1. Novel Biodegradable pH/Thermosensitive Hydrogels: Part 1. Preparation and Characterization.
- Author
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Dong, Kai, Xu, Wei, You, CuiYu, Xing, JianFeng, Zhang, YeJi, Gao, Yang, and Wang, Ke
- Subjects
BIODEGRADABLE plastics ,HYDROGEN-ion concentration ,POLYMER colloids ,POLYETHYLENE glycol ,METHACRYLIC acid ,ULTRAVIOLET radiation ,POLYMERIZATION - Abstract
A series of biodegradable and pH/thermosensitive hydrogels based on monomethoxyl poly(ethylene glycol) (MPEG), poly(ϵ-caprolactone) (PCL), methylacrylic acid (MAA), and N-Isopropylacrylamide (NIPAAm) were prepared by UV-initiated free radical polymerization method. Swelling behavior and hydrolytic degradable behavior in aqueous medium with different pH values and pH/thermosensitivity of the hydrogels were studied in detail. The prepared biodegradable pH/thermo-sensitive hydrogels based on PCL, MPEG, MAA, and NIPAAm may have great potential application in smart drug delivery system. [ABSTRACT FROM PUBLISHER]
- Published
- 2013
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