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A recent study conducted by researchers at Southern Medical University in Guangzhou, China, explores the development of nanostructured cruciform phototheranostic agents for efficient multimodal imaging-guided type I photodynamic/photothermal synergistic therapy. The researchers designed and synthesized a series of organic phototheranostic agents and fabricated corresponding nanoparticles. These nanoparticles demonstrated excellent photoacoustic and photothermal imaging abilities, as well as superior tumoricidal activity in in vitro and in vivo experiments. The study provides valuable insights into the design and development of intelligent phototheranostic agents for multimodal imaging-guided synergistic therapy, with potential applications in the future. [Extracted from the article]

Researchers from Nanfang Hospital in Guangzhou, China have developed a deep learning model based on transformer models to accurately recognize gastric structures in capsule endoscopy images. The model achieved a high level of diagnostic accuracy, sensitivity, and specificity in identifying upper gastrointestinal structures. The researchers compared the model's performance to that of endoscopists and found that it was comparable, suggesting that the model could assist doctors in diagnosing gastric lesions and improve the efficiency of examinations. This research has been peer-reviewed and published in the Journal of Clinical Gastroenterology. [Extracted from the article]

A new report discusses research conducted at the Guangdong Provincial Hospital of Traditional Chinese Medicine in Guangzhou, China, on the effect of combining radioiodine therapy and Euthyrox in treating thyroid cancer with BRAF gene mutation following total thyroidectomy. The retrospective study analyzed records of 98 differentiated thyroid cancer patients with BRAF gene mutation who underwent total thyroidectomy between February 2018 and January 2020. The study found that combining radioiodine therapy and Euthyrox improved therapeutic outcomes, enhanced thyroid function, and reduced the risk of recurrence without increasing adverse reactions. The researchers suggest that further studies with larger sample sizes are needed to validate these findings. [Extracted from the article]

Researchers from Guangzhou Medical University in China have made a breakthrough in the treatment of bladder cancer. They have developed a method called cytomembrane-targeted photodynamic priming (PDP) that triggers an extracellular vesicle storm, allowing for deep penetration and complete destruction of bladder cancer cells. The PDP method disrupts and permeabilizes the extracellular matrix, promoting the penetration of nanotherapeutics. This research has the potential to improve the efficacy of antitumor drug delivery and provide better therapeutic outcomes for bladder cancer patients. [Extracted from the article]

A study conducted by researchers at the South China University of Technology explores the use of photodynamic therapy (PDT) as a non-invasive treatment for cancer. PDT relies on the generation of reactive oxygen species (ROS) by photosensitizers (PSs) under light irradiation to induce cancer cell death. However, solid tumors often have a hypoxic microenvironment that limits the efficacy of PDT. The researchers propose a new strategy for the development of efficient type I PSs that are less oxygen-dependent, using the photoinduced electron transfer (PET) mechanism. The study concludes that this PET strategy shows promise for PDT applications against hypoxic tumors. [Extracted from the article]

Researchers from Sun Yat-sen University in Guangzhou, China have discovered that a specific protein called fat mass and obesity-associated protein (FTO) plays a role in the development of rheumatoid arthritis (RA). The study found that FTO promotes synovial inflammation and joint damage in RA patients. Inhibiting FTO or reducing its expression resulted in reduced migration, invasion, and inflammatory response in RA fibroblast-like synoviocytes (FLS). The findings suggest that FTO could be a potential therapeutic target for RA. [Extracted from the article]

A recent report from Guangzhou Medical University in China discusses advancements in siRNA-based therapy. The researchers explored the use of PEGylated guanidinylated linear synthetic polypeptides (PGLSPs) to enhance the delivery of siRNA into the nucleus. The PGLSPs showed improved membrane penetration, reduced toxicity, high cellular uptake, and the ability to transport siRNA directly to the nucleus. The researchers concluded that PGLSPs hold promise as delivery vectors for transcriptional gene silencing and have potential for future therapeutic applications. [Extracted from the article]

A study conducted by the Guangdong Academy of Science in Guangzhou, China, explores the challenges of repairing critical-size bone defects and the need for biomaterials that promote osteogenesis, vascularization, and neurogenesis. The researchers developed a novel organic-inorganic composite material using 3D printing, which showed enhanced hydrophilicity, mineralization ability, compressive strength, and elastic modulus. The material also exhibited good cytocompatibility and effectively promoted osteogenesis, angiogenesis, and neurogenesis in vitro. In vivo experiments demonstrated that the material effectively repaired cranium defects and promoted the secretion of proteins related to bone regeneration and neurovascular formation. The study suggests that this composite material could be used in bone tissue engineering and presents a new concept for neurovascularized bone repair. [Extracted from the article]

