099 individuals aged 65+, focusing on chronic diseases and disability. Uric acid (UA) levels were dichotomized using 6.0 mg/dL (females) and 7.0 mg/dL (males), and multivariate logistic regression models were used to estimate odds ratios (ORs) between HU and single comorbidity. HU prevalence was 21.5% in females and 15.8% in males. HU was associated with most anthropometric and laboratory variables in women, but not in men. After adjustment for age, body mass index, and renal function, HU was independently associated with the presence of cardiovascular diseases in both sexes. In women, HU was associated with hand osteoarthritis (OR = 1.52; 95%CI: 1.12-2.08) and edentulism (OR = 1.31; 95%CI: 1.01-1.71), while resulted protective for osteoporosis (OR = 0.69; 95%CI: 0.53-0.91). In men, HU was significantly related with knee osteoarthritis (OR = 1.72; 95%CI: 1.06-2.79) and chronic obstructive pulmonary disease (OR = 1.60; 95%CI: 1.04-2.45). The presence of ≥4 comorbidities was a stronger determinant of HU in men (OR = 2.54; 95%CI: 1.21-5.37) than in women (ns). Patterns of age-dependent UA increase are markedly different in men and women. HU prevalence is substantial and its association with other diseases is gender specific, connoting a peculiar clinical profile.
Published: 2017

22. Familial hypercholesterolemia: The Italian Atherosclerosis Society Network (LIPIGEN)

Author: Averna, Maurizio, Cefalã¹, Angelo B., Casula, Manuela, Noto, Davide, Arca, Marcello, Bertolini, Stefano, Calandra, Sebastiano, Catapano, Alberico L., Tarugi, Patrizia, Catapano, Alberico Luigi, Pellegatta, Fabio, Angelico, Francesco, Bartuli, Andrea, Biasucci, Giacomo, Biolo, Gianni, Bonanni, Luca, Bonomo, Katia, Borghi, Claudio, Bossi, Antonio Carlo, Branchi, Adriana, Carubbi, Francesca, Cipollone, Francesco, Citroni, Nadia, Federici, Massimo, Ferri, Claudio, Fiorenza, Anna Maria, Giaccari, Andrea, Giorgino, Francesco, Guardamagna, Ornella, Iannuzzi, Arcangelo, Iughetti, Lorenzo, Lupattelli, Graziana, Mandraffino, Giuseppe, Marcucci, Rossella, Mombelli, Giuliana, Muntoni, Sandro, Pecchioli, Valerio, Pederiva, Cristina, Pipolo, Antonio, Pisciotta, Livia, Pujia, Arturo, Purrello, Francesco, Repetti, Elena, Rubba, Paolo, SabbÃ&nbsp, Carlo, Sampietro, Tiziana, Sarzani, Riccardo, Tagliabue, Milena Paola, Trenti, Chiara, Vigna, Giovanni Battista, Werba, JosÃ Pablo, Zambon, Sabina, Zenti, Maria Grazia, Montali, Anna, Fortunato, Giuliana, Grigore, Liliana, Del Ben, Maria, Maranghi, Marianna, Barbagallo, Carlo M., Buonuomo, Paola Sabrina, Capra, Maria Elena, Vinci, Pierandrea, D'Addato, Sergio, Galbiati, Stella, Nascimbeni, Fabio, Bucci, Marco, Spagnoli, Walter, Cardolini, Iris, Cervelli, Nazzareno, Emanuela, Colombo, Vinsin, A. Sun, Laviola, Luigi, Bello, Francesca, Chiariello, Giuseppe, Predieri, Barbara, Siepi, Donatella, Saitta, Antonino, Giusti, Betti, Pavanello, Chiara, Lussu, Milena, Prati, Lucia, Banderali, Giuseppe, Balleari, Giulia, Montalcini, Tiziana, Scicali, Roberto, Gentile, Luigi, Gentile, Marco, Suppressa, Patrizia, Sbrana, Francesco, Cocci, Guido, Benso, Andrea, Negri, Emanuele Alberto, Ghirardello, Omar, Lorenzo, Vigo, Zambon, Alberto, Enzo, Bonora, Minicocci, Ilenia, Spina, Rossella, Orlando, Camilla, Di Taranto, Maria Donata, Chiodo, Lorenzo, Garlaschelli, Katia, Manzato, Enzo, Tragni, Elena, Averna, M., Cefalu', A., Casula, M., Noto, D., Arca, M., Bertolini, S., Calandra, S., Catapano, A., Tarugi, P., Pellegatta, F., Angelico, F., Bartuli, A., Biasucci, G., Biolo, G., Bonanni, L., Bonomo, K., Borghi, C., Bossi, A., Branchi, A., Carubbi, F., Cipollone, F., Citroni, N., Federici, M., Ferri, C., Fiorenza, A., Giaccari, A., Giorgino, F., Guardamagna, O., Iannuzzi, A., Iughetti, L., Lupattelli, G., Mandraffino, G., Marcucci, R., Mombelli, G., Muntoni, S., Pecchioli, V., Pederiva, C., Pipolo, A., Pisciotta, L., Pujia, A., Purrello, F., Repetti, E., Rubba, P., Sabbã , C., Sampietro, T., Sarzani, R., Tagliabue, M., Trenti, C., Vigna, G., Werba, J., Zambon, S., Zenti, M., Montali, A., Fortunato, G., Grigore, L., Del Ben, M., Maranghi, M., Cefalã¹, A., Barbagallo, C., Buonuomo, P., Capra, M., Vinci, P., D'Addato, S., Galbiati, S., Nascimbeni, F., Bucci, M., Spagnoli, W., Cardolini, I., Cervelli, N., Emanuela, C., Vinsin, A., Laviola, L., Bello, F., Chiariello, G., Predieri, B., Siepi, D., Saitta, A., Giusti, B., Pavanello, C., Lussu, M., Prati, L., Banderali, G., Balleari, G., Montalcini, T., Scicali, R., Gentile, L., Gentile, M., Suppressa, P., Sbrana, F., Cocci, G., Benso, A., Negri, E., Ghirardello, O., Lorenzo, V., Zambon, A., Enzo, B., Minicocci, I., Spina, R., Orlando, C., Di Taranto, M., Chiodo, L., Garlaschelli, K., Manzato, E., Tragni, E., Averna, Maurizio, Cefalã¹, Angelo B., Casula, Manuela, Noto, Davide, Arca, Marcello, Bertolini, Stefano, Calandra, Sebastiano, Catapano, Alberico L., Tarugi, Patrizia, Catapano, Alberico Luigi, Pellegatta, Fabio, Angelico, Francesco, Bartuli, Andrea, Biasucci, Giacomo, Biolo, Gianni, Bonanni, Luca, Bonomo, Katia, Borghi, Claudio, Bossi, Antonio Carlo, Branchi, Adriana, Carubbi, Francesca, Cipollone, Francesco, Citroni, Nadia, Federici, Massimo, Ferri, Claudio, Fiorenza, Anna Maria, Giaccari, Andrea, Giorgino, Francesco, Guardamagna, Ornella, Iannuzzi, Arcangelo, Iughetti, Lorenzo, Lupattelli, Graziana, Mandraffino, Giuseppe, Marcucci, Rossella, Mombelli, Giuliana, Muntoni, Sandro, Pecchioli, Valerio, Pederiva, Cristina, Pipolo, Antonio, Pisciotta, Livia, Pujia, Arturo, Purrello, Francesco, Repetti, Elena, Rubba, Paolo, Sabbã , Carlo, Sampietro, Tiziana, Sarzani, Riccardo, Tagliabue, Milena Paola, Trenti, Chiara, Vigna, Giovanni Battista, Werba, Josã Pablo, Zambon, Sabina, Zenti, Maria Grazia, Montali, Anna, Fortunato, Giuliana, Grigore, Liliana, DEL BELLO, Francesca, Maranghi, Marianna, Barbagallo, Carlo M., Buonuomo, Paola Sabrina, Capra, Maria Elena, Vinci, Pierandrea, D'Addato, Sergio, Galbiati, Stella, Nascimbeni, Fabio, Bucci, Marco, Spagnoli, Walter, Cardolini, Iri, Cervelli, Nazzareno, Emanuela, Colombo, Vinsin, A. Sun, Laviola, Luigi, Bello, Francesca, Chiariello, Giuseppe, Predieri, Barbara, Siepi, Donatella, Saitta, Antonino, Giusti, Betti, Pavanello, Chiara, Lussu, Milena, Prati, Lucia, Banderali, Giuseppe, Balleari, Giulia, Montalcini, Tiziana, Scicali, Roberto, Gentile, Luigi, Gentile, Marco, Suppressa, Patrizia, Sbrana, Francesco, Cocci, Guido, Benso, Andrea, Negri, Emanuele Alberto, Ghirardello, Omar, Lorenzo, Vigo, Zambon, Alberto, Enzo, Bonora, Minicocci, Ilenia, Spina, Rossella, Orlando, Camilla, Di Taranto, Maria Donata, Chiodo, Lorenzo, Garlaschelli, Katia, Manzato, Enzo, Tragni, Elena, Cefalù, Angelo B., Sabbà, Carlo, Werba, Josè Pablo, Del Ben, Maria, and Colombo, Emanuela
Subjects: 0301 basic medicine, Candidate gene, Genetic testing, Settore MED/09 - Medicina Interna, Databases, Factual, DNA Mutational Analysis, Disease, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, 0302 clinical medicine, Dyslipidemias, National network, Internal Medicine, Cardiology and Cardiovascular Medicine, Risk Factors, Prospective Studies, Program Development, Prospective cohort study, medicine.diagnostic_test, General Medicine, Prognosis, Cholesterol, Phenotype, Italy, Genetic Markers, medicine.medical_specialty, MEDLINE, Hyperlipoproteinemia Type II, 03 medical and health sciences, Databases, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Factual, Retrospective Studies, business.industry, Settore MED/13 - ENDOCRINOLOGIA, Retrospective cohort study, medicine.disease, Atherosclerosis, Mutation, 030104 developmental biology, Endocrinology, Dyslipidemia, Genetic marker, business
Abstract: Background and aims: Primary dyslipidemias are a heterogeneous group of disorders characterized by abnormal levels of circulating lipoproteins. Among them, familial hypercholesterolemia is the most common lipid disorder that predisposes for premature cardiovascular disease. We set up an Italian nationwide network aimed at facilitating the clinical and genetic diagnosis of genetic dyslipidemias named LIPIGEN (LIpid TransPort Disorders Italian GEnetic Network). Methods: Observational, multicenter, retrospective and prospective study involving about 40 Italian clinical centers. Genetic testing of the appropriate candidate genes at one of six molecular diagnostic laboratories serving as nationwide DNA diagnostic centers. Results and conclusions: From 2012 to October 2016, available biochemical and clinical information of 3480 subjects with familial hypercholesterolemia identified according to the Dutch Lipid Clinic Network (DLCN) score were included in the database and genetic analysis was performed in 97.8% of subjects, with a mutation detection rate of 92.0% in patients with DLCN score >= 6. The establishment of the LIPIGEN network will have important effects on clinical management and it will improve the overall identification and treatment of primary dyslipidemias in Italy. (C) 2017 The Authors. Published by Elsevier Ireland Ltd.
Published: 2017

