60 results on '"Su, Jiang"'
Search Results
2. Integration of Genomic and Transcriptomic Markers Improves the Prognosis Prediction of Acute Promyelocytic Leukemia
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Xiao Jing Lin, Sai-Juan Chen, Bing Chen, Qing Xue, Bowen Cui, Yu Chen, Bing-Shun Wang, Hongming Zhu, Su-Jiang Zhang, Li Chen, Zhu Chen, Lu Jiang, Hai Fang, Shengyue Wang, Junmin Li, Niu Qiao, and Yang Shen
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Adult ,Male ,0301 basic medicine ,Neuroblastoma RAS viral oncogene homolog ,Acute promyelocytic leukemia ,Oncology ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Genomics ,Disease ,Targeted therapy ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Leukemia, Promyelocytic, Acute ,White blood cell ,Internal medicine ,medicine ,Humans ,Chemotherapy ,Genome ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Survival Rate ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,Transcriptome ,business - Abstract
Purpose: The current stratification system for acute promyelocytic leukemia (APL) is based on the white blood cell (WBC) and the platelet counts (i.e., Sanz score) over the past two decades. However, the borderlines among different risk groups are sometimes ambiguous, and for some patients, early death and relapse remained challenges. Besides, with the evolving of the treatment strategy from all-trans-retinoic acid (ATRA) and chemotherapy to ATRA–arsenic trioxide-based synergistic targeted therapy, the precise risk stratification with molecular markers is needed. Experimental Design: This study performed a systematic analysis of APL genomics and transcriptomics to identify genetic abnormalities in 348 patients mainly from the APL2012 trial (NCT01987297) to illustrate the potential molecular background of Sanz score and further optimize it. The least absolute shrinkage and selection operator algorithm was used to analyze the gene expression in 323 cases to establish a scoring system (i.e., APL9 score). Results: Through combining NRAS mutations, APL9 score, and WBC, 321 cases can be stratified into two groups with significantly different outcomes. The estimated 5-year overall (P = 0.00031), event-free (P < 0.0001), and disease-free (P = 0.001) survival rates in the revised standard-risk group (95.6%, 93.8%, and 98.1%, respectively) were significantly better than those in the revised high-risk group (82.9%, 77.4%, and 88.4%, respectively), which could be validated using The Cancer Genome Atlas dataset. Conclusions: We have proposed a two-category system for improving prognosis in patients with APL. Molecular markers identified in this study may also provide genomic insights into the disease mechanism for improved therapy.
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- 2021
3. Hyperselective neurectomy in the treatment of elbow and wrist spasticity: an anatomical study and incision design
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Su Jiang, Yin Huawei, Ai-Ping Yu, Shen Yundong, Yongchun Yu, Qiu Yanqun, and Wen-Dong Xu
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musculoskeletal diseases ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Elbow ,Neurectomy ,General Medicine ,Wrist ,musculoskeletal system ,body regions ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Physical medicine and rehabilitation ,030220 oncology & carcinogenesis ,medicine ,Spastic ,Surgery ,Arm paralysis ,Neurology (clinical) ,Spasticity ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Hyperselective neurectomy is used to treat spastic arm paralysis. The aim of the study was to analyze the nerve branching patterns of elbow and wrist flexors/pronator to inform hyperselective neurectomy approached.Eighteen upper extremities of fresh cadaver specimen were dissected. The number of motor branches from the musculocutaneous nerve to biceps brachii and brachialis, median nerve to pronator teres, flexor carpi radialis and ulnar nerve to flexor carpi ulnaris were counted. The origin site of each primary motor branch was documented.Either biceps or brachialis was innervated by one or two primary motor branches. Pronator teres was innervated by one to three motor trunks and the pattern for flexor carpi radialis was a common trunk with other branches. The origin of the biceps and brachialis nerve trunk was located approximately 30% to 60% of the length of the arm. The median nerve branched to pronator teres and flexor carpi radialis at the region about 34mm (SD 18.8mm) above and 50mm (SD 14.9mm) below the medial epicondyle. Flexor carpi ulnaris was innervated by one to three motor trunks and the mean distance from the medial epicondyle to the origin of flexor carpi ulnaris nerve on ulnar nerve was 18.7 mm (SD 6.5mm).Primary motor branches to elbow flexors, wrist flexors and pronators were various, while the regions of their origins were relatively settled. It was recommended the incisions be designed according to the location of the primary motor trunks.
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- 2020
4. Unusual ectopic ACTH syndrome in a patient with orbital neuroendocrine tumor, resulted false-positive outcome of BIPSS:a case report
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Weiming He, Dawei Chen, Yerong Yu, Zhenmei An, Bowen Cai, Su Jiang, Ying Tang, Nanwei Tong, Huiwen Tan, and Kai Yu
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medicine.medical_specialty ,Hydrocortisone ,Endocrinology, Diabetes and Metabolism ,Ectopic Cushing’s syndrome ,030209 endocrinology & metabolism ,Case Report ,Petrosal Sinus Sampling ,Gastroenterology ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Lesion ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Adrenocorticotropic Hormone ,Internal medicine ,medicine ,Endocrine system ,Humans ,False Positive Reactions ,Pituitary Neoplasms ,Orbital neuroendocrine tumor ,Desmopressin ,Pathological ,Cushing Syndrome ,Dexamethasone ,lcsh:RC648-665 ,business.industry ,General Medicine ,Middle Aged ,Inferior petrosal sinus sampling ,ACTH Syndrome, Ectopic ,Neuroendocrine Tumors ,Bilateral inferior petrosal sinus sampling (BIPSS) ,Cushing’s syndrome ,Moon face ,Orbital Neoplasms ,Female ,medicine.symptom ,Differential diagnosis ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background Cushing’s syndrome has been described as a complex endocrine disorder characterized with high cortisol concentration. Correct and early diagnosis of Cushing’s syndrome is challenging. According to the latest guideline, bilateral inferior petrosal sinus sampling (BIPSS) is considered to be the gold standard for the differential diagnosis. However, in some unusual cases, this method may be false positive. Here, we presented a rare case of orbital neuroendocrine tumor secreting adrenocorticotrophic hormone with false positive inferior petrosal sinus sampling. Case presentation A 48-year-old woman was admitted to West China Hospital of Sichuan University, presenting with fatigue, whole body edema for 1 year, alopecia and skin pigmentation for 5 months. Hormonal profiles including plasma cortisol and adrenocorticotrophic hormone (ACTH) measurements and low-dose dexamethasone inhibition test suggested that the patient had Cushing’s syndrome. However, during tumor location phase, the results of high-dose dexamethasone inhibition test (HDDST) contradicted desmopressin (DDAVP) stimulation test. Thus, BIPSS was employed, and its results indicated a pituitary origin. Interestingly, MRI of sellar region showed an innocent pituitary but caught a serendipitous lesion in the lateral rectus muscle of left eye, which was later proved to be an orbital neuroendocrine tumor secreting ACTH by pathological and immunohistochemical results. ACTH level of the patients was Conclusion We reported a rare case of endogenous Cushing’s syndrome due to ectopic ACTH secreting from an orbital neuroendocrine tumor. This unique case of orbital EAS suggests that orbital venous blood backflow, owning to abnormal anatomic structures, may possibly lead to false positive BIPSS results.
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- 2020
5. Neuroinflammation Mediates Faster Brachial Plexus Regeneration in Subjects with Cerebral Injury
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Li Tie, Xiao-Min Wang, Wendong Xu, Ai-Ping Yu, Guo-Bao Wang, Fan Su, and Su Jiang
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Pathology ,medicine.medical_specialty ,Physiology ,Macrophage polarization ,Inflammation ,Mice ,medicine ,Macrophage ,Animals ,Humans ,Brachial Plexus ,Peripheral Nerves ,Brachial Plexus Neuropathies ,Nerve Transfer ,Neuroinflammation ,business.industry ,General Neuroscience ,Regeneration (biology) ,General Medicine ,medicine.disease ,Spinal Nerves ,Brachial plexus injury ,Original Article ,medicine.symptom ,business ,Brachial plexus - Abstract
Our previous investigation suggested that faster seventh cervical nerve (C7) regeneration occurs in patients with cerebral injury undergoing contralateral C7 transfer. This finding needed further verification, and the mechanism remained largely unknown. Here, Tinel's test revealed faster C7 regeneration in patients with cerebral injury, which was further confirmed in mice by electrophysiological recordings and histological analysis. Furthermore, we identified an altered systemic inflammatory response that led to the transformation of macrophage polarization as a mechanism underlying the increased nerve regeneration in patients with cerebral injury. In mice, we showed that, as a contributing factor, serum amyloid protein A1 (SAA1) promoted C7 regeneration and interfered with macrophage polarization in vivo. Our results indicate that altered inflammation promotes the regenerative capacity of the C7 nerve by altering macrophage behavior. SAA1 may be a therapeutic target to improve the recovery of injured peripheral nerves.
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- 2021
6. Application of simple bladder volume measurement and cystography in rehabilitation training of patients with neurogenic bladder dysfunction
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Jin-Xia Sun, Hao Li, Yu-Long Zhao, and Su Jiang
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medicine.medical_specialty ,Cystography ,medicine.diagnostic_test ,RD1-811 ,business.industry ,Bladder ,Urinary Bladder ,Urology ,Neurogenic ,medicine.disease ,Simple bladder volume measurement ,Dysfunction ,Rehabilitation training ,Bladder examination ,medicine ,Bladder volume ,Humans ,Surgery ,Urinary Bladder, Neurogenic ,business ,Neurogenic bladder dysfunction - Published
- 2021
7. DHA-enriched phosphatidylserine ameliorates non-alcoholic fatty liver disease and intestinal dysbacteriosis in mice induced by a high-fat diet
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Tao Han, Shanshan Tian, Yafeng Zhou, Tang Yunping, Su Jiang, and Li Qian
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0301 basic medicine ,Male ,medicine.medical_specialty ,Docosahexaenoic Acids ,Phosphatidylserines ,medicine.disease_cause ,Diet, High-Fat ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,0302 clinical medicine ,Functional food ,Functional Food ,Non-alcoholic Fatty Liver Disease ,Phosphatidylcholine ,Internal medicine ,medicine ,Animals ,Dyslipidemias ,chemistry.chemical_classification ,Triglyceride ,Fatty liver ,Body Weight ,food and beverages ,Fatty acid ,General Medicine ,Phosphatidylserine ,medicine.disease ,Lipid Metabolism ,Gastrointestinal Microbiome ,Mice, Inbred C57BL ,030104 developmental biology ,Endocrinology ,Enzyme ,chemistry ,Adipose Tissue ,Liver ,Dietary Supplements ,Dysbiosis ,lipids (amino acids, peptides, and proteins) ,030211 gastroenterology & hepatology ,Oxidative stress ,Food Science - Abstract
Docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) has attracted increasing attention because of its unique health benefits. In this study, DHA-PS was biosynthesized from DHA-enriched phosphatidylcholine (DHA-PC), which was extracted from herring roe, Clupea harengus. The ameliorating effect of DHA-PS on high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) was investigated using a mouse model. The DHA-PS treatment ameliorated NAFLD and effectively decreased the serum total cholesterol, triglyceride, non-esterified fatty acid, and low-density lipoprotein cholesterol levels and considerably increased the serum high-density lipoprotein cholesterol levels. Moreover, the DHA-PS treatment reduced the levels of liver-function enzymes and pro-inflammatory cytokines and also the oxidative stress indices. Furthermore, DHA-PS increased the diversity and richness of the beneficial intestinal microorganisms, suggesting its potential as a dietary supplement and functional food to combat HFD-induced NAFLD.
