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Your search keyword '"Ingegnere, Tiziano"' showing total 2 results
Start Over Author "Ingegnere, Tiziano" Topic natural killer cells
2 results on '"Ingegnere, Tiziano"'

1. 'Markers and function of human NK cells in normal and pathological conditions.'

Author

Del Zotto, Genny, Marcenaro, Emanuela, Vacca, Paola, Sivori, Simona, Pende, Daniela, DELLA CHIESA, Mariella, Moretta, Francesca, Ingegnere, Tiziano, Mingari, MARIA CRISTINA, Moretta, Alessandro, and Moretta, Lorenzo

Subjects
Cytotoxicity, Immunologic, Histology, immune monitoring, immunophenotypin, viral infections, innate lymphoid cells, Graft vs Host Disease, immune check-points, immunophenotyping, Bone marrow transplant, cancer, cell biology, flow cytometry, haploidentical stem cell transplantation, immune check points, immune monitoring, immunophenotypin, immunotherapy, innate lymphoid cells, natural killer cells, viral infections, Animals, Graft vs Host Disease, Humans, Killer Cells, Natural, Leukemia, Phenotype, Receptors, KIR, Hematopoietic Stem Cell Transplantation, 2734, Histology, Cell Biology, Receptors, cell biology, Animals, Killer Cells, cancer, Humans, Leukemia, natural killer cells, Hematopoietic Stem Cell Transplantation, bone marrow transplant, immune check points, Flow Cytometry, KIR, Killer Cells, Natural, Phenotype, Natural, flow cytometry, haploidentical stem cell transplantation, immunotherapy, Biomarkers
Published
2017

2. PD-1 in human NK cells: evidence of cytoplasmic mRNA and protein expression.

Author

Mariotti, Francesca R., Petrini, Stefania, Ingegnere, Tiziano, Tumino, Nicola, Besi, Francesca, Scordamaglia, Francesca, Munari, Enrico, Pesce, Silvia, Marcenaro, Emanuela, Moretta, Alessandro, Vacca, Paola, and Moretta, Lorenzo

Subjects
KILLER cells, PROGRAMMED cell death 1 receptors, PROTEIN expression, ASCITIC fluids, CONFOCAL microscopy
Abstract

Under physiological conditions, PD-1/PD-L1 interactions regulate unwanted over-reactions of immune cells and contribute to maintain peripheral tolerance. However, in tumor microenvironment, this interaction may greatly compromise the immune-mediated anti-tumor activity. PD-1+ NK cells have been detected in high percentage in peripheral blood and ascitic fluid of ovarian carcinoma patients. To acquire information on PD-1 expression and physiology in human NK cells, we analyzed whether PD-1 mRNA and protein are present in resting, surface PD-1−, NK cells from healthy donors. Both different splicing isoforms of PD-1 mRNA and a cytoplasmic pool of PD-1 protein were detected. Similar results were obtained also from both in vitro-activated and tumor-associated NK cells. PD-1 mRNA and protein were higher in CD56dim than in CD56bright NK cells. Confocal microscopy analyses revealed that PD-1 protein is present in virtually all NK cells analyzed. The present findings are compatible with a rapid surface expression of PD-1 in NK cells in response to appropriate, still undefined, stimuli. [ABSTRACT FROM AUTHOR]

Published
2019
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