23. Results of an Observational Cohort Study of Hyperuricemia as a Predictor of Poor Physical Performance in the Elderly

Author: S Zambon, Egle Perissinotto, Gaetano Crepaldi, Brendon Stubbs, Giuseppe Sergi, Caterina Trevisan, Stefania Maggi, Nicola Veronese, Enzo Manzato, Francesco Bolzetta, Marianna Noale, Leonardo Sartori, Marina De Rui, Estella Musacchio, Veronese, N., Stubbs, B., Trevisan, C., Bolzetta, F., De Rui, M., Maggi, S., Sartori, L., Musacchio, E., Zambon, S., Perissinotto, E., Noale, M., Crepaldi, G., Manzato, E., and Sergi, G.
Subjects: Male, medicine.medical_specialty, Hyperuricemia, Cohort Studies, 03 medical and health sciences, Aged, Aged, 80 and over, Exercise, Female, Follow-Up Studies, Humans, Italy, Longitudinal Studies, Muscle Strength, Predictive Value of Tests, Psychomotor Performance, Rheumatology, 0302 clinical medicine, Internal medicine, medicine, 80 and over, 030212 general & internal medicine, Exercise physiology, Cohort Study, Hyperuricemia, 030203 arthritis & rheumatology, business.industry, Odds ratio, medicine.disease, Confidence interval, Physical performance, Predictive value of tests, Older people, business, Cohort study
Abstract: Objective: Hyperuricemia is frequent in older people and associated with several medical conditions. The relationship between hyperuricemia and physical performance is limited. We aimed to investigate the association between hyperuricemia and physical performance over a 4.4-year followup in the elderly. Methods: A total of 1,904 community-dwelling older participants were followed for a mean of 4.4 years. Hyperuricemia at baseline was defined using serum uric acid concentrations ≥6 and ≥7 mg/dl for women and men, respectively. Objective physical performance tests measured included the Short Physical Performance Battery (SPPB), 4-meter gait speed, chair-stands time, leg extension and flexion, handgrip strength, and the 6-minute walking test. Results: At baseline, participants with hyperuricemia (n = 98 men, 232 women) scored significantly worse in all the tests investigated. After adjusting for 19 covariates, men with hyperuricemia at baseline had an increased risk of having poor SPPB scores at followup (odds ratio [OR] 1.44 [95% confidence interval (95% CI) 1.21–1.72]; P < 0.0001), poor chair-stands time (OR 1.40 [95% CI 1.18–1.6]; P < 0.0001), poor leg extension (OR 1.47 [95% CI 1.21–1.7]; P < 0.0001), and poor handgrip strength (OR 1.54 [95% CI 1.24–1.90]; P < 0.0001). Among women, hyperuricemia was associated with an increased risk of having poor scores in all the SPPB items and in leg flexion (OR 1.26 [95% CI 1.08–1.49]; P = 0.03). Conclusion: Hyperuricemia seems to be significantly associated with poor physical performance in older people, over a followup of 4.4 years. The relationship appears to be more consistent in men than in women. Further longitudinal research is required to better understand the relationships and potential biologic pathways. © 2016, American College of Rheumatology
Published: 2017

24. Spectrum of mutations in Italian patients with familial hypercholesterolemia: New results from the LIPIGEN study

Author: Pirillo, Angela, Garlaschelli, Katia, Arca, Marcello, Averna, Maurizio, Bertolini, Stefano, Calandra, Sebastiano, Tarugi, Patrizia, Catapano, Alberico L., Catapano, Alberico Luigi, Pellegatta, Fabio, Angelico, Francesco, Bartuli, Andrea, Biasucci, Giacomo, Biolo, Gianni, Bonanni, Luca, Bonomo, Katia, Borghi, Claudio, Bossi, Antonio Carlo, Branchi, Adriana, Carubbi, Francesca, Cipollone, Francesco, Citroni, Nadia, Federici, Massimo, Ferri, Claudio, Fiorenza, Anna Maria, Giaccari, Andrea, Giorgino, Francesco, Guardamagna, Ornella, Iannuzzi, Arcangelo, Iughetti, Lorenzo, Lupattelli, Graziana, Mandraffino, Giuseppe, Marcucci, Rossella, Mombelli, Giuliana, Muntoni, Sandro, Pecchioli, Valerio, Pederiva, Cristina, Pipolo, Antonio, Pisciotta, Livia, Pujia, Arturo, Purrello, Francesco, Repetti, Elena, Rubba, Paolo, SabbÃ&nbsp, Carlo, Sampietro, Tiziana, Sarzani, Riccardo, Tagliabue, Milena Paola, Trenti, Chiara, Vigna, Giovanni Battista, Werba, JosÃ Pablo, Zambon, Sabina, Zenti, Maria Grazia, Montali, Anna, Noto, Davide, Fortunato, Giuliana, Grigore, Liliana, Del Ben, Maria, Maranghi, Marianna, Cefalã¹, A. Baldassarre, Buonuomo, Paola Sabrina, Capra, Maria Elena, Vinci, Pierandrea, D'Addato, Sergio, Galbiati, Stella, Nascimbeni, Fabio, Bucci, Marco, Spagnoli, Walter, Cardolini, Iris, Cervelli, Nazzareno, Emanuela, Colombo, Sun, Vinsin A., Laviola, Luigi, Bello, Francesca, Chiariello, Giuseppe, Predieri, Barbara, Siepi, Donatella, Saitta, Antonino, Giusti, Betti, Pavanello, Chiara, Lussu, Milena, Prati, Lucia, Banderali, Giuseppe, Balleari, Giulia, Montalcini, Tiziana, Scicali, Roberto, Gentile, Luigi, Gentile, Marco, Suppressa, Patrizia, Sbrana, Francesco, Cocci, Guido, Benso, Andrea, Negri, Emanuele Alberto, Ghirardello, Omar, Lorenzo, Vigo, Zambon, Alberto, Enzo, Bonora, Minicocci, Ilenia, Spina, Rossella, Orlando, Camilla, Di Taranto, Maria Donata, Casula, Manuela, Chiodo, Lorenzo, Manzato, Enzo, Tragni, Elena, Pirillo, Angela, Garlaschelli, Katia, Arca, Marcello, Averna, Maurizio, Bertolini, Stefano, Calandra, Sebastiano, Tarugi, Patrizia, Catapano, Alberico L., Catapano, Alberico Luigi, Pellegatta, Fabio, Angelico, Francesco, Bartuli, Andrea, Biasucci, Giacomo, Biolo, Gianni, Bonanni, Luca, Bonomo, Katia, Borghi, Claudio, Bossi, Antonio Carlo, Branchi, Adriana, Carubbi, Francesca, Cipollone, Francesco, Citroni, Nadia, Federici, Massimo, Ferri, Claudio, Fiorenza, Anna Maria, Giaccari, Andrea, Giorgino, Francesco, Guardamagna, Ornella, Iannuzzi, Arcangelo, Iughetti, Lorenzo, Lupattelli, Graziana, Mandraffino, Giuseppe, Marcucci, Rossella, Mombelli, Giuliana, Muntoni, Sandro, Pecchioli, Valerio, Pederiva, Cristina, Pipolo, Antonio, Pisciotta, Livia, Pujia, Arturo, Purrello, Francesco, Repetti, Elena, Rubba, Paolo, Sabbã , Carlo, Sampietro, Tiziana, Sarzani, Riccardo, Tagliabue, Milena Paola, Trenti, Chiara, Vigna, Giovanni Battista, Werba, Josã Pablo, Zambon, Sabina, Zenti, Maria Grazia, Montali, Anna, Noto, Davide, Fortunato, Giuliana, Grigore, Liliana, DEL BELLO, Francesca, Maranghi, Marianna, Cefalã¹, A. Baldassarre, Buonuomo, Paola Sabrina, Capra, Maria Elena, Vinci, Pierandrea, D'Addato, Sergio, Galbiati, Stella, Nascimbeni, Fabio, Bucci, Marco, Spagnoli, Walter, Cardolini, Iri, Cervelli, Nazzareno, Emanuela, Colombo, Sun, Vinsin A., Laviola, Luigi, Bello, Francesca, Chiariello, Giuseppe, Predieri, Barbara, Siepi, Donatella, Saitta, Antonino, Giusti, Betti, Pavanello, Chiara, Lussu, Milena, Prati, Lucia, Banderali, Giuseppe, Balleari, Giulia, Montalcini, Tiziana, Scicali, Roberto, Gentile, Luigi, Gentile, Marco, Suppressa, Patrizia, Sbrana, Francesco, Cocci, Guido, Benso, Andrea, Negri, Emanuele Alberto, Ghirardello, Omar, Lorenzo, Vigo, Zambon, Alberto, Enzo, Bonora, Minicocci, Ilenia, Spina, Rossella, Orlando, Camilla, Di Taranto, Maria Donata, Casula, Manuela, Chiodo, Lorenzo, Manzato, Enzo, Tragni, Elena, Sabbà, Carlo, Werba, Josè Pablo, Del Ben, Maria, Cefalù, A. Baldassarre, DI BELLO, Francesca, Pirillo, A., Garlaschelli, K., Arca, M., Averna, M., Bertolini, S., Calandra, S., Tarugi, P., Catapano, A., Pellegatta, F., Angelico, F., Bartuli, A., Biasucci, G., Biolo, G., Bonanni, L., Bonomo, K., Borghi, C., Bossi, A., Branchi, A., Carubbi, F., Cipollone, F., Citroni, N., Federici, M., Ferri, C., Fiorenza, A., Giaccari, A., Giorgino, F., Guardamagna, O., Iannuzzi, A., Iughetti, L., Lupattelli, G., Mandraffino, G., Marcucci, R., Mombelli, G., Muntoni, S., Pecchioli, V., Pederiva, C., Pipolo, A., Pisciotta, L., Pujia, A., Purrello, F., Repetti, E., Rubba, P., Sabbã , C., Sampietro, T., Sarzani, R., Tagliabue, M., Trenti, C., Vigna, G., Werba, J., Zambon, S., Zenti, M., Montali, A., Noto, D., Fortunato, G., Grigore, L., Del Ben, M., Maranghi, M., Cefalu', A., Buonuomo, P., Capra, M., Vinci, P., D'Addato, S., Galbiati, S., Nascimbeni, F., Bucci, M., Spagnoli, W., Cardolini, I., Cervelli, N., Emanuela, C., Sun, V., Laviola, L., Bello, F., Chiariello, G., Predieri, B., Siepi, D., Saitta, A., Giusti, B., Pavanello, C., Lussu, M., Prati, L., Banderali, G., Balleari, G., Montalcini, T., Scicali, R., Gentile, L., Gentile, M., Suppressa, P., Sbrana, F., Cocci, G., Benso, A., Negri, E., Ghirardello, O., Lorenzo, V., Zambon, A., Enzo, B., Minicocci, I., Spina, R., Orlando, C., Di Taranto, M., Casula, M., Chiodo, L., Manzato, E., Tragni, E., and Colombo, Emanuela
Subjects: 0301 basic medicine, Apolipoprotein E, Candidate gene, Settore MED/09 - Medicina Interna, Databases, Factual, Apolipoprotein B, DNA Mutational Analysis, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, Compound heterozygosity, PCSK9, 0302 clinical medicine, Risk Factors, Receptors, Genetics, Homozygote, Autosomal dominant trait, Pathogenic variants, General Medicine, Prognosis, APOB, LDLR, Cholesterol, Phenotype, Italy, Autosomal Recessive Hypercholesterolemia, Apolipoprotein B-100, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, Cardiology and Cardiovascular Medicine, Preliminary Data, Genetic Markers, Familial hypercholesterolemiaLDLRPCSK9APOBPathogenic variants, Heterozygote, Biology, Pathogenic variant, LDL, Hyperlipoproteinemia Type II, 03 medical and health sciences, Databases, medicine, Internal Medicine, Humans, Genetic Predisposition to Disease, Factual, Settore MED/13 - ENDOCRINOLOGIA, medicine.disease, Atherosclerosis, 030104 developmental biology, Receptors, LDL, Mutation, biology.protein
Abstract: Background Familial hypercholesterolemia (FH) is an autosomal dominant disease characterized by elevated plasma levels of LDL-cholesterol that confers an increased risk of premature atherosclerotic cardiovascular disease. Early identification and treatment of FH patients can improve prognosis and reduce the burden of cardiovascular mortality. Aim of this study was to perform the mutational analysis of FH patients identified through a collaboration of 20 Lipid Clinics in Italy (LIPIGEN Study). Methods We recruited 1592 individuals with a clinical diagnosis of definite or probable FH according to the Dutch Lipid Clinic Network criteria. We performed a parallel sequencing of the major candidate genes for monogenic hypercholesterolemia (LDLR, APOB, PCSK9, APOE, LDLRAP1, STAP1). Results A total of 213 variants were detected in 1076 subjects. About 90% of them had a pathogenic or likely pathogenic variants. More than 94% of patients carried pathogenic variants in LDLR gene, 27 of which were novel. Pathogenic variants in APOB and PCSK9 were exceedingly rare. We found 4 true homozygotes and 5 putative compound heterozygotes for pathogenic variants in LDLR gene, as well as 5 double heterozygotes for LDLR/APOB pathogenic variants. Two patients were homozygous for pathogenic variants in LDLRAP1 gene resulting in autosomal recessive hypercholesterolemia. One patient was found to be heterozygous for the ApoE variant p.(Leu167del), known to confer an FH phenotype. Conclusions This study shows the molecular characteristics of the FH patients identified in Italy over the last two years. Full phenotypic characterization of these patients and cascade screening of family members is now in progress.
Published: 2017