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- 2021
8. Preliminary clinical application of an aromatase inhibitor and a gonadotropin-releasing hormone agonist combination for inoperable endometrial cancer patients with comorbidities: case report and literature review
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Jinping Gao, Ye Yan, Yan Sheng, Fengxia Xue, Su Jiang, Mengting Dong, Yingmei Wang, Wenyan Tian, and Chao Gao
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0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,medicine.drug_class ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Gonadotropin-releasing hormone agonist ,Internal medicine ,medicine ,Adverse effect ,Pharmacology ,Bedside to Bench Report ,Aromatase inhibitor ,business.industry ,Endometrial cancer ,Therapeutic effect ,medicine.disease ,Menopause ,030104 developmental biology ,Estrogen ,030220 oncology & carcinogenesis ,Molecular Medicine ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Background: Endometrial cancer (EC) occurs most commonly after menopause. A proportion of patients present with advanced age and comorbidities, and become ineligible for surgery. The optimal treatment strategy of these patients remains a clinical challenge. Aromatase inhibitor (AI) combined with Gonadotropin-releasing hormone agonist (GnRH-a) possesses profound effect in suppressing the estrogen level, has become a valid treatment in the breast cancer. However, the combined use of an AI and a GnRH-a in EC has rarely been studied. Case presentation: Herein, we report the combination of an AI and a GnRH-a in the treatment of three patients with advanced age or comorbidities who were ineligible for surgery. The disease remained stable for two years in patients who received the combination treatment as an initial approach without any adverse effects. Moreover, an AI combined with a GnRH-a also effective as salvage treatment of recurrent patients. Further, we provide a brief review of the literature. Conclusion: The combination of an AI and a GnRH-a presents satisfactory therapeutic effect and provides an optimal option for inoperable EC patients.
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- 2018
9. The Design of a Phase 2 Study to Evaluate the Safety and Efficacy of Ropeginterferon Alfa-2b (P1101) in Chinese Patients with Polycythemia Vera Resistant or Intolerant to Hydroxyurea (HU)
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Warren Shen, Zhijian Xiao, Suning Chen, Lei Zhang, Oleh Zagrijtschuk, Jingjing Zhang, Minghui Duan, Wei Wang, Jie Jin, Raymond Urbanski, Albert Qin, and Su-Jiang Zhang
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medicine.medical_specialty ,Polycythemia vera ,business.industry ,Internal medicine ,Immunology ,medicine ,Phases of clinical research ,Cell Biology ,Hematology ,medicine.disease ,business ,Biochemistry ,Gastroenterology - Abstract
Background: Polycythemia vera (PV) is the most common type of Philadelphia-negative myeloproliferative neoplasms (MPNs). PV is a long-term debilitating and life-threatening cancer that is associated with the risk of thrombosis, hemorrhage, and a long-term risk of developing myelofibrosis and acute myeloid leukemia. Early intervention with a disease-modifying treatment that can eradicate the mutated clones is needed to prevent disease progression and transformation. To date, therapeutic options for PV are limited and they only address the signs and symptoms. Most low-risk patients with PV are treated with phlebotomy and low-dose aspirin to manage increased blood viscosity and reduce the risk of vascular events, whereas high-risk and certain low-risk patients are treated with cytoreductive agents. Several cytoreductive agents are available such as hydroxyurea (HU) which is commonly used as a first-line therapy. Ruxolitinib, a JAK2 inhibitor, is also used. While interferon alfa agents have been used off label in clinical practice for more than three decades, their use has been limited due to the tolerability concerns. Ropeginterferon alfa-2b (P1101), a long-acting, mono-pegylated proline interferon, was developed for the treatment of MPNs, including PV. The novel formulation of P1101 improves its pharmacokinetic properties allowing treatment every 2 weeks with improved tolerability and convenience. P1101 was evaluated for the treatment of PV in the phase 3 PROUD-PV trial and its extension study CONTINUATION-PV. In the PROUD-PV study, due to the slow P1101 titration schedule, the maximum P1101 dose was not reached until week 28 and the primary analysis was done at 52 weeks. In CONTINUATION-PV, when patients were on their effective doses, a significantly higher proportion of patients treated with P1101 achieved a complete hematologic response (CHR) with improved disease burden compared to HU-treated patients. At 48 months there was a significant reduction in allelic burden from a baseline of 37.3% to 9.8% with 13.8% of patients achieving a complete molecular response (CMR). The molecular response rates (complete + partial) at 60 months was 69.1%. P1101 was approved by the European Medicines Agency in 2019 and the Taiwan Food and Drug Administration in 2020 as monotherapy in adults for the treatment of PV without symptomatic splenomegaly. Here, we describe a phase 2 study of P1101 in Chinese patients with PV utilizing an accelerated P1101 dose titration schedule. Study Design and Methods: This phase 2, multicenter, single-arm study is designed to evaluate safety and efficacy of P1101 in Chinese patients with PV utilizing a 250-350-500 ug P1101 dose titration schedule. The primary analysis will be conducted at 24 weeks. The study will recruit approximately 49 subjects in 15-20 sites in China. Key eligibility criteria include diagnosis of PV according to the 2016 WHO criteria, and resistance or intolerance to prior HU according to 2020 guidelines of CSCO. Patients who previously received interferon therapy have to be anti-P1101 binding antibody negative during the screening visit to be eligible. The study excludes patients with symptomatic splenomegaly. Eligible patients receive subcutaneous administration of P1101. Patients will receive an initial dose of 250 µg at Week 0, 350 µg at Week 2, and then 500 µg at Week 4. The dose is maintained at the highest dose that can be tolerated and delivers the best disease response. The maximum recommended dose is 500 μg every 2 weeks. Low-dose aspirin is administered during the 52 weeks of study treatment, unless contraindicated. The primary efficacy endpoint is the phlebotomy-free CHR rate at Week 24. Secondary endpoints include changes in hematocrit, white blood cell count, platelet count; time requiring no phlebotomy; time to first response; and duration of response. All patients will continue receiving treatment until week 52 to provide long-term follow-up information (blood parameters, molecular and cytogenetic data, safety parameters, and optional bone marrow data). This study has been granted IND approval by China CDE on Apr2021. Recruitment is expected to begin in early September 2021 with trial results expected in Q3 2022. Figure : Study Design Figure 1 Figure 1. Disclosures Zagrijtschuk: PharmaEssentia U.S.A. Corp.: Current Employment. Urbanski: PharmaEssentia Corporation: Current Employment. Qin: PharmaEssentia Corp.: Current Employment.
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- 2021
10. A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy
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Jianfei Gao, Yuanjue Sun, Baorui Liu, Rongsheng Zheng, Ping Liu, Yongchuan Deng, Bin Jiang, Yongqian Shu, Nong Xu, Chaofan Liang, Xiaohua Zhang, Su Jiang, Changping Wu, Qing Xu, Xiaoyi Li, Xuenong Ouyang, Leizhen Zheng, Zhixiang Zhuang, and Yang Yao
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Cancer Research ,medicine.medical_specialty ,Chemotherapy ,business.industry ,medicine.medical_treatment ,Articles ,General Medicine ,Pharmacology ,Placebo ,medicine.disease ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Peripheral neuropathy ,Immunology and Microbiology (miscellaneous) ,Chemotherapy-induced peripheral neuropathy ,Oral administration ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Clinical endpoint ,Adverse effect ,business ,Prospective cohort study ,030217 neurology & neurosurgery - Abstract
The present study aimed to evaluate the efficacy and safety of acetyl-L-carnitine (ALC) for the treatment of chemotherapy-induced peripheral neuropathy (CIPN). The study was carried out as a prospective, randomized, double-blind, placebo-controlled and paralleled clinical study. A total of 239 patients with CIPN were selected as the study subjects. Of the 239 subjects, 118 subjects received 3 g/day ALC orally for 8 weeks and 121 received a placebo. The primary endpoint was improvement of peripheral neuropathy by at least one grade. Patient status was assessed at week 4, 8 and 12 after enrollment into the study. In both the full analysis set (FAS) and the per-protocol set (PPS), peripheral sensory neuropathy was significantly ameliorated in the ALC group with 50.5 and 51.6% patients meeting the primary endpoint at week 8, compared with 24.1 and 23.1% of patients in the placebo group (P
- Published
- 2016
11. Predictive value of P‑selectin and endothelin‑1 for vascular restenosis after interventional procedures for peripheral artery disease
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Linwei Chen, Su Jiang, Nan Chen, Zichuan Wang, and Liu Tao
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0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,P-selectin ,Arterial disease ,Disease ,peripheral artery disease ,03 medical and health sciences ,0302 clinical medicine ,Immunology and Microbiology (miscellaneous) ,Restenosis ,Internal medicine ,medicine ,Computed tomography angiography ,medicine.diagnostic_test ,business.industry ,Cancer ,Articles ,General Medicine ,medicine.disease ,Endothelin 1 ,Molecular medicine ,030104 developmental biology ,030220 oncology & carcinogenesis ,endothelin-1 ,Cardiology ,business ,vascular restenosis - Abstract
Peripheral artery disease (PAD) is caused by the building up of plaques in the arteries that carry blood to the lower limbs. The present study aimed to assess the predictive value of the plasma levels of P-selectin (Ps) or endothelin-1 (ET-1) regarding the occurrence of vascular restenosis after endovascular therapy for PAD. Patients with or without vascular restenosis confirmed by computed tomography angiography after endovascular therapy between March and December 2015 (n=20 per group) were enrolled. The serum levels of Ps and ET-1 prior to the operation and at 1 h, as well as 1, 2 and 3 weeks after the operation were compared between the two groups. At 1 h after the operation, the serum levels of Ps and ET-1 were significantly increased as compared with the pre-operative levels (P0.05). The diagnostic sensitivity and specificity of the serum ET-1 levels at 1 h after the operation for predicting post-operative restenosis in PAD patients with a cut-off of 0.1089 pg/ml were 85 and 85%, respectively. In conclusion, the serum levels of Ps and ET-1 have a high predictive value for post-operative vascular restenosis after endovascular therapy for PAD patients.
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- 2019
12. C7 transfer in a posterior intradural approach for treating hemiplegic upper-limbs: hypothesis and a cadaver feasibility study
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Qiu Yanqun, Wen-Dong Xu, Wei Chen, Ai-Ping Yu, Su Jiang, and Shen Yundong
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medicine.medical_specialty ,Nerve root ,Hemiplegia ,Anastomosis ,Anatomical space ,Upper Extremity ,03 medical and health sciences ,0302 clinical medicine ,Cadaver ,medicine ,Humans ,In patient ,Brachial Plexus ,Nerve Transfer ,Surgeons ,business.industry ,Laminectomy ,General Medicine ,Plastic Surgery Procedures ,Spinal cord ,Cadaver model ,Surgery ,medicine.anatomical_structure ,Neurosurgeons ,Cervical laminectomy ,Spinal Cord ,030220 oncology & carcinogenesis ,Cervical Vertebrae ,Feasibility Studies ,Neurology (clinical) ,Dura Mater ,Arachnoid ,business ,Spinal Nerve Roots ,030217 neurology & neurosurgery - Abstract
Objective: Contralateral C7 nerve root transfer surgery has been successfully applied to rescue motor function of a hemiplegic upper extremity in patients with central neurological injury. This surgical technique is challenging, and limited anatomical space makes it difficult to manipulate tissues and may lead to higher complication rates. The authors hypothesis a new surgical route in which cervical nerve roots of both donor and recipient sides are exposed from a posterior intradural approach and neurorrhaphy is performed easily and clearly. The feasibility of this operation is tested in a cadaver model. Methods: A fresh cadaver was placed prone. After a standard midline incision and extensive cervical laminectomy, the dura and arachnoid were widely opened, and the spinal nerve roots of C6, C7, and C8 were exposed bilaterally. Nerve grafting was attempted between pairs of donor and recipient nerve roots on contralateral sides of the spinal cord. After completion of neurorrhaphy, the dura was closed. Results: Precise neurorrhaphy could be performed intradurally between posterior and anterior nerve roots of C7 on both sides. Multiple anastomoses of C7 to various nerve roots on the contralateral side could also be performed within the same surgical field with an interposition nerve graft. Conclusion: The posterior intradural repair idea affords many advantages, the pathway is shorter and more straightforward, which provides more access to multiple nerve roots repair in one surgical field, and is more familiar to many neurosurgeons and spine surgeons. It may potentially be adapted for clinical use.
