1. Long-Term Near-Infrared Signal Tracking of the Therapeutic Changes of Glioblastoma Cells in Brain Tissue with Ultrasound-Guided Persistent Luminescent Nanocomposites
- Author
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Ru-Shi Liu, Chiao-Ling Cheng, Michael Hsiao, Sheng-Jan Feng, and Ming-Hsien Chan
- Subjects
Materials science ,Cell Survival ,Infrared Rays ,Surface Properties ,Ultrasonic Therapy ,02 engineering and technology ,Brain tissue ,Nanocomposites ,03 medical and health sciences ,Cell Line, Tumor ,Temozolomide ,medicine ,Animals ,Humans ,General Materials Science ,Particle Size ,Antineoplastic Agents, Alkylating ,030304 developmental biology ,0303 health sciences ,Molecular Structure ,Brain Neoplasms ,business.industry ,Ultrasound ,Neoplasms, Experimental ,021001 nanoscience & nanotechnology ,medicine.disease ,Ultrasound guided ,Ultrasonic Waves ,nervous system ,Physical Barrier ,Blood-Brain Barrier ,Signal tracking ,Drug delivery ,cardiovascular system ,Glioblastoma ,0210 nano-technology ,business ,Biomedical engineering - Abstract
The blood-brain barrier (BBB) is a physical barrier that selectively prevents certain substances from entering the brain through the blood. The BBB protects the brain from germs and causes difficulty in intracranial treatment. The chemotherapy drug temozolomide (TMZ), embedded in nanobubbles (NBs) and combined with persistent luminescent nanoparticles (PLNs), has been used to treat glioblastoma (GBM) effectively through image tracking. Through ultrasound induction, NBs produce cavitation that temporarily opens the BBB. Additionally, the PLNs release near-infrared emission and afterglow, which can penetrate deep tissues and improve the signal-to-noise ratio of bioimages. In this work, the nanosystem crossed the BBB for drug delivery and image tracking over time, allowing the enhancement of the drug's therapeutic effect on GBM. We hope that this nanosystem can be applied to the treatment of different brain diseases by embedding different drugs in NBs.
- Published
- 2021