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ŁopuszyńskaAnna,PawlickiMateusz,KozioMagdalenał,KrasaAleksandra,PiekarskaEwa,Piecewicz-SzczęsnaHalina. The influence of diet on polycystic ovary syndrome.Journal of Education, Healthand Sport. 2021;11(9):131-136. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.09.018 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.09.018 https://zenodo.org/record/5485007 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 25.08.2021. Revised: 26.08.2021. Accepted: 07.09.2021. The influence of diet on polycystic ovary syndrome Anna Łopuszyńska1, Mateusz Pawlicki1, Magdalena Kozioł1, Aleksandra Krasa1, Ewa Piekarska1, Halina Piecewicz-Szczęsna2 1Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland 2Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland Corresponding author: Anna Łopuszyńska, lopuszynskaania@gmail.com ORCID ID: Anna Łopuszyńskahttps://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Mateusz Pawlickihttps://orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Magdalena Koziołhttps://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Aleksandra Krasahttps://orcid.org/0000-0002-0733-202X, ola.AK62@gmail.com Ewa Piekarskahttps://orcid.org/0000-0002-4954-379X; piekarskaewaa@gmail.com Dr n. med. Halina Piecewicz-Szczęsnahttps://orcid.org/0000-0002-0573-7226, halpiec@gmail.com Abstract Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women inreproductive age. It is estimated that it affects about 5-10% of women aged 18-44. This disease is associated with reproductive dysfunction and metabolic disorders. According to the American Society for Reproductive Medicine (ASRM) 2018 guidelines, the first line treatment for PCOS are lifestyle adjustments, including dietary control and exercise. Hence a lot of research on the diet that is most appropriate for this group of people. Material and methods: PubMed research base was searched using the following keywords: diet, pcos, policystic ovary syndrome in 2017-2021. Results: The diet of women with PCOS is poorly composed,and dietary errors may affect the metabolic disorders occurring in these patients. Women with PCOS tend to have insufficient intakes of vitamin D, fiber, and vitamin B9, as well as excessive sodium intake. Mediterranean, ketogenic, low-carbohydrate, low-glycemic, low-AGE and pod-based diets positively affect this disease in variousways. Conclusions: PCOS is a very diverse disease that affects a large number of women around the world. Changing your lifestyle, including diet and exercise, is the first line treatment. This is why creating the best diet for these patients is extremely important. Current discoveries are very promising and give hope to create a model of nutrition that will be the best for these women. Large, multicentre randomized trials are still needed to develop diets that are appropriate for different patients because the disease picture is heterogeneous. Keywords: diet, policystic ovary syndrome, bmi

KrasaAleksandra,KoziołMagdalena,Piecewicz-SzczęsnaHalina,ŁopuszyńskaAnna,PiekarskaEwa,WięsykPiotr,PawlickiMateusz. Neurological manifestations and complications of COVID-19. A literature review. Journal of Education, Healthand Sport. 2021;11(8):349-360. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.08.039 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.08.039 https://zenodo.org/record/5300055 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.08.2021. Revised: 15.08.2021. Accepted: 28.08.2021. Neurological manifestations and complications of COVID-19. A literature review Aleksandra Krasaa, Magdalena Kozioła, Halina Piecewicz-Szczęsnab, Anna Łopuszyńskaa,Ewa Piekarskaa, Piotr Więsyka, Mateusz Pawlickia aStudent Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland bDepartment of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland Corresponding author: Aleksandra Krasa, aleksandra.krasa97@gmail.com ORCID ID: Aleksandra Krasa, 0000-0002-0733-202X, aleksandra.krasa97@gmail.com Magdalena Kozioł, 0000-0002-8671-5968, magdalena.koziol@icloud.com dr n. med. Halina Piecewicz-Szczęsna, 0000-0002-0573-7226, halpiec@gmail.com Anna Łopuszyńska, 0000-0001-5133-4180, lopuszynskaania@gmail.com