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- 2019
13. Simple Grading for Motor Function in Spastic Arm Paralysis: Hua-Shan Grading of Upper Extremity
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Jie Jia, Wen-Dong Xu, Guo-Bao Wang, Yan-Qun Qiu, Xiaofeng Jia, Ying Ying, Ai-Ping Yu, and Su Jiang
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Motor disorder ,Adult ,Male ,medicine.medical_specialty ,China ,medicine.medical_treatment ,Motor Activity ,Severity of Illness Index ,Upper Extremity ,03 medical and health sciences ,Disability Evaluation ,Young Adult ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,medicine ,Spastic ,Humans ,Range of Motion, Articular ,Grading (education) ,Retrospective Studies ,Neurologic Examination ,Rehabilitation ,business.industry ,Retrospective cohort study ,Microsurgery ,Middle Aged ,medicine.disease ,Biomechanical Phenomena ,Paresis ,Physical therapy ,Surgery ,Female ,Neurology (clinical) ,Neurosurgery ,Spastic hemiplegia ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Abstract
Spastic arm paralysis after central neurological injury has a long-term effect on the patient's quality of life. Effective neurosurgical treatment for this dysfunction has been described in our previous studies. It is of great significance to determine a set of unified and concise clinical standards for motor function grading in the neurosurgical treatment and management.We first conducted a retrospective study that included 51 hemiplegic patients from the Neurosurgery and Microsurgery outpatient database of Huashan Hospital. The neurosurgeons cooperated with rehabilitation experts to design and administer the new rating system (Hua-Shan Grading of Upper Extremity, H-S grading) after analyzing the scale scores and video records of these patients. We then randomly enrolled 64 patients with unilateral spastic arm paralysis after stroke or brain trauma. The Fugl-Meyer Assessment, the Ashworth scale and the new grading system were applied and analyzed to evaluate the participants' motor function.Based on rehabilitation medicine scales and long-term follow-up, a feasible and concise grading system was applied that was based on the patients' characteristics and the examination experiences of neurosurgeons and rehabilitation experts in clinical practice. This method could effectively grade upper extremity motor function, usually in 3-5 minutes. A significant correlation was found between H-S grading and the Fugl-Meyer score by the Spearman test (r = .937, P.01). The mean difference between any two levels of the new grading system was significant (P.05). And good test-retest reliability, the Cronbach's alpha coefficient and the validity indices were presented. In addition, it was more sensitive to motor function compared with the Ashworth scale.As a supplement to the classic scales, H-S grading was developed in the area of spastic hemiplegia treatment. It is standardized and simplified for patients in the chronic stage after central neurological injury.
- Published
- 2019
14. Robot-assisted C7 nerve root transfer from the contralateral healthy side: A preliminary cadaver study
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Brett Peterson, Philippe Liverneaux, Su Jiang, Guillaume Prunières, Sybille Facca, Wen-dong Xu, Satoshi Ichihara, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
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medicine.medical_specialty ,Nerve root ,030230 surgery ,Cerebral palsy ,03 medical and health sciences ,0302 clinical medicine ,Robotic Surgical Procedures ,Cadaver ,medicine ,Humans ,Brachial Plexus ,Orthopedics and Sports Medicine ,Spasticity ,Brachial Plexus Neuropathies ,Nerve Transfer ,business.industry ,Cerebral Palsy ,Rehabilitation ,[PHYS.MECA]Physics [physics]/Mechanics [physics] ,Anatomy ,medicine.disease ,Surgery ,Treatment Outcome ,Cerebral hemisphere ,Feasibility Studies ,medicine.symptom ,Spastic hemiplegia ,Spinal Nerve Roots ,business ,Brachial plexus ,030217 neurology & neurosurgery - Abstract
Patients with cerebral palsy and spastic hemiplegia may have extremely poor upper extremity function. Unfortunately, many current therapies and treatments for patients with spastic hemiplegia offer very limited improvements. One innovative technique for treating these patients is the use a contralateral C7 nerve root transfer to neurotize the C7 nerve root in the affected limb. This may result not only in less spasticity in the affected limb, but also improved control and motor function vis-a-vis the new connection to the normal cerebral hemisphere. However, contralateral C7 transfers can require large incisions and long nerve grafts. The aim of this study was to test the feasibility of a contralateral C7 nerve root transfer procedure with the use of a prevertebral minimally invasive robot-assisted technique. In a cadaver, both sides of the C7 root were dissected. The right recipient C7 root was resected as proximally as possible, while the left donor C7 root was resected as distally as possible. With the use of the da Vinci (®) SI surgical robot (Intuitive Surgical ™, Sunnyvale, CA, USA), we were able to eliminate the large incision and use a much shorter nerve graft when performing contralateral C7 nerve transfer.
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- 2016
15. Effect of intravenous l-carnitine in Chinese patients with chronic heart failure
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Shuiping Zhao, Jue Li, Valentina Carubelli, Lei Pan, Benjamin Xiaoyi Li, Jianqiang Peng, Su Jiang, Chaofan Liang, Guo-Tai Sheng, Zhi-Cheng Jing, Bing-Xiang Wu, Zai-Xin Yu, Erika Salvi, Jian-Bin Gong, Xin-Li Li, Qing-Yan Zhao, Jia-Ning Cao, and Dong-Ye Li
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Ejection fraction ,business.industry ,Surrogate endpoint ,Cardiac muscle ,030204 cardiovascular system & hematology ,Placebo ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Heart failure ,Internal medicine ,Clinical endpoint ,Cardiology ,Medicine ,cardiovascular diseases ,Carnitine ,Cardiology and Cardiovascular Medicine ,business ,Adverse effect ,medicine.drug - Abstract
Chronic heart failure (CHF) may be associated with an energy deficit in cardiac muscle. As levo-carnitine (LC) is involved in the production of myocardial energy, it is hypothesized that LC supplementation may ameliorate CHF symptoms. This multicentre, randomized, double-blind, and placebo-controlled study included 265 patients with CHF. Patients were randomized to receive either LC or placebo, twice a day. Endpoints were measured after 7 days of treatment. Primary endpoint was a reduction of at least one NYHA class. Secondary endpoints were changes in 6-min walk distance (6-MWD) compared with baseline, either alone or in combination with NYHA class decrease, left ventricular ejection fraction, and NT-proBNP level, together with adverse events. The primary endpoint was reached in 60.9% of patients treated with LC, compared with only 44.7% of the placebo group ( P = 0.012). Among the secondary endpoints, 6-MWD, alone or in combination with NYHA class, improved significantly in the LC group compared with placebo ( P = 0.0497 and P = 0.003, respectively). l-Carnitine was well tolerated. The lowest baseline values of plasma-free carnitine were observed in patients with NYHA classes III and IV where the effect of LC supplementation was greatest ( P = 0.002). Treatment with LC significantly improved CHF symptoms in Chinese patients, probably by correcting a status of carnitine insufficiency.
- Published
- 2016
16. MMP-12 as a potential biomarker to forecast ischemic stroke in obese patients
- Author
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Bo-jie Li, Chu-yao Wang, Ying Tian, Su-su Jiang, Caiping Zhang, Wei-he He, and Shiyin Long
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Longevity ,Apoptosis ,Matrix metalloproteinase ,Brain Ischemia ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Matrix Metalloproteinase 12 ,Internal medicine ,Animals ,Humans ,Medicine ,Obesity ,Stroke ,Ischemic Stroke ,Inflammation ,business.industry ,Incidence ,Incidence (epidemiology) ,Thrombin ,General Medicine ,medicine.disease ,030104 developmental biology ,Ischemic stroke ,Cardiology ,business ,Body mass index ,Biomarkers ,030217 neurology & neurosurgery ,Obesity paradox - Abstract
Human health is threatened by obesity which causes the increasing incidence of various diseases, especially stroke. Ischemic stroke (IS) is mostly caused by the rupture of arterial plaque, whose instability is positively associated with matrix metalloproteinases (MMPs) that degrades extracellular matrix components. Studies have shown that matrix metalloproteinase-12 (MMP-12) may be involved in the pathogenesis of IS. Because of the higher incidence of stroke in obese patients than that in normal weight people, it is urgent for obesity to forecast stroke early. Considering high levels MMP-12 in obesity, we put forward that MMP-12 may be a potential biomarker for IS in obese patients.
- Published
- 2020
17. Contralateral Lumbar to Sacral Nerve Rerouting for Hemiplegic Patients After Stroke: A Clinical Pilot Study
- Author
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Su Jiang, Feng Juntao, Qiu Yanqun, Bao-Fu Yu, Wen-Dong Xu, Mao-Xin Du, and Shen Yundong
- Subjects
Adult ,Male ,medicine.medical_specialty ,Hemiplegia ,Pilot Projects ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Randomized controlled trial ,law ,medicine ,Humans ,Spasticity ,Stroke ,Nerve Transfer ,Cerebral Hemorrhage ,Back ,business.industry ,Cerebral infarction ,Neurological Rehabilitation ,Muscle weakness ,Middle Aged ,medicine.disease ,Surgery ,Peripheral ,Spinal Nerves ,Muscle Spasticity ,030220 oncology & carcinogenesis ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Background Spasticity and muscle weakness are common severe neurologic sequelae after stroke. Contralateral peripheral neurotization has been applied successfully to promote motor function of the hemiplegic upper extremity in patients with central neurological injury. To our knowledge, we present the first report of contralateral lumbar to sacral nerve transfer for the lower extremities in hemiplegic patients after stroke. Case Description Two patients were enrolled in the study. The first patient is a 57-year-old man who experienced permanent muscle weakness in his left leg after a right cerebral infarction. The second patient is a 42-year-old man who had spasticity and hemiplegia in both upper and lower limbs on the right side 32 months after a left cerebral hemorrhage. Both patients underwent contralateral lumbar–to–sacral nerve rerouting to improve lower-limb motor function. Twenty months after surgery, both patients experienced significant improvement in ambulatory status. Conclusions Although long-term follow-up and a randomized controlled trial are required, this study demonstrates the safety and possible benefits of contralateral lumbar–to–sacral nerve transfer for hemiplegic patients after stroke. This novel surgical approach could provide a new means for lower-limb motor functional recovery.
- Published
- 2018
18. Contralateral Peripheral Neurotization for Hemiplegic Upper Extremity After Central Neurologic Injury
- Author
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Su Jiang, Mou-Xiong Zheng, Wen-Dong Xu, Tie Li, Yu-Dong Gu, Yun-Dong Shen, Jian-Guang Xu, Xu-Yun Hua, and Yan-Qun Qiu
- Subjects
Adult ,Male ,medicine.medical_specialty ,Modified Ashworth scale ,medicine.medical_treatment ,Hemiplegia ,Upper Extremity ,Young Adult ,Physical medicine and rehabilitation ,Humans ,Medicine ,Spasticity ,Nerve Transfer ,Pathological ,Paresis ,Rehabilitation ,business.industry ,Motor control ,Recovery of Function ,Nerve Regeneration ,Peripheral ,Treatment Outcome ,Brain Injuries ,Female ,Surgery ,Neurology (clinical) ,medicine.symptom ,business - Abstract
BACKGROUND Central neurological injury (CNI) is a major contributor to physical disability that affects both adults and children all over the world. The main sequelae of chronic stage CNI are spasticity, paresis of specific muscles, and poor selective motor control. Here, we apply the concept of contralateral peripheral neurotization in spasticity releasing and motor function restoration of the affected upper extremity. OBJECTIVE A clinical investigation was performed to verify the clinical efficacy of contralateral C7 neurotization for rescuing the affected upper extremity after CNI. METHODS In the present study, 6 adult hemiplegia patients received the nerve transfer surgery of contralateral C7 to C7 of the affected side. Another 6 patients with matched pathological and demographic status were assigned to the control group that received rehabilitation only. During the 2-year follow-up, muscle strength of bilateral upper extremities was assessed. The Modified Ashworth Scale and Fugl-Meyer Assessment Scale were used for evaluating spasticity and functional use of the affected upper extremity, respectively. RESULTS Both flexor spasticity release and motor functional improvements were observed in the affected upper extremity in all 6 patients who had surgery. The muscle strength of the extensor muscles and the motor control of the affected upper extremity improved significantly. There was no permanent loss of sensorimotor function of the unaffected upper extremity. CONCLUSION This contralateral C7 neurotization approach may open a door to promote functional recovery of upper extremity paralysis after CNI.
