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Objectives. This study aimed to analyze the effect of a four-week moderate-intensity exercise regimen on increasing growth hormone (GH) levels in individuals with obesity. Materials and methods. A total of 25 female individuals aged 20-25 years, with a body mass index (BMI) of 27.50-37.00 kg/m², were involved in the study and randomly divided into two groups, namely the control group (CON; n = 12) and the moderate-intensity exercise group (MIE; n = 13). The moderate-intensity exercise regimen (treadmill exercise for 30 minutes at 60-70% of HRmax, and resistance exercise for 30 minutes at 60-70% of 1RM) was conducted 3 times per week for a period of 4 weeks. Blood samples from participants were collected pre- and post-exercise sessions, and GH levels were analyzed using the Enzyme-Linked Immunosorbent Assay method. Data analysis techniques used the paired sample t-test with a significance level of 5 %. Results. The paired sample t-test results of GH levels between the pre-exercise and post-exercise sessions in the CON group showed a change from (1291.79 ± 383.76 to 1151.53 ± 484.80 pg/mL; p = 0.694), while the MIE group demonstrated the following dynamics of change — from (1161.79 ± 133.72 to 2103.83 ± 357.09 pg/mL; p = 0.006). Conclusions. The main findings of this study revealed that after implementing a four-week moderate-intensity exercise intervention, a significant increase in GH levels was observed in obese females.

The link between serum irisin levels and body fat markers has long been questioned in adult populations. However, there is scant research specifically addressing this link in obese female individuals. This study will thoroughly evaluate the relationship between serum irisin levels and adiposity indices in an obese female population. The study involved a group of 40 women, aged between 20 and 24 years, who were experiencing obesity. The correlations of serum irisin with adiposity markers measurements were determined. The statistical evaluation was conducted using a parametric linear correlation approach. Serum irisin levels, quantified in ng/mL, positively correlated with several adiposity indicators. Notably, there was a meaningful relationship with body weight in kilograms (r = 0.385, p = 0.014), body mass index (BMI) (r = 0.588, p ≤ 0.001), body fat percentage (r = 0.450, p = 0.004), total fat mass in kilograms (r = 0.342, p = 0.031), and lean body mass in kilograms (r = 0.344, p = 0.029). Furthermore, waist circumference in centimeters (r = 0.329, p = 0.038), hip circumference in centimeters (r = 0.321, p = 0.043), and the waist-to-hip ratio (r = 0.447, p = 0.004) also demonstrated positive correlations with irisin concentrations. Conversely, body height in meters showed no significant correlation (r = -0.003, p ≥ 0.05). Serum irisin’s relationship with adiposity markers is evident, yet it does not extend to body height. Interrelationships among adiposity markers might influence serum irisin in obese women after single-session exercise. Keywords: Serum irisin, adiposity markers, female, obesity.

The objective of this research is to establish the impact of endurance training of moderate intensity and resistance exercises on the mitigation of oxidative stress in students with obesity. The research engaged a cohort of 30 female students, characterized by obesity, with an age average of 22.30±1.92 years and a Body Mass Index (BMI) averaging 31.77±2.72 kg/m2. These participants were randomly allocated into three distinct groups: the control group (CN, n=10), the group undergoing endurance training (ET, n=10), and the group subjected to strength training (ST, n=10). The intervention involving endurance training was executed at an intensity level of 60-70% HRmax, with each training session lasting between 40 to 60 minutes. Whereas, the strength training regimen was implemented with a load intensity of 60-70% 1RM, 4-6 sets, and 12-15 repetitions for each set. The intervention was administered with a regularity of three times per week for four weeks. Data collection was carried out by taking blood samples before and 24 hours after the last intervention—analysis of MDA levels utilizing the TBARs technique served as an indicator of oxidative stress. The technique employed for data analysis was the ANOVA test, then continued with the LSD post hoc test with a significant level (p≤0.05). The results showed that the average pre-MDA levels in CN, ET, and ST were (31.07±5.97, 32.12±8.91, and 31.36±8.52 ng/mL) respectively p=0.953. The mean post-MDA levels in CN, ET, and ST were (32.14±11.46, 15.21±8.01, and 22.02±7.33 ng/mL) respectively p=0.001. The mean delta MDA levels in CN, ET, and ST were (1.08±14.83, -16.91±9.68, and -9.34±7.51 ng/mL) respectively p=0.005. The average changes in MDA levels in CN, ET, and ST were (9.09±48.42, -51.71±24.77, and - 27.85±25.31 %) respectively p=0.002. Our findings revealed that both the endurance and strength training interventions resulted in a reduction of oxidative stress, as evidenced by the observed decrease in MDA levels following the training sessions. However, endurance training intervention has a higher effect on suppressing the secretion of oxidative stress than strength training in obese students. Keywords: Endurance training, MDA levels, obesity, oxidative stress, strength training