25. Validation of bioelectrical impedance analysis for estimating limb lean mass in free-living Caucasian elderly people

Author: Egle Perissinotto, S. Carraro, Francesco Bolzetta, Enzo Manzato, Nicola Veronese, Caterina Trevisan, Giulia Bano, Linda Berton, Alessandra Coin, Giuseppe Sergi, S. Pizzato, Marina De Rui, De Rui, M., Veronese, N., Bolzetta, F., Berton, L., Carraro, S., Bano, G., Trevisan, C., Pizzato, S., Coin, A., Perissinotto, E., Manzato, E., and Sergi, G.
Subjects: Male, Sarcopenia, medicine.medical_specialty, Urology, 030209 endocrinology & metabolism, Critical Care and Intensive Care Medicine, Body weight, White People, NO, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Absorptiometry, Photon, medicine, Electric Impedance, Elderly people, Humans, 030212 general & internal medicine, Muscle, Skeletal, Sarcopenia, Body composition, Prediction equation, Limb lean mass, Older adults, Aged, Multiple regression equation, Aged, 80 and over, Nutrition and Dietetics, business.industry, Body Weight, Reproducibility of Results, Healthy elderly, Limb lean mass, Middle Aged, medicine.disease, Resistive index, Prediction equation, Cross-Sectional Studies, Older adults, Lean body mass, Physical therapy, Body Composition, Body composition, Female, business, Bioelectrical impedance analysis
Abstract: Background & aims Aging is characterized by a loss of limb lean mass (LLM) that can lead to physical disability and death. Regional bioelectrical impedance analysis (BIA) may be a reliable method for estimating LLM, but no prediction equations are available for elderly Caucasian subjects. The aim of this study was to develop and validate a BIA-based equation for predicting LLM in healthy elderly Caucasians, taking dual X-ray absorptiometry (DXA) as the reference method. Methods Using a cross-sectional design, 244 free-living healthy Caucasian subjects (117 men, 179 women) over 60 years of age were enrolled. LLM was measured with DXA (LLMDXA), and the resistance (Rz) and reactance (Xc) of each limb were measured with a regional bioelectrical impedance analyzer. A resistive index (RI) was calculated from stature in meters divided by Rz of each arm. A BIA-based multiple regression equation for predicting the lean mass (LM) of dominant and non-dominant limbs was developed using a double cross-validation technique. Results Using the sample as a whole, cross-validation resulted in an equation specific for each limb, as follows, where sex equals 1 for males, and 0 for females: LM (kg)=−0.081+(0.061*RI)+(0.010*body weight)+(0.299*sex) for the dominant arm; LM (kg)=−0.026+(0.014*RI)+(0.009*body weight)+(0.352*sex) for the non-dominant arm; LM (kg)=−0.462+(0.027*RI)+(0.047*body weight)+(0.639*sex)+(0.026*Xc) for the dominant leg; and for the non-dominant leg, LM (kg)=−0.522+(0.029*RI)+(0.045*body weight)+(0.569*sex)+(0.025*Xc). The DXA-measured and BIA-predicted LLM for each limb did not differ significantly. Conclusion Our newly-developed BIA equations seem to provide a valid estimation of LLM in older Caucasian adults. © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism
Published: 2017

26. Serum 25-Hydroxyvitamin D and Incidence of Diabetes in Elderly People: The PRO.V.A. Study

Author: Giovannella Baggio, Francesco Bolzetta, Leonardo Sartori, Elena Debora Toffanello, Estella Musacchio, Egle Perissinotto, S Zambon, Enzo Manzato, Marina De Rui, Maria Chiara Corti, Gaetano Crepaldi, Giuseppe Sergi, Nicola Veronese, Veronese, N., Sergi, G., De Rui, M., Bolzetta, F., Toffanello, E.D., Zambon, S., Corti, M.-C., Sartori, L., Musacchio, E., Baggio, G., Crepaldi, G., Perissinotto, E., and Manzato, E.
Subjects: Male, medicine.medical_specialty, Waist, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Population, Context (language use), Type 2 diabetes, Biochemistry, not known, Cohort Studies, Endocrinology, Internal medicine, Diabetes mellitus, medicine, Humans, Vitamin D, education, Aged, Aged, 80 and over, education.field_of_study, business.industry, Incidence, Incidence (epidemiology), Biochemistry (medical), Vitamin D Deficiency, medicine.disease, Diabetes Mellitus, Type 2, Italy, Female, business, Body mass index, Cohort study
Abstract: Context: Increasing research has shown that low levels of serum 25-hydroxyvitamin (25OHD) predict the onset of diabetes, but no research is available on this issue in elderly people. Objective: Our objective was to examine whether low serum levels of 25OHD are associated with a higher risk of incident type 2 diabetes over a lengthy follow-up in a representative group of elderly people. Design and Setting: This was a population-based cohort study as part of the Progetto Veneto Anziani (Pro.V.A.) Study over a follow-up of 4.4 years in the general community. Participants: Participants included 2227 participants (1728 with follow-up visits and 499 died during the follow-up) over 65 years of age without diabetes at baseline, of 2352 initially included. Main Outcome Measure: The main outcome measure was incident diabetes. Results: There were no baseline differences in known factors for the onset of diabetes (body mass index, waist circumference, total cholesterol, renal function, and hemoglobin A1c levels) between the groups with different serum 25OHD levels (≤25, 25–50, 50–75, and ≥75 nmol/L). Over a 4.4-year follow-up, 291 individuals developed diabetes, with an incidence of 28 events per 1000 person-years. No significant difference in the incidence of diabetes emerged between the baseline 25OHD groups. Cox's regression analysis, adjusted for potential confounders, revealed no relationship between low vitamin D levels and incident diabetes during the follow-up (hazard ratio [HR] = 1.05, 95% confidence interval [CI] = 0.76–1.45, P = .77; HR = 1.44, 95% CI = 0.95–1.98, P = .12; and HR = 1.37, 95% CI = 0.87–2.16, P = .17 for those with 25OHD ≤25, 25–50, and 50–75 nmol/L, respectively). Conclusion: Baseline serum concentrations of 25OHD were not associated with the incidence of diabetes in community-dwelling elderly people over a follow-up of 4.4 years.
Published: 2014

27. Osteoarthritis and mortality: a prospective cohort study and systematic review with meta-analysis

Author: Marco Solmi, Michael Denkinger, Giuseppe Sergi, Stefania Maggi, Claudio Luchini, Enzo Manzato, Brendon Stubbs, Emanuele Cereda, Trevor Thompson, Michael Hurley, Toby O. Smith, Nicola Veronese, Veronese, N., Cereda, E., Maggi, S., Luchini, C., Solmi, M., Smith, T., Denkinger, M., Hurley, M., Thompson, T., Manzato, E., Sergi, G., and Stubbs, B.
Subjects: medicine.medical_specialty, Cardiovascular disease, Mortality, Osteoarthritis, Rheumatology, Anesthesiology and Pain Medicine, Disease, Comorbidity, 03 medical and health sciences, 0302 clinical medicine, cardiovascular disease, Risk Factors, Internal medicine, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, 030203 arthritis & rheumatology, business.industry, Hazard ratio, Osteoarthritis, Mortality, Cardiovascular disease, medicine.disease, R1, mortality, osteoarthritis, Increased risk, Cardiovascular Diseases, Meta-analysis, Physical therapy, business
Abstract: Objectives: Osteoarthritis (OA) is a leading cause of disability, but the relationship with premature mortality remains uncertain. We aimed to investigate the relationship between OA and mortality from any cause and from cardiovascular disease (CVD).\ud \ud Methods: Electronic literature databases searches were conducted to identify prospective studies comparing mortality in a sample of people with and without OA. Risk of all-cause and CVD mortality were summarized using adjusted hazard ratios (HRs) for joint specific (hand, hip, and knee) and joint non-specific OA. New data from the Progetto Veneto Anziani (PRO.V.A.) study were also included. Results: From the PRO.V.A. study (N 1⁄4 2927), there was no significant increase in mortality risk for participants with any joint OA (N 1⁄4 1858) compared to non-OA (all-cause, HR 1⁄4 0.95, 95% CI: 0.77–1.15 and CVD, HR 1⁄4 1.12, 95% CI: 0.82–1.54). On meta-analysis, seven studies (OA 1⁄4 10,018/non-OA 1⁄4 18,541), with a median 12-year follow-up, reported no increased risk of any-cause mortality in those with OA (HR 1⁄4 1.10, 95% CI: 0.97–1.25). After removing data on hand OA, a significant association between OA and mortality was observed (HR 1⁄4 1.18, 95% CI: 1.08–1.28). There was a significant higher risk of overall mortality for (1) studies conducted in Europe, (2) patients with multi-joint OA; and (3) a radiological diagnosis of OA. OA was associated with significantly higher CVD mortality (HR 1⁄4 1.21, 95% CI: 1.10–1.34).\ud \ud Conclusions: People with OA are at increased risk of death due to CVD. The relationship with overall mortality is less clear and may be moderated by the presence of hand OA.
Published: 2016

28. Prevalence of Sarcopenia Based on Different Diagnostic Criteria Using DEXA and Appendicular Skeletal Muscle Mass Reference Values in an Italian Population Aged 20 to 80

Author: Elena Ruggiero, Antonio Del Puente, Maurizio Rossini, S Sarti, Sandro Giannini, Enzo Manzato, Giuseppe Sergi, Salvatore Minisola, Mario Pedrazzoni, Emine Meral Inelmen, Alessandra Coin, Coin, A, Sarti, S, Ruggiero, E, Giannini, S, Pedrazzoni, M, Minisola, S, Rossini, M, DEL PUENTE, Antonio, Inelmen, Em, Manzato, E, and Sergi, G.
Subjects: Adult, Male, Gerontology, Aging, Percentile, DEXA, Osteoporosis, Population, body composition, dexa, lean mass, reference values, sarcopenia, Young Adult, Absorptiometry, Photon, Reference Values, Prevalence, medicine, Humans, skeletal muscle, Young adult, education, General Nursing, Aged, Retrospective Studies, Aged, 80 and over, Analysis of Variance, Sex Characteristics, education.field_of_study, business.industry, Health Policy, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Italy, Sarcopenia, Body Composition, Lean body mass, Female, Geriatrics and Gerontology, business, Demography, Sex characteristics
Abstract: Objective To identify the mean values and percentiles for ASMM (appendicular skeletal muscle mass) and the prevalence of sarcopenia, in terms of muscle mass reduction, using different cutoffs in a European population. Design A retrospective analysis on the dataset from a multicenter study on apparently healthy Italian adults conducted between 1999 and 2002. A significant muscle mass loss, necessary to diagnose sarcopenia, was defined in 3 different ways: (1) by subtracting 2 SDs from the mean ASMM index (ASMMI) of a young adult population (20–39 year-olds), as in the Rosetta study and the NHANES survey; (2) by calculating the 15th percentile of the distribution of our young population, corresponding to about 1 SD below the mean ASMMI; (3) by calculating the 20th percentile of the distribution of the ASMMI (as in the Health ABC study) of an elderly population. Setting Five centers for the diagnosis and treatment of osteoporosis in various parts of the country (Padova, Verona, Parma, Roma, Napoli). Participants Participants were 1535 volunteers (1208 women and 327 men) aged 20 to 80 years, drawn from among staff members, university students, lay people contacted by word of mouth, and patients presenting spontaneously for osteoporosis screening. Measurements Body weight and height were measured for all participants. Body composition was assessed by DEXA, and the ASMMI was calculated as the ASMM divided by body height in meters squared. Results Both men's and women's lean mass in the arms and ASMM were highest in the young group and became lower in older age. In men, the ASMMI dropped gradually from age 20 to 29 to age 60 to 69, then remained stable in the oldest group. In women, the ASMMI gradually increased from age 20 to 29 to age 60 to 69, then dropped among the 70- to 80-year-olds. Based on the 15th percentile of the ASMMI for our young adult reference population, the cutoffs for sarcopenia were 7.59 kg/m 2 in men and 5.47 kg/m 2 in women; if the 20th percentile of the ASMMI in our elderly subjects (>65 years) was considered, the cutoffs were 7.64 kg/m 2 in men and 5.78 kg/m 2 in women. Applying the different diagnostic criteria to the those older than 65, the prevalence of sarcopenia ranged from 0% to about 20% in both genders. Conclusion The 15th percentile (or 1 SD below the mean) of the ASMMI of our young adults, and the 20th percentile of this index for an elderly reference population proved more effective in identifying cases of sarcopenia than subtracting 2 SD from the mean ASMMI of a young adult population.
Published: 2013

