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2 results on '"Ruomou Wu"'

1. Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer

Author

Olalekan Olanrewaju Bakare, Arun Gokul, Ruomou Wu, Lee-Ann Niekerk, Ashwil Klein, and Marshall Keyster

Subjects
anticancer peptides, apoptosis, cancer, cytolysis, host-defense peptides, peptide delivery, Microbiology, QR1-502
Abstract

The global increase in cancer mortality and economic losses necessitates the cautious quest for therapeutic agents with compensatory advantages over conventional therapies. Anticancer peptides (ACPs) are a subset of host defense peptides, also known as antimicrobial peptides, which have emerged as therapeutic and diagnostic candidates due to several compensatory advantages over the non-specificity of the current treatment regimens. This review aimed to highlight the ravaging incidence of cancer, the use of ACPs in cancer treatment with their mechanisms, ACP discovery and delivery methods, and the limitations for their use. This would create awareness for identifying more ACPs with better specificity, accuracy and sensitivity towards the disease. It would also promote their efficacious utilization in biotechnology, medical sciences and molecular biology to ease the severity of the disease and enable the patients living with these conditions to develop an accommodating lifestyle.

Published
2021
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2. Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer

Author

Ruomou Wu, Marshall Keyster, Ashwil Klein, Lee-Ann Niekerk, Olalekan Olanrewaju Bakare, and Arun Gokul

Subjects
0301 basic medicine, anticancer peptides, peptide delivery, Antimicrobial peptides, Antineoplastic Agents, Disease, Review, host-defense peptides, Bioinformatics, Biochemistry, Microbiology, 03 medical and health sciences, Delivery methods, 0302 clinical medicine, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Humans, cancer, Amino Acid Sequence, Molecular Targeted Therapy, Molecular Biology, Cancer mortality, business.industry, Treatment regimen, Cell Membrane, apoptosis, Cancer, medicine.disease, QR1-502, Cancer treatment, 030104 developmental biology, 030220 oncology & carcinogenesis, cytolysis, business, Antimicrobial Cationic Peptides
Abstract

The global increase in cancer mortality and economic losses necessitates the cautious quest for therapeutic agents with compensatory advantages over conventional therapies. Anticancer peptides (ACPs) are a subset of host defense peptides, also known as antimicrobial peptides, which have emerged as therapeutic and diagnostic candidates due to several compensatory advantages over the non-specificity of the current treatment regimens. This review aimed to highlight the ravaging incidence of cancer, the use of ACPs in cancer treatment with their mechanisms, ACP discovery and delivery methods, and the limitations for their use. This would create awareness for identifying more ACPs with better specificity, accuracy and sensitivity towards the disease. It would also promote their efficacious utilization in biotechnology, medical sciences and molecular biology to ease the severity of the disease and enable the patients living with these conditions to develop an accommodating lifestyle.

Published
2021

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