Researchers at Guangzhou Medical University in China have conducted a study on the use of niobium nanoparticles in tissue engineering. The study found that niobium nanoparticles promote angiogenesis and bone regeneration by activating endothelial tip cells. The researchers identified the FOXA1-PAK4-YAP signaling pathway as the mechanism through which niobium nanoparticles regulate angiogenesis. This study provides insights into the potential use of niobium nanoparticles in tissue engineering and expands our understanding of their applications in this field. [Extracted from the article]

A pharmacovigilance study conducted by researchers at Sun Yat-sen University in Guangzhou, China, evaluated the safety profile of sugammadex, a neuromuscular blocking agent reversal agent. The study analyzed adverse events related to sugammadex reported in the FDA Adverse Event Reporting System (FAERS) database from 2009 to 2023. The researchers identified 98 sugammadex-related adverse events, including anaphylactic reactions, bradycardia, bronchospasm, and cardiac arrest. They also found 37 unexpected events not mentioned in official FDA labeling and 50 adverse events requiring observation. The study concluded that clinicians should be cautious of these potential risks, especially in patients with allergies or existing cardiovascular or respiratory conditions. [Extracted from the article]

A recent study conducted by researchers at South China Normal University examined the cultivation dynamics of dragon fruit in China and Vietnam from 2014 to 2022. Using nighttime light data and a random forest classifier, the researchers generated a historical map of dragon fruit cultivation areas and analyzed the spatiotemporal dynamics and drivers of dragon fruit trends. The results showed that the cultivation area and intensity of facility dragon fruit in China consistently increased, while those in Vietnam exhibited an increasing-decreasing trend. The study also found that the COVID-19 pandemic and government policies had significant impacts on dragon fruit cultivation in both countries. Overall, the research contributes to a better understanding of the global dynamics and drivers of dragon fruit cultivation. [Extracted from the article]

A recent report from Guangzhou Medical University in China discusses the challenges of classifying Hashimoto's thyroiditis (HT) lesions using ultrasound images. The researchers propose a Feature-level Boosting Ensemble Network (FBENet) to address these challenges. The FBENet was trained on 6,503 HT ultrasound images and achieved an average accuracy of 82.92% and an AUC of 89.24% when tested on 1,626 HT ultrasound images. This research provides valuable insights into improving the classification of HT lesions using ultrasound imaging. [Extracted from the article]

A study conducted by researchers at Southern Medical University in Guangzhou, China, has found that the cannabinoid receptor 2 (CB2) plays a significant role in renal fibrosis by inhibiting lipid metabolism in renal tubular cells. Renal fibrosis is a common feature in chronic kidney diseases, and tubular cell damage is a key characteristic resulting from dysregulated fatty acid oxidation and lipid accumulation. The study used CB2 knockout mice to establish a nephropathy model and found that CB2 activation led to dysfunction in fatty acid oxidation, lipid deposition, and fibrogenesis in tubular cells. Inhibition of CB2 or activation of peroxisome proliferator-activated receptor alpha (PPAR alpha) could effectively mitigate lipid accumulation and fibrogenesis induced by CB2. The study suggests that targeted inhibition of CB2 could be a potential therapeutic strategy for combating renal fibrosis. [Extracted from the article]

A recent study from Guangzhou Medical University in China explores the use of drug-eluting ureteral stents to combat bacterial infections and complications associated with urinary tract surgery. Ureteral stents are vulnerable to bacterial attack and can cause discomfort and complications. The study discusses various strategies, including drug-eluting stents, to reduce complications and improve stent performance. The research concludes that drug-eluting stents show promise and may be used in clinical settings in the future. [Extracted from the article]

Researchers from South China Agricultural University have conducted a study on the immunomodulatory activity of Caulerpa chemnitzia polysaccharides (CRVP) in macrophages. The study found that CRVP promotes cell proliferation, upregulates cytokine expression, and increases levels of nitric oxide and reactive oxygen species. The researchers also discovered that succinic acid plays a key role in the immunomodulatory effects of CRVP by regulating the expression of prolyl hydroxylase domain 2 (PHD2) and hypoxia-inducible factor-1 alpha (HIF1 alpha), thereby enhancing IL-1(3 expression. The study concludes that CRVP exerts its immunomodulatory activity in macrophages through the succinate/PHD2/HIF-1 alpha/IL-1(3 pathway. [Extracted from the article]

