1. Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6.
- Author
-
Dijokaite-Guraliuc, Aiste, Das, Raksha, Nutalai, Rungtiwa, Zhou, Daming, Mentzer, Alexander J., Liu, Chang, Supasa, Piyada, Dunachie, Susanna J., Lambe, Teresa, Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Huo, Jiandong, Stuart, David I., and Screaton, Gavin R.
- Subjects
SARS-CoV-2 Omicron variant ,SARS-CoV-2 ,MEDICAL sciences ,BOOSTER vaccines ,MEDICAL research ,MONOCLONAL antibodies - Abstract
Neutralization titers against BA.4.6 were significantly reduced compared to BA.4/5 for both breakthrough BA.1 (1.5-fold; I P i = 0.0006) and BA.2 (1.2-fold; I P i = 0.0384) serum samples. A small non-significant increase in neutralization titers against BA.4.6 was observed in the BA.4/5 breakthrough cohort compared to BA.4/5. It is not clear why the BA.2 and BA.4/5 neutralization titers using BA.2 and BA.4/5 serum respectively were not higher than titers for other SARS-CoV-2 variants as one might expect. [Extracted from the article]
- Published
- 2022
- Full Text
- View/download PDF