- Published
- 2015
19. The Effect of Sleep Deprivation on Ocular Vestibular Evoked Myogenic Potentials Using Air Conducted Sound
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Su-Jiang Xie, Hong-Zhe Bi, and Qin Yao
- Subjects
medicine.medical_specialty ,Vestibular evoked myogenic potential ,Healthy subjects ,General Medicine ,Ocular Vestibular Evoked Myogenic Potentials ,Audiology ,Extraocular muscles ,Left eye ,Sleep deprivation ,medicine.anatomical_structure ,Ophthalmology ,medicine ,medicine.symptom ,Psychology - Abstract
Vestibular evoked myogenic potential (VEMP) in response to a loud air conducted sound (ACS) recorded from extraocular muscles, the so-called ocular VEMP (oVEMP), has been confirmed to be able to evaluate utricular function. This study aimed to evaluate the effect of sleep deprivation (SD) on oVEMP parameters. oVEMPs were recorded in 20 male healthy subjects once after an ordinary sleep and once after 26–29 h of SD. The latencies of peak N1 and P1, N1-P1 amplitude, N1-P1 interval, and asymmetry ratio (AR) of oVEMP recorded from both eyes under normal sleep and SD conditions were 10.04 ± 0.59 ms versus 10.56 ± 0.69 ms (left eye), 14.95 ± 0.92 ms versus 15.64 ± 1.05 ms (left eye), and 7.44 ± 2.86 µV versus 5.26 ± 2.15 µV (left eye); 10.08 ± 0.66 ms versus 10.64 ± 0.73 ms (right eye), 14.88 ± 0.89 ms versus 15.59 ± 1.02 ms (right eye), and 7.16 ± 2.88 µV versus 5.04 ± 2.05 µV(right eye); 10.40 ± 5.81% versus 11.43 ± 6.37%, respectively. After SD, the latencies of oVEMP were delayed and N1-P1 amplitude was lower, whereas N1-P1 interval and AR remained unchanged. The present study showed that oVEMP test could be used to evaluate the fatigue induced by SD.
- Published
- 2014
20. Clinical Features and Prognosis Analysis of Hodgkin Lymphoma: A Multicenter Retrospective Study Over a Decade of Patients in China
- Author
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Su-Jiang Zhang, Jian-Qing Mi, Mei Chen, Jin Wang, Mei Geng, Wen-Yan Yu, and Jie Hao
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,China ,Adolescent ,medicine.medical_treatment ,Kaplan-Meier Estimate ,Disease-Free Survival ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,030212 general & internal medicine ,Young adult ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,Radiotherapy ,Proportional hazards model ,business.industry ,Retrospective cohort study ,Hematology ,Middle Aged ,Prognosis ,Hodgkin Disease ,Surgery ,Radiation therapy ,Oncology ,B symptoms ,Positron emission tomography ,030220 oncology & carcinogenesis ,Cohort ,Female ,medicine.symptom ,Risk assessment ,business - Abstract
Objective There is little information available regarding Chinese patients with Hodgkin lymphoma (HL). We analyzed the clinical features, outcome, and prognostic factors of Chinese patients with HL, aiming to establish a new risk model for better risk-adapted therapeutic strategy. Patients and Methods Patients with newly diagnosed HL at 4 medical centers from January 2000 to August 2014 were recruited. Results A total of 150 patients were reviewed. The median age was 30 years (range, 15-91 years). At completion of initial therapy, 73.65% of patients achieved complete remission. The 5-year event-free survival (EFS) of the entire cohort was 61.1%, the overall survival was 84.7%, and the disease-free survival was 78.8%. B symptoms, extranodal involvement, and International Prognostic Score ≥ 3 remained as independent prognostic factors of EFS. Patients who failed to reach complete remission on interim positron emission tomography/computed tomography or computed tomography had a significantly worse outcome than those who did. A new risk model incorporating traditional risk factors and interim response stratified patients into 3 classes, with a 5-year EFS of 100%, 83.1%, and 33.1%, respectively ( P Conclusions General clinical features were comparable with those of Western patients, whereas therapeutic outcomes were slightly inferior. The novel risk assessment model showed potential as a more powerful prognostic tool by identifying 3 subsets of patients with significantly distinct outcomes, which warrants further validations.
- Published
- 2016
21. Giant Cranionasal and Cystic-Solid Craniopharyngioma Associated With Extensive Bone Erosion and Ossification
- Author
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Gang Guo, Su Jiang, Chao You, Liangxue Zhou, Linli Luo, and Haifeng Chen
- Subjects
Diagnostic Imaging ,Male ,Reoperation ,Nasal cavity ,medicine.medical_specialty ,medicine.medical_treatment ,Nose Neoplasms ,Skull Base Neoplasms ,Bone erosion ,Craniopharyngioma ,Young Adult ,Fatal Outcome ,medicine ,Humans ,Craniotomy ,Transsphenoidal surgery ,business.industry ,Ossification ,Endoscopy ,General Medicine ,medicine.disease ,Immunohistochemistry ,Skull ,medicine.anatomical_structure ,Otorhinolaryngology ,Surgery ,Radiology ,medicine.symptom ,business ,Calcification - Abstract
Craniopharyngioma (CP), a rare benign and slow-growing epithelial tumor, is mainly located within the sellar/parasellar region. Primary CP involving the nasal cavity and the sellar region with extensive erosion of the skull base and ossification simultaneity has not been described previously. The authors report a 23-year-old man who presented to our institute with complaints of repeated nasal cavity bloodshed, liquid flow, and progressive visual loss. A neuroimaging examination showed a giant cranionasal and cystic-solid CP extending from the suprasellar region to the nasopharynx with inhomogeneous enhancement, which is associated with extensive erosion of the skull base and ossification. The patient underwent a transsphenoidal surgery to resect the nasopharyngeal component of CP and a subfrontal craniotomy with a total removal of intracranial component by grinding 3 months later. A histopathologic examination revealed characteristic features of adamantinomatous CP associated with ossification. The current study demonstrates that CP can exhibit cranionasal growth pattern and arise from residue of craniopharyngeal duct. Extensive erosion of the skull base, calcification, and ossification can present in tumor simultaneity. A 2-stage stratagem is important for its total removal because of the peculiar hardness. Postsurgical course is unevenly and should be dealt with carefully.
- Published
- 2013
22. Inferior Vestibular Neuritis in a Fighter Pilot: A Case Report
- Author
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Ying Juan Zheng, Hong Bo Jia, Po Xu, and Su Jiang Xie
- Subjects
Male ,Vestibular system ,medicine.medical_specialty ,Proprioception ,business.industry ,Vestibular evoked myogenic potential ,Neuritis ,Poison control ,Middle Aged ,Audiology ,Vestibular nerve ,Vestibular Evoked Myogenic Potentials ,Otorhinolaryngology ,Spatial disorientation ,Orientation (mental) ,Aerospace Medicine ,Caloric Tests ,otorhinolaryngologic diseases ,Humans ,Medicine ,sense organs ,business ,Vestibular Neuronitis - Abstract
Spatial disorientation in airplane pilots is a leading factor in many fatal flying accidents. Spatial orientation is the product of integrative inputs from the proprioceptive, vestibular, and visual systems. One condition that can lead to sudden pilot incapacitation in fight is vestibular neuritis. Vestibular neuritis is commonly diagnosed by a finding of unilateral vestibular failure, such as a loss of caloric response. However, because caloric response testing reflects the function of only the superior part of the vestibular nerve, it cannot detect cases of neuritis in only the inferior part of the nerve. We describe the case of a Chinese naval command fighter pilot who exhibited symptoms suggestive of vestibular neuritis but whose caloric response test results were normal. Further testing showed a unilateral loss of vestibular evoked myogenic potentials (VEMPs). We believe that this pilot had pure inferior nerve vestibular neuritis. VEMP testing plays a major role in the diagnosis of inferior nerve vestibular neuritis in pilots. We also discuss this issue in terms of aeromedical concerns.
- Published
- 2013
23. Application of Crystalline Cellulose Membrane (Veloderm®) on Split-Thickness Skin Graft Donor Sites in Burn or Reconstructive Plastic Surgery Patients
- Author
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Jian Liu, Weihua Lin, Yeyang Li, Bing-Shun Wang, Qin Zhang, Xinzhou Rong, Xiaoyi Benjamin Li, Tao Zhang, and Su Jiang
- Subjects
Adult ,Male ,China ,medicine.medical_specialty ,Adolescent ,Petrolatum ,Erythema ,Statistics, Nonparametric ,Dressing change ,Vaseline ,law.invention ,Split thickness skin graft ,Randomized controlled trial ,Polysaccharides ,law ,Humans ,Medicine ,Prospective Studies ,Prospective cohort study ,Aged ,Pain Measurement ,Wound Healing ,Chi-Square Distribution ,Emollients ,business.industry ,Rehabilitation ,Exudates and Transudates ,Skin Transplantation ,Split skin graft ,Middle Aged ,Surgery ,Plastic surgery ,Treatment Outcome ,Emergency Medicine ,Female ,medicine.symptom ,Burns ,business - Abstract
The present study was performed in China to compare the efficacy and safety of an advanced wound dressing made of crystalline cellulose (Veloderm) to a conventional treatment of three Vaseline gauzes in the management of skin donor sites of burns or reconstructive plastic surgery. In this prospective, multicenter, open-labeled, randomized clinical trial performed in three Chinese burn centers in China, 96 patients who required autologous split skin graft were randomized into either the test (Veloderm) group or the control (Vaseline gauze) group. Average healing times in the test group and in the control group were 8.40±2.90 and 8.92±2.58 days, respectively, with median values of 7.00 and 8.00 days, respectively: the difference between two groups was statistically significant (P=.045). Scores for exudates, pain intensity, and peripheral erythema showed no difference between the groups; however, composite scores of three variables on day 10 postoperatively was significantly lower in the test group (0.00±0.00 vs. 0.13±0.49; P = .043). The need for a dressing change was also significantly lower in the test group (12.5 vs. 31.25%; P = .036). Veloderm is a safe and effective dressing that may offer some advantages over the traditional application of Vaseline gauze in the management of donor sites in burn or reconstructive plastic surgery patients.
- Published
- 2013
24. The role of statin therapy in the prevention of atrial fibrillation: a meta-analysis of randomized controlled trials
- Author
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Haibo Zhang, Wentong Fang, Su Jiang, and Hong-jian Li
- Subjects
Pharmacology ,Secondary prevention ,medicine.medical_specialty ,business.industry ,nutritional and metabolic diseases ,Atrial fibrillation ,medicine.disease ,law.invention ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Randomized controlled trial ,law ,Primary prevention ,Meta-analysis ,Internal medicine ,medicine ,Cardiology ,lipids (amino acids, peptides, and proteins) ,Pharmacology (medical) ,Observational study ,cardiovascular diseases ,Statin therapy ,Intensive care medicine ,business - Abstract
AIMS The use of statins has been suggested to protect against atrial fibrillation (AF) in some clinical observational and experimental studies but has remained inadequately explored. This study was designed to examine whether statins can reduce the risk of AF.
