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Your search keyword '"Shuyi Yao"' showing total 3 results
Start Over Author "Shuyi Yao" Topic organic chemistry
3 results on '"Shuyi Yao"'

1. Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives

Author

Jingkang Shen, Shuyi Yao, Shengli Pan, Lin Chen, Xin Wang, Yongliang Zhang, Tao Meng, Hui Xie, and Li Zhang

Subjects
laetispicine derivatives, antidepressant, total synthesis, forced swimming test, Organic chemistry, QD241-441
Abstract

The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds.

Published
2012
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3. Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives

Author

Hui Xie, Yongliang Zhang, Lin Chen, Li Zhang, Tao Meng, Shuyi Yao, Sheng-Li Pan, Jingkang Shen, and Xin Wang

Subjects
Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, laetispicine derivatives, antidepressant, total synthesis, forced swimming test, Article, Analytical Chemistry, lcsh:QD241-441, chemistry.chemical_compound, lcsh:Organic chemistry, Laetispicine, Amide, Drug Discovery, Benzodioxoles, Physical and Theoretical Chemistry, biology, Chemistry, Alkaloid, Organic Chemistry, Total synthesis, Piperaceae, biology.organism_classification, Antidepressive Agents, Chemistry (miscellaneous), Molecular Medicine, Antidepressant, Piper laetispicum, Behavioural despair test
Abstract

The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds.

Published
2012

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