Ewa Piekarska, 0000-0002-4954-379X, piekarskaewaa@gmail.com Piotr Więsyk, 0000-0001-6785-6741, piotrwiesyk@gmail.com Mateusz Pawlicki, 0000-0001-8318-6573, pawlak32@gmail.com ABSTRACT Introduction. The first case of SARS-CoV-2 infection was identified in December 2019 in Wuhan, China. The disease spread rapidly worldwide and the WHO declared a pandemic on March 11, 2020. Although coronavirus disease 2019 (COVID-19) has been associated primarily with respiratory disorders, more and more research is focusing on neurological manifestations and complications. Objective. The aim of the review is to systematize and update the knowledge and available research on neurological complications among COVID-19 patients. Review methods. A systematic search of PubMed and Google Scholar databases was conducted for studies. The following keywords combinations were used: COVID-19, SARS-CoV-2 infection, neurological complications, neurological manifestations, neuroinvasion, neurovirulence. Results. The disease in most patients is characterized by mild to medium fever, fatigue, dry cough, dyspnea, muscle pain and headache. ACE2, which is the receptor for SARS-COV-2, is ubiquitously expressed in a variety of human organs, including the brain. Following previous reports, these receptors are expressed in both glial cells and neurons. Many studies have reported neurological symptoms and complications among COVID-19 patients. The reported manifestations include: smell and taste disturbance, non-specific symptoms such as myalgia, headache and dizziness, acute cerebrovascular complications, encephalopathy, meningoencephalitis/encephalitis, seizure and complications of the peripheral nervous system. Conclusion.Healthcare professionals dealing with COVID-19, neuroscientists, and the general public should be aware of the neurological complications of COVID-19. Further studies are needed to assess the incidence of COVID-19 neurological complications in different populations and more analyzes are also required to understand the detailed mechanism of how the virus affects the nervous system. Keywords:COVID-19, SARS-CoV-2 infection, neurological complications, neurological manifestations, neuroinvasion, neurovirulence.

Pawlicki Mateusz, Łopuszyńska Anna, Kozioł Magdalena, Krasa Aleksandra, Piekarska Ewa, Piecewicz-Szczęsna Halina. Sleep disorders in patients with neoplasm. Journal of Education, Health and Sport. 2020;10(9):514‑519. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.09.062 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.09.062 https://zenodo.org/record/4042199 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 16.09.2020. Revised: 21.09.2020. Accepted: 22.09.2020. Sleep disorders in patients with neoplasm Mateusz Pawlicki1, Anna Łopuszyńska1, Magdalena Kozioł1, Aleksandra Krasa1, EwaPiekarska1, Halina Piecewicz-Szczęsna2 1Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland 2Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland Corresponding author: Mateusz Pawlicki, pawlak32@gmail.com ORCID ID: Mateusz Pawlicki https//orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Anna Łopuszyńska https://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Magdalena Kozioł https://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Aleksandra Krasa https://orcid.org/0000-0002-0733-202X, ola.AK62@gmail.com Ewa Piekarska https://orcid.org/0000-0002-4954-379X; piekarskaewaa@gmail.com Abstract: Introduction: Sleep disorders are a big group of disturbances affecting many people in the world. They can appear as insomnia, interrupted sleep, worsened sleep quality or trouble falling asleep. Although they may not seem very dangerous, they lead to various unpleasant complications and even diseases. Cancer is said to be one of the possible sources of the problem. Results: Studies show relationship between cancer and sleep disruptions. They are frequent in lung, head and neck, gynecologic and breast neoplasms. Patients report higher scores of Pittsburgh Sleep Quality Index, insomnia severity scale and Epworth Sleepiness Scale meaning that they can be considered as poor sleepers. In addition, they often develop psychiatric disorders which are linked with higher risk of sleep problems. Conclusions: According to many research, cancer often comes with somnipathies. It should be taken into consideration when planning oncologic treatment and care to obtain the best effects of the therapy. Key words: cancer, neoplasm, sleep, insomnia, sleep disorders

