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Twelve novel 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives were synthesized via iodine-mediated oxidative cyclisation and confirmed by 1H NMR, 13C NMR and HRMS. The result of these derivatives' activities inhibiting acetylcholinesterase in vitro showed that 4 g and 4i had moderate inhibitory activities with 69.19% and 65.06%, respectively. The preliminary structure-activity relationships revealed that introduction of halogen atom on the para-position of phenyl of 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives could enhance their activities. Molecular docking study suggested that 4 g possessed an optimal docking pose with interactions inside AChE. [ABSTRACT FROM AUTHOR]

Prenylated hydroquinones are the main meroterpenoids found in fungal species of the genus Ganoderma. A new prenylated hydroquinone ganocalidin G (1) was isolated from the fruiting bodies of Ganoderma calidophilum. The structure of compound 1 was identified based on 1D and 2D NMR spectroscopy as well as MS. Its absolute structure was elucidated from optical rotation calculation. The bioassay for inhibitory activity against AChE showed compound 1 had weak activity with an inhibition rate of 28.7% at a concentration of 100 μM. [ABSTRACT FROM AUTHOR]

A new macrolide cephalolidedifuran A (1), together with two known cephalosporolides B (2), and I (3), was isolated from the fungus Cordyceps spp., a strain from cell fusion between Cordyceps militaris and Cordyceps cicadae. Their structures were identified on the basis of 1D and 2D NMR spectroscopy as well as MS. The bioassay for anti-nematode activity of all the isolates showed that compounds 1 and 3 revealed moderate inhibitory activity against the nematode Panagrellus redivivus, with a mortality ratio of 48.35 and 59.16% at 2.5 mg/mL, respectively. Moreover, compounds 1–3 showed weak inhibitory activity against AChE at the concentration of 100 μM. [ABSTRACT FROM AUTHOR]

Four new ansamycin derivatives, named 1,19-epithio-geldanamycin A (1), 17-demethoxylherbimycin H (2), herbimycin M (3), and seco-geldanamycin B (4), together with eight known ansamycin analogues (5 – 12) were isolated from the solid fermentation of marine-derived actinomycete Streptomyces sp. ZYX-F-97. The structures of new compounds were elucidated by extensive spectroscopic analysis as well as nuclear magnetic resonance (NMR) and electronic circular dichroism (ECD) calculations. All the compounds were assayed for their antibacterial activity. Among them, compounds 4 , 8 , and 12 exhibited remarkable inhibition against Listeria monocytogenes with minimum inhibitory concentrations (MIC) values ranging from 8 μg·mL−1 to 64 μg·mL−1, and displayed moderate inhibition against methicillin-resistant Staphylococcus aureus (MRSA) with MIC value of 64 μg·mL−1. Compounds 4 , 8 , 9 , and 12 showed moderate inhibition activities against both Staphylococcus aureus and Bacillus subtilis with MIC values ranging from 32 μg·mL−1 to 128 μg·mL−1. [Display omitted] [ABSTRACT FROM AUTHOR]

A new alkaloid named methyl 2-(3,4-dihydro-2H-pyrrol-5-yl)acetate (1), together with 24 known compounds, was isolated from the acetone extract of the fruiting bodies of Ramaria stricta. Their structures were elucidated on HR-ESI-MS and extensive 1D and 2D NMR spectroscopy. The nematocidal assay showed that three compounds, benzoic acid, 3-hydroxy-2-methylbenzaldehyde, and 4-(hydroxy)benzylbenzoic acid, exhibited a certain activity against Panagrellus redivivus. [ABSTRACT FROM AUTHOR]

Three new compounds, 2-methyl-2,5,6-bornantriol (1), 4,4′-(3-hydroxypropane-1,1-diyl)diphenol (2), and 7-(4-methoxybenzyl)-4,5,6,7-tetrahydro-1,3-oxazepine-5,6-diol (3), were isolated from the fermentation broth of the soil actinomycete Streptomyces albospinus 15-4-2. Their structures were completely elucidated using the combination of 1D, 2D NMR techniques (COSY, HMQC, HMBC, and ROESY), and HR-ESI-MS analysis. None of the compounds 1–3 showed any inhibitory effect on Fusarium oxysporum f.sp. cubense race 4. [ABSTRACT FROM PUBLISHER]

A novel degraded sesquiterpene, named aquilarin B (1), together with two known compounds (2 and 3), was isolated from the EtOH extract of the fresh stem of Aquilaria sinensis (Lour.) Gilg. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR (HMQC, 1H–1H COSY, HMBC, and ROESY). The cytotoxic activities of the three compounds against three human tumor cell lines K562, SMMC-7721, and SGC-7901 were evaluated, and compound 3 exhibited obvious cytotoxic activity. [ABSTRACT FROM AUTHOR]

