1. Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2
- Author
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Surya Pavan Yenamandra, Han Shi Jeri Lim, Carmen Koo, Hapuarachchige Chanditha Hapuarachchi, Lee Ching Ng, Zhen Yuan Yeo, Suzanna Chiang, and School of Biological Sciences
- Subjects
0301 basic medicine ,Genotype ,Science ,Lineage (evolution) ,030231 tropical medicine ,Biology ,Dengue virus ,medicine.disease_cause ,Genome ,Molecular Evolution ,Article ,Dengue fever ,Dengue ,Evolution, Molecular ,03 medical and health sciences ,0302 clinical medicine ,Viral Envelope Proteins ,medicine ,Humans ,Gene ,Phylogeny ,Multidisciplinary ,Molecular epidemiology ,Biological sciences [Science] ,Dengue Virus ,medicine.disease ,Phylogenetics ,030104 developmental biology ,Evolutionary biology ,Medicine ,Biological dispersal ,Molecular evolution - Abstract
Dengue virus type 2 (DENV-2) contributes substantially to the dengue burden and dengue-related mortality in the tropics and sub-tropics. DENV-2 includes six genotypes, among which cosmopolitan genotype is the most widespread. The present study investigated the evolution, intra-genotype heterogeneity and dispersal of cosmopolitan genotype to understand unique genetic characteristics that have shaped the molecular epidemiology and distribution of cosmopolitan lineages. The spatial analysis demonstrated a wide geo-distribution of cosmopolitan genotype through an extensive inter-continental network, anchored in Southeast Asia and Indian sub-continent. Intra-genotype analyses using 3367 envelope gene sequences revealed six distinct lineages within the cosmopolitan genotype, namely the Indian sub-continent lineage and five other lineages. Indian sub-continent lineage was the most diverged among six lineages and has almost reached the nucleotide divergence threshold of 6% within E gene to qualify as a separate genotype. Genome wide amino acid signatures and selection pressure analyses further suggested differences in evolutionary characteristics between the Indian sub-continent lineage and other lineages. The present study narrates a comprehensive genomic analysis of cosmopolitan genotype and presents notable genetic characteristics that occurred during its evolution and global expansion. Whether those characteristics conferred a fitness advantage to cosmopolitan genotype in different geographies warrant further investigations.
- Published
- 2021