Introduction: Endometriosis is a common gynaecological disorder associated with pelvic pain and sub-fertility, affecting 7–15% of women of reproductive age. The disease is defined as the presence of endometrial-like tissue outside the uterine cavity, primarily on pelvic organs. The aetiology of endometriosis is still uncertain. The disease rarely causes mortality, however, it may have a significant impact on a patient's quality of life. Moreover, several studies have consistently shown that endometriosis is associated with a higher risk of some types of malignancies.Results: Endometriosis shares several molecular characteristics with invasive cancer, such as inflammation, tissue invasion, angiogenesis, dysfunction of immune cells and pro-survival features. Studies have shown that ovarian cancer, especially clear cell, endometrioid and serous, has been associated with endometriosis. Furthermore, the risk of cancer of the uterine cervix has shown to be decreased and the results on the risk of the cancers of uterine corpus or breast are inconsistent. Among non‐gynecological cancers, melanoma of the skin, non‐Hodgkin‐lymphoma, brain and thyroid cancers have also been associated with endometriosis.Conclusions: Research results indicate that women with endometriosis have an increased risk for some types of malignancies, therefore, they should be under strict gynecological control, even many years after menopause. Further research is needed to prove the real risk of different types of malignant tumors among women with endometriosis. In addition, it is necessary to establish periodic examination schedules among these patients in order to prevent certain types of malignancies.

Łopuszyńska Anna, Pawlicki Mateusz, Piekarska Ewa, Kozioł Magdalena, Krasa Aleksandra, Piecewicz-Szczęsna Halina. Methods of contraception for men. Journal of Education, Health and Sport. 2020;10(9):284‑289. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.09.032 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.09.032 https://zenodo.org/record/4026076 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.08.2020. Revised: 25.08.2020. Accepted: 12.09.2020. Methods of contraception for men Anna Łopuszyńska1, Mateusz Pawlicki1, Ewa Piekarska1, Magdalena Kozioł1, Aleksandra Krasa1, Halina Piecewicz-Szczęsna2 1 Student Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland; 2 Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland Corresponding author: Anna Łopuszyńska, lopuszynskaania@gmail.com ORCID ID: Anna Łopuszyńska https://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Magdalena Kozioł https://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Aleksandra Krasa https://orcid.org/0000-0002-0733-202X,ola.AK62@gmail.com Mateusz Pawlicki https://orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Ewa Piekarska https://orcid.org/0000-0002-4954-379X; piekarskaewaa@gmail.com Abstract Many pregnancies in the world are unintentional and some of them end in abortion, hence there is a great need and amount of research on contraceptives. There are many methods of pregnancy prevention for women. However, men also want to be responsible for their reproductive health. Currently, there are few methods of contraception for men (male condoms, vasectomy, withdrawal) and they have their drawbacks, so research on new contraceptives for men is ongoing. Hormonal methods under research include testosterone, nestorone, and DMAU. On the other hand, adjudin, WIN 18.446, BMS-189453 and RISUG are promising methods of non-hormonal male contraception. These substances can be a discovery and a breakthrough in male contraception, they will allow men to better control their fertility and reproductive health, and can also be a suitable solution for couples in which there are contraindications for women to use contraception. Key words: fertility; reproductive health; male contraception.