A new diterpene, named yucalexin P-23 (1), together with three known compounds, yucalexin P-15 (2), protocatechuic acid (3), and catalpinic acid (4), was isolated from the stems of Manihot esculenta. Their structures were determined by means of physicochemical evidence and spectral analysis. Compounds 3 and 4 exhibited antimicrobial activity. [ABSTRACT FROM AUTHOR]

A new drimane sesquiterpenoid glycoside, named 7-drimen-3β,11-diol 3-O-β-d-glucopyranoside, was isolated from the 95% EtOH extract of the seeds of Antiaris toxicaria (Pers.) Lesch. The chemical structure was completely elucidated using a combination of 1D and 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analysis. The compound showed inhibitory activities toward methicillin-resistant Staphylococcus aureus (MRSA), chronic myelogenous leukemia (K562), and human hepatoma (SMMC-7721) cell lines. [ABSTRACT FROM AUTHOR]

Seven compounds were isolated from a marine-derived fungus Aspergillus sp. ZF-79, including three new polyketides (1–3), named asperochrins D-F, along with four known compounds 4–7. Their structures were determined on the basis of spectroscopic methods. All the compounds were tested for quorum sensing inhibitory (QSI) activity. Compounds 1, 3, 4, 5, and 6 exhibited QSI activity against Chromobacterium violaceum CV026 with MIC values of 50, 100, 50, 50, and 6.25 μM, respectively. [ABSTRACT FROM AUTHOR]

A new sterol, named 6β-methoxyergosta-7,9(11),22E-triene-3β,5α-diol (1), together with seven known ones (2–8), was isolated from the fruiting bodies of Haddowia longipes. Their structures were identified on the basis of 1D and 2D NMR spectroscopy as well as MS. The inhibitory activity of these isolates against acetylcholinesterase (AChE) showed that compound 1 exhibited weak inhibitory activity. [ABSTRACT FROM AUTHOR]

Two new compounds, philippin (1) and 3β,9α,14α-trihydroxy-(22E,24R)-ergost-22-en-7-one (2), were isolated from the fruiting bodies of Ganoderma philippii. Their structures were elucidated on the basis of the spectroscopic technologies, including 1D and 2D NMR as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) showed compound 1 exhibited weak inhibitory activity against AChE. [ABSTRACT FROM AUTHOR]

Daphnauranins A ( 1 ) and B ( 2 ), two sesquiterpenoids were isolated from the roots of Daphne aurantiaca Diels. One is an unprecedented 5/7 oxacycloheptane ring system, the other is a sesquiterpene-lignan complex. Their structures were elucidated by comprehensive spectroscopic methods including MS and NMR. Their absolute configurations were further confirmed by the quantum ECD calculations. Daphnauranins A and B showed anti-insect activities against male fruit fly with anti-feeding rate up to 46.2 ± 7.1 and 44.7 ± 5.4% at 1 mM, respectively. [ABSTRACT FROM AUTHOR]

Nine lanostanoids, together with nine known ones, were isolated from the ethyl acetate extract of the fruiting bodies of the mushroom Haddowia longipes . Their structures were elucidated as 11-oxo-ganoderiol D, lanosta-8-en-7,11-dioxo-3β-acetyloxy-24,25,26-trihydroxy, lanosta-8-en-7-oxo-3β-acetyloxy-11β,24,25,26-tetrahydroxy, lanosta-7,9(11)-dien-3β-acetyloxy-24,25,26-trihydroxy, lanosta-7,9(11)-dien-3β-acetyloxy-24,26-dihydroxy-25-methoxy, 11-oxo-lucidadiol, 11β-hydroxy-lucidadiol, lucidone H and lanosta-7,9(11),24 E -trien-3β-acetyloxy-26,27-dihydroxy by analysing their 1D/2D NMR and MS spectra. In addition, bioassays of inhibitory activity against acetylcholinesterase (AChE) of all compounds showed that thirteen compounds possessed inhibitory activity against AChE with the percentage inhibition ranging from 10.3% to 42.1% when tested at 100 μM. [ABSTRACT FROM AUTHOR]