29. Monoclonal gammopathy of undetermined significance and bone health outcomes: a systematic review and exploratory meta-analysis

Author: Claudio Luchini, Nicola Veronese, Brendon Stubbs, Enzo Manzato, Marco Solmi, Giuseppe Sergi, Veronese, N., Luchini, C., Solmi, M., Sergi, G., Manzato, E., and Stubbs, B.
Subjects: Male, medicine.medical_specialty, Aging, Endocrinology, Diabetes and Metabolism, Osteoporosis, 030209 endocrinology & metabolism, Monoclonal Gammopathy of Undetermined Significance, Bone and Bones, 03 medical and health sciences, Fractures, Bone, 0302 clinical medicine, Endocrinology, Bone Density, Internal medicine, medicine, Odds Ratio, Prevalence, Humans, Orthopedics and Sports Medicine, Longitudinal Studies, Femoral neck, Aged, Bone mineral, business.industry, Incidence (epidemiology), Incidence, General Medicine, Middle Aged, medicine.disease, Confidence interval, Fractures, Monoclonal gammopathy of undetermined significance, Surgery, Diabetes and Metabolism, medicine.anatomical_structure, Cross-Sectional Studies, Monoclonal gammopathy of undetermined signifcance, Osteoporosis, Fractures, Aging, 030220 oncology & carcinogenesis, Meta-analysis, Relative risk, Case-Control Studies, Female, business
Abstract: Monoclonal gammopathy of undetermined significance (MGUS) is a common condition in the elderly. A number of studies have investigated the relationship between MGUS and bone health outcomes including bone mineral density (BMD), osteoporosis and fractures, but no meta-analysis exists. We conducted a systematic review and exploratory meta-analysis comparing bone health outcomes in patients with MGUS. Two independent authors searched PubMed and Scopus from inception until 19 October 2016. A meta-analysis of cross-sectional and longitudinal studies investigating fractures and BMD was conducted. Standardised mean differences (SMD)±95% confidence intervals (CIs) were calculated for BMD, and risk ratios (RRs) were calculated for prevalent and incident fractures. Of 174 initial hits, 10 studies of moderate methodological quality were eligible, including 8711 individuals with MGUS vs. 52,865 controls. Compared to controls, subjects with MGUS showed significantly lower values for radial cortical volumetric BMD (1 study; SMD=−5.45, 95% CI: −7.24 to −3.66), but not at the lumbar spine, femoral neck or hip. The incidence of fractures was higher in people with MGUS (n=7466) vs. controls (n=52,304) (RR=1.36, 95% CI 1.28–1.44, I2=0%) over a median of 12.5-year follow-up. The incidence of vertebral fractures was particularly elevated (RR=2.50, 95% CI 1.53–4.06) although limited to two studies. In conclusion, although with limitations, our preliminary meta-analysis suggests that patients with MGUS are at higher risk of fractures despite evidence for differences in BMD being equivocal. Future longitudinal research is required to confirm our findings and determine if fracture prevention interventions are warranted in people with MGUS. © 2017, The Japanese Society for Bone and Mineral Research and Springer Japan.
Published: 2016

30. Extranodal Extension of Nodal Metastases Is a Poor Prognostic Indicator in Gastric Cancer: a Systematic Review and Meta-analysis

Author: Alessia Nottegar, Enzo Manzato, Liang Cheng, Marco Maruzzo, Marco Solmi, Claudio Luchini, Nicola Veronese, Antonio Pea, Mattia Barbareschi, Paola Capelli, S. Carraro, Giuseppe Sergi, Laura D. Wood, Ivana Cataldo, Giovanni de Manzoni, Fabio Bagante, Maria Bencivenga, Matteo Fassan, Brendon Stubbs, Veronese, N., Fassan, M., Wood, L.D., Stubbs, B., Solmi, M., Capelli, P., Pea, A., Nottegar, A., Sergi, G., Manzato, E., Carraro, S., Maruzzo, M., Cataldo, I., Bagante, F., Barbareschi, M., Cheng, L., Bencivenga, M., de Manzoni, G., and Luchini, C.
Subjects: Oncology, medicine.medical_specialty, 03 medical and health sciences, Nodal Metastases, Extranodal Extension, Gastric Cancer, 0302 clinical medicine, extranodal extension, nodal metastases, gastric cancer, Recurrence, Stomach Neoplasms, Internal medicine, Extranodal extension, medicine, Odds Ratio, Humans, Gastric cancer . ENE . Extranodal extension, ENE, Gastric cancer, Lymph node metastasis, Surgery, Gastroenterology, Proportional Hazards Models, business.industry, Proportional hazards model, Nodal Metastases, Hazard ratio, Confounding, Cancer, Odds ratio, medicine.disease, Prognosis, Confidence interval, 030220 oncology & carcinogenesis, Meta-analysis, Relative risk, Lymphatic Metastasis, 030211 gastroenterology & hepatology, Lymph Nodes, Neoplasm Recurrence, Local, business
Abstract: Introduction: The extranodal extension (ENE) of nodal metastases (the extension of neoplastic cells through the nodal capsule into the perinodal soft tissue) is a histological feature that has been considered a prognostic factor in several cancers, but the role in gastric cancer was not yet investigated. We aimed to investigate the prognostic role of ENE in patients affected by gastric cancer through a systematic review and meta-analysis. Material and Methods: Two independent authors searched major databases until 09/30/2015 to identify studies providing data on gastric cancer patients’ prognostic parameters and comparing patients with ENE (ENE+) vs intra-nodal extension (ENE−). The data were summarized using risk ratios (RRs) for the number of deaths/recurrences and hazard ratios (HRs) with 95% confidence intervals (CI), adjusted for potential confounders. Results: Nine studies followed up 3250 patients with gastric cancer (1064 ENE+ and 2186 ENE−). ENE+ was associated with a significantly higher risk of all-cause mortality (RR = 1.70; 95% CI: 1.43–2.03, I2 = 66%; HR = 2.14; 95% CI: 1.66–2.75, I2 = 0%), cancer-specific mortality (RR = 1.59; 95% CI: 1.42–1.79; HR = 1.52; 95% CI: 1.19–1.96), and disease recurrence (RR = 3.43, 95% CI: 1.80–6.54, I2 = 0%). Discussion: Judging from our results, ENE in gastric cancer patients should be considered for prognostic purposes from the gross sample to the pathology report. © 2016, The Society for Surgery of the Alimentary Tract.
Published: 2016

31. Prognostic implications of extranodal extension in node-positive squamous cell carcinoma of the vulva: A systematic review and meta-analysis

Author: Paola Capelli, Aldo Scarpa, Claudio Luchini, Giuseppe Sergi, Marco Solmi, Nicola Veronese, Enzo Manzato, Alessia Nottegar, Luchini, C., Nottegar, A., Solmi, M., Sergi, G., Manzato, E., Capelli, P., Scarpa, A., and Veronese, N.
Subjects: Oncology, medicine.medical_specialty, Extranodal metastasis, Vulva, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Extranodal extension, medicine, Humans, 030212 general & internal medicine, Prospective cohort study, Lymph node, Gynecology, Vulvar neoplasm, Vulvar Neoplasms, Vulvar cancer, business.industry, ENE, Surgery, Hazard ratio, medicine.disease, Prognosis, Extranodal metastasi, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Meta-analysis, Relative risk, Carcinoma, Squamous Cell, Female, Lymph Nodes, business
Abstract: Squamous cell carcinoma (SCC) of the vulva is the fourth most common gynecological cancer, usually staged with the TNM or FIGO systems. Since 2009, FIGO staging has taken the extranodal extension (ENE) of lymph node metastases into account. ENE is defined as the spread of a lymph node metastasis into surrounding soft tissue. Although the TNM and FIGO systems acknowledge the importance of ENE in SCC, no comprehensive studies have analyzed the prognostic impact of this parameter. We therefore queried the PubMed and SCOPUS databases from their inception up until 04/01/2015, adopting no language restrictions: all prospective studies reporting on prognostic parameters in patients with vulvar SCC, and comparing participants with and without ENE were eligible for our analysis. Data were summarized using risk ratios (RR) for the number of deaths/recurrences and hazard ratios (HR) for the time-dependent risk related to ENE positivity, adjusting for potential confounders. Among 859 hits, 13 studies were found eligible and were included in our meta-analysis. Compared with ENE-negative (ENE-) cases, the ENE-positive (ENE+) patients had significantly higher rates of all-cause mortality (6 studies: RR = 3.18; 95%CI: 2.02-5.00, p < 0.0001, I2 = 56%), cancer-specific mortality (3 studies: RR = 2.03; 95%CI: 1.12-3.69, p = 0.02, I2 = 80%), and recurrence (4 studies: RR = 2.69, 95%CI: 1.61-3.76, p < 0.0001, I2 = 57%). Using HRs after adjusting for potential confounders, ENE + carried a significantly higher risk of all-cause mortality (6 studies: HR = 3.08, 95%CI: 1.73-5.48, p < 0.0001, I2 = 66%), and recurrence (5 studies: HR = 3.93, 95%CI: 2.33-6.62, p < 0.0001, I2 = 28%). Our meta-analysis clarifies the prognostic significance of ENE in vulvar SCC, also pointing to its implications for gross sampling, histology and oncological staging. © 2015 Elsevier Ltd.All rights reserved.
Published: 2016

32. Low Hemoglobin Levels and the Onset of Cognitive Impairment in Older People: The PRO.V.A. Study

Author: Francesco Bolzetta, Stefania Maggi, Gaetano Crepaldi, Caterina Trevisan, Nicola Veronese, Egle Perissinotto, S Zambon, Giuseppe Sergi, Leonardo Sartori, Enzo Manzato, Marina De Rui, Estella Musacchio, Trevisan, C., Veronese, N., Bolzetta, F., De Rui, M., Maggi, S., Zambon, S., Musacchio, E., Sartori, L., Perissinotto, E., Crepaldi, G., Manzato, E., and Sergi, G.
Subjects: Gerontology, Male, sex differences, Aging, medicine.medical_specialty, Anemia, elderly, NO, hemoglobin concentration, 03 medical and health sciences, Hemoglobins, 0302 clinical medicine, Internal medicine, medicine, Dementia, Humans, Cognitive Dysfunction, 030212 general & internal medicine, Hemoglobin, Risk factor, Cognitive impairment, Aged, cognitive impairment, Aged, 80 and over, Sex Characteristics, Mini–Mental State Examination, medicine.diagnostic_test, business.industry, Incidence (epidemiology), Incidence, medicine.disease, anemia, Confidence interval, dementia, Female, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Sex characteristics, Follow-Up Studies
Abstract: Low hemoglobin (Hb) levels are attracting interest as a risk factor for cognitive impairment, but with contrasting evidence emerging from the current literature. The aim of our work was to investigate the relationship between baseline serum Hb levels and the incidence of cognitive impairment in older people over a follow-up of 4.4 years. Our study considered a sample of 1227 elderly subjects cognitively intact at baseline, enrolled under the Progetto Veneto Anziani (Pro.V.A.) among 3099 screened subjects. For all participants, we measured serum Hb levels on blood samples; incident cognitive impairment was defined as a Mini Mental State Examination (MMSE) score
Published: 2016

33. Nephrolithiasis, bone mineral density, osteoporosis, and fractures: a systematic review and comparative meta-analysis