- Published
- 2012
25. Open, multicenter, phase Ⅳ clinical trial of Shenbei Guchang capsules in treatment of diarrhea type irritable bowel syndrome
- Author
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Liang-Ping Li, Yang Zhang, Guang-Shang Wang, Chun-Hua Qiu, Dong Chen, Jing Liao, Bi Liu, Tao Liang, Chun-Sheng Liu, Wei-Ming He, Hong-Bin Wang, Yi Jian, Wen-Bin Pan, Xu Zhang, Xin-Xi Xie, Chu-Min Zhang, Shu-An Chen, and Yong-Su Jiang
- Subjects
Diarrhea ,Abdominal pain ,medicine.medical_specialty ,business.industry ,Nausea ,Incidence (epidemiology) ,Capsules ,Abdominal distension ,medicine.disease ,Irritable Bowel Syndrome ,Clinical trial ,Treatment Outcome ,Complementary and alternative medicine ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,Medicine, Chinese Traditional ,General Pharmacology, Toxicology and Pharmaceutics ,medicine.symptom ,Adverse effect ,business ,Irritable bowel syndrome ,Drugs, Chinese Herbal - Abstract
To evaluate the safety and effectiveness of Shenbei Guchang capsules in treatment of diarrhea type irritable bowel syndrome (yang deficiency of spleen and kidney) under widely used conditions, an open, multicenter, controlled, phase Ⅳ clinical trial was conducted in the drug clinical trial centers of 16 domestic hospitals. 2 123 patients from June 10, 2011 to November 29, 2012 were enrolled in the trial. Drug clinical trial was approved by Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital Ethics Committee before implementation. Before the start of trial, subjects were selected according to the research scheme and inclusion criteria, then they would step into the 14 d study after signing Informed Consent Form. All subjects were treated according to the research scheme, evaluated the conditions and filled in CFR sheet, to provide the evaluation data and information on safety and efficacy of Shenbei Guchang capsules. Shenbei Guchang capsules were used to treat diarrhea type irritable bowel syndrome in widely used conditions (2 123 cases), and 2 029 cases of them entered FAS set, cure+markedly effective in 1 921 cases, with a comprehensive curative effect rate of 94.68%; 2 010 cases of them entered PPS set, cure+markedly effective in 1 906 cases, with a comprehensive curative effect rate of 94.83%. The primary symptoms of IBS were abdominal pain and diarrhea. After treatment, both abdominal pain and diarrhea were improved, with significant differences (P
- Published
- 2016
26. Enhancement of Contralesional Motor Control Promotes Locomotor Recovery after Unilateral Brain Lesion
- Author
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Jian Guang Xu, Tie Li, Yan Qun Qiu, Yu Dong Gu, Yun Dong Shen, Joe Z. Tsien, Meng Wang, Wen Dong Xu, Xu Yun Hua, Mou Xiong Zheng, and Su Jiang
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Time Factors ,Motor Activity ,Article ,Functional Laterality ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Peripheral nerve ,medicine ,Recovery mechanism ,Animals ,Multidisciplinary ,Behavior, Animal ,business.industry ,Motor Cortex ,Motor control ,Anatomy ,Recovery of Function ,X-Ray Microtomography ,Functional recovery ,Rats ,Disease Models, Animal ,030104 developmental biology ,medicine.anatomical_structure ,Nerve Transfer ,Brain Injuries ,Positron-Emission Tomography ,Brain lesions ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Motor cortex - Abstract
There have been controversies on the contribution of contralesional hemispheric compensation to functional recovery of the upper extremity after a unilateral brain lesion. Some studies have demonstrated that contralesional hemispheric compensation may be an important recovery mechanism. However, in many cases where the hemispheric lesion is large, this form of compensation is relatively limited, potentially due to insufficient connections from the contralesional hemisphere to the paralyzed side. Here, we used a new procedure to increase the effect of contralesional hemispheric compensation by surgically crossing a peripheral nerve at the neck in rats, which may provide a substantial increase in connections between the contralesional hemisphere and the paralyzed limb. This surgical procedure, named cross-neck C7-C7 nerve transfer, involves cutting the C7 nerve on the healthy side and transferring it to the C7 nerve on the paretic side. Intracortical microstimulation, Micro-PET and histological analysis were employed to explore the cortical changes in contralesional hemisphere and to reveal its correlation with behavioral recovery. These results showed that the contralesional hemispheric compensation was markedly strengthened and significantly related to behavioral improvements. The findings also revealed a feasible and effective way to maximize the potential of one hemisphere in controlling both limbs.
- Published
- 2016
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27. A Novel Method of HCC Pathological Images Recognition based on Morphological Distribution of Liver Cell Cords
- Author
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Aoshuang Dong, Huiyan Jiang, Keming Mao, and Su Jiang
- Subjects
Pathology ,medicine.medical_specialty ,Human life ,Liver cell ,Poorly differentiated ,Hepatocellular carcinoma ,medicine ,Biology ,medicine.disease ,Pathological - Abstract
The morbidity of hepatocellular carcinoma (HCC), which has become a significant killer to human life, is getting higher over the years. Not only the shape and structure of liver cells are abnormal in pathological images, but also liver cell cords show some unusual phenomena, such as incrassation and disorder. So our paper proposes a novel method of HCC pathological images recognition based on morphological distribution of liver cell cords, to assist pathologist to diagnose hepatic pathology. In the method, we firstly apply binarization and morphological operation to hepatic pathological images, and screen connected regions with their area and circularity. Adopted regions are considered as candidate centers of liver cell cords (vein center). Secondly we define different features (irregularity feature), according to the number of candidate centers in a pathological image, to recognize how structured liver cell cords are. Finally, we utilize the feature and classifier to identify HCC pathological images. The experiments indicate that the proposed method shows high accuracy of all HCC pathological images in well, moderately, poorly differentiated and normal forms.
- Published
- 2016
28. Ocular Vestibular Evoked Myogenic Potentials and Motion Sickness Susceptibility
- Author
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Su-jiang Xie, Jiang Yuanyuan, Zhi-Jie Wang, Chen Wei, Jia Hongbo, and Qin Yao
- Subjects
Male ,Vestibular system ,medicine.medical_specialty ,Motion Sickness ,business.industry ,Public Health, Environmental and Occupational Health ,Ocular Vestibular Evoked Myogenic Potentials ,Audiology ,medicine.disease ,Vestibular Evoked Myogenic Potentials ,Young Adult ,medicine.anatomical_structure ,Motion sickness ,Statistical significance ,Utricle ,medicine ,Humans ,Female ,Disease Susceptibility ,Objective evaluation ,Saccule ,business ,Anxiety scale - Abstract
BACKGROUND A functional vestibular system is a prerequisite for motion sickness (MS) to occur. The otolithic organs (saccule and utricle) are currently considered to be important in the pathogenesis of MS. Recent investigations have demonstrated that the ocular vestibular evoked myogenic potentials (oVEMP) test is an objective evaluation of utricular function. To date, there is no functional guide that can serve as a diagnostic tool for individual susceptibility to MS. Therefore, we investigated the link between oVEMP and MS susceptibility. METHOD The oVEMP test was performed on 31 MS susceptible and 23 nonsusceptible individuals. MS susceptibility was determined by self-declaration and by using the MS susceptibility questionnaire (MSSQ) and the Hamilton Anxiety Scale (HAS). RESULTS Bilateral oVEMP responses were obtained in all subjects. HAS and MSSQ scores between the susceptible and nonsusceptible group were 18.27 +/- 5.23 vs. 2.34 +/- 1.21 and 28.12 +/- 6.53 vs. 2.34 +/- 1.45, respectively. Statistically significant differences in MSSQ and HAS scores were found between the MS susceptible and nonsusceptible groups. No differences were found between MS susceptible and nonsusceptible subjects in N10 and P15 wave latencies, N10-P15 interval, or peak-to-peak N10-P15 amplitude. However, there was a trend toward greater asymmetry ratio in the MS susceptible group than in the MS nonsusceptible group (18.55 +/- 10.24% vs. 13.25 +/- 9.47%), although statistical significance was not reached. DISCUSSION It appears that no relation exists between oVEMP results and MS susceptibility. Nevertheless, the differences in the asymmetry ratios of oVEMP interpeak amplitude between the two groups revealed a trend toward marginal statistical significance.
- Published
- 2012
29. Clinical significance of CSF3R, SRSF2 and SETBP1 mutations in chronic neutrophilic leukemia and chronic myelomonocytic leukemia
- Author
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Chun Qiao, Su-Jiang Zhang, Yuan Ouyang, and Yu Chen
- Subjects
Oncology ,Male ,Pediatrics ,Chronic neutrophilic leukemia ,DNA Mutational Analysis ,Disease ,Gene mutation ,medicine.disease_cause ,Biochemistry ,Gastroenterology ,0302 clinical medicine ,hemic and lymphatic diseases ,Receptors, Colony-Stimulating Factor ,gene mutation ,Aged, 80 and over ,Mutation ,Hematology ,Serine-Arginine Splicing Factors ,Nuclear Proteins ,Leukemia, Myelomonocytic, Chronic ,CSF3R ,Middle Aged ,Prognosis ,Gene Expression Regulation, Neoplastic ,Survival Rate ,SRSF2 ,030220 oncology & carcinogenesis ,Cohort ,Female ,CNL ,Research Paper ,Adult ,medicine.medical_specialty ,Poor prognosis ,Immunology ,Chronic myelomonocytic leukemia ,03 medical and health sciences ,Young Adult ,Internal medicine ,medicine ,Biomarkers, Tumor ,Mutation type ,Humans ,Clinical significance ,Leukemia, Neutrophilic, Chronic ,Aged ,Neoplasm Staging ,CMML ,business.industry ,Cancer ,Cell Biology ,medicine.disease ,business ,Carrier Proteins ,030215 immunology - Abstract
Objective: To investigate the gene mutation and the clinical features of CSF3R, SETBP1 and SRSF2 in chronic neutrophilic leukemia (CNL) and chronic myelomonocytic leukemia (CMML) patients. Method: Sequence analysis of CSF3R, SETBP1 and SRSF2 were performed in 10 CNL and 56 CMML patients whose clinical features were also studied. Result: Among 10 CNL patients, 8(8/10, 80%) patients had CSF3R mutations and 7(7/8, 87.5%) of them were with CSF3R T618I. In 56 cases of patients with CMML, SRSF2 mutations were found in 14(14/56,25%), CSF3R in 4(4/56,7.1%) and SETBP1 in 3(3/56, 5.3%) patients. In CMML, compared to wild-type(wt) SRSF2 patients, SRSF2 mutated patients appeared to be more possible with SETBP1 mutations [1/14(7.1%) vs. 2/42(4.8%), P>0.05], less possible with CSF3R mutation [0/14(0%) vs. 4/42(9.5%), P Conclusion: The majority of patients with WHO-defined CNL have oncogenic mutations in CSF3R and the T618I mutation type is a highly sensitive and specific molecular marker of the disease. While mutations of SRSF2 are common in CMML and may be of prognostic significance. As a non-specific molecular marker, SETBP1 was found in CNL, CMML and other blood cancers, which have poor prognosis. Disclosures No relevant conflicts of interest to declare.
- Published
- 2015
30. An anatomical study of the full-length phrenic nerve and its blood supply: clinical implications for endoscopic dissection
- Author
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Jian-Guang Xu, Wen-Dong Xu, Yun-Dong Shen, Yu-Dong Gu, and Su Jiang
- Subjects
Adult ,medicine.medical_specialty ,Pericardiacophrenic artery ,Dissection (medical) ,Internal thoracic artery ,Cadaver ,medicine.artery ,medicine ,Humans ,Pericardium ,Body Weights and Measures ,Mammary Arteries ,Phrenic nerve ,Thoracic cavity ,business.industry ,Dissection ,Endoscopy ,General Medicine ,Anatomy ,medicine.disease ,Surgery ,Phrenic Nerve ,medicine.anatomical_structure ,business ,Artery - Abstract
For surgeries aimed at the dissection of full-length phrenic nerve, a full appreciation of its trajectory, blood supply and correlation with adjacent anatomical structures is necessary, especially for endoscopic manipulations. A fresh cadaver study was conducted with the purpose of avoiding surgical complications and ensuring further efficacy and efficiency of endoscopic manipulations. Ten fresh adult cadavers were dissected. Special attention was paid to the topography of the origin, the trajectory of the phrenic nerve, and its anatomic communication with the surrounding vessels and organs. In the second side of the cadavers, thoracic endoscopic manipulations and observations were also performed. The full length of the phrenic nerve was 24.6 ± 1.7 and 30.6 ± 1.8 cm on the right and left side, respectively; the blood supply of the phrenic nerve in the thoracic cavity came exclusively from the pericardiacophrenic artery; the distance between the origin of the pericardiacophrenic artery and that of the internal thoracic artery ranged from 0.5 to 5.2 cm on the right side, and from 1.4 to 5.6 cm on the left; most of the pericardiacophrenic veins intermingled with small vessels of pericardium and pleura, forming a venous network and joining the innominate vein. Endoscopic dissection of the thoracic phrenic nerve together with the accompanying pericardiacophrenic artery can be performed. Extreme attention should be paid during surgery to a section of about 6 cm in length of the artery originating from the internal thoracic artery, while the accompanying veins do not require to be spared.