Kozioł Magdalena, Lewicki Marcin, Pawlicki Mateusz , Łopuszyńska Anna, Krasa Aleksandra, Piekarska Ewa, Krasowska Danuta. A rare case of Raoultella planticola urinary tract infection. A case report with literature review. Journal of Education, Health and Sport. 2020;10(8):470‑475. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.08.057 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.08.057 https://zenodo.org/record/4009554 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 10.08.2020. Revised: 15.08.2020. Accepted: 31.08.2020. A rare case of Raoultella planticola urinary tract infection. A case report with literature review Magdalena Kozioła, Marcin Lewickib, Mateusz Pawlickia , Anna Łopuszyńskaa, Aleksandra Krasaa, Ewa Piekarskaa, Danuta Krasowskac aStudent Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland; bDepartment of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland; cStudents’ Scientific Association at the Department of Dermatology, Venerology and Pediatric Dermatology, Medical University of Lublin, ul. Staszica 11, Lublin 20-081, Poland. Corresponding author: Magdalena Kozioł, magdalena.koziol@icloud.com ORCID ID: Magdalena Kozioł https://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Marcin Lewicki https://orcid.org/0000-0003-1906-9326, lewicki-marcin@wp.pl Aleksandra Krasa https://orcid.org/0000-0002-0733-202X,ola.AK62@gmail.com Danuta Krasowska https://orcid.org/0000-0002-3015-1120, dana.krasowska@gmail.com Mateusz Pawlicki https://orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Anna Łopuszyńska https://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Ewa Piekarska https://orcid.org/0000-0002-4954-379X; piekarskaewaa@gmail.com Abstract: Urine infections represent 40-50% of all infections in hospitalized patients. The most common uropathogens are E.coli, S.saprophitycus, and less commonly Enterobacteriaceae, such as Proteus mirabilis and Klebsiella pneumoniae. The spectrum of microorganisms isolated in hospital conditions may be wider. Raoultella planticola is a rare cause of human infections, so far only few cases of ZUM with this etiology have been described. A 56-years-old patient, with a history of cardiac disease, with exacerbation of chronic kidney disease, was admitted to the Department of Internal Medicine. The reason for admission was general deterioration. Many abnormalities in laboratory tests were detected. The doctors' attention was focused on the significant bacteriuria. Moreover, the patient reported dysuria symptoms. Material for urine microbiological culture was taken and empirical antibiotic therapy with ciprofloxacin started. The obtained result of urine culture allowed to identify the bacteria by R. planticola. As a result of the applied treatment, the patient's condition improved. An increasing number of infections with R. planticolla etiology is observed. The bacterium may lead to infections in many systems. The group of patients at risk of the disease includes people with renal dysfunction, who are immunosuppressed. Infections of R. planticolla etiology are usually characterized by good antibiotic response and positive prognosis. Key words: Raoultella planticola; urine infections; resistance

Kozioł Magdalena, Krasowska Danuta,LewickiMarcin,Pawlicki Mateusz, Łopuszyńska Anna, Krasa Aleksandra, Piekarska Ewa. The analysis of a wide spectrum of activity of Sodium-Glucose co-transporter-2 inhibitors. A literature review. Journal of Education, Health and Sport.2020;10(8):439449. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.08.054 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.08.054 https://zenodo.org/record/4008150 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.08.2020. Revised: 05.08.2020. Accepted: 30.08.2020. The analysisof a wide spectrum of activity of sodium-glucose co-transporter-2 inhibitors. A literature review Magdalena Kozioła, Danuta Krasowskac, Marcin LewickibMateusz Pawlickia, AnnaŁopuszyńskaa, Aleksandra Krasaa, Ewa Piekarskaa aStudent Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland; bDepartment of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland; cStudents’ Scientific Association at the Department of Dermatology, Venerology and Pediatric Dermatology, Medical University of Lublin, ul. Staszica 11, Lublin 20-081, Poland. Corresponding author: Magdalena Kozioł, magdalena.koziol@icloud.com ORCID ID: Magdalena Kozioł https://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Danuta Krasowska https://orcid.org/0000-0002-3015-1120, dana.krasowska@gmail.com