1. Dissociation of cerebrospinal fluid amyloid-β and tau levels in patients with prolonged posttraumatic disorders of consciousness
- Author
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Giuseppe Galardi, Maria Andriolo, Antonino Sant'Angelo, Sergio Bagnato, Maria Enza D'Ippolito, and Cristina Boccagni
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Dissociation (neuropsychology) ,Time Factors ,Adolescent ,Consciousness ,Traumatic brain injury ,Amyloid beta ,Neuroscience (miscellaneous) ,Total tau ,tau Proteins ,Disease ,Spinal Puncture ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Level of consciousness ,Cerebrospinal fluid ,Internal medicine ,mental disorders ,Brain Injuries, Traumatic ,Developmental and Educational Psychology ,medicine ,Humans ,Phosphorylation ,Correlation of Data ,Amyloid beta-Peptides ,biology ,business.industry ,Middle Aged ,medicine.disease ,Peptide Fragments ,030104 developmental biology ,Endocrinology ,nervous system ,Italy ,Tau phosphorylation ,biology.protein ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Background: Traumatic brain injury (TBI) is a major risk factor for Alzheimer’s disease (AD). Although the mechanisms that lead to AD after a TBI are unclear, we hypothesize that changes in amyloid-β (Aβ) metabolism and abnormal tau phosphorylation are reasonable candidates.Objective: To investigate Aβ and tau dynamics in the chronic phase of TBI.Methods: We evaluated Aβ1-42, total tau (t-tau), and phosphorylated tau (p-tau) levels in the cerebrospinal fluid (CSF) of 15 patients who developed a prolonged disorder of consciousness after a severe TBI (mean time from TBI 271.6 ± 176.5 days).Results: Reduced Aβ1-42 levels (median 258 pg/ml, range 90–833.6) were observed in 14/15 patients (93.3%) with severe post-TBI disorders of consciousness. These CSF analysis data did not correlate with time since TBI or with the patients’ level of consciousness as determined by the Coma Recovery Scale Revised. Normal t-tau levels (median 95.2 pg/ml, range 52–256.9) were found in all patients. Normal p-tau levels (...
- Published
- 2018