Author: Brendon Stubbs, G. Girotti, Maria Fusaro, S. Pizzato, G. Sergi, Sandro Giannini, Paola Lucato, Marco Solmi, Nicola Veronese, Bruno Micael Zanforlini, Enzo Manzato, Claudio Luchini, Caterina Trevisan, Lucato, P., Trevisan, C., Stubbs, B., Zanforlini, B.M., Solmi, M., Luchini, C., Girotti, G., Pizzato, S., Manzato, E., Sergi, G., Giannini, S., Fusaro, M., and Veronese, N.
Subjects: Adult, medicine.medical_specialty, Bone mineral density, Fractures, Kidney stone, Nephrolithiasis, Osteoporosis, Endocrinology, Diabetes and Metabolism, Osteoporosis, 030232 urology & nephrology, 030209 endocrinology & metabolism, Bone mineral density, Fractures, Kidney stone, Nephrolithiasis, NO, 03 medical and health sciences, Fractures, Bone, 0302 clinical medicine, Bone Density, Risk Factors, Internal medicine, medicine, Humans, Femoral neck, Bone mineral, business.industry, Hazard ratio, medicine.disease, Confidence interval, Rheumatology, medicine.anatomical_structure, Meta-analysis, Orthopedic surgery, business
Abstract: Summary: Our meta-analysis demonstrates that people with nephrolithiasis have decreased bone mineral density, an increased odds of osteoporosis, and potentially an elevated risk of fractures. Introduction: People with nephrolithiasis might be at risk of reduced bone mineral density (BMD) and fractures, but the data is equivocal. We conducted a meta-analysis to investigate if patients with nephrolithiasis have worse bone health outcomes (BMD), osteoporosis, and fractures versus healthy controls (HCs). Methods: Two investigators searched major databases for articles reporting BMD (expressed as g/cm2 or a T- or Z-score), osteoporosis or fractures in a sample of people with nephrolithiasis, and HCs. Standardized mean differences (SMDs), 95% confidence intervals (CIs) were calculated for BMD parameters; in addition odds (ORs)for case-control and adjusted hazard ratios (HRs) in longitudinal studies for categorical variables were calculated. Results: From 1816 initial hits, 28 studies were included. A meta-analysis of case-control studies including 1595 patients with nephrolithiasis (mean age 41.1years) versus 3402 HCs (mean age 40.2years) was conducted. Patients with nephrolithiasis showed significant lower T-scores values for the spine (seven studies; SMD = −0.69; 95% CI = −0.86 to −0.52; I2 = 0%), total hip (seven studies; SMD = −0.82; 95% CI = −1.11 to −0.52; I2 = 72%), and femoral neck (six studies; SMD = −0.67; 95% CI = −−1.00 to −0.34; I2 = 69%). A meta-analysis of thecase-controlled studies suggests that people with nephrolithiasis are at increased risk of fractures (OR = 1.15, 95% CI = 1.12–1.17, p < 0.0001, studies = 4), while the risk of fractures in two longitudinal studies demonstrated trend level significance (HR = 1.31, 95% CI = 0.95–1.62). People with nephrolithiasis were four times more likely to have osteoporosis than HCs (OR = 4.12, p < 0.0001). Conclusions: Nephrolithiasis is associated with lower BMD, an increased risk of osteoporosis, and possibly, fractures. Future screening/preventative interventions targeting bone health might be indicated. © 2016, International Osteoporosis Foundation and National Osteoporosis Foundation.
Published: 2016

34. Hyperuricemia protects against low bone mineral density, osteoporosis and fractures: a systematic review and meta-analysis

Author: Riccardo Caccialanza, Nicola Veronese, Marco Solmi, Claudio Luchini, Enzo Manzato, S. Carraro, Davide Nicetto, Giulia Bano, Caterina Trevisan, Giuseppe Sergi, Emanuele Cereda, Veronese, N., Carraro, S., Bano, G., Trevisan, C., Solmi, M., Luchini, C., Manzato, E., Caccialanza, R., Sergi, G., Nicetto, D., and Cereda, E.
Subjects: Male, medicine.medical_specialty, Bone density, Clinical Biochemistry, Osteoporosis, 030209 endocrinology & metabolism, Bone mineral density, fractures, hyperuricemia, osteoporosis, uric acid, Bone Density, Epidemiologic Methods, Female, Humans, Hyperuricemia, Osteoporotic Fractures, Uric Acid, Biochemistry, Bone remodeling, NO, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Femoral neck, 030203 arthritis & rheumatology, Bone mineral, business.industry, Hazard ratio, General Medicine, Odds ratio, medicine.disease, medicine.anatomical_structure, Endocrinology, business, Bone mineral density, fractures, hyperuricemia, osteoporosis, uric acid
Abstract: Background: Serum uric acid (SUA) accounts for about 50% of extracellular antioxidant activity, suggesting that hyperuricemia may have a protective role in diseases characterized by high levels of oxidative stress, such as osteoporosis. We aimed to meta-analyse data regarding bone mineral density (BMD), osteoporosis and fractures in people with higher SUA vs. lower SUA concentrations. Materials and methods: Two investigators conducted a literature search using PubMed and Scopus, without language restrictions. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were used for BMD; risk ratios (RRs) and adjusted odds ratios (ORs) for cross-sectional data. Most possible adjusted hazard ratios (HRs) were used to assess the association between baseline SUA and incident fractures. Results: Of 1405 initial hits, 19 studies were eligible including a total of 55 859 participants. Subjects with higher SUA levels had significantly higher BMD values for the spine (six studies; SMD = 0·29; 95% CI: 0·22–0·35; I2 = 47%), total hip (seven studies; SMD = 0·29; 95% CI: 0·24–0·34; I2 = 33%) and femoral neck (six studies; SMD = 0·25; 95% CI: 0·16–0·34; I2 = 71%). Simple correlation analyses substantially confirmed these findings. An increase of one standard deviation in SUA levels reduced the number of new fractures at follow-up (three studies; HR = 0·83; 95% CI: 0·74–0·92; I2 = 0%). No significant differences between men and women emerged, although data about women were limited. Conclusions: Hyperuricemia was found independently associated with BMD and fractures, supporting a protective role for uric acid in bone metabolism disorders. © 2016 Stichting European Society for Clinical Investigation Journal Foundation
Published: 2016

35. Acetylcholinesterase inhibitors are associated with weight loss in older people with dementia: A systematic review and meta-analysis

Author: Ahmet Turan Isik, Nicola Veronese, Marco Volpe, Brendon Stubbs, Marco Solmi, Claudio Luchini, Alberto Pilotto, Patricia Schofield, Grazia D'Onofrio, Pinar Soysal, Enzo Manzato, Giuseppe Sergi, SOYSAL, PINAR, Soysal, P., Isik, A.T., Stubbs, B., Solmi, M., Volpe, M., Luchini, C., D'Onofrio, G., Pilotto, A., Manzato, E., Sergi, G., Schofield, P., and Veronese, N.
Subjects: Male, medicine.medical_specialty, Placebo, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Arts and Humanities (miscellaneous), Weight loss, Alzheimer Disease, Internal medicine, Weight Loss, medicine, Dementia, Humans, Cumulative incidence, 030212 general & internal medicine, Aged, Randomized Controlled Trials as Topic, Geriatrics, business.industry, DEMENTIA, medicine.disease, META-ANALYSIS, ALZHEIMER'S DISEASE, GERIATRICS, Neurology (clinical), Psychiatry and Mental Health, Surgery, Acetylcholinesterase inhibitors, Meta-analysis, Physical therapy, Observational study, Female, Cholinesterase Inhibitors, medicine.symptom, business, Older people, 030217 neurology & neurosurgery
Abstract: We conducted a systematic review and meta-analysis investigating the influence of acetylcholinesterase inhibitors (AChEIs) therapy on nutritional status and weight across observational and interventional studies. Two authors searched major electronic databases from inception until 10/14/2015 for longitudinal, open-label and randomised double-blind placebo controlled (randomised controlled trials (RCTs)) studies of AChEIs in patients with dementia reporting nutritional status outcome data. Out of 3551 initial hits, 25 studies (12 open-label trials, 9 RCTs and 4 longitudinal studies) including 10 792 patients with dementia were meta-analysed. In longitudinal studies (median follow-up 6 months), a significant cumulative incidence of weight loss between baseline and follow-up evaluation was observed (studies=2; 5%; 95% CI 1% to 34%, p
Published: 2016

36. Hypovitaminosis D predicts the onset of orthostatic hypotension in older adults

Author: Marina De Rui, Egle Perissinotto, Giuseppe Sergi, Francesco Bolzetta, Enzo Manzato, Sabina Zambon, Nicola Veronese, Leonardo Sartori, Brendon Stubbs, Estella Musacchio, Caterina Trevisan, Gaetano Crepaldi, Veronese, N., Trevisan, C., Bolzetta, F., De Rui, M., Zambon, S., Musacchio, E., Sartori, L., Stubbs, B., Perissinotto, E., Crepaldi, G., Manzato, E., and Sergi, G.
Subjects: Male, medicine.medical_specialty, Cross-sectional study, vitamin D, 030204 cardiovascular system & hematology, Logistic regression, vitamin D deficiency, NO, Cohort Studies, orthostatic hypotension, 03 medical and health sciences, Orthostatic vital signs, Hypotension, Orthostatic, 0302 clinical medicine, Sex Factors, Risk Factors, Internal medicine, Internal Medicine, medicine, Vitamin D and neurology, Humans, 030212 general & internal medicine, Aged, Aged, 80 and over, business.industry, Age Factors, Hypovitaminosis D, Blood Pressure Determination, medicine.disease, Vitamin D Deficiency, aged, Endocrinology, Blood pressure, Cross-Sectional Studies, Quartile, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Cohort study, Follow-Up Studies
Abstract: A number of small cross sectional studies have demonstrated that hypovitaminosis D (represented by low 25 hydroxyvitamin D (25OHD) levels) is associated with orthostatic hypotension (OH). We investigated if hypovitaminosis D is associated with the onset of OH in older adults over a follow-up of 4.4years. 25OHD was categorized using sex-specific quartiles; OH was defined as a drop of ≤20mm Hg in systolic or ≤10mm Hg in diastolic blood pressure
Published: 2016

37. Hypovitaminosis D and fat mass in healthy older people

Author: Alessandra Coin, Giuseppe Sergi, Caterina Trevisan, S. Carraro, S Sarti, M. De Rui, Bruno Micael Zanforlini, Nicola Veronese, Enzo Manzato, Veronese, N., Trevisan, C., Carraro, S., Sarti, S., Zanforlini, B.M., De Rui, M., Coin, A., Manzato, E., and Sergi, G.
Subjects: Male, Vitamin, medicine.medical_specialty, Calorie, Cross-sectional study, Abdominal Fat, Medicine (miscellaneous), 030209 endocrinology & metabolism, Logistic regression, Body Mass Index, NO, 03 medical and health sciences, chemistry.chemical_compound, Absorptiometry, Photon, 0302 clinical medicine, Internal medicine, Vitamin D and neurology, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Vitamin D, Prospective cohort study, Nutrition and Dietetics, business.industry, Middle Aged, Vitamin D Deficiency, medicine.disease, Obesity, Cross-Sectional Studies, Endocrinology, chemistry, Obesity, Abdominal, Body Composition, Female, business, Body mass index, Follow-Up Studies
Abstract: Prospective studies have suggested that hypovitaminosis D can predict the onset of obesity, but they relied mainly on body mass index, which could be scarcely reliable in older people. We investigated whether baseline hypovitaminosis D could predict higher fat mass (FM) levels using dual-energy X-ray absorptiometry in a sample of 116 fit and healthy older subjects. Although no significant differences in FM estimates emerged between subjects with and without hypovitaminosis D at the baseline, abdominal FM was found significantly higher in the former group (with hypovitaminosis D at the baseline) than in the latter after 3 years of follow-up. Adjusted logistic regression analysis confirmed these findings: hypovitaminosis D coincided with an approximately sixfold higher risk of subjects having higher abdominal FM levels at the follow-up. In conclusion, hypovitaminosis D predicts higher abdominal FM levels in the elderly. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Published: 2016

38. Extranodal extension of lymph node metastasis is a marker of poor prognosis in oesophageal cancer: A systematic review with meta-analysis