- Published
- 2011
31. Ocular Vestibular-Evoked Myogenic Potentials in Healthy Pilots and Student Pilots
- Author
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Yan Xu, Hong-Bo Jia, Ying-juan Zheng, Su-Jiang Xie, Yan-Ge Zhang, and Hongzhe Bi
- Subjects
Adult ,Male ,Vestibular system ,China ,medicine.medical_specialty ,business.industry ,Significant difference ,Public Health, Environmental and Occupational Health ,Normal values ,Ocular Vestibular Evoked Myogenic Potentials ,Audiology ,Vestibular Evoked Myogenic Potentials ,Age and gender ,Young Adult ,Military Personnel ,SOUND STIMULATION ,Reference Values ,Aerospace Medicine ,medicine ,Humans ,Female ,business ,Binaural recording - Abstract
INTRODUCTION Excellent vestibular function (including utricular function) is important for pilots to maintain correct spatial orientation during flight. Vestibular-evoked myogenic potential (VEMP) recorded from extraocular muscles, the so-called ocular VEMP (oVEMP), can be used to evaluate utricular function. However, oVEMP has not been applied to pilots because of lack of reliable normative data. Hence, this study is designed to establish preliminary normative data for oVEMP induced by air-conducted sound in pilots and student pilots. METHODS There were 62 healthy student pilots (30 male and 32 age-matched female) and 31 healthy male fighter pilots who were recruited as study participants. During binaural air-conducted sound stimulation oVEMP was recorded bilaterally. The latencies of nI and pI, nI-pI interval, peak-to-peak nI-pI amplitude, and asymmetry ratio (AR) of oVEMP in all participants were collected. Meanwhile, the effects of gender and age on oVEMP were also investigated. RESULTS The latencies of nI and pI, nI-pI interval, nI-pI interpeak amplitude, and AR of oVEMP in all participants were 10.35 +/- 0.66 ms, 15.18 +/- 1.07 ms, 4.75 +/- 0.99 ms, 6.75 +/- 4.13 microV, and 13.22 +/- 9.13%, respectively. No significant difference existed between male student pilots and male pilots in terms of oVEMP parameters. The only significant difference was the nI-pI amplitude between age-matched male and female student pilots: 6.96 +/- 3.85 microV for male student pilots and 5.47 +/- 3.10 microV for female student pilots. CONCLUSIONS oVEMP should be interpreted with the AR rather than raw amplitude itself. Each institution should determine its own normal values.
- Published
- 2011
32. Clinical importance of different calreticulin gene mutation types in wild-type JAK2 essential thrombocythemia and myelofibrosis patients
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Chao Sun, Su-Jiang Zhang, Ju-Juan Wang, Chun Qiao, Yuan Ouyang, Jianyong Li, and Si-Xuan Qian
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medicine.medical_specialty ,Chronic myelomonocytic leukemia ,Gene mutation ,Gastroenterology ,hemic and lymphatic diseases ,Enhancer binding ,Internal medicine ,medicine ,Humans ,Online Only Articles ,Myelofibrosis ,biology ,Essential thrombocythemia ,business.industry ,Hematology ,Janus Kinase 2 ,medicine.disease ,Leukemia ,Primary Myelofibrosis ,Mutation ,Immunology ,biology.protein ,Mutation testing ,Calreticulin ,business ,Thrombocythemia, Essential - Abstract
The Janus kinase 2 (JAK2) V617F mutation (JAK2 V617F), JAK2 exon 12 mutations and myeloproliferative leukemia virus oncogene W515L/K mutation (MPL W515L/K) have become three major molecular diagnosis criteria for myeloproliferative neoplasms (MPNs) including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) from 2005.1 However, diagnosing MPNs with non-mutated JAK2 and MPL remains a major diagnostic challenge.2–4 Some recent studies have reported calreticulin (CALR) gene mutations in patients with non-mutated JAK2 V617F MPNs.5–7 There are some distinct mutation types in MPN subtypes, but the differences in the clinical significance and prognosis among the different mutation types are obscure.8–10 Here, we report our data on CALR mutation in wild-type (wt) JAK2 MPN on patients. It should also be mentioned that this is undoubtedly the first report regarding CALR mutations in Chinese MPN patients. From January 2008 to December 2013, bone marrow or peripheral blood samples from 301 MPNs patients were collected in the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province, China, including ET (n=222), PV (n=37), PMF (n=33), post-ET MF (PET-MF; n=6), and post-PV MF (PPV-MF; n=3). We also obtained bone marrow samples from 174 patients with other myeloid neoplasms including: myelodysplastic syndrome (MDS; n=8), chronic myelogeneous leukemia (CML; n=55), acute myeloid leukemia (AML; n=104), and chronic myelomonocytic leukemia (CMML; n=7), as well as peripheral blood samples from 121 healthy controls. All participants provided their informed consent. Genomic PCR combined with direct and cloning sequencing was applied to screen CALR mutations. A total of 24.3% (73 of 301) patients with MPNs were found harboring CALR mutations. The CALR mutation was detected in 31.1% (69 of 222) and 12.1% (4 of 33) of patients with ET and PMF, respectively (Figure 1A). Moreover, CALR mutations were found in 57.0% (69 of 121) ET patients with wt JAK2 and 30.8% (4 of 13) PMF patients with wt JAK2. No CALR mutation in patients with PV, PET-MF, PPV-MF (Figure 1A) was found. The CALR mutations have multiple deletions or insertions including: L367fs*46 (33 of 74; 44.6%), K385fs*47 (25 of 74; 33.8%), K368fs*51 (3 of 74; 4.1%), Q365fs*50 (3 of 74; 4.1%), E364fs*49 (2 of 74; 2.7%), K374fs*56 (2 of 74; 2.7%), L367fs*48 (1 of 74; 1.4%), Q365fs*48 (1 of 74; 1.4%), E364fs*55 (1 of 74; 1.4%), K375fs*48 (1 of 74; 1.4%), K375fs*55 (1 of 74; 1.4%), and K377fs*50 (1 of 74; 1.4%). Figure 1. (A) Frequency of CALR mutations in myeloid neoplasms and healthy control. The CALR mutation was detected in 31.1% (69 of 222) and 12.1% (4 of 33) of ET and PMF patients, respectively. Approximately 1% of patients (1 of 104) with AML were found to harbor ... These patients with MPNs were simultaneously examined for the presence of other gene mutations. PV patients were screened for JAK2 V617F and JAK2 exon 12 mutations, while ET and MF patients were screened for JAK2 V617F and MPL W515L/K mutation. Among the total 301 patients with MPNs, 52.2% (157 of 301) were found to harbor JAK2 V617F mutation. Among the 222 patients with ET and 37 patients with PV, 0.9% (2 of 222) were found to harbor MPL W515L/K mutations and 2.7% (1 of 37) to harbor JAK2 exon 12 mutation, respectively (Figure 1B). JAK2 V617F, JAK2 exon 12 mutation, MPL W515L/K mutations and CALR mutations were found exclusively in these MPNs patients. We also screened CALR mutations in 104 AML patients, 55 CML patients, 7 CMML patients, and 8 MDS patients (including 5 refractory cytopenia with multilineage dysplasis, 2 refractory anemia with excess blasts, and one refractory anemia) to investigate whether CALR mutations were present in other myeloid neoplasms. Although most of these patients had negative results, one AML patient (59-years old, male, M2 subtype) was found to harbor CALR mutation (L367fs*46) without JAK2 V617F and MPL W515L/K mutations (Figure 1A). This patient had no previous history of MPN or MDS, Fms-related tyrosine kinase 3 internal tandem duplication, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog mutation, nucleophosmin mutation. CCAAT/enhancer binding protein alpha mutation was all negative and cytogenetics analysis showed normal karyotype. In addition, no CALR mutation was detected in the 121 healthy controls (Figure 1A). For mutation types, a total of 12 distinct variants of CALR mutation, including 11 deletions and one insertion, were identified in our patients. L367fs*46, which resulted from a 52-bp deletion, and K385fs*47, which resulted from a 5-bp insertion, were the most frequent CALR mutations. The two mutations accounted for 44.6% (33 of 74) and 33.8% (25 of 74) in all cases with mutant CALR, respectively. For ET patients, the two mutations were 14.0% (31 of 222) and 10.4% (23 of 222), respectively. For PMF patients, the two mutations were 3.0% (1 of 33) and 6.1% (2 of 33), respectively. There was no significant difference in the two mutation types between patients with ET and PMF (P=0.137 and P=0.645, respectively). Moreover, the two mutations were 44.9% (31 of 69) and 33.3% (23 of 69) in CALR mutation positive ET patients (Figure 1C), as well as 25% (1 of 4) and 50% (2 of 4) in CALR mutation positive PMF patients (P=0.793 and P=0.888, respectively). There were few other mutation types in the CALR-mutated samples (Figure 1C). ET patients with mutant CALR were significantly younger (P
- Published
- 2014
33. Vestibular Function in Military Pilots Before and After 10 s at +9 Gz on a Centrifuge
- Author
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Su-Jiang Xie, Hongzhe Bi, ShiJun Guo, GuangBin Cui, Da-wei Tian, and Hong-Bo Jia
- Subjects
Vestibular system ,Hypergravity ,medicine.medical_specialty ,Centrifuge ,genetic structures ,business.industry ,Public Health, Environmental and Occupational Health ,Nystagmus ,Optokinetic reflex ,Audiology ,otorhinolaryngologic diseases ,Reflex ,medicine ,sense organs ,medicine.symptom ,Vestibulo–ocular reflex ,Aviation medicine ,business ,Simulation - Abstract
Background Effects of high Gz acceleration can threaten flight safety through loss of consciousness or a lesser-known phenomenon, G-induced vestibular dysfunction (GIVD). There are reports of GIVD following high-G flight or centrifuge exposure. The aim of this study was to explore this problem under controlled conditions using a human centrifuge. Methods There were 11 pilots who were exposed to +9 Gz for 10 s. Measurements were made before and after G exposure to assess vestibular function, including spontaneous nystagmus, positioning nystagmus, optokinetic nystagmus, vestibular ocular reflex, vestibular-vision interaction, subjective vision vertical perception, and vestibular-evoked myogenic potentials. Results No significant change was found for vestibular function after the Gz exposure. Conclusion It appears +9 Gz for 10 s does not produce GIVD. However, the possible effects of prolonged high G maneuvers in modern aircraft combined with head movements may warrant further study.
- Published
- 2009
34. An update of molecular pathogenesis and diagnosis of myeloproliferative disorders in the JAK2 era
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Su-Jiang Zhang and Jian-Yong Li
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Pathology ,medicine.medical_specialty ,Myeloproliferative Disorders ,business.industry ,Molecular pathogenesis ,General Medicine ,Janus Kinase 2 ,Bioinformatics ,Thrombocytopenia ,Primary Myelofibrosis ,Mutation (genetic algorithm) ,Humans ,Point Mutation ,Medicine ,business ,Polycythemia Vera - Published
- 2008
35. Outcome of treatment with Hyper-CVAD regimen in Chinese patients with acute lymphocytic leukemia
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Hua Lu, Lijuan Chen, Rui-Lan Sheng, Si-Xuan Qian, Jianyong Li, Su-Jiang Zhang, Rui-Lan Lu, Han-Xin Wu, and Wei Xu
- Subjects
Adult ,Male ,China ,Cancer Research ,medicine.medical_specialty ,Vincristine ,Cyclophosphamide ,Hyper-CVAD ,Gastroenterology ,Dexamethasone ,Internal medicine ,Acute lymphocytic leukemia ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Leukocytosis ,Survival rate ,Retrospective Studies ,business.industry ,Retrospective cohort study ,Hematology ,Middle Aged ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Prognosis ,medicine.disease ,Surgery ,Survival Rate ,Regimen ,Treatment Outcome ,Oncology ,Doxorubicin ,Female ,medicine.symptom ,business ,Follow-Up Studies ,medicine.drug - Abstract
Modern intensive chemotherapy regimens have improved the prognosis for adult patients with acute lymphocytic leukemia (ALL). With these regimens, the complete response (CR) rates are approximately 75% and long-term disease-free survival (DFS) rates are about 20-35%. For patients with high-risk ALL, DFS rates are only 20% or less. Hyper-CVAD regimen is effective in ALL and aggressive non-Hodgkin lymphomas (NHL) with increased CR rates and DFS rates. Between June 2002 and October 2006, 53 consecutive adult patients with newly diagnosed adult ALL were treated with Hyper-CVAD regimen for six to eight cycles. The alternating courses were given every 3-4 weeks or earlier if count recovery occurred. CR rates of 73.6% were achieved in 39 patients, the estimated 2-year survival rate was 82.9% and the estimated 2-year event-free survival (EFS) rate was 87.3%. Side effects were as expected, mostly attributed to myelosuppression. Analysis of prognostic factors suggested that some previously well-established poor prognostic factors such as the degree of leukocytosis and central nervous system (CNS) or testicular involvement were less important with this dose-intensive regimen. However, patients with mediastinal disease had lower CR rates (P
- Published
- 2008
36. JAK2V617F patients with essential thrombocythemia present with clinical features of polycythemia vera
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Jianyong Li, Bruce S Fischer, Limin Duan, Hong-Xia Qiu, Xuemei Sun, Wei Xu, Wei-Da Li, and Su-Jiang Zhang
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Neutrophils ,Hematocrit ,Gastroenterology ,Hemoglobins ,Myelogenous ,Polycythemia vera ,Asian People ,Leukemia, Myelogenous, Chronic, BCR-ABL Positive ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,Point Mutation ,Genetic Testing ,Polycythemia Vera ,Aged ,Myeloproliferative Disorders ,medicine.diagnostic_test ,Essential thrombocythemia ,business.industry ,Point mutation ,Myelodysplastic syndromes ,Myeloid leukemia ,Hematology ,Janus Kinase 2 ,Middle Aged ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,medicine.disease ,Leukemia ,Oncology ,Myelodysplastic Syndromes ,Immunology ,Female ,business ,Thrombocythemia, Essential - Abstract
Recent studies have shown that Janus tyrosine kinase 2 (JAK2) V617F mutation is found in nearly all patients with polycythemia vera (PV) and underlie the basis of PV molecular pathogenesis. Moreover, JAK2 V617F patients with essential thrombocythemia (ET) have been found to have some clinical features similar to PV. To determine whether the same is true in a different Chinese patient population, we employed Allele-specific polymerase chain reaction in combination with sequence analysis to investigate the point mutation in a series of Chinese patients with hematological malignancies. A total of 99 Chinese myeloproliferative disorder patients and 120 additional patients with acute myeloid leukemia, acute lymphoblastic leukemia and myelodysplastic syndromes were studied. The V617F mutation was detected in genomic DNA of peripheral blood samples of 16 of 23 PV patients (69.6%), 21 of 45 ET patients (46.7%) and 3 of 8 patients with idiopathic myelofibrosis (37.5%). There were striking differences in clinical features such as hemoglobin, hematocrit and neutrophils percentages between V617F positive and negative patients with ET. Hence, our data support the idea that JAK2 V617F mutation divides ET patients into two subtypes, with the V617F positive group showing phenotypic similar to that of PV.
