1. Effects of repetitive transcranial magnetic stimulation on neuropathic pain: A systematic review and meta-analysis
- Author
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Yuling Wang, Kangyong Zheng, Ruihan Wan, Xue Jiang, Wangwang Yan, Xue-Qiang Wang, Lin Yangyang, Xiaoxia Zhu, and Ge Song
- Subjects
medicine.medical_specialty ,Cognitive Neuroscience ,medicine.medical_treatment ,Analgesic ,Cochrane Library ,Lesion ,Behavioral Neuroscience ,Physical medicine and rehabilitation ,Humans ,Pain Management ,Medicine ,Cerebral Cortex ,business.industry ,Therapeutic effect ,Chronic pain ,medicine.disease ,Transcranial Magnetic Stimulation ,Transcranial magnetic stimulation ,Treatment Outcome ,Neuropsychology and Physiological Psychology ,Meta-analysis ,Neuropathic pain ,Neuralgia ,Chronic Pain ,medicine.symptom ,business - Abstract
Neuropathic pain (NP) is a chronic pain condition caused by lesion or disease of the somatosensory nervous system. Repetitive transcranial magnetic stimulation (rTMS) is a neuroregulatory tool that uses pulsed magnetic fields to modulate the cerebral cortex. This review aimed to ascertain the therapeutic effect of rTMS on NP and potential factors regulating the therapeutic effect of rTMS. Database search included Web of Science, Embase, Pubmed, and Cochrane Library from inception to July 2021. Eligible studies included randomized controlled studies of the analgesic effects of rTMS in patients with NP. Thirty-eight studies were included. Random effect analysis showed effect sizes of -0.66 (95 % CI, -0.87 to -0.46), indicating that real rTMS was better than sham condition in reducing pain (P < 0.001). This comprehensive review indicated that stimulation frequency, intervention site, and location of lesion were important factors affecting the therapeutic effect. The findings of this study may guide clinical decisions and future research.
- Published
- 2022