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2024 OCT 5 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Nerve myo-inositol depletion, which has been implicated in the pathogenesis of acute experimental diabetic neuropathy, can be reproduced in normal rats by feeding diets enriched in L-fucose, a competitive inhibitor [...]

myo-Inositol depletion as a result of hyperglycemia is considered one of the leading contributors to chronic diabetic complications. We investigated the possible mechanisms through which elevated extracellular glucose levels affect [...]

To clarify the relationship between abnormality of sorbitol and/or myo-inositol metabolism caused by hyperglycemia and diabetic macroangiopathy, we investigated the effects of high glucose concentrations and epalrestat, an aldose reductase [...]

L-Fucose is a monosaccharide that occurs in low concentrations in normal serum but has been shown to be increased in diabetic individuals. In cultured mammalian cells, L-fucose is a potent [...]

We evaluated whether insulin-receptor tyrosine kinase activity is required for activation of PDH, insulin-induced hydrolysis of PIG and generation of IG and 1-2-DAG. For the analysis, we used stable-transfected CHO [...]

Culture of the postimplantation rat conceptus in hyperglycemic medium causes developmental abnormalities and is associated with a diminished water-soluble myo-inositol content. We investigated the effect myo-inositol depletion has on lipid-soluble [...]

Abnormal myoinositol metabolism has been implicated as a contributor to the development of diabetic nueropathy. Futhermore, in vitro glucose inhibits animal and human myoinositol transport is abnormal in diabetic subjects [...]

Diabetes mellitus is associated with a significant reduction in the serum concentration of [Mg.sup.2+]. Several studies have suggested that hypomagnesemia may be implicated in the etiology of diabetic complications; however, no mechanism has been proposed. This study demonstrates that [Mg.sup.2+] is a positive effector of inositol transport and is capable of promoting a 2.5-fold increase in the affinity of the transporter for inositol. Analysis of the kinetics of inositol transport shows that, at physiological concentrations of inositol, the reductions in [Mg.sup.2+] concentrations that occur in diabetic patients would result in a significant decline in the rate of inositol transport (1.5- to 2-fold). We suggest that hypomagnesemia may be linked to the development of diabetic complications via reduction in the rate of inositol transport and subsequent intracellular inositol depletion. This assertion allows hypomagnesemia and the polyol theory to be unified into one mechanistic model for the development of diabetic complications. Diabetes 41:35-39, 1992, The polyol or sorbitol theory has been proposed as a unifying mechanism underlying the diversity of diabetic complications[1]. This hypothesis states that hyperglycemia drives the intracellular accumulation of sorbitol with [...]

Still a popular choice for the treatment of manic depression despite the emergence of more-modem drugs, lithium is an enigma. No one really knows how it evens out the moods [...]

Last March, the Food and Drug Administration announced it would soon require U.S. food manufacturers to fortify many of their products with folate. This B vitamin can cut the risk [...]