- Published
- 2008
37. Efficacy and safety of decitabine in combination with G-CSF, low-dose cytarabine and aclarubicin in newly diagnosed elderly patients with acute myeloid leukemia
- Author
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Kang Yu, Ming Hong, Yanli Xu, Run Zhang, Jianfeng Zhou, Hua-Yuan Zhu, Peng Liu, Han-Xin Wu, Jian Gu, Jinning Shi, Si-Xuan Qian, Yu Zhu, Liang-Qin Pan, Hua Lu, Su-Jiang Zhang, Jianyong Li, Shanhua Zhou, Ji Xu, Hong-Xia Qiu, Jiahua Ding, Ling Pan, Yan Li, Yaoyu Chen, Limin Duan, and Jianmin Wang
- Subjects
Male ,medicine.medical_specialty ,Low dose cytarabine ,Decitabine ,Newly diagnosed ,elderly patients ,AML ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,Granulocyte Colony-Stimulating Factor ,Medicine ,Humans ,In patient ,Prospective Studies ,China ,Aclarubicin ,Survival rate ,Aged ,Aged, 80 and over ,Traditional medicine ,business.industry ,Cytarabine ,Survival Analysis ,Regimen ,Leukemia, Myeloid, Acute ,Treatment Outcome ,Oncology ,D-CAG ,Azacitidine ,Female ,Clinical Research Paper ,business ,medicine.drug - Abstract
// Jianyong Li 1,2,* , Yaoyu Chen 1,2,* , Yu Zhu 1,2 , Jianfeng Zhou 3 , Yanli Xu 4 , Yan Li 5 , Kang Yu 6 , Ling Pan 7 , Jianmin Wang 8 , Jiahua Ding 9 , Jian Gu 10 , Shanhua Zhou 11 , Jinning Shi 12 , Ming Hong 1,2 , Ji Xu 1,2 , Liangqin Pan 1,2 , Limin Duan 1,2 , Run Zhang 1,2 , Sujiang Zhang 1,2 , Huayuan Zhu 1,2 , Hua Lu 1,2 , Peng Liu 1,2 , Hongxia Qiu 1,2 , Hanxin Wu 1,2 and Sixuan Qian 1,2 1 First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China 2 Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China 3 Tongji Hospital affiliated to Tongji medical college of Huazhong University of Science and Technology, Wuhan, China 4 Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing, China 5 First Affiliated Hospital of China Medical University, Shenyang, China 6 First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China 7 West China Hospital of Sichuan University, Chengdu, China 8 Changhai Hospital, Secondary Military Medical University, Shanghai, China 9 Zhongda Hospital, Southeast University, Nanjing, China 10 Clinic Medical College of Yangzhou University, Yangzhou, China 11 Zhongshan Hospital, Fudan University, Shanghai, China 12 Jiangning Hospital, Nanjing, China * The authors contributed equally to this work Correspondence: Sixuan Qian, email: // Keywords : D-CAG, elderly patients, AML Received : December 01, 2014 Accepted : January 13, 2015 Published : January 31, 2015 Abstract Purpose: This prospective phase II, open label, study was designed to assess the efficacy and safety of D-CAG induction treatment for elderly patients with newly diagnosed AML. Experimental Design: All patients in this study were treated with decitabine of 15 mg/m 2 for 5 days and G-CSF for priming, in combination with cytarabine of 10-mg/m 2 q12h for 7 days and aclarubicin of 10 mg/day for 4 days (D-CAG). Results: Among 85 evaluable patients, overall response rate (ORR) and complete remission (CR) were 82.4% and 64.7%, respectively, after 1 cycle of therapy. The ORR in patients aged
- Published
- 2014
38. Significance of soluble interleukin-2 receptor in patients with hemophagocytic lymphohistiocytosis
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Jianyong Li, Su-Jiang Zhang, Wei Xu, Peng Liu, Ji Xu, Yixin Hu, Li-Juan Zhang, Hong-Xia Qiu, Ling-Ling Wang, and Xiaoyan Zhang
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Interleukin 2 ,Cancer Research ,medicine.medical_specialty ,Hemophagocytic lymphohistiocytosis ,business.industry ,fungi ,Interleukin-2 Receptor alpha Subunit ,Kaplan-Meier Estimate ,Hematology ,Prognosis ,medicine.disease ,Gastroenterology ,Lymphohistiocytosis, Hemophagocytic ,Solubility ,Oncology ,Internal medicine ,medicine ,Rheumatologic disease ,Humans ,In patient ,business ,Receptor ,hormones, hormone substitutes, and hormone antagonists ,Familial disease ,medicine.drug - Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder occurring as a familial disease (FHL) or secondary to other diseases including infection (IAHS), rheumatologic disease (MAS),...
- Published
- 2011
39. Transfert robot-assisté de la racine C7 du côté controlatéral sain : étude de faisabilité sur cadavre
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Guillaume Prunières, Brett Peterson, Wen-dong Xu, Satoshi Ichihara, Philippe Liverneaux, Su Jiang, and Sybille Facca
- Subjects
medicine.medical_specialty ,Nerve root ,business.industry ,Transfer procedure ,Rehabilitation ,Anatomy ,medicine.disease ,Cerebral palsy ,Surgery ,Nerve Transfer ,Cerebral hemisphere ,medicine ,Orthopedics and Sports Medicine ,Spasticity ,medicine.symptom ,Spastic hemiplegia ,Cadaveric spasm ,business - Abstract
Patients with cerebral palsy and spastic hemiplegia may have extremely poor upper extremity function. Unfortunately, many current therapies and treatments for patients with spastic hemiplegia offer very limited improvements. One innovative technique for treating these patients is to use a contralateral C7 nerve root transfer to neurotize the C7 nerve root in the affected limb. This may result not only in less spasticity in the affected limb, but also improved control and motor function vis-a-vis the new connection to the normal cerebral hemisphere. However, contralateral C7 transfers can require large incisions and long nerve grafts. The aim of this study was to test the feasibility of a contralateral C7 nerve root transfer procedure with the use of a minimally invasive robot-assisted technique. In a cadaveric experiment, both sides of C7 root were dissected. The right recipient C7 root was resected as proximally as possible, while the left donor C7 root was resected as distally as possible. With the use of the robot Da Vinci SIy (Intuitive Surgical™, Sunnyvale, CA, USA), we were able to eliminate the large incision and use a much shorter nerve graft when performing the contralateral C7 nerve transfer.
- Published
- 2016
40. A rare presentation of pemphigus vulgaris as multiple pustules
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Su Jiang Huang, Wan Qing Liao, Chen Min, Min Lin, and Yang Yang
- Subjects
medicine.medical_specialty ,business.industry ,Pemphigus vulgaris ,Correspondence ,lcsh:Dermatology ,Medicine ,Dermatology ,Presentation (obstetrics) ,lcsh:RL1-803 ,business ,medicine.disease - Published
- 2010
41. Horizontal Canal Benign Paroxysmal Positional Vertigo (HC-BPPV) in A Fighter Pilot : A Case Report
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Yao Qin, Xu Po, Jia Hong Bo, Xie Su Jiang, and Zhen Ying
- Subjects
medicine.medical_specialty ,Horizontal Canal ,Benign paroxysmal positional vertigo ,business.industry ,medicine ,General Medicine ,Radiology ,business ,medicine.disease - Published
- 2010
42. High-dose idarubicin plus busulfan as conditioning regimen to autologous stem cell transplantation: promising post-remission therapy for acute myeloid leukemia in first complete remission?
- Author
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Kou-Rong Miao, Jianyong Li, Su-Jiang Zhang, Ming Hong, Hua Lu, Han-Xin Wu, Lijuan Chen, Peng Liu, Hong-Xia Qiu, Wei Xu, Si-Xuan Qian, and Run Zhang
- Subjects
Oncology ,Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Transplantation Conditioning ,Adolescent ,medicine.medical_treatment ,Hematopoietic stem cell transplantation ,Transplantation, Autologous ,Disease-Free Survival ,Young Adult ,Autologous stem-cell transplantation ,Internal medicine ,Medicine ,Idarubicin ,Humans ,Busulfan ,Retrospective Studies ,business.industry ,Hematopoietic Stem Cell Transplantation ,Myeloid leukemia ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Transplantation ,Regimen ,Leukemia ,Leukemia, Myeloid, Acute ,Treatment Outcome ,Female ,business ,medicine.drug - Abstract
The optimal post-remission therapy (PRT) for acute myeloid leukemia (AML) remains uncertain. We reported 32 AML patients in first complete remission (CR1) undergoing autologous hematopoietic stem cell transplantation (ASCT) with a characteristic conditioning regimen, termed I-Bu, based on high-dose idarubicin plus busulfan, which considerably strengthened antileukemic activity. Most patients were in better or intermediate-risk group except that cytogenetic or molecular risk information was missing for 18.7 % of the patients. Unpurged peripheral blood stem cells were used in all the cases. The adverse effects were mild and reversible. Only one case of transplant-related mortality was observed. All the patients in this study acquired hematopoietic reconstitution after ASCT. After a median follow-up of 30 (6–119) months, 24 patients (75.0 %) were alive in which 20 (62.5 %) patients were in continuous CR. There were 11 (34.4 %) patients who relapsed after HSCT. Cumulative relapse probability was about 40 % after 24 months. Median OS and DFS have not been reached. Patients in the better and intermediate-risk group had different clinical outcomes, but the differences were not statistically significant. ASCT with I-Bu regimen is possibly promising PRT for better and intermediate-risk AML patients in CR1.
