Search

Research has been conducted on the allene chemistry. The results of the palladium(0)-catalyzed coupling-cyclization of 2,3-allenamides and organic iodides are presented.

Research has been conducted on palladium(II)-catalyzed lactonization reaction. Results indicate that regioconvergent lactone synthesis from the olefin equimolar mixture has been achieved via palladium(II) chemistry.

Research has been conducted on the farnesol's alpha-phosphono lactone derivative. The preparation of this derivative in racemic and nonracemic forms has been carried out in producing farnesyl pyrophosphate analogue and the details are presented.

Research has been conducted on the sphingomyelin carbon analogues. The stereocontrolled synthesis of these analogues has been carried out via Hoffmann rearrangement of beta-hydroxyamide which has been prepared by asymmetric hydrogenation of alpha-acyl-gamma-butyrolactone and ring opening with NH (sub)3.

Research has been conducted on the catalytic asymmetric acyl halide-aldehyde cyclocondensation reaction. The implementation of the reaction design is described and the results indicate that the reaction strategy allows to employ differentially substituted organocuprates in the 4-substituted 2-oxetanone ring opening.

Research has been conducted on the ginkgolide C. Selective acetylation of ginkgolide C hydroxyl groups has been carried out and the results are reported.

Research has been conducted on the terpenoid lactones isolated from a marine sponge. The results of the Diels-Alder cyclization reaction which has produced tricyclic lactones are reported.

Research has been conducted on the samarium(II) iodide. The use of this compound in the presence of nickel(II) iodide in promoting intramolecular conjugate alkyl halide additions onto alpha,beta-unsaturated lactones is described.

Research has been conducted on the exo-glycans. Different methods used for the stereoselective synthesis of these compounds have been investigated and the details are reported.

Research has been conducted on the intramolecular Diels-Alder reaction. The thermolysis of dienals prepared in the presence of zinc metal with ethyl 2-bromo-methylacrylate has produced tricyclic cycloadducts in the intramolecular Diels-Alder reaction.

Research has been conducted on the Pauson-Khand reaction. The study of this reaction of enyne systems built on the 1,2-isopropylidenedioxyfuranoside scaffold which leads to the chiral cyclopenta[c]-pyran skeleton constituting the irridoid skeleton framework such as loganin, iridomyrmecin and boschanialactone has been carried out and the results are reported.

Research has been conducted on the tandem [2+2] cycloaddition-Dieckmann condensation via the ynolate anions which are important for the reactive beta-lactone enolate formation. The use of this reaction in a one-pot synthesis of highly substituted naphthalenes is described.

Research has been conducted on the asteriscanolide. The use of the intramolecular Pauson-Khand cycloaddition and a ring-closing metathesis in the synthesis of this asteriscanolide is described.

Research has been conducted on the macrocyclic lactones. The synthesis of these lactones carried out via the ring-closing olefin metathesis is described.

Research has been conducted on the ring-opening lactone halosilation. The halosilation of the lactones with different reagents, such as Et (sub)3 SiH/MeI(PdCl (sub)2) and Et (sub)3 SiH/AllylBr(PdCl (sub)2) has been explored.

Research has been conducted on the C18 methyl group with the fused C-ring lactone rearranged to a spiro lactone. The oxidative functionalization method developed for this group is described.