1. Restless Legs Symptoms and Periodic Leg Movements in Sleep Among Patients with Parkinson's Disease.
- Author
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Bliwise DL, Karroum EG, Greer SA, Factor SA, and Trotti LM
- Subjects
- Humans, Leg, Sleep physiology, Nocturnal Myoclonus Syndrome complications, Nocturnal Myoclonus Syndrome epidemiology, Parkinson Disease complications, Parkinson Disease epidemiology, Restless Legs Syndrome epidemiology, Restless Legs Syndrome etiology
- Abstract
Background: The association between restless legs syndrome (RLS) and Parkinson's disease (PD) remains controversial, with epidemiologic and descriptive evidence suggesting some potential overlap while mechanistic/genetic studies suggesting relative independence of the conditions., Objective: To examine a known, objectively measured endophenotype for RLS, periodic leg movements (PLMS) in sleep, in patients with PD and relate that objective finding to restless legs symptoms., Methods: We performed polysomnography for one (n = 8) or two (n = 67) consecutive nights in 75 PD patients and examined the association of PLMS with restless legs symptoms., Results: We found no association between restless legs symptoms and PLMS in PD. Prevalence of both was similar to data reported previously in other PD samples., Conclusion: We interpret these results as suggesting that restless legs symptoms in PD patients may represent a different phenomenon and pathophysiology than RLS in the non-PD population.
- Published
- 2022
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