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Your search keyword '"Hailin Cong"' showing total 5 results
Start Over Author "Hailin Cong" Topic microfluidics
5 results on '"Hailin Cong"'

1. Synthesis of Monodisperse PEG/SiO2Hybrid Microspheres by Microfluidic Methods

Author

Hua Yuan, Yuezhong Wang, Xiao-Hui Gao, Bing Yu, Hailin Cong, and Xiaodan Xu

Subjects
Materials science, Dispersity, Microfluidics, Nanotechnology, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, law.invention, Photopolymer, Control and Systems Engineering, law, PEG ratio, Materials Chemistry, Ceramics and Composites, Calcination, Interpenetrating polymer network, Electrical and Electronic Engineering, Porosity, Microfabrication
Abstract

In this paper, we reported an effective microfluidic-based method for fast continuous synthesis of monodisperse PEG/SiO2 hybrid microspheres. The T-junction microfluidic chip equipped with rounded channels and the online photopolymerization system were applied for the microspheres microfabrication. The size of the microspheres was well controlled by the rounded channels and flow rate ratios of immiscrible fluids. We can obtain porous PEG microspheres when the hybrid microspheres were corroded by hydrofluoric acid. What's more, the interpenetrating polymer network structures of SiO2 microspheres were obtained after the hybrid microspheres treated via a calcination process.

Published
2015

2. Fabrication of anti-protein-fouling poly(ethylene glycol) microfluidic chip electrophoresis by sandwich photolithography

Author

Xiaodan Xu, Hua Yuan, Bing Yu, Hailin Cong, and Huwei Liu

Subjects
Materials science, Microfluidics, Biomedical Engineering, Nanotechnology, 02 engineering and technology, 01 natural sciences, Soft lithography, law.invention, chemistry.chemical_compound, Colloid and Surface Chemistry, law, General Materials Science, Fluid Flow and Transfer Processes, Microchannel, Polydimethylsiloxane, 010401 analytical chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Electrophoresis, chemistry, Photolithography, 0210 nano-technology, Ethylene glycol, Regular Articles, Microfabrication
Abstract

Microfluidic chip electrophoresis (MCE) is a powerful separation tool for biomacromolecule analysis. However, adsorption of biomacromolecules, particularly proteins onto microfluidic channels severely degrades the separation performance of MCE. In this paper, an anti-protein-fouling MCE was fabricated using a novel sandwich photolithography of poly(ethylene glycol) (PEG) prepolymers. Photopatterned microchannel with a minimum resolution of 10 μm was achieved. After equipped with a conventional online electrochemical detector, the device enabled baseline separation of bovine serum albumin, lysozyme (Lys), and cytochrome c (Cyt-c) in 53 s under a voltage of 200 V. Compared with a traditional polydimethylsiloxane MCE made by soft lithography, the PEG MCE made by the sandwich photolithography not only eliminated the need of a master mold and the additional modification process of the microchannel but also showed excellent anti-protein-fouling properties for protein separation.

Published
2016

4. Fabrication of anti-protein-fouling poly(ethylene glycol) microfluidic chip electrophoresis by sandwich photolithography.

Author

Hailin Cong, Xiaodan Xu, Bing Yu, Huwei Liu, and Hua Yuan

Subjects
*FABRICATION (Manufacturing), *FOULING, *MICROFLUIDICS, *PHOTOLITHOGRAPHY, *ELECTROPHORESIS
Abstract

Microfluidic chip electrophoresis (MCE) is a powerful separation tool for biomacromolecule analysis. However, adsorption of biomacromolecules, particularly proteins onto microfluidic channels severely degrades the separation performance of MCE. In this paper, an anti-protein-fouling MCE was fabricated using a novel sandwich photolithography of poly(ethylene glycol) (PEG) prepolymers. Photopatterned microchannel with a minimum resolution of 10 μm was achieved. After equipped with a conventional online electrochemical detector, the device enabled baseline separation of bovine serum albumin, lysozyme (Lys), and cytochrome c (Cyt-c) in 53 s under a voltage of 200 V. Compared with a traditional polydimethylsiloxane MCE made by soft lithography, the PEG MCE made by the sandwich photolithography not only eliminated the need of a master mold and the additional modification process of the microchannel but also showed excellent anti-protein-fouling properties for protein separation. [ABSTRACT FROM AUTHOR]

Published
2016
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5. Preparation of monodisperse PEG hydrogel composite microspheres via microfluidic chip with rounded channels.

Author

Bing Yu, Hailin Cong, Xuesong Liu, Yumin Ren, Jilei Wang, Lixin Zhang, Jianguo Tang, Yurong Ma, and Akasaka, Takeshi

Subjects
*MONODISPERSE colloids, *ETHYLENE glycol, *HYDROGELS, *MICROSPHERES, *MICROFLUIDIC devices, *MICROFLUIDICS, *PHOTOPOLYMERIZATION, *EQUIPMENT & supplies
Abstract

An effective microfluidic method to fabricate monodisperse polyethylene glycol (PEG) hydrogel composite microspheres with tunable dimensions and properties is reported in this paper. A T-junction microfluidic chip equipped with rounded channels and online photopolymerization system is applied for the microsphere microfabrication. The shape and size of the microspheres are well controlled by the rounded channels and PEG prepolymer/silicon oil flow rate ratios. The obtained PEG/aspirin composite microspheres exhibit a sustained release of aspirin for a wide time range; the obtained PEG/Fe3O4 nanocomposite microspheres exhibit excellent magnetic properties; and the obtained binary PEG/dye composite microspheres show the ability to synchronously load two functional components in the same peanut-shaped or Janus hydrogel particles. [ABSTRACT FROM AUTHOR]

Published
2013
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