Search

Guaiane sesquiterpenoids ( 1 , 2 ) were isolated from the gorgonian Menella woodin and their structures elucidated by extensive spectroscopic analysis. A complex approach was used to determine the configurations of the asymmetric centres in these natural products, based on the application of Mosher’s method, and the calculation of stable conformations of the rings along with a comparison of experimental ECD, NMR spectra, and specific optical rotations with those theoretically calculated by quantum-chemical methods. [ABSTRACT FROM AUTHOR]

Four new polyoxygenated sterol derivatives ( 1 – 4 ) along with the compounds ( 5 – 7 ) previously known from other biological sources were isolated from the gorgonian Menella woodin , collected from the Vietnamese waters. Structures of 1 – 4 were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses as well as comparison with those reported in literature data. Compounds 1 , 4 , and 6 decrease the production of reactive oxygen species (ROS) by the murine macrophages of RAW 264.7 line at induction by endotoxic lipopolysaccharide (LPS) from Escherichia coli . [ABSTRACT FROM AUTHOR]