A study conducted by researchers at the South China University of Technology explores the effects of silicon (Si) and zinc (Zn) ions on the osteogenic differentiation of mesenchymal stem cells (mBMSCs). The researchers found that both Si and Zn ions have positive effects on cell proliferation, alkaline phosphatase (ALP) activity, and the expression of osteogenesis-related genes. In particular, the combination of Si (1.5 mM) and Zn (50 μM) had a synergistic enhancement on osteogenic differentiation compared to the individual ions. This study provides insights into the regulation mechanism of osteogenic differentiation by dual ions. [Extracted from the article]

Researchers from South China University of Technology have conducted a study to enhance the bone-forming performance of (3-TCP ceramic scaffolds by incorporating porosity-generating polystyrene microspheres. The study found that increasing the volume of microspheres enhanced porosity but reduced compressive strength. The optimal microsphere content was determined to be 20%, resulting in increased alkaline phosphatase activity and up-regulated expression of osteogenesis-related genes. The integration of microspheres and 3D printing enabled the fabrication of hierarchical porous (3-TCP ceramic scaffolds, which demonstrated superior ectopic osteogenic performance and bone defect repair efficacy. These findings have implications for clinical bone repair applications. [Extracted from the article]

Researchers from the South China University of Technology have conducted a preliminary transcriptome study on tendon aging to identify age-related genes in rotator cuff tendons. The study aimed to understand the potential differential gene expressions in tendons across different age groups and investigate their roles in tendon degeneration. The researchers identified 49 genes associated with advancing age in torn supraspinatus tendons, and five of these genes showed differential expression in lesioned tendons compared to normal tendons. The findings contribute to our understanding of tendon degeneration and may lead to strategies for reducing the incidence of rotator cuff tears. [Extracted from the article]

A recent study conducted by researchers at Southern Medical University in Guangzhou, China, has found that microRNA-29b (miR-29b) plays a crucial role in podocyte injury and the progression of diabetic kidney disease (DKD) by inducing mitochondrial dysfunction. The study discovered that miR-29b was induced in the urine of patients with DKD and was negatively correlated with kidney function and podocyte homeostasis. The researchers also found that miR-29b targeted a protein called peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha), which is involved in mitochondrial biogenesis and energy metabolism. Inhibition of miR-29b alleviated podocyte injury and preserved kidney function in animal models of DKD. The study suggests that miR-29b could serve as a novel biomarker for early diagnosis of DKD. [Extracted from the article]

A recent study conducted at South China Agricultural University has identified and characterized two novel xanthine oxidase inhibitory peptides, PDEAVAYG and IAAGLQNTG, from tea protein hydrolysate. These peptides showed significant inhibitory activity against xanthine oxidase, an enzyme involved in the production of uric acid. The study also found that PDEAVAYG and IAAGLQNTG were able to decrease cellular uric acid levels and regulate mRNA expression for factors associated with hyperuricemia. This research provides valuable insights for the development of functional foods or nutritional supplements targeting hyperuricemia. [Extracted from the article]

A study conducted by researchers at South China Agricultural University explores the use of electrospun nanofibers (ENFs) in food safety and quality analysis. ENFs are being recognized for their potential in developing high-performance sensing platforms for monitoring food safety and quality due to their customizable structures and high surface area. The study highlights the various applications of ENFs in detecting environmental toxins, identifying foodborne pathogens, analyzing food components, and monitoring freshness. However, challenges related to standardization and environmental impact need to be addressed for practical implementation. [Extracted from the article]

A recent study conducted by the Chinese Academy of Fishery Sciences has investigated the molecular mechanism of Vibrio parahaemolyticus (V. parahaemolyticus) infecting mud crabs. The study utilized genome sequencing analysis, survival experiments, and the expression patterns of related functional genes to understand the pathogenicity and lethality of V. parahaemolyticus. The results showed that V. parahaemolyticus LG2206, a strain with high pathogenicity, contained various adherence coding genes, virulence factor coding genes, and type III secretion system (T3SS) coding genes. The study provides valuable information for analyzing the molecular mechanism of V. parahaemolyticus infection and developing measures for disease prevention and control. [Extracted from the article]