Eight tetranortriterpenoids (1–8) and two sesquiterpenoids (9 and 10) including two new compounds, cineracipadesin G (1) and 1β-hydroperoxy-6α-hydroxy-eudesm-4(15)-ene (9), were isolated from the EtOAc extract of branches of Cipadessa cinerascens. The structures of two new compounds were elucidated by 1D and 2D NMR and MS spectroscopic analyses. The anti-feedant activity of two tetranortriterpenoids (1 and 7) was tested and obvious anti-feedant effects were detected. [ABSTRACT FROM AUTHOR]

Daphnauranols A–C (1–3), three new sesquiterpenoids with an unprecedented 5/6/7 ring system, were isolated from the stems of Daphne aurantiaca Diels. Their structures were elucidated on the basis of comprehensive spectroscopic methods including MS and NMR. The absolute configuration of daphnauranol A was further confirmed by single crystal X-ray diffraction (Cu Kα). Their anti-feedant activity was tested, and the fruit fly antifeedant index (AI) were 39.8±7.2%, 29.4±7.2%, and 26.3±6.4%, respectively. [ABSTRACT FROM AUTHOR]

Abstract: Six new steroidal saponins, cambodianosides A–F (1–6), together with seven known ones, were isolated from the dragon's blood of Dracaena cambodiana. The structures of 1–6 were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. The cytotoxicities of all the isolated compounds were evaluated in vitro against three human cancer cell lines, and compounds 7, 8, and 11 showed significant inhibitory activities. [Copyright &y& Elsevier]

Abstract: Five new diterpenoids named excocarinols A–E (1–5) including three pimaranes, one cleistanthane, and one nor-beyerane, together with nine known compounds, were isolated from the EtOAc extract of the Chinese ethnodrug Gua-jing-ban (Excoecaria acerifolia Didr.). Their structures were elucidated by the analysis of spectroscopic data including 1D, 2D NMR and HR-MS. The anti-HIV-1 bioassay on the diterpenoids showed that excocarinol A (1) exhibited moderate anti-HIV-1 activity with EC50 5.58?M and SI (Selection Index) over 112.71. [Copyright &y& Elsevier]

Twelve lanostane triterpenoids (1–12) including a new one 16α,26-dihydroxylanosta-8,24-dien-3-one (1) were isolated from the fruiting bodies of Ganoderma hainanense. The structure of the new compound was elucidated by 1D and 2D NMR and MS spectroscopic analyses. All isolates were evaluated for their cytotoxicities against human tumor cell lines K-562, SMMC-7721, and SGC-7901 and five compounds (1, 2, 5,7, and 9) showed definite cytotoxicities against K-562 cell line. Meanwhile, compounds 2, 5,7, and 9 exhibited cytotoxic activities against SMMC-7721 and SGC-7901 cell lines. [ABSTRACT FROM AUTHOR]

Three new isopimarane diterpenoids named excoecarins F–H (1–3) were isolated from the EtOAc extract of the Chinese ethnodrug Gua-jing-ban (Excoecaria acerifolia Didr.). Their structures were elucidated by the analysis of spectroscopic data including 1D, 2D NMR and HR-MS. The anti-HIV-1 bioactivity test of 1 and 2 showed weak activity. [ABSTRACT FROM AUTHOR]

Three new lanostanoid triterpenes, 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid (1), 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid methyl ester (2), and 3β,15β-dihydroxy-7,11,23-trioxo-lanost-8,16-dien-26-oic acid methyl ester (3) were isolated from the EtOAc extract of the fruiting bodies ofGanoderma tropicum. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) of these isolates was evaluated and compound2exhibited definite inhibitory activity against AChE. [ABSTRACT FROM PUBLISHER]

A new tigliane-type diterpene ester, wiksphyllamin B ( 1), and one known compound, 12- O-benzoylphorbol 13-octanoate ( 2), were isolated from the stems of Wikstroemia scytophylla Diels. Their structures were identified using spectroscopic methods. The incorrect assignment of C NMR data of compound 2 in the literature was revised according to the 2D NMR spectra. [ABSTRACT FROM AUTHOR]

Two new norlignan derivatives, crassifoside I ( 1 ) and sinensigenin C ( 2 ), were isolated from the rhizomes of Curculigo capitulate, along with six known norlignan derivatives, 1,1-bis(3,4-dihydroxyphenyl)-1-(2-furan)-methane ( 3 ), crassifogenin B ( 4 ), crassifoside A ( 5 ), breviscaside A ( 6 ), crassifoside D ( 7 ), and curcapital ( 8 ). Their structures were elucidated on the basis of spectral evidence and comparisons with literature data. The 1H and 13C NMR data of compound 3 was first assigned. Compounds 3 – 7 were isolated from this plant for the first time. [Copyright &y& Elsevier]