Marcin Lewicki https://orcid.org/0000-0003-1906-9326, lewicki-marcin@wp.pl Mateusz Pawlicki https://orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Anna Łopuszyńska https://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Aleksandra Krasa https://orcid.org/0000-0002-0733-202X,ola.AK62@gmail.com Ewa Piekarska https://orcid.org/0000-0002-4954-379X; piekarskaewaa@gmail.com ABSTRACT Introduction: The discovery of sodium-glucose co-transporter-2 inhibitors is attributed to phlorizin, which after oral administration caused the excretion of glucose in urine. Later studies showed that this effect was conditioned by SGLT-2 inhibition. However, this substance has not been used in the treatment of diabetes mellitus due to its non-selective action. Beeing also active against SGLT-1 transporters in alimentary tract, it causes osmotic diarrhea, dehydration and eventually malnutrition. Currently in Poland, gliflozins are used only in the treatment of diabetes mellitus, mainly type 2, especially with coexisting obesity and high cardio-vascular risk. However, as many human and animal studies show, the effect of SGLT2 inhibitors can be observed in many systems and organs. Results: The best known non-anti-diabetic action is the reduction of body fat and protection against fat accumulation following a high-calorie diet. These compounds reduce the production of endogenous fatty acids. Moreover, gliflozines lower the levels of cholesterol, triglycerides, uric acid and aminotransferases. They have a protective effect on the liver because they cause remission of nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD). They lower the cardiovascular risk and have an anti-inflammatory effect. Moreover, they inhibit vascular remodeling and improve hemodynamic conditions. Conclusions: According to many research, gliflozines have many collateral effects which can be used in the clinic as a treatment of diseases other than diabetes or coexisting with it. Obesity and cardiovascular diseases are among the most important health problems in the modern world. SGLT-2 inhibitors can prevent the above-mentioned diseases and reduce them. Key words: Sodium-glucose co-transporter-2 (SGLT2) inhibitors; obesity; weight loss; mechanisms; kidney.

PawlickiMateusz, Łopuszyńska Anna, Kozioł Magdalena, Krasa Aleksandra,Piekarska Ewa, Piecewicz-Szczęsna Halina. Acne vulgaris and mental health.Journal of Education, Healthand Sport. 2021;11(9):208-214. eISSN 2391-8306. DOIhttp://dx.doi.org/10.12775/JEHS.2021.11.09.026 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.09.026 https://zenodo.org/record/5502488 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received:01.09.2021. Revised: 12.09.2021. Accepted: 15.09.2021. Acne vulgaris and mental health Mateusz Pawlicki1, Anna Łopuszyńska1, Magdalena Kozioł1, Aleksandra Krasa1, EwaPiekarska1, Halina Piecewicz-Szczęsna2 1Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska11, Lublin 20-080, Poland 2Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska11, Lublin 20-080, Poland Corresponding author: Mateusz Pawlicki, pawlak32@gmail.com ORCID ID: Mateusz Pawlickihttps//orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Anna Łopuszyńskahttps://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Magdalena Koziołhttps://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Aleksandra Krasahttps://orcid.org/0000-0002-0733-202X, ola.AK62@gmail.com Ewa Piekarskahttps://orcid.org/0000-0002-4954-379X; piekarskaewaa@gmail.com Halina Piecewicz-Szczęsnahttps://orcid.org/0000-0002-0573-7226, halpiec@gmail.com Abstract Introduction: Acne vulgaris is one of the most common diseases in the world, which affects millions of people. Despite its objectively mild clinical severity, it is able to markedly change one’s appearance. Moreover it is said to be one of many factors that are responsible for mental health impairments. Results: Studies showed significant relation between acne and psychological disorders. Both depression and anxiety scores were higher in individuals with acne compared to healthy ones. Some studies reported an increased risk of suicide in this group as well. Research which included quality of life evaluation showed its impairment in larger part of respondents. Conclusions: Acne vulgaris is linked with an increased risk of serious psychiatric disorders. Therefore it is important to think about them when this condition is diagnosed. Key words: acne; mental health; depression; anxiety; suicide; quality of life