A recent study conducted by Sun Yat-Sen University in Guangzhou, China, examined the effects of Mindfulness-enhanced Tai Chi Chuan (MTCC) training on mental and physical health among beginners. The study found that participants in the MTCC group experienced greater improvements in mindfulness, anxiety, stress, and physical fitness compared to those in the traditional Tai Chi Chuan (TCC) group. However, there were no significant differences between the two groups in terms of depression. The researchers concluded that MTCC can be recommended as an accessible and beneficial intervention for beginners to improve mental health and strengthen their bodies. [Extracted from the article]

New research from Southern Medical University in Guangzhou, China explores the link between maternal immune activation (MIA) and the risk of psychiatric disorders in offspring. The study used a mouse model to investigate the behaviors and gene expression profiles of female and male offspring. The findings suggest that MIA upregulates the AU020206-IRFs-STAT1 axis, which controls brain immunity and is linked to abnormal behaviors. This study provides insight into the role of MIA in psychiatric disorders. [Extracted from the article]

A report from the South China University of Technology explores the impact of upgrading strategies within ride-sourcing platforms, such as Uber and Lyft. The study suggests that offering high-class ride services without additional charges can help balance supply and demand and reduce the number of idle vehicles on the streets. The research provides operational insights for platform decisions and highlights the importance of adapting strategies to different supply-demand dynamics. The study was peer-reviewed and offers valuable information for those interested in travel behavior and society. [Extracted from the article]

A report from the Affiliated Brain Hospital of Guangzhou Medical University in Guangzhou, China, discusses the use of theme game-based learning in psychiatric violence risk assessment and response training for nursing students. The study found that integrating theme game-based learning into the training resulted in nursing students demonstrating superior skills and confidence in violence risk assessment and response compared to students in the situational simulation group. However, there was no significant difference in knowledge between the two groups. The research suggests that theme game-based learning can be effective in enhancing the violence management abilities of nursing students. [Extracted from the article]

A study conducted at Sun Yat-sen University in Guangzhou, China, focused on the delayed diagnosis of chronic ocular graft-versus-host disease (coGVHD) after allogeneic hematopoietic stem cell transplantation (alloHCT). The study included 118 patients newly diagnosed with coGVHD and found that most patients experienced a delay in diagnosis longer than 3 months. The delay in diagnosis was associated with disease severity and was more common among alloHCT recipients in southern China. The researchers concluded that improving patient education and awareness among ophthalmologists could facilitate early diagnosis of coGVHD. [Extracted from the article]

A study conducted at Sun Yat-sen University in Guangzhou, China, focused on improving the survival and integration ability of neural stem cell (NSC)-derived neural tissueoids for spinal cord development and repair. The researchers genetically engineered neural tissueoids in a NT-3 delivery scaffold to enhance retention and relay properties. By transplanting these LINGO-1-deficient neural tissueoids into a rat model with spinal cord injury, the researchers observed improved nerve fiber regeneration and connection, restored relay from the brain to the spinal cord, and improved hindlimb movement function. The study suggests that LINGO-1-deficient tissueoids could be an effective strategy for treating spinal cord injuries. [Extracted from the article]

Researchers at South China University of Technology have developed a new method for managing diabetic wounds. The study focused on the use of photo-responsive antibacterial therapy, specifically leveraging the properties of 2D heterojunction materials. The researchers engineered composite sprayed hydrogels that integrated Bi/MoS2 nano-heterojunctions, which demonstrated outstanding antibacterial efficacy when exposed to near-infrared light. The hydrogel not only accelerated wound healing but also promoted endothelial cell proliferation, vascularization, and angiogenesis. This research offers a promising avenue for the development of antimicrobial dressings for diabetic wound healing. [Extracted from the article]

New research from Southern Medical University in Guangzhou, China, explores the mechanism of hepatitis B virus (HBV) naked capsid egress. The study reveals that the K96 residue of the HBV core protein is critical for naked capsid egress, and intracellular egress-competent capsids are associated with ubiquitinated host proteins. The ESCRT-III-binding protein Alix and its Bro1 domain are required for naked capsid secretion, and the NEDD4 E3 ubiquitin ligase family member AIP4 stimulates the release of naked capsid. These findings provide new insights into the understanding of HBV naked capsid egress. [Extracted from the article]