Author: Fabio Bagante, Simone Giacopuzzi, Brendon Stubbs, Antonio Pea, Nicola Veronese, Elfriede Bollschweiler, Marco Solmi, Giovanni de Manzoni, Alessia Nottegar, Aldo Scarpa, Takuma Kaneko, Giuseppe Sergi, Enzo Manzato, Mattia Barbareschi, Matteo Fassan, Claudio Luchini, Paola Capelli, Laura D. Wood, Liang Cheng, Luchini, C., Wood, L.D., Cheng, L., Nottegar, A., Stubbs, B., Solmi, M., Capelli, P., Pea, A., Sergi, G., Manzato, E., Fassan, M., Bagante, F., Bollschweiler, E., Giacopuzzi, S., Kaneko, T., De Manzoni, G., Barbareschi, M., Scarpa, A., and Veronese, N.
Subjects: Poor prognosis, medicine.medical_specialty, OESOPHAGUS, Lymph node metastasis, Gastroenterology, CANCER, METASTASIS, 2734, Pathology and Forensic Medicine, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Extranodal extension, Internal medicine, medicine, business.industry, Extranodal Extension, Confounding, Cancer, General Medicine, medicine.disease, Surgery, 030220 oncology & carcinogenesis, Meta-analysis, Relative risk, 030211 gastroenterology & hepatology, business
Abstract: The extranodal extension (ENE) of nodal metastasis is the extension of neoplastic cells through the nodal capsule into the perinodal adipose tissue. This histological feature has recently been indicated as an important prognostic factor in different types of malignancies; in this manuscript, we aim at defining its role in the prognosis of oesophageal cancer with the tool of meta-analysis. Two independent authors searched SCOPUS and PubMed until 31 August 2015 without language restrictions. The studies with available data about prognostic parameters in subjects with oesophageal cancer, comparing patients with the presence of ENE (ENE+) versus only intranodal extension (ENE-), were considered as eligible. Data were summarised using risk ratios (RRs) for number of deaths/recurrences and HRs together with 95% CIs for time-dependent risk related to ENE+, adjusted for potential confounders. Fourteen studies were selected; they followed-up 1437 patients with oesophageal cancer for a median follow-up of 39.4months. The presence of ENE was associated with a significantly increased risk of all-cause mortality (RR=1.33; 95% CI 1.18 to 1.50, p
Published: 2016

39. Nutritional status, physical performance and disability in the elderly of the Peruvian Andes

Author: Nicola Veronese, Giuseppe Sergi, Valter Giantin, Alessandra Tramontano, Caterina Trevisan, Francesca De Zaiacomo, Diana Rodríguez-Hurtado, Enzo Manzato, Tramontano, A., Veronese, N., Giantin, V., Manzato, E., Rodriguez-Hurtado, D., Trevisan, C., De Zaiacomo, F., and Sergi, G.
Subjects: Gerontology, Male, Aging, Activities of daily living, Instrumental activities of daily living, Malnutrition, Mini-Nutritional Assessment, Physical performance, Short Physical Performance Battery, 030209 endocrinology & metabolism, NO, 03 medical and health sciences, 0302 clinical medicine, Prevalence, Medicine, Humans, 030212 general & internal medicine, Aged, physical performance, disability, Aged, 80 and over, Nutritional Status/physiology, business.industry, Confounding, Nutritional status, medicine.disease, Nutrition Assessment, Functional status, Female, Geriatrics and Gerontology, Rural area, business, purl.org/pe-repo/ocde/ford#3.02.26 [https], human activities
Abstract: Background: Although nutritional status plays an important part in the physical performance and disability of older people, this relationship has been little studied in developing countries. Aims: A study on the effects of nutritional status on the physical performance and functional status of elderly people living in rural areas of the Peruvian Andes. Methods: The study concerned 222 people aged ≥65years living in a rural area of the Peruvian Andes. The Mini-Nutritional Assessment (MNA) was used to classify participants as malnourished (MNA=24). The short physical performance battery (SPPB) and six-minute walking test (6MWT) were used to measure participants’ physical performance. Disabilities were investigated by assessing participants’ self-reported difficulty in performing one or more basic activities of daily living (ADL), and instrumental activities of daily living (IADL). Results: The prevalence of malnutrition was 9.4%, and more than half of our samples were at risk of malnutrition. After adjusting for potential confounders, malnourished individuals performed significantly worse than the other MNA groups in the SPPB (p for trend=0.001), 6MWT and IADL (p for trend&nbsp
Published: 2016

40. Hypovitaminosis D and orthostatic hypotension: A systematic review and meta-analysis

Author: Francesca Ometto, Ahmet Turan Isik, Cédric Annweiler, Marco Solmi, Brendon Stubbs, Nicola Veronese, Guillaume T. Duval, Claudio Luchini, Wooyoung Jang, Giuseppe Sergi, Conal Cunningham, Hee Tae Kim, Pinar Soysal, Kevin McCarroll, Enzo Manzato, Ometto, F., Stubbs, B., Annweiler, C., Duval, G.T., Jang, W., Kim, H.-T., McCarroll, K., Cunningham, C., Soysal, P., Isik, A.T., Luchini, C., Solmi, M., Sergi, G., Manzato, E., Veronese, N., Laboratoire de Psychologie des Pays de la Loire (LPPL), Université d'Angers (UA)-Université de Nantes - UFR Lettres et Langages (UFRLL), Université de Nantes (UN)-Université de Nantes (UN), Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, and SOYSAL, PINAR
Subjects: medicine.medical_specialty, Odds ratios, Cross-sectional study, Physiology, CMA, 030204 cardiovascular system & hematology, vitamin D deficiency, serum 25 hydroxyVitamin D, orthostatic hypotension, 03 medical and health sciences, Orthostatic vital signs, Hypotension, Orthostatic, 0302 clinical medicine, Risk Factors, Internal medicine, meta-analysis, orthostatic hypotension, serum 25 hydroxyvitamin D, vitamin D, Orthostatic hypotension, vitamin D, medicine, Vitamin D and neurology, Prevalence, Internal Medicine, Humans, 030212 general & internal medicine, Vitamin D, ORs, business.industry, Confounding, Confidence interval, Case-control study, Odds ratio, Parathyroidhormone, Comprehensive meta-analysis, CI, medicine.disease, Vitamin D Deficiency, 3. Good health, meta-analysis, 25 hydroxyvitamin D, Cross-Sectional Studies, Meta-analysis, Case-Control Studies, Physical therapy, 25OHD, Cardiology and Cardiovascular Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, PTH
Abstract: Objectives: Orthostatic hypotension is a common condition among older adults and is associated with a range of deleterious outcomes. Recently, interest has developed in hypovitaminosis D (defined as low 25 hydroxiyVitamin D levels) as a potential risk factor for orthostatic hypotension. We conducted a systematic review and meta-analysis examining the association of orthostatic hypotension between study participants with and without hypovitaminosis D, including the adjustment of potential confounders (age, sex, BMI, renal function, comorbidities, seasonality, use of antihypertensive medications, and supplementation with cholecalciferol). Methods: A systematic literature search of major electronic databases from inception until 09/2015 was made for articles providing data on orthostatic hypotension and hypovitaminosis D. A random effects meta-analysis of cross-sectional studies investigating orthostatic hypotension prevalence comparing participants with vs. those without hypovitaminosis D was undertaken, calculating the odds ratios (ORs) and 95% confidence intervals (CIs). Results: Of 317 initial hits, five cross-sectional studies were meta-analysed including 3646 participants (1270 with hypovitaminosis D and 2376 without). The participants with hypovitaminosis D had a higher prevalence of orthostatic hypotension (OR = 1.88; 95% CI: 1.25-2.84; I 2 = 68%) that was not affected by adjusting for a median of five potential confounders (OR = 2.03; 95% CI: 1.13-3.68; I 2 = 73%). People with orthostatic hypotension had significantly reduced serum Vitamin D concentrations (standardized mean difference = -0.42; 95% CI: -0.72 to -0.12). One longitudinal study confirmed the association between hypovitaminosis D and orthostatic hypotension. Conclusion: Our meta-analysis highlights that hypovitaminosis D is associated with orthostatic hypotension, independent of potential confounders. Further longitudinal studies and clinical trials are required to confirm these findings. © Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.
Published: 2016

41. High serum uric acid levels increase the risk of metabolic syndrome in elderly women: The PRO.V.A study

Author: G. Sergi, Nicola Veronese, Egle Perissinotto, Anna Zurlo, Stefania Maggi, Sabina Zambon, Monica Maselli, Luigi Sartori, Gaetano Crepaldi, Elena Debora Toffanello, Estella Musacchio, Enzo Manzato, Valter Giantin, Zurlo, A., Veronese, N., Giantin, V., Maselli, M., Zambon, S., Maggi, S., Musacchio, E., Toffanello, E.D., Sartori, L., Perissinotto, E., Crepaldi, G., Manzato, E., and Sergi, G.
Subjects: Male, Time Factors, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), 030204 cardiovascular system & hematology, chemistry.chemical_compound, Endocrinology, 0302 clinical medicine, Elderly, Longitudinal Studies, Prospective Studies, Prospective cohort study, Aged, 80 and over, Metabolic Syndrome, Cohort study, Community-dwelling adults, Metabolic syndrome X, Uric acid, Nutrition and Dietetics, Cardiology and Cardiovascular Medicine, Incidence (epidemiology), Incidence, Age Factors, Up-Regulation, Diabetes and Metabolism, Italy, Cohort, Female, Community-dwelling adult, medicine.medical_specialty, National Health and Nutrition Examination Survey, 030209 endocrinology & metabolism, Hyperuricemia, Risk Assessment, 03 medical and health sciences, Sex Factors, Internal medicine, medicine, Humans, Aged, Proportional Hazards Models, business.industry, medicine.disease, Logistic Models, chemistry, Linear Models, Metabolic syndrome, business, Body mass index, Biomarkers, Follow-Up Studies
Abstract: Background and aims: Serum uric acid (SUA) is the end-product of purine metabolism in humans, and its levels often increase in subjects with metabolic syndrome (MetS). Despite several studies demonstrating a relationship between increased SUA levels and the prevalence of MetS, prospective data on SUA as a predictor of the incidence of MetS in the elderly are limited. Our aim was to conduct a prospective study on the association between SUA concentrations and the onset of MetS in an elderly Italian cohort. Methods and results: This is a cohort study (Progetto Veneto Anziani Pro.V.A.) involving community-dwelling subjects aged ≥65 years and followed up for a mean 4.4 years. We included 1128 participants (aged 74.7 ± 7.1 years) without MetS at the baseline. Gender-specific SUA groups according to the standard deviation (SD) from the mean were considered, taking the incidence of MetS as the main outcome.The mean SUA level was significantly higher in men than in women (5.4 ± 1.2 vs. 4.5 ± 1.2 mg/dl; p < 0.0001). Over the 4.4-year follow-up, 496 individuals developed MetS. After adjusting for potential confounders, Cox's regression analysis revealed no relationship between higher baseline SUA concentrations and the incidence of MetS in men or in the sample as whole, while women with SUA levels more than 1 SD above the mean (≥5.7 mg/dl) carried a 58% higher risk (95%CI: 1.03-2.40; p = 0.03) of being newly diagnosed with MetS during the follow-up. Conclusion: High SUA levels significantly and independently predicted MetS in older women, but not in men, over a 4.4-year follow-up. © 2015 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University.
Published: 2016

42. Global cardiovascular risk management in different Italian regions: An analysis of the evaluation of final feasible effect of control training and ultra sensitisation (EFFECTUS) educational program