- Published
- 2013
43. The decrease of JAK2 V617F allele burden in leukemia transformation of an elderly patient with myelofibrosis
- Author
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Han-Xin Wu, Jianyong Li, Jonathan D. Finn, Si-Xuan Qian, Wei Xu, Hui Lu, Jian-Fu Zhang, and Su-Jiang Zhang
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,Hematology ,medicine.disease ,Transformation (genetics) ,Leukemia ,Text mining ,Internal medicine ,medicine ,Allele ,business ,Myelofibrosis ,Elderly patient ,JAK2 V617F - Published
- 2009
44. Distinctive microRNA signature is associated with the diagnosis and prognosis of acute leukemia
- Author
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Chao Sun, Yuan-Dong Zhu, Wei Xu, Yin-Hua Wang, Zhi-Jian Zou, Dan-Xia Zhu, Su-Jiang Zhang, Lei Fan, Cheng Fang, Li Wang, and Jianyong Li
- Subjects
Adult ,Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Adolescent ,Karyotype ,Molecular Sequence Data ,Biology ,Gastroenterology ,Pathogenesis ,hemic and lymphatic diseases ,Internal medicine ,microRNA ,medicine ,Humans ,Child ,In Situ Hybridization, Fluorescence ,Aged ,Aged, 80 and over ,Acute leukemia ,Hematology ,Leukemia ,Base Sequence ,Significant difference ,Myeloid leukemia ,Infant ,General Medicine ,Middle Aged ,Prognosis ,MicroRNAs ,Real-time polymerase chain reaction ,Oncology ,fms-Like Tyrosine Kinase 3 ,Child, Preschool ,Acute Disease ,Female - Abstract
MicroRNAs (miRNAs) are of great importance in pathogenesis, diagnosis and prognosis of acute leukemia (AL). We studied five AL-related miRNAs to confirm the significance of these miRNAs in AL. Samples tested included acute myeloid leukemia (AML), 107 cases; acute lymphoblastic leukemia (ALL), 40 cases. Five AL-related miRNAs: miR-128, let-7b, miR-223, miR-181a and miR-155 expression were detected by qRT-PCR. Analysis showed that miRNA-128 expression was significantly higher in ALL (P
- Published
- 2011
45. Endoscopy-assisted cubital tunnel release under carbon dioxide insufflation and anterior transposition
- Author
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Yun-Dong Shen, Yu-Dong Gu, Wendong Xu, Su Jiang, and Jian-Guang Xu
- Subjects
Insufflation ,Adult ,Male ,medicine.medical_specialty ,Endoscope ,Anterior transposition ,Cubital Tunnel Syndrome ,medicine ,Humans ,Rating system ,Carbon dioxide insufflation ,Ulnar Nerve ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Cubital tunnel release ,Retrospective cohort study ,Carbon Dioxide ,Middle Aged ,Endoscopy ,Surgery ,Treatment Outcome ,Neuroendoscopy ,Female ,business ,Follow-Up Studies - Abstract
Purpose The optimal treatment for cubital tunnel syndrome is widely debated. The purpose of this study is to describe the technique of an endoscopic-assisted ulnar nerve decompression using carbon dioxide insufflation in association with subcutaneous anterior transposition and to assess the success or failure of the method of treatment. Methods In all, 8 male and 4 female patients with an average age of 42 years (range, 25-56) who presented signs, symptoms, and abnormal neurophysiological studies of cubital tunnel syndrome were recruited in the retrospective study. Between August 2008 and June 2009, they were operated on using a 0-degree lens endoscope. Preoperatively, they were classified according to the Dellon scale, and the Bishop rating system was used to evaluate the postoperative outcomes. Results Preoperatively, 5 patients were rated as mild, another 5 as moderate, and the remaining 2 as severe. The average length of the incision was 15 ± 3 mm, the mean length of the ulnar nerve decompression was 18 ± 2 cm, and the whole duration of surgery (skin to skin) lasted 30 ± 5 minutes. The endoscopic-assisted cubital tunnel release under carbon dioxide insufflation and subcutaneous anterior transposition surgeries in all patients were performed with no difficulty. All the patients had improvement in symptoms of cubital tunnel syndrome and 10 of 12 patients scored excellent according to the modified Bishop Rating System at a minimum of 1 year after surgery. Conclusions Endoscopy-assisted cubital tunnel release under carbon dioxide insufflation demonstrated similar results compared with conventional open surgeries, besides, it may avoid problems such as long incision, painful scarring, and have additional advantages of providing an extended endoscopic view, which is safe and mini-invasive with favorable results in a 12-month follow-up.
- Published
- 2011
46. Splenectomy for an adult patient with refractory secondary hemophagocytic lymphohistiocytosis
- Author
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Yongqian Shu, Hong-Xia Qiu, Ling-Ling Wang, Ji Xu, Yixin Hu, Li-Juan Zhang, Jianyong Li, and Su-Jiang Zhang
- Subjects
Secondary Hemophagocytic Lymphohistiocytosis ,Male ,endocrine system ,medicine.medical_specialty ,Pediatrics ,medicine.medical_treatment ,Treatment outcome ,Splenectomy ,Drug Resistance ,Lymphohistiocytosis, Hemophagocytic ,Refractory ,hemic and lymphatic diseases ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Cyclophosphamide ,CHOP regimen ,Pharmacology ,Hemophagocytic lymphohistiocytosis ,business.industry ,Treatment regimen ,fungi ,General Medicine ,Middle Aged ,musculoskeletal system ,medicine.disease ,Surgery ,Treatment Outcome ,Male patient ,Doxorubicin ,Vincristine ,Splenomegaly ,Prednisone ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Treatment regimens of secondary hemophagocytic lymphohistiocytosis (sHLH) are complicated and individualized. CHOP regimen is well known for the treatment of adult sHLH, but it was not so effective for the 56-year-old male patient in our study. Splenomegaly, one of clinical manifestations of HLH, has urged us to investigate the role of splenectomy in HLH patients. Splenectomy is not only beneficial to confirm the underlying diseases, but also beneficial for the treatment of HLH. Here, we present a case diagnosed as sHLH who has recovered from HLH following comprehensive treatment based on splenectomy. The therapeutic value of splenectomy in sHLH needs further study.
- Published
- 2010
47. The effect of S-nitrosoglutathione and L-cysteine on chloride efflux from cystic fibrosis airway epithelial cells
- Author
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Anca Dragomir, Su Jiang, Zhanna Servetnyk, Godfried M. Roomans, Lena Hjelte, and Benjamin Gaston
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Time Factors ,Cystic Fibrosis ,Clinical Biochemistry ,Endogeny ,Respiratory Mucosa ,Pharmacology ,Cystic fibrosis ,Pathology and Forensic Medicine ,Cell Line ,S-Nitrosoglutathione ,chemistry.chemical_compound ,Chlorides ,Internal medicine ,medicine ,Humans ,Cysteine ,Molecular Biology ,Cysteine metabolism ,Transepithelial potential difference ,business.industry ,Drug Synergism ,respiratory system ,medicine.disease ,digestive system diseases ,Transmembrane protein ,respiratory tract diseases ,Bronchodilator Agents ,Endocrinology ,chemistry ,Efflux ,business - Abstract
The endogenous bronchodilator, S-nitrosoglutathione (GSNO), has been proposed as a possible pharmacological remedy that reverses the ΔF508-CFTR (cystic fibrosis transmembrane conductance regulator) maturation defect and increases CFTR-mediated chloride efflux in cultured cystic fibrosis airway epithelial cells (CFBE41o(-)). It has also been reported that L-cysteine enhanced S-nitrosothiol uptake and increased the intracellular S-nitrosothiol levels, likely through transnitrosation chemistry. The present study investigated whether L-cysteine augmented the effect of GSNO on chloride efflux from CF airway epithelial cells. Treatment with 10 μM GSNO combined with 20 μM L-cysteine resulted in increased chloride efflux from CFBE41o(-) cells after 5 minutes exposure compared to the control efflux rate and to the efflux rate in the presence of L-cysteine alone as measured using the fluorescent dye N-(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide (MQAE). Chloride efflux rates from these cells after 4h exposure to GSNO and L-cysteine were not different from control. Treatment with 10 μM GSNO alone increased chloride efflux from CFBE41o(-) cells after 4h but not at shorter incubation times. GSNO with or without L-cysteine did not alter epithelial tight junction integrity. In conclusion, a combination of GSNO with L-cysteine led to significant increase in chloride efflux in CFBE41o(-) cells but the effect was transient and not sustained beyond minutes.
- Published
- 2010
48. Multidrug resistance gene (MDR1) polymorphisms correlate with imatinib response in chronic myeloid leukemia
- Author
-
Chun Qiao, Lingna Ni, Su-Jiang Zhang, Jianyong Li, Hai-Rong Qiu, Kou-Rong Miao, and Si-Xuan Qian
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,ATP Binding Cassette Transporter, Subfamily B ,Adolescent ,Genotype ,Single-nucleotide polymorphism ,Antineoplastic Agents ,Drug resistance ,Gastroenterology ,Piperazines ,Young Adult ,Internal medicine ,Leukemia, Myelogenous, Chronic, BCR-ABL Positive ,Medicine ,Humans ,ATP Binding Cassette Transporter, Subfamily B, Member 1 ,Allele ,neoplasms ,Aged ,Polymorphism, Genetic ,business.industry ,Myeloid leukemia ,Imatinib ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Survival Rate ,Leukemia ,Imatinib mesylate ,Pyrimidines ,Oncology ,Drug Resistance, Neoplasm ,Immunology ,Benzamides ,Imatinib Mesylate ,Female ,business ,medicine.drug - Abstract
The human multidrug resistance gene (MDR1, ABCB1) codes for P-glycoprotein (P-gp) that affects the pharmacokinetics of many drugs. MDR1 single nucleotide polymorphisms (SNPs) are associated with drug clearance. Imatinib is a substrate of P-gp-mediated efflux. We investigated the MDR1 T1236C, G 2677T/A, and C3435T polymorphism in 52 patients with chronic myeloid leukemia treated with imatinib. The distribution of MDR1 1236, 2677, or 3435 genotypes was significantly different between the resistance patients and sensitivity patients. The resistance incidence correlated with the number of T alleles at locus 1236 and 3435. Resistance was higher for patients homozygous for the 1236T allele when compared to patients with CT/CC genotype groups (75% vs. 31.3%, P = 0.004). For the G2677T/A polymorphism, a better complete cytogenetic remission was observed for patients with genotype AG/AT/AA, when compared to other genotype groups (TT/GT/GG, P = 0.02). Patients with 3435 TT/CT genotypes showed a higher resistance when compared with patients with CC genotype (59.4% vs. 25%, P = 0.023). In conclusion, determination of 1236T, C3435T, and G2677T MDR1 polymorphisms might be useful in response prediction to therapy with imatinib in patients with CML.
- Published
- 2010
49. Effect of low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor priming (CAG regimen) on the outcome of elderly patients with acute myeloid leukemia
- Author
-
Si-Xuan Qian, Wei Xu, Jianyong Li, Han-Xin Wu, Hua Lu, Yuanqiang Jiang, Tian Tian, Su-Jiang Zhang, and Yunfeng Shen
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Kaplan-Meier Estimate ,Gastroenterology ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,Granulocyte Colony-Stimulating Factor ,medicine ,Humans ,Aclarubicin ,Aged ,Aged, 80 and over ,business.industry ,Cytarabine ,Myeloid leukemia ,Hematology ,Middle Aged ,medicine.disease ,Granulocyte colony-stimulating factor ,Clinical trial ,Leukemia ,Regimen ,Treatment Outcome ,Oncology ,Leukemia, Myeloid ,Toxicity ,Immunology ,Acute Disease ,Female ,business ,medicine.drug - Abstract
The aim of this study was to evaluate the efficacy and toxicity of low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor (G-CSF) protocol in elderly patients with acute myeloid leukemia (AML). A total of 50 elderly patients including 8 aged over 70 years were enrolled. All patients were treated with CAG regimen including low-dose cytarabine (10mg/m(2) every 12h, days 1-14), aclarubicin (10mg every day, days 1-8), and G-CSF (200 microg/m(2) every day, days 1-14) priming. The overall response rate was 72.0%, and 29 of 50 (58.0%) patients achieved complete remission, including 23 of 35 (65.8%) with previously untreated AML, 6 of 15 (40.0%) with refractory, relapsed or secondary AML, 4 of 8 (50.0%) aged over 70 years, 4 of 10 (40.0%) with unfavorable cytogenetic aberrations. The early death rate was 7.6%. The median overall survival was 14 months. Myelosuppression was mild to moderate, severe nonhematologic toxicity was not observed. Thus CAG priming regimen as the induction therapy is well tolerated and effective in elderly patients with AML.
- Published
- 2006
50. P-289 Effect of low-dose cytarabine and aclarubicin in combination with decitabine on the outcome of patients with high-risk myelodysplastic syndromes
- Author
-
Run Zhang, Yu Zhu, S. Pian, Hua Lu, Peng Liu, Han-Xin Wu, Ming Hong, Su-Jiang Zhang, Junmin Li, L. Duan, and Hong-Xia Qiu
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,Myelodysplastic syndromes ,Low dose cytarabine ,Decitabine ,Hematology ,medicine.disease ,Internal medicine ,Medicine ,business ,medicine.drug ,Aclarubicin - Published
- 2013
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