A report from Southern Medical University in Guangzhou, China, explores the correlation between hepatitis B core antibody (anti-HBc) and the immune response to the hepatitis B virus (HBV). The study found that elevated levels of certain anti-HBc subtypes were associated with a favorable treatment response and virological response in patients with chronic hepatitis B. Additionally, the research identified a significant correlation between anti-HBc levels and the frequencies of HBV-specific CD8+ T cells. The findings suggest that anti-HBc may reflect the activation of an HBV-specific CD8+ T cell immune response and could potentially have anti-HBV activity. [Extracted from the article]

A study conducted by researchers at South China Normal University examined the association between depression, anxiety, and the development of obesity in children and adolescents in China. The study included over 200,000 school-aged children between the ages of 5 and 18. The findings revealed that there were bidirectional associations between obesity and psychological distress, with depression and anxiety increasing the risk of obesity over time, and obesity aggravating the risk of depression and anxiety. The researchers suggest that continuous monitoring of BMI and psychological conditions in children and adolescents is important to prevent negative interactions between these factors. [Extracted from the article]

A recent study conducted by researchers at the South China University of Technology has found that reducing iron levels in adipose tissue may help manage the metabolic complications associated with obesity. The study focused on the specific accumulation of oleic acid-modified polyoxovanadates (OPOVs) in adipose tissue, which led to a reduction in iron concentrations and improved glucose tolerance and insulin sensitivity in mice fed with a high-fat diet. The findings suggest that vanadate-based clusters could be used to target iron overload caused by obesity and improve metabolic health. This research has been peer-reviewed and provides valuable insights into the complex relationship between iron metabolism and obesity. [Extracted from the article]

Researchers from Guangzhou University of Chinese Medicine have developed a method for the detection of long non-coding RNAs (lncRNAs) in hepatocyte and serum samples, which could aid in the early diagnosis of liver cancer. The method utilizes a DNA-peptide probe coupled with mass spectrometry-based quasi-targeted proteomics to directly quantify lncRNAs without the need for amplification. The researchers successfully applied this method to analyze the levels of highly upregulated in liver cancer (HULC) lncRNA in liver cancer cell lines and serum samples. The integration of mass spectrometry and DNA-peptide probe technology shows promise for enhancing liver cancer diagnostics. [Extracted from the article]

A study conducted by researchers at Guangzhou University in China has developed a new model for predicting occult lymph node metastasis in non-small cell lung cancer (NSCLC) patients. The model, called OLNM-Net, utilizes a self-supervised learning approach and hyperbolic metric few-shot learning to improve the accuracy of predicting occult metastases. The research demonstrates that OLNM-Net outperforms existing models and provides new insights into the preoperative assessment of NSCLC, advancing the application of machine learning in medical diagnostics. The study was supported by the Guangzhou Youth Science and Technology Education Project and has been peer-reviewed. [Extracted from the article]

A study conducted by researchers at South China Normal University in Guangzhou, China, explores the use of aerobic granular sludge (AGS) for the treatment of swine wastewater. Swine wastewater contains high levels of pollutants, antibiotics, and antibiotic resistance genes (ARGs), which require effective elimination. The study found that AGS reactors showed promising results in removing antibiotics, particularly sulfonamides, from the wastewater. Process optimization, including the introduction of an additional anoxic phase, improved denitrification and reduced ARG levels. The study provides valuable insights into the application of AGS for real swine wastewater treatment. [Extracted from the article]

A study conducted by researchers at Sun Yat-sen University in Guangzhou, China, explores the role of RNA modifications in cancer development. Specifically, the study focuses on the RNA ac4C 4 C modification, also known as N4-acetylcytidine, and its influence on various stages of the RNA lifecycle. The researchers discuss the molecular mechanisms and biological functions of this modification and its impact on the pathogenesis and progression of cancer. They also highlight the potential for manipulating this modification as a novel therapeutic strategy for more effective cancer treatments in the future. The study has been peer-reviewed and provides an integrated overview of current methodologies for detecting RNA ac4C 4 C modification. [Extracted from the article]

Researchers at Guangzhou University in China have developed a new photocatalytic hydrogel system for removing oxytetracycline (OTC) from wastewater. OTC is an antibiotic that poses environmental risks due to its persistence in ecosystems. The hydrogel, called CA-BiOBr 0.75 I 0.25 , demonstrated rapid adsorption and achieved a 90.92% degradation rate of OTC within 60 minutes under visible light. The system also showed excellent stability and reusability. This research highlights the potential of the hydrogel as a sustainable solution for advanced wastewater treatment technologies. [Extracted from the article]