Author: Gerardo Medea, Angelo Avogaro, Piero Guida, Massimo Volpe, Andrea Ferrucci, Carlo Giorda, Gian Francesco Mureddu, Giuliano Tocci, Giulio Titta, Giuseppe Ventriglia, Gabriele Riccardi, Giovanni Battista Zito, Claudio Cortese, Marco Comaschi, Alberto Corsini, Enzo Manzato, Tocci, G, Ferrucci, A, Guida, P, Corsini, A, Avogaro, A, Comaschi, M, Cortese, C, Giorda, Gb, Manzato, E, Medea, G, Mureddu, Gf, Tritta, G, Ventriglia, G, Riccardi, Gabriele, Zito, Gb, and Volpe, M.
Subjects: Male, Health Knowledge, Attitudes, Practice, Time Factors, Settore MED/09 - Medicina Interna, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Residence Characteristics, Risk Factors, Preventive Health Services, Prevalence, Practice Patterns, Physicians', Risk management, general practice, education, Nutrition and Dietetics, CVD prevention, education, general practice, Settore BIO/12, Medical record, Awareness, Middle Aged, Clinical Practice, Treatment Outcome, Italy, Cardiovascular Diseases, Practice Guidelines as Topic, Risk stratification, Education, Medical, Continuing, Female, Guideline Adherence, Lipid lowering, Cardiology and Cardiovascular Medicine, Adult, medicine.medical_specialty, Attitude of Health Personnel, Risk Assessment, Environmental health, medicine, Humans, Aged, CVD prevention, Chi-Square Distribution, business.industry, Cardiovascular Agents, medicine.disease, Obesity, Physical therapy, Feasibility Studies, business, Risk Reduction Behavior, Educational program, Program Evaluation
Abstract: Background and Aim The Final Evaluation Feasible Effect of Ultra Control Training and Sensitization (EFFECTUS) is an educational program, aimed at improving global CV risk stratification and management in Italy. The present study evaluates differences on clinical approach to global CV risk among physicians involved in the EFFECTUS program and stratified in three geographical macro-areas (North, Center, South) of our Country. Methods and Results Physicians were asked to submit data already available in their medical records, covering the first 10 adult outpatients, consecutively seen in the month of May 2006. Overall, 1.078 physicians (27% females, aged 50 ± 7 years) collected data of 9.904 outpatients (46.5% females, aged 67 ± 9 years), among which 3.219 (32.5%) were residents in Northern, 3.652 (36.9%) in Central and 3.033 (30.6%) in Southern Italy. A significantly higher prevalence of major CV risk factors, including obesity, physical inactivity, hypertension and diabetes, was recorded in Southern than in other areas. Accordingly, Southern physicians more frequently prescribed antihypertensive, glucose and lipid lowering agents than other physicians, who paid significantly more attention to life-style changes in their clinical practice. Conclusions This analysis of the EFFECTUS study demonstrates a high prevalence of CV risk factors in Italy, particularly in Southern areas, and indicates some important discrepancies in the clinical management of global CV risk among physcians working in different Italian regions.
Published: 2012

43. Serum dehydroepiandrosterone sulfate and osteoarthritis in older people: the Pro.V.A. study

Author: Marina De Rui, Stefania Maggi, Egle Perissinotto, Estella Musacchio, Nicola Veronese, Francesco Bolzetta, Caterina Trevisan, Gaetano Crepaldi, S Zambon, Enzo Manzato, Leonardo Sartori, Marianna Noale, Giuseppe Sergi, Veronese, N., Maggi, S., Noale, M., Trevisan, C., De Rui, M., Bolzetta, F., Zambon, S., Sartori, L., Musacchio, E., Perissinotto, E., Crepaldi, G., Manzato, E., and Sergi, G.
Subjects: Male, medicine.medical_specialty, DHEAS, Physical examination, Osteoarthritis, 030204 cardiovascular system & hematology, Logistic regression, NO, 03 medical and health sciences, chemistry.chemical_compound, Community-dwelling adults, DHEAS, Elderly, Osteoarthritis, 0302 clinical medicine, Dehydroepiandrosterone sulfate, Elderly, Rheumatology, Internal medicine, medicine, Community-dwelling adults, Humans, Aged, Aged, 80 and over, Analgesics, 030214 geriatrics, medicine.diagnostic_test, business.industry, Dehydroepiandrosterone Sulfate, Confounding, General Medicine, medicine.disease, Cross-Sectional Studies, chemistry, Italy, Cohort, Physical therapy, Female, business, Cohort study
Abstract: Although osteoarthritis (OA) and low levels of dehydroepiandrosterone sulfate (DHEAS) are common in the elderly, no studies on human beings are available concerning the possible relationship between them. We aimed to examine the relationship between DHEAS levels and any presence of OA in a cohort of community-dwelling older subjects. This study was part of the Progetto Veneto Anziani (Pro.V.A.), an Italian population-based cohort study on people over 65years old. In this cross-sectional work, we considered 2050 individuals with a mean age of 74.2 ± 7.1years (818 M and 1232 F), and with a complete set of information on OA and DHEAS levels. OA was defined using a standardized algorithm investigating disease history, medical records, symptoms, use of analgesic drugs for OA, and physical examination of the hand, hip, and knee. DHEAS levels were classified using gender-specific tertiles. OA at the three sites investigated was significantly more common in women than in men, and in individuals with lower serum DHEAS concentrations. On logistic regression analysis, taking those in the highest DHEAS tertile for reference and adjusting for potential confounders, subjects in the lowest tertile had significantly higher odds of OA involving the hand (men: OR = 1.49; 95% CI 1.31–1.70, women: 1.28; 95% CI 1.16–1.41), hip (men: 1.55; 95% CI 1.33–1.81; women: 1.17; 95% CI 1.06–1.30), and knee (men: 1.54; 95% CI 1.35–1.76; women: 1.31 95% CI 1.19–1.45). Similar findings emerged for individuals in the intermediate DHEAS tertile. Low DHEAS levels are associated with OA, irrespective of site and gender. © 2016, International League of Associations for Rheumatology (ILAR).
Published: 2015

44. Imaging of sarcopenia

Author: Giuseppe Sergi, Nicola Veronese, Paola Lucato, Caterina Trevisan, Enzo Manzato, Sergi, G., Trevisan, C., Veronese, N., Lucato, P., and Manzato, E.
Subjects: Adult, medicine.medical_specialty, Sarcopenia, Fat infiltration, Computed tomography, Muscle mass, NO, 03 medical and health sciences, 0302 clinical medicine, Absorptiometry, Photon, Nuclear Medicine and Imaging, Ultrasound, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Muscle, Skeletal, Aged, Ultrasonography, medicine.diagnostic_test, business.industry, Reproducibility of Results, Magnetic resonance imaging, General Medicine, Gold standard (test), medicine.disease, Dual X-ray absorptiometry, Magnetic Resonance Imaging, Rapid assessment, Magnetic resonance, Radiology, Nuclear Medicine and Imaging, Body Composition, Radiology, business, Tomography, X-Ray Computed, 030217 neurology & neurosurgery, Biomedical engineering
Abstract: Sarcopenia is currently considered a geriatric syndrome increasing in older people. The consequences of sarcopenia – in terms of impaired mobility, limited self-sufficiency and disability – have been amply demonstrated, increasing the need to develop methods to identify muscle mass loss as early as possible. Although sarcopenia involves a reduction in both muscle mass and function, loss of muscle mass remains the essential criterion for diagnosing this condition in daily practice. Computed tomography and magnetic resonance imaging represent the gold standard for studying body composition, and can identify quantitative and qualitative changes in muscle mass. These techniques are costly, time-consuming and complex, however, so their applicability is limited to the research field. Sonography, on the other hand, has the advantage of being a relatively quick and inexpensive method for detecting loss of muscle fibers and fat infiltration by analyzing muscle thickness and echo intensity. To the best of our knowledge, however, only few studies have compared the results of ultrasound with those obtained by other methods in order to establish its reliability in this setting. Dual X-ray absorptiometry thus remains the most often used technology for studying body composition, detecting quantitative changes in muscle mass with the advantages of a low radiation dose, a simple technology and a rapid assessment. © 2016 Elsevier Ireland Ltd
Published: 2015

45. An Analysis of the Management of Cardiovascular Risk Factors in Routine Clinical Practice in Italy

Author: Giuseppe Ventriglia, Andrea Ferrucci, Giovanni Battista Zito, Massimo Volpe, Claudio Cortese, Angelo Avogaro, Gian Francesco Mureddu, Marco Comaschi, Gerardo Medea, Alberto Corsini, Gabriele Riccardi, Giuliano Tocci, Enzo Manzato, Pietro Guida, Carlo Giorda, Giulio Titta, Tocci, G, Ferrucci, A, Guida, P, Avogaro, A, Comaschi, M, Corsini, A, Cortese, C, Giorda, Cb, Manzato, E, Medea, G, Mureddu, Gf, Riccardi, Gabriele, Titta, G, Ventriglia, G, Zito, Gb, and Volpe, M.
Subjects: cardiovascular risk factors, medicine.medical_specialty, cardiovascular risk management, hypertension, General Practice, Cardiovascular risk factors, diabetes, global cardiovascular risk, hypercholesterolaemia, Disease, Pharmacotherapy, Risk Factors, Diabetes mellitus, Internal Medicine, medicine, Humans, Outpatient clinic, Routine clinical practice, Disease markers, Disease management (health), Intensive care medicine, business.industry, medicine.disease, Italy, Cardiovascular Diseases, Medical emergency, Cardiology and Cardiovascular Medicine, business
Abstract: Cardiovascular diseases represent the leading cause of morbidity and mortality, worldwide. Early detection and appropriate management of cardiovascular risk factors and disease markers in daily clinical practice may improve preventive strategies and reduce the burden of cardiovascular disease. The EFFECTUS (Evaluation of Final Feasible Effect of Control Training and Ultra Sensitisation) programme was an educational programme aimed at evaluating prevalence of major cardiovascular risk factors among outpatients, and preferences and attitudes for cardiovascular disease management among Italian physicians in their routine clinical practice. This article provides an overview of the main findings of different analyses from the EFFECTUS database, which have demonstrated a high prevalence of cardiovascular risk factors, irrespective of the clinical settings and outpatient clinics in which patients were followed. Also, findings from this database suggest that more intensive clinical data recording was paralleled by better adherence to guidelines, and that use of electronic rather than conventional support for clinical data collection and registration improved accuracy in data recording, which translated into better management of patients at risk in daily clinical practice.
Published: 2011

46. Low Hemoglobin Levels and Risk of Developing Depression in the Elderly: Results From the Prospective PRO.V.A. Study

Author: Leonardo Sartori, Christoph U. Correll, Giuseppe Sergi, S Zambon, Gaetano Crepaldi, Estella Musacchio, Egle Perissinotto, Enzo Manzato, Marco Solmi, Caterina Trevisan, Marina De Rui, Francesco Bolzetta, Nicola Veronese, Trevisan, C., Veronese, N., Bolzetta, F., De Rui, M., Correll, C.U., Zambon, S., Musacchio, E., Sartori, L., Perissinotto, E., Crepaldi, G., Solmi, M., Manzato, E., and Sergi, G.
Subjects: Male, Risk, medicine.medical_specialty, Anemia, Comorbidity, NO, older people, 03 medical and health sciences, Hemoglobins, 0302 clinical medicine, Sex Factors, 030502 gerontology, Internal medicine, medicine, Humans, 030212 general & internal medicine, Depression (differential diagnoses), Aged, Aged, 80 and over, business.industry, Depression, Incidence (epidemiology), Incidence, Hazard ratio, medicine.disease, Confidence interval, Psychiatry and Mental health, Italy, Cohort, Geriatric Depression Scale, Female, Hemoglobin, 0305 other medical science, business, Follow-Up Studies
Abstract: OBJECTIVE Low hemoglobin negatively affects health in the elderly, but research about the association with risk for depression is limited. We investigated the association between baseline hemoglobin concentrations and incident depression in a cohort of nondepressed elderly individuals. METHODS As part of the Northern Italian Progetto Veneto Anziani (PRO.V.A.) study, randomly drawn, community-dwelling subjects aged ≥ 65 years underwent prospective clinical and laboratory assessments between October 1995 and December 2002. The association between baseline hemoglobin and depression was assessed with adjusted Cox regression analyses. Baseline serum hemoglobin concentrations were further categorized in gender-specific tertiles; anemia was defined as serum hemoglobin < 13 g/dL for men and < 12 g/dL for women. Moreover, hemoglobin concentration was measured at follow-up, and changes in concentration from baseline to follow-up were investigated. Depression was defined by a score of ≥ 11/30 on the validated Geriatric Depression Scale and confirmed by psychogeriatric specialists. RESULTS Among 1,303 elderly individuals (566 men, 737 women) without depression at baseline, 294 subjects (177 women, 117 men; global incidence rate = 50 [95% confidence interval (CI), 0-170] per 1,000 patient years) developed depression during 4.4 years of follow-up. Low baseline serum hemoglobin concentration was most strongly associated with incident depression at follow-up in men (hazard ratio [HR] = 1.39; 95% CI, 1.12-1.69; P = .002), but not in women (P = .50). Men with the lowest baseline tertile hemoglobin concentration (HR = 1.68; 95% CI, = 1.02-3.08; P = .04) or with anemia (HR = 2.02; 95% CI, = 1.13-3.64; P = .02) had greater risk of depression, whereas findings were nonsignificant for women. Low follow-up hemoglobin concentration in men was less strongly associated with incident depression (HR = 1.15; 95% CI, 1.01-1.33; P = .05), as were the lowest endpoint tertile hemoglobin concentration (P = .03) and presence of anemia (P = .05). CONCLUSIONS Low baseline hemoglobin strongly predicted incident depression in older men, but not in women..
Published: 2015

