1. Contribution of Loss of Large Fiber Function to Pain in 2 Samples of Oncology Patients
- Author
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Steven W. Cheung, Mark Schumacher, Margaret A. Chesney, David Borsook, Judy Mastick, Christine Miaskowski, Gary W. Abrams, Marilyn J. Hammer, Steven M. Paul, Betty Smoot, Kord M. Kober, Yvette P. Conley, Jon D. Levine, and Kimberly S. Topp
- Subjects
Male ,Cross-sectional study ,Sensation ,Pain ,Antineoplastic Agents ,Breast Neoplasms ,Nerve Fibers, Myelinated ,Vibration ,Article ,Hypesthesia ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,030202 anesthesiology ,Sensory threshold ,Numeric Rating Scale ,Humans ,Medicine ,Longitudinal Studies ,Aged ,Pain Measurement ,Pain, Postoperative ,business.industry ,Peripheral Nervous System Diseases ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,Anesthesiology and Pain Medicine ,Peripheral neuropathy ,Chemotherapy-induced peripheral neuropathy ,Sensory Thresholds ,Anesthesia ,Neuropathic pain ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
OBJECTIVES Numbness associated with neuropathic pain suggests the loss of function in myelinated, large diameter sensory neurons. The purpose of this study was to examine the relationships between pain severity and subjective (ie, severity of numbness) and objective (ie, loss of light touch sensations, vibration thresholds) measures of loss of large fiber function in adult survivors with chemotherapy-induced peripheral neuropathy (CIPN, n=426) and breast cancer patients with persistent postsurgical pain (n=80). MATERIAL AND METHODS For both samples, average pain and numbness were evaluated using a 0 to 10 numeric rating scale. Loss of light touch sensations in the hands and feet of patients with CIPN and in the upper arm of patients at 5 and 6 months following breast cancer surgery were assessed using Semmes Weinstein monofilaments. Loss of vibration in the hands and feet of patients with CIPN was assessed using a biothesiometer. Pearson Product Moment correlation coefficients were calculated between average pain and the number or percentage of sites with loss of light touch sensations, mean vibration thresholds, and the severity of numbness. RESULTS For both pain conditions, average pain scores were significantly correlated with objective measures of large fiber function (r=0.12 to 0.34; all P
- Published
- 2019