1. Phenolic composition, antioxidant and antinociceptive activities of Syringa vulgaris L. bark and leaf extracts.
- Author
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Varga E, Barabás C, Tóth A, Boldizsár I, Noszál B, and Tóth G
- Subjects
- Analgesics chemistry, Animals, Antioxidants chemistry, Chromatography, High Pressure Liquid methods, Drug Evaluation, Preclinical methods, Flavonoids analysis, Glucosides analysis, Male, Mice, Phenylpropionates analysis, Plant Bark chemistry, Plant Extracts analysis, Plant Leaves chemistry, Tandem Mass Spectrometry, Analgesics pharmacology, Antioxidants pharmacology, Phenols analysis, Plant Extracts pharmacology, Syringa chemistry
- Abstract
Metabolite profile, antioxidant and antinociceptive activities of Syringa vulgaris bark and leaf methanolic extracts were investigated. By means of HPLC-DAD-ESI-TOF and HPLC-DAD-ESI-MS/MS, a total of 33 phenolics were identified, including 15 secoiridoids, 6 phenylpropanoids, 3 flavonoids, 3 lignans and 6 low molecular weight phenols. Validated quantitative analysis show that syringin (2.52%) and rutin (1.13%) are the main phenolic compounds in bark and leaf, respectively. Notable radical scavenging and antinociceptive activities of the bark and leaf extracts were confirmed by in vitro DPPH
● and ABTS●+ assays and by in vivo hot-plate method in mice, respectively. Our results could lay the scientific basic of future clinical perspectives of lilac bark and leaf.- Published
- 2019
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