1. Multispecies reconstructions uncover widespread conservation, and lineage-specific elaborations in eukaryotic mRNA metabolism.
- Author
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Bannerman, Bridget P., Kramer, Susanne, Dorrell, Richard G., and Carrington, Mark
- Subjects
EUKARYOTES ,MESSENGER RNA ,CYTOPLASMIC inheritance ,EXONS (Genetics) ,INTRONS - Abstract
The degree of conservation and evolution of cytoplasmic mRNA metabolism pathways across the eukaryotes remains incompletely resolved. In this study, we describe a comprehensive genome and transcriptome-wide analysis of proteins involved in mRNA maturation, translation, and mRNA decay across representative organisms from the six eukaryotic super-groups. We demonstrate that eukaryotes share common pathways for mRNA metabolism that were almost certainly present in the last eukaryotic common ancestor, and show for the first time a correlation between intron density and a selective absence of some Exon Junction Complex (EJC) components in eukaryotes. In addition, we identify pathways that have diversified in individual lineages, with a specific focus on the unique gene gains and losses in members of the Excavata and SAR groups that contribute to their unique gene expression pathways compared to other organisms. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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