Researchers at South China Agricultural University have discovered that trans-cinnamaldehyde, a compound found in cinnamon, can effectively inhibit the growth of multidrug-resistant Escherichia coli (E. coli) by disrupting the integrity of its cell wall. The compound causes an imbalance between lipopolysaccharide (LPS) and phospholipids in the cell wall, leading to structural changes and the leakage of proteins and DNA/RNA. This ultimately results in the death of the bacteria. The findings suggest that trans-cinnamaldehyde could be a potential drug candidate for preventing and treating infectious diseases caused by resistant E. coli strains. [Extracted from the article]

A recent study conducted by researchers at Sun Yat-sen University in Guangzhou, China, has found that a novel gold-based complex called GC7 has the potential to suppress cancer cell proliferation by impacting energy metabolism mediated by mitochondria. The researchers synthesized and evaluated GC7 in various cancer cell lines and found that it exhibited a broad-spectrum anticancer effect, with greater potency than the gold-based compound auranofin. GC7 was shown to induce apoptosis in cancer cells, inhibit cellular thioredoxin reductase activity, suppress mitochondrial oxygen consumption rate, reduce glucose uptake, and possibly suppress glycolysis. Animal models also demonstrated the tumor-suppressing effects of GC7. The study suggests that GC7 could be a promising candidate for cancer therapy. [Extracted from the article]

A recent report from Guangzhou University of Chinese Medicine discusses the development of a potential therapeutic strategy for hepatocellular carcinoma, a common and fatal form of liver cancer. The researchers focused on using dihydroartemisinin (DHA), a derivative of artemisinin, to target mitochondria and induce apoptosis in cancer cells. They created carrier-free nanoparticles that delivered DHA to the tumor site, increasing intracellular reactive oxygen species and mitochondrial stress. In vivo experiments showed promising anti-tumor effects. This research provides insight into a potential treatment option for hepatocellular carcinoma. [Extracted from the article]

Researchers from Guangdong Pharmaceutical University in Guangzhou, China have discovered a new water-soluble polysaccharide called PF90-1, derived from the fibrous root of Pseudostellaria heterophylla. PF90-1 has been found to have anti-inflammatory and antioxidant properties, as it inhibits nitric oxide production and reduces the levels of pro-inflammatory factors. The researchers suggest that PF90-1 could potentially be used as a therapeutic treatment for inflammatory and oxidative injuries. This research has been peer-reviewed and published in the journal Natural Product Research. [Extracted from the article]

Researchers from South China University of Technology have conducted a study on the use of metal-organic frameworks (MOFs) for drug delivery enhancement in cancer treatment. The study focused on the elimination of gelation, a common issue in the dissolution of co-amorphous (COAM) systems. The researchers used a Zr-based MOF called nanoUiO-67 as a drug carrier for the anti-cancer drug gefitinib (GTB) and co-former saccharin (SAC). The study demonstrated the potential of this strategy in gelation elimination and the development of multi-component drug-loaded MOFs. The research has been peer-reviewed and published in the Chemical Engineering Journal. [Extracted from the article]

Researchers at the South China University of Technology have developed composite nanofibers that can efficiently deliver the compound quercetin to the colon and achieve sustained release. Quercetin is known for its multiple biological activities and potential anticancer properties. The nanofibers, which were coated with pH-responsive shellac on hydrophilic gelatin, demonstrated high stability in the upper gastrointestinal tract and released quercetin in the colon after oral administration. In vitro and in vivo studies confirmed the enhanced anticancer activity of the composite nanofibers. The researchers believe that this system could also be used to deliver other bioactives to the colon and exert their functional effects. [Extracted from the article]

A recent study conducted by researchers at Sun Yat-sen University in Guangzhou, China, aimed to identify potential drug targets for myopia. The study utilized Mendelian randomization to assess the effect of pharmacologically targetable genes on the risk of myopia. The researchers identified six potential genetically causal targets for myopia, including CD34, CD55, Wnt3, LCAT, BTN3A1, and TSSK6. Functional analysis suggested that pathways involved in dopaminergic neuron differentiation, cell adhesion, Wnt signaling, and plasma lipoprotein may be implicated in myopia pathogenesis. The study provides new insights into the development of therapeutic interventions for myopia and a better understanding of its underlying mechanisms. [Extracted from the article]