47. Inflammatory cytokines and anorexia nervosa: A meta-analysis of cross-sectional and longitudinal studies

Author: Paolo Santonastaso, Enzo Manzato, Marco Solmi, Christoph U. Correll, Nicola Veronese, Giuseppe Sergi, Angela Favaro, Solmi, M., Veronese, N., Favaro, A., Santonastaso, P., Manzato, E., Sergi, G., and Correll, C.U.
Subjects: Adult, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Inflammation, Gastroenterology, Proinflammatory cytokine, Young Adult, Endocrinology, Internal medicine, medicine, Humans, Cytokine, Biological Psychiatry, Endocrine and Autonomic Systems, business.industry, Interleukin, Anorexia nervosa, medicine.disease, Confidence interval, Psychiatry and Mental health, Eating disorders, Anorexia nervosa (differential diagnoses), Meta-analysis, Cytokines, Female, medicine.symptom, business, Weight gain
Abstract: Objective: Although inflammation is increasingly implicated in psychiatric disorders, less is known about its role in anorexia nervosa (AN), an illness with low body mass index (BMI). Methods: We performed a systematic PubMed literature search until 12/31/2013 and meta-analyzed cross-sectional and longitudinal studies comparing circulating pro- and anti-inflammatory cytokines between patients with anorexia nervosa (AN) and healthy controls (HCs) (1) before and (2) after weight gain, and (3) within AN patients before and after weight gain. Standardized mean differences (SMDs). ±. 95% confidence intervals (CIs) for results from ≥2 studies were calculated. Results: Of 999 initial hits, 22 studies with 924 participants (AN. =. 512, HCs. =. 412) were eligible. Compared to HCs, tumor necrosis factor (TNF)-alpha (SMD. =. 0.35, 95%CI. =. 0.09-0.61, p=. 0.008), interleukin (IL)1-beta (SMD. =. 0.51, 95%CI. =. 0.18-0.84, p=. 0.003), IL-6 (SMD. =. 0.43, 95%CI. =. 0.11-0.76, p=. 0.009), and TNF-receptor-II (SMD. =. 0.42, 95%CI:0.07-0.78, p=. 0.02) were significantly elevated in AN, while C-reactive protein (SMD. =. -0.53, 95%CI. =. -.77, -0.28, p
Published: 2015

48. Effect of weight loss on mortality in overweight and obese nursing home residents during a 5-year follow-up

Author: M. De Rui, S. Pizzato, Egle Perissinotto, A Imoscopi, Giuseppe Sergi, S. Carraro, Alessandra Coin, E Orr, Linda Berton, Francesco Bolzetta, I. De Ronch, Nicola Veronese, Enzo Manzato, Pizzato, S., Sergi, G., Bolzetta, F., De Rui, M., De Ronch, I., Carraro, S., Berton, L., Orr, E., Imoscopi, A., Perissinotto, E., Coin, A., Manzato, E., and Veronese, N.
Subjects: Male, medicine.medical_specialty, Activities of daily living, Medicine (miscellaneous), Nutritional Status, Overweight, Body Mass Index, Weight loss, Risk Factors, Activities of Daily Living, Weight Loss, medicine, Homes for the Aged, Humans, Longitudinal Studies, Obesity, Aged, Proportional Hazards Models, Aged, 80 and over, Nutrition and Dietetics, business.industry, Proportional hazards model, medicine.disease, body mass, Nursing Homes, Italy, Physical therapy, Female, medicine.symptom, business, Nursing homes, Weight gain, Body mass index, Demography, Follow-Up Studies
Abstract: Background/Objectives:The objective of this study was to ascertain the effect of weight loss over the course of 1 year on 5-year mortality in old nursing home (NH) residents in different classes of body mass index (BMI).Subjects/Methods:A longitudinal study was conducted on 161 NH residents aged ≥70 years at the Istituto di Riposo per Anziani, Padova, Italy. Data were collected using a comprehensive geriatric assessment at baseline and at a 1-year follow-up visit. Mortality was recorded over a 5-year follow-up. We divided our sample into four groups using as cutoffs a BMI of 25 and a weight gain or loss of 5% at 1 year (BMI ≥25 and weight stable/gain, BMI ≥25 and weight loss, BMI
Published: 2015

49. Prognostic role and implications of mutation status of tumor suppressor gene ARID1A in cancer: A systematic review and meta-analysis

Author: Aldo Scarpa, Jae Hoon Kim, George M. Yousef, Hai Bo Yan, Duck Woo Kim, Andreas Scorilas, Angela Chou, Giuseppe Sergi, Anthony J. Gill, Da Pang, Marco Solmi, Alcides Chaux, Yoshihito Yokoyama, Gregg Nelson, Nicola Veronese, Martin Köbel, Christoph U. Correll, David F. Schaeffer, George J. Netto, Satoru Kyo, Feng Liu, Claudio Luchini, Laura D. Wood, Soo Young Lee, Zsuzsanna Lichner, Hanbyoul Cho, Kentaro Nakayama, Paola Capelli, Sheila F. Faraj, Steve E. Kalloger, Xianyu Zhang, Enzo Manzato, Luchini, C., Veronese, N., Solmi, M., Cho, H., Kim, J.-H., Chou, A., Gill, A.J., Faraj, S.F., Chaux, A., Netto, G.J., Nakayama, K., Kyo, S., Lee, S.Y., Kim, D.-W., Yousef, G.M., Scorilas, A., Nelson, G.S., Köbel, M., Kalloger, S.E., Schaeffer, D.F., Yan, H.-B., Liu, F., Yokoyama, Y., Zhang, X., Pang, D., Lichner, Z., Sergi, G., Manzato, E., Capelli, P., Wood, L.D., Scarpa, A., and Correll, C.U.
Subjects: Oncology, Male, medicine.medical_specialty, Bioinformatics, ARID1A, SWI/SNF, chromatin remodeling, targeted therapy, tumor suppressor gene, chromatin remodeling, Cohort Studies, ARID1A, Chromatin remodeling, SWI/SNF, Targeted therapy, Tumor suppressor gene, Internal medicine, Neoplasms, Medicine, Humans, targeted therapy, tumor suppressor gene, Genes, Tumor Suppressor, Prospective cohort study, business.industry, Confounding, Hazard ratio, Cancer, Nuclear Proteins, Middle Aged, medicine.disease, Prognosis, Confidence interval, DNA-Binding Proteins, Relative risk, Meta-analysis, Mutation, Female, business, Cohort study, Research Paper, Transcription Factors
Abstract: Loss of the tumor suppressor gene AT-rich interactive domain-containing protein 1A (ARID1A) has been demonstrated in several cancers, but its prognostic role is unknown. We aimed to investigate the risk associated with loss of ARID1A (ARID1A-) for all-cause mortality, cancer-specific mortality and recurrence of disease in subjects with cancer. PubMed and SCOPUS search from database inception until 01/31/2015 without language restriction was conducted, contacting authors for unpublished data. Eligible were prospective studies reporting data on prognostic parameters in subjects with cancer, comparing participants with presence of ARID1A (ARID1A+) vs. ARID1A-, assessed either via immunohistochemistry (loss of expression) or with genetic testing (presence of mutation). Data were summarized using risk ratios (RR) for number of deaths/recurrences and hazard ratios (HR) for time-dependent risk related to ARID1A- adjusted for potential confounders. Of 136 hits, 25 studies with 5,651 participants (28 cohorts; ARID1A-: n = 1,701; ARID1A+: n = 3,950), with a mean follow-up period of 4.7 ± 1.8 years, were meta-analyzed. Compared to ARID1A+, ARID1A- significantly increased cancer-specific mortality (studies = 3; RR = 1.55, 95% confidence interval (CI) = 1.19-2.00, I(2) = 31%). Using HRs adjusted for potential confounders, ARID1A- was associated with a greater risk of cancer-specific mortality (studies = 2; HR = 2.55, 95%CI = 1.19-5.45, I(2) = 19%) and cancer recurrence (studies = 10; HR = 1.93, 95%CI = 1.22-3.05, I(2) = 76%). On the basis of these results, we have demonstrated that loss of ARID1A shortened time to cancer-specific mortality, and to recurrence of cancer when adjusting for potential confounders. For its role, this gene should be considered as an important potential target for personalized medicine in cancer treatment.
Published: 2015

50. Are the Recommended Dietary Allowances for Vitamins Appropriate for Elderly People?

Author: Marina De Rui, Lorenzo M. Donini, Francesco Bolzetta, Emine Meral Inelmen, Elena Debora Toffanello, Egle Perissinotto, Linda Berton, Alessandra Coin, Giuseppe Sergi, Enzo Manzato, S. Carraro, F. Miotto, Nicola Veronese, Bolzetta, F., Veronese, N., De Rui, M., Berton, L., Toffanello, E.D., Carraro, S., Miotto, F., Inelmen, E.M., Donini, L.M., Manzato, E., Coin, A., Perissinotto, E., and Sergi, G.
Subjects: Dietary Fiber, Riboflavin, Ascorbic Acid, Recommended Dietary Allowances, Pantothenic Acid, Body Mass Index, chemistry.chemical_compound, Pantothenic acid, 80 and over, Micronutrient, Micronutrients, Older people, Recommended Dietary Allowances (RDA), Vitamins, Aged, Aged, 80 and over, Body Weight, Cross-Sectional Studies, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Energy Intake, Female, Folic Acid, Humans, Nutrition Assessment, Nutritional Status, Portion Size, Vitamin A, Vitamin B 12, Vitamin B 6, Food Science, Nutrition and Dietetics, Medicine (all), General Medicine, Vitamin, vitamis, elderly, Environmental health, medicine, Recommended Dietary Allowances (RDAs), business.industry, Retinol Equivalent, medicine.disease, Ascorbic acid, Malnutrition, chemistry, business, Body mass index
Abstract: Background: An adequate vitamin intake is essential for a good nutritional status, especially in older women, who are more sensitive to nutritional deficiencies. The American, European and Italian Recommended Dietary Allowances (RDAs) derive mainly from studies on adults, and it is not clear whether they also apply to elderly people. Comparing the RDAs with the actual vitamin intake of a group of healthy older women could help to clarify the real needs of elderly people. Objective: Our aim was to compare the American, European, and Italian RDAs with the actual vitamin intake of a group of healthy older women. Design: This was a cross-sectional study. Participants: The study included 286 healthy women aged older than 65 years. Main outcome measures: For each micronutrient, the 50th percentile of the distribution of its intake was considered as the average requirement, and the corresponding calculated RDA for our sample was the average requirement×1.2, as recommended by the US Food and Nutrition Board. This calculated RDA was then compared with the American, European, and Italian RDAs. Statistical analyses performed: Student's t test or the Mann-Whitney test (after checking the normal distribution of the micronutrient) for continuous variables; the χ2 test for categorical variables. Results: The calculated RDA were 2,230 μg retinol equivalents for vitamin A, 2.8 μg for vitamin B-12, 0.9 mg for thiamin, 1.4 mg for riboflavin, 3.6 mg for pantothenic acid, 1.4 mg for vitamin B-6, 320 μg for folic acid, and 115 mg for vitamin C. Conclusions: Our findings suggest that the current RDAs are adequate for older women's intake of riboflavin, vitamin B-6, and folic acid, but should be raised for vitamin B-12 and for vitamin C. © 2015 Academy of Nutrition and